Suchergebnisse - "Phosphorylation drug effects"

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

Autoren: Conchita Fraguas Bringas Mohd Syed Ahangar Joyceline Cuenco et al.

Quelle: Fraguas Bringas, C, Ahangar, M S, Cuenco, J, Liu, H, Addinsall, A B, Lindahl, M, Ovens, A J, Febbraio, M A, Foretz, M, Göransson, O, Scott, J W, Zeqiraj, E & Sakamoto, K 2025, ' Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827 ', Science Advances, vol. 11, no. 34, pp. eadx2434 . https://doi.org/10.1126/sciadv.adx2434

Schlagwörter: Models, Molecular, AMP-Activated Protein Kinases/antagonists & inhibitors, Pyrones, Protein Kinase Inhibitors/pharmacology, Biphenyl Compounds, Humans, Phosphorylation/drug effects, Animals, Hepatocytes/metabolism, Thiophenes/pharmacology, Lipogenesis/drug effects

Dateibeschreibung: application/pdf

Zugangs-URL: https://curis.ku.dk/ws/files/499155713/sciadv.adx2434.pdf

T cell toxicity induced by tigecycline binding to the mitochondrial ribosome

Autoren: Qiuya Shao Anas Khawaja Minh Duc Nguyen et al.

Quelle: Nat Commun
Nature Communications, Vol 16, Iss 1, Pp 1-13 (2025)
Shao, Q, Khawaja, A, Nguyen, M D, Singh, V, Zhang, J, Liu, Y, Nordin, J, Adori, M, Axel Innis, C, Castro Dopico, X & Rorbach, J 2025, 'T cell toxicity induced by tigecycline binding to the mitochondrial ribosome', Nature Communications, vol. 16, no. 1, 4080. https://doi.org/10.1038/s41467-025-59388-9

Schlagwörter: Protein Biosynthesis/drug effects, Binding Sites, Science, T-Lymphocytes, Cryoelectron Microscopy, Mitochondrial Ribosomes/metabolism, Minocycline, Tigecycline, Article, Oxidative Phosphorylation, Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents, Mitochondria, Mitochondrial Ribosomes, T-Lymphocytes/drug effects, Minocycline/analogs & derivatives, Protein Biosynthesis, Mitochondria/metabolism, Humans, Tigecycline/toxicity, Oxidative Phosphorylation/drug effects

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40312422
https://doaj.org/article/e532be8fc8144233af66616996fe94f8

Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer

Autoren: Alicia-Marie K. Beier Celina Ebersbach Tiziana Siciliano et al.

Quelle: Oncogene

Schlagwörter: Male, 0301 basic medicine, 0303 health sciences, Glutamine, Prostatic Neoplasms, Antineoplastic Agents, Docetaxel, Article, Oxidative Phosphorylation, 03 medical and health sciences, Glutaminase, Drug Resistance, Neoplasm, Cell Line, Tumor, 96/34, Cell Line, Tumor [MeSH], Prostatic Neoplasms/metabolism [MeSH], Prostatic Neoplasms/drug therapy [MeSH], Prostatic Neoplasms/pathology [MeSH], Antineoplastic Agents/pharmacology [MeSH], 96/109, 96/31, 13/51, Glutaminase/antagonists, Male [MeSH], 631/67/2327, Glutaminase/genetics [MeSH], 96/63, Drug Resistance, Neoplasm [MeSH], Docetaxel/pharmacology [MeSH], Humans [MeSH], Glutamine/metabolism [MeSH], 631/67/589/466, Oxidative Phosphorylation/drug effects [MeSH], Prostatic Neoplasms/genetics [MeSH], Glutaminase/metabolism [MeSH], Antineoplastic Agents/therapeutic use [MeSH], 38/89, 13/105, Cell Proliferation/drug effects [MeSH], article, Humans, Cell Proliferation

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38750263
https://repository.publisso.de/resource/frl:6504923

CDK6 kinase inhibition unmasks metabolic dependencies in BCR::ABL1+ leukemia

Autoren: Scheiblecker, Lisa Klampfl, Thorsten Doma, Eszter et al.

Quelle: Cell Death Dis
Cell Death and Disease, Vol 16, Iss 1, Pp 1-11 (2025)

Schlagwörter: Cyclin-Dependent Kinase 6 Antagonists & Inhibitors, Imatinib Mesylate Pharmacology, Pyridines, Mitochondria Drug Effects, Fusion Proteins, bcr-abl, Protein Kinase Inhibitors Pharmacology, Deoxy Glucose, Leukemia, Myelogenous, Chronic, BCR-ABL Positive Pathology, Imatinib Mesylate Therapeutic Use, Apoptosis, Deoxyglucose, Article, Piperazines, Oxidative Phosphorylation, Leukemia, Myelogenous, Chronic, BCR-ABL Positive Metabolism, Cell Drug Effects, Drug Resistance, Neoplasm Drug Effects, Cell Line, Tumor, Fusion Proteins, bcr-abl Metabolism, Oxidative Phosphorylation Drug Effects, Humans, Mitochondria Metabolism, Protein Kinase Inhibitors, Cell Proliferation, Glycolysisdrug Effects, Leukemia, QH573-671, Cyclin-Dependent Kinase 6, Leukemia, Myelogenous, Chronic, BCR-ABL Positive Genetics, Piperazines Pharmacology, Pyridines Pharmacology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive Drug Therapy, Fusion Proteins, bcr-abl Genetics, Mitochondria, Cyclin-Dependent Kinase 6 Metabolism, Drug Resistance, Neoplasm, Apoptosisdrug Effects, Imatinib Mesylate, Deoxy Pharmacology, K562 Cells, Cytology, Glycolysis

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39966356
https://doaj.org/article/febe63f417904fd6ae1fd7ef05515b55
https://phaidra.vetmeduni.ac.at/o:3977
https://doi.org/10.1038/s41419-025-07434-1

Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival

Autoren: Komza, M. Khatun, J. Gelles, J.D. et al.

Quelle: Cell Commun Signal
Cell Communication and Signaling, Vol 23, Iss 1, Pp 1-23 (2025)
Cell communication and signaling, vol. 23, no. 1, pp. 47

Schlagwörter: Adaptations, Leukemia, QH573-671, Cell Survival, Research, Humans, Mitochondria/metabolism, Mitochondria/drug effects, Glucose/metabolism, Cell Survival/drug effects, Leukemia, Myeloid, Acute/pathology, Leukemia, Myeloid, Acute/metabolism, Leukemia, Myeloid, Acute/genetics, Leukemia, Myeloid, Acute/drug therapy, Cell Respiration/drug effects, Glycolysis/drug effects, Oxidative Phosphorylation/drug effects, Cell Line, Tumor, Adaptation, Physiological, Bioenergetics, Cancer, Chemotherapy, Glucose, Metabolism, Mitochondria, Oncogenes, Stem cells, Cell Respiration, Oxidative Phosphorylation, Leukemia, Myeloid, Acute, Medicine, Cytology, Glycolysis

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39863913
https://doaj.org/article/1ee0edd56afb478b807dd13d66caf1ab
https://serval.unil.ch/resource/serval:BIB_903FD8FB36B8.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_903FD8FB36B8
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_903FD8FB36B84

Semiautomatic quantification of 3D Histone H3 phosphorylation signals during cell division in Arabidopsis root meristems

Autoren: Kelemen, Adrienn Uyttewaal, Magalie Máthé, Csaba et al.

Weitere Verfasser: Kelemen, Adrienn Uyttewaal, Magalie Máthé, Csaba et al.

Quelle: ISSN: 0028-646X.

Schlagwörter: 3D image analysis, signal quantification, PP2A, histone phosphorylation, cell division, MESH: Arabidopsis Proteins / metabolism, MESH: Arabidopsis* / cytology, MESH: Mitosis / drug effects, MESH: Mutation / genetics, MESH: Phosphorylation / drug effects, MESH: Plant Roots* / cytology, MESH: Plant Roots* / metabolism, MESH: Signal Transduction* / drug effects, MESH: Arabidopsis* / drug effects, MESH: Arabidopsis* / metabolism, MESH: Cell Division* / drug effects, MESH: Histones* / metabolism, MESH: Imaging, Three-Dimensional* / methods, MESH: Meristem* / cytology, MESH: Meristem* / drug effects, MESH: Meristem* / metabolism, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/40619913; PUBMED: 40619913; WOS: 001523618500001

Verfügbarkeit: https://hal.inrae.fr/hal-05233351
https://hal.inrae.fr/hal-05233351v1/document
https://hal.inrae.fr/hal-05233351v1/file/2025_Kelemen-nph70365.pdf
https://doi.org/10.1111/nph.70365

Targeting the Electron Transport System for Enhanced Longevity

Autoren: Radovic, Marko Gartzke, Lucas P Wink, Simon E et al.

Quelle: Radovic, M, Gartzke, L P, Wink, S E, van der Kleij, J A, Politiek, F A & Krenning, G 2025, 'Targeting the Electron Transport System for Enhanced Longevity', Biomolecules, vol. 15, no. 5, 614. https://doi.org/10.3390/biom15050614

Schlagwörter: Humans, Longevity/drug effects, Electron Transport/drug effects, Metformin/pharmacology, Animals, Mitochondria/metabolism, Sirolimus/pharmacology, Reactive Oxygen Species/metabolism, Oxidative Phosphorylation/drug effects

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/40427507; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/ba16c68f-7ad9-4011-90d6-dde37981aaf8; info:eu-repo/semantics/altIdentifier/pissn/2218-273X; info:eu-repo/semantics/altIdentifier/eissn/2218-273X

Verfügbarkeit: https://hdl.handle.net/11370/ba16c68f-7ad9-4011-90d6-dde37981aaf8
https://research.rug.nl/en/publications/ba16c68f-7ad9-4011-90d6-dde37981aaf8
https://doi.org/10.3390/biom15050614
https://pure.rug.nl/ws/files/1326108163/biomolecules-15-00614-v2.pdf
https://www.scopus.com/pages/publications/105006678175

Histone Deacetylase 7‐Derived 7‐Amino Acid Peptide Increases Skin Wound Healing via Regulating Epidermal Fibroblast Proliferation and Migration

Autoren: Liu, H Li, H Bai, X et al.

Quelle: J Cell Mol Med
Liu, H, Li, H, Bai, X, Zhao, Y, Cai, Y, Pan, H, Guo, L, Liu, K, Liu, Q, Huang, X, Zampetaki, A, Margariti, A, Zeng, L & Cai, T 2024, 'Histone deacetylase 7-derived 7-amino acid peptide increases skin wound healing via regulating epidermal fibroblast proliferation and migration', Journal of Cellular and Molecular Medicine, vol. 28, no. 22, e70209. https://doi.org/10.1111/jcmm.70209

Schlagwörter: Male, 0301 basic medicine, Cell Movement/drug effects, Histone Deacetylases, Cell Proliferation/drug effects, Rats, Sprague-Dawley, 03 medical and health sciences, Cell Movement, Signal Transduction/drug effects, Animals, Humans, Phosphorylation, Wound Healing/drug effects, Cell Proliferation, Skin, Fibroblasts/metabolism, Peptides/pharmacology, Wound Healing, 0303 health sciences, Phosphorylation/drug effects, Cyclin-Dependent Kinase 6, Fibroblasts, Cyclin-Dependent Kinase 6/metabolism, Rats, Skin/drug effects, Original Article, Sprague-Dawley, Histone Deacetylases/metabolism, Epidermis, Peptides, Epidermis/metabolism, Signal Transduction

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39601342
https://pure.qub.ac.uk/en/publications/e3aeeeff-73c7-44c4-9f37-e47063296fb0

Chitinase 3-like 1 is involved in the induction of IL-8 expression by double-stranded RNA in airway epithelial cells

Autoren: Jae Woo Lee Mi Na Kim Eun Gyul Kim et al.

Weitere Verfasser: Jae Woo Lee Mi Na Kim Eun Gyul Kim et al.

Quelle: Biochemical and Biophysical Research Communications. 592:106-112

Schlagwörter: 0301 basic medicine, Respiratory Syncytial Virus Infections / pathology, MAP Kinase Signaling System, Lung / cytology, Respiratory Syncytial Virus Infections, Epithelial Cells / virology, Cell Line, MAP Kinase Signaling System / drug effects, 03 medical and health sciences, Airway epithelial cell, Inflammation Mediators / metabolism, Human / drug effects, MAPK signaling Pathway, Humans, Chitinase-3-Like Protein 1, Phosphorylation, Lung, Poly I-C / pharmacology, RNA, Double-Stranded, Phosphorylation / drug effects, 0303 health sciences, Epithelial Cells / drug effects, Interleukin-8, Epithelial Cells / metabolism, Epithelial Cells, Chitinase-3-Like Protein 1 / metabolism, Respiratory Syncytial Virus Infections / virology, Double-Stranded / metabolism, 3. Good health, Chitinase 3-like 1, Cytokines / metabolism, Poly I-C, Human / physiology, Respiratory Syncytial Virus, Human, RNA, Cytokines, Interleukin-8 / metabolism, Respiratory Syncytial Virus, Inflammation Mediators

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/35033868

PPARβ/δ attenuates hepatic fibrosis by reducing SMAD3 phosphorylation and p300 levels via AMPK in hepatic stellate cells.

Autoren: Zhang, M. Barroso, E. Peña, L. et al.

Quelle: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol. 179, pp. 117303

Schlagwörter: Hepatic Stellate Cells/metabolism, Hepatic Stellate Cells/drug effects, Hepatic Stellate Cells/pathology, Animals, Phosphorylation/drug effects, PPAR-beta/agonists, PPAR-beta/metabolism, PPAR-beta/genetics, Liver Cirrhosis/metabolism, Liver Cirrhosis/pathology, PPAR delta/metabolism, PPAR delta/agonists, PPAR delta/genetics, Smad3 Protein/metabolism, AMP-Activated Protein Kinases/metabolism, Mice, Inbred C57BL, E1A-Associated p300 Protein/metabolism, Male, Humans, Thiazoles/pharmacology, Diet, High-Fat/adverse effects, Knockout, Insulin Resistance, Cell Line, Transforming Growth Factor beta1/metabolism, AMPK, ERK1/2, Fibrosis

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/39153437; info:eu-repo/semantics/altIdentifier/eissn/1950-6007; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_1C8038E5F6C16; https://serval.unil.ch/notice/serval:BIB_1C8038E5F6C1; https://serval.unil.ch/resource/serval:BIB_1C8038E5F6C1.P001/REF.pdf

Verfügbarkeit: https://serval.unil.ch/notice/serval:BIB_1C8038E5F6C1
https://doi.org/10.1016/j.biopha.2024.117303
https://serval.unil.ch/resource/serval:BIB_1C8038E5F6C1.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_1C8038E5F6C16

Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis

Autoren: Edlund, Sofia Lee, So Young Grimsby, Susanne et al.

Quelle: Molecular and Cellular Biology. 25(4):1475-1488

Schlagwörter: Animals, Apoptosis/drug effects/*physiology, COS Cells, Cell Fractionation, Cercopithecus aethiops, Cytoskeletal Proteins/*metabolism, DNA-Binding Proteins/*metabolism, Glycogen Synthase Kinase 3/metabolism, Humans, Male, Mice, Phosphorylation/drug effects, Prostatic Neoplasms/metabolism, Protein Binding/drug effects, Protein-Serine-Threonine Kinases/metabolism, Proto-Oncogene Proteins/metabolism, RNA, Small Interfering/metabolism, Research Support, Non-U.S. Gov't, Serine/metabolism, Trans-Activators/*metabolism, Transcription Factors/*metabolism, Transforming Growth Factor beta/*pharmacology, Tumor Cells, Cultured, p38 Mitogen-Activated Protein Kinases/metabolism

Dateibeschreibung: print

Zugangs-URL: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72728
https://doi.org/10.1128/MCB.25.4.1475-1488.2005

Lithium chloride inhibits the migration and invasion of osteosarcoma cells by blocking nuclear translocation of phospho-Erk

Autoren: Ju Yeong Kim Hun Hee Park Tai Soon Yong et al.

Weitere Verfasser: Ju Yeong Kim Hun Hee Park Tai Soon Yong et al.

Quelle: Biochemical and Biophysical Research Communications. 581:74-80

Schlagwörter: 0301 basic medicine, Osteoblasts / pathology, Culture, Proliferation, Osteoblasts / drug effects, Cell Nucleus / drug effects, MAP Kinase Signaling System / drug effects, Invasion, Cell Movement, beta Catenin / metabolism, Bone Marrow Cells / drug effects, Phosphorylation, Wnt Signaling Pathway, beta Catenin, Bone Marrow Cells / cytology, Mitogen-Activated Protein Kinase 1, Cell Movement / genetics, Diffusion Chambers, Osteosarcoma, 0303 health sciences, Tumor, Mitogen-Activated Protein Kinase 3, Protein Transport / drug effects, Cell Movement / drug effects, Osteoblasts / metabolism, Mitogen-Activated Protein Kinase 3 / genetics, 3. Good health, Gene Expression Regulation, Neoplastic, Protein Transport, Mitogen-Activated Protein Kinase 1 / genetics, Diffusion Chambers, Culture, Cell Proliferation / genetics, beta Catenin / genetics, Mitogen-Activated Protein Kinase 1 / antagonists & inhibitors, MAP Kinase Signaling System, Primary Cell Culture, Epidermal Growth Factor / pharmacology, Bone Marrow Cells, Cell Line, 03 medical and health sciences, Cell Line, Tumor, Glycogen Synthase Kinase 3 beta / genetics, Humans, Cell Proliferation, Cell Nucleus, Neoplastic, Phosphorylation / drug effects, Glycogen Synthase Kinase 3 beta, Osteoblasts, Mitogen-Activated Protein Kinase 3 / antagonists & inhibitors, Epidermal Growth Factor, Cell Nucleus / metabolism, Epidermal growth factor, Bone Marrow Cells / metabolism, Glycogen Synthase Kinase 3 beta / metabolism, Lithium Chloride / pharmacology, Lithium chloride, Gene Expression Regulation, Mitogen-Activated Protein Kinase 1 / metabolism, Wnt Signaling Pathway / drug effects, Cell Proliferation / drug effects, Lithium Chloride, Mitogen-Activated Protein Kinase 3 / metabolism

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/34656851
https://pubmed.ncbi.nlm.nih.gov/34656851/
https://www.sciencedirect.com/science/article/pii/S0006291X21014327
https://www.ncbi.nlm.nih.gov/pubmed/34656851
https://yonsei.pure.elsevier.com/en/publications/lithium-chloride-inhibits-the-migration-and-invasion-of-osteosarc

Identification of Thieno[3,2-d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3

Autoren: Injae Shin Sunghoon Kim Hojong Yoon et al.

Weitere Verfasser: Injae Shin Sunghoon Kim Hojong Yoon et al.

Quelle: Journal of Medicinal Chemistry. 64:11934-11957

Schlagwörter: Focal Adhesion Kinase 1 / antagonists & inhibitors, 0301 basic medicine, Thiophenes / pharmacology, Nude, Antineoplastic Agents / pharmacology, Drug Screening Assays, Mice, Protein Kinase Inhibitors / metabolism, Neoplasms, Pyrimidines / therapeutic use, fms-Like Tyrosine Kinase 3 / metabolism, Antineoplastic Agents / chemical synthesis, Neoplasm Metastasis, Phosphorylation, Neoplasms / drug therapy, Inbred BALB C, Antineoplastic Agents / metabolism, Pyrimidines / pharmacology, Mice, Inbred BALB C, 0303 health sciences, Tumor, Molecular Structure, Focal Adhesion Kinase 1 / metabolism, 3. Good health, Molecular Docking Simulation, Thiophenes / chemical synthesis, Female, Pyrimidines / metabolism, Thiophenes / therapeutic use, Mice, Nude, fms-Like Tyrosine Kinase 3 / antagonists & inhibitors, Antineoplastic Agents, Neoplasm Metastasis / prevention & control, Thiophenes, Antineoplastic Agents / therapeutic use, Thiophenes / metabolism, Cell Line, Protein Kinase Inhibitors / therapeutic use, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Protein Kinase Inhibitors / chemical synthesis, Protein Kinase Inhibitors, Phosphorylation / drug effects, Protein Kinase Inhibitors / pharmacology, Antitumor, Xenograft Model Antitumor Assays, Pyrimidines, fms-Like Tyrosine Kinase 3, Focal Adhesion Kinase 1, Drug Screening Assays, Antitumor, Pyrimidines / chemical synthesis

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/34324343

Deletion or inhibition of prolyl oligopeptidase blocks lithium‐induced phosphorylation of GSK3b and Akt by activation of protein phosphatase 2A

Autoren: Freke Mertens Timo T. Myöhänen Susanna Norrbacka et al.

Weitere Verfasser: Freke Mertens Timo T. Myöhänen Susanna Norrbacka et al.

Quelle: Basic & Clinical Pharmacology & Toxicology. 129:287-296

Schlagwörter: 0301 basic medicine, Proline, Pharmacy, Lithium, Glycogen Synthase Kinase 3 beta/metabolism, ta3111, Lithium/pharmacology, Cell Line, 03 medical and health sciences, Okadaic Acid/pharmacology, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Okadaic Acid, Proto-Oncogene Proteins c-akt/metabolism, Humans, Protein Phosphatase 2/antagonists & inhibitors, Protein Phosphatase 2, Phosphorylation, Proline/analogs & derivatives, 0303 health sciences, Tumor, Glycogen Synthase Kinase 3 beta, Phosphorylation/drug effects, Prolyl Oligopeptidases/antagonists & inhibitors, HEK293 Cells, Prolyl Oligopeptidases, Proto-Oncogene Proteins c-akt

Dateibeschreibung: application/pdf

Zugangs-URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcpt.13632
https://pubmed.ncbi.nlm.nih.gov/34196102
https://europepmc.org/article/MED/34196102
https://onlinelibrary.wiley.com/doi/10.1111/bcpt.13632
https://pubmed.ncbi.nlm.nih.gov/34196102/
https://www.ncbi.nlm.nih.gov/pubmed/34196102
http://hdl.handle.net/10138/341563

Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma

Autoren: Chiara Raggi Maria Letizia Taddei Elena Sacco et al.

Weitere Verfasser: Chiara Raggi Maria Letizia Taddei Elena Sacco et al.

Quelle: Raggi, C, Taddei, M L, Sacco, E, Navari, N, Correnti, M, Piombanti, B, Pastore, M, Campani, C, Pranzini, E, Iorio, J, Lori, G, Lottini, T, Peano, C, Cibella, J, Lewinska, M, Andersen, J B, di Tommaso, L, Viganò, L, Di Maira, G, Madiai, S, Ramazzotti, M, Orlandi, I, Arcangeli, A, Chiarugi, P & Marra, F 2021, ' Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma ', Journal of Hepatology, vol. 74, no. 6, pp. 1373-1385 . https://doi.org/10.1016/j.jhep.2020.12.031

Schlagwörter: Male, 0301 basic medicine, Indoles, Carcinogenesis, PGC-1α, Mice, SCID, Oxidative Phosphorylation, CCLP1, HUCCT1, OXPHOS, SR-18292, Cholangiocarcinoma, Mice, Metformin/administration & dosage, Mice, Inbred NOD, Signal Transduction/drug effects, PGC-1?, Propanols/administration & dosage, Oxidative Phosphorylation/drug effects, 0303 health sciences, Tumor, Electron Transport Complex II, Indoles/administration & dosage, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/antagonists & inhibitors, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Progression-Free Survival, Metformin, Mitochondria, 3. Good health, Treatment Outcome, Phenotype, Neoplastic Stem Cells, Epithelial-Mesenchymal Transition/drug effects, Electron Transport Complex II/metabolism, Tumor Burden/drug effects, Epithelial-Mesenchymal Transition, SCID, Transfection, Cell Line, 03 medical and health sciences, Neoplastic Stem Cells/metabolism, Cell Line, Tumor, Mitochondria/metabolism, Cholangiocarcinoma/drug therapy, Animals, Humans, Gene Silencing, Bile Duct Neoplasms/drug therapy, Carcinogenesis/drug effects, Xenograft Model Antitumor Assays, Bile Duct Neoplasms, Inbred NOD

Dateibeschreibung: application/pdf; STAMPA

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/33484774
https://www.ncbi.nlm.nih.gov/pubmed/33484774
https://boa.unimib.it/handle/10281/314811
https://pubmed.ncbi.nlm.nih.gov/33484774/
https://air.unimi.it/handle/2434/825203
https://www.sciencedirect.com/science/article/pii/S0168827821000246
https://europepmc.org/article/MED/33484774
https://hdl.handle.net/20.500.14243/450171
http://www.scopus.com/record/display.url?eid=2-s2.0-85104152123&origin=inward
https://doi.org/10.1016/j.jhep.2020.12.031
https://hdl.handle.net/2434/825203
https://doi.org/10.1016/j.jhep.2020.12.031
https://hdl.handle.net/10281/314811
https://doi.org/10.1016/j.jhep.2020.12.031
https://www.journal-of-hepatology.eu/article/S0168-8278(21)00024-6/fulltext
https://hdl.handle.net/11365/1286695
https://doi.org/10.1016/j.jhep.2020.12.031
https://curis.ku.dk/ws/files/333036705/mitochondrial_oxidative_metabolism_in_cca.pdf
https://hdl.handle.net/2158/1223058
https://doi.org/10.1016/j.jhep.2020.12.031

The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells

Autoren: Gerst F. Kemter E. Lorza-Gil E. et al.

Quelle: Diabetologia
Diabetologia 64, 1358–1374 (2021)

Schlagwörter: 0301 basic medicine, Swine, alpha-2-HS-Glycoprotein, Smad Proteins, Pancreatic beta cells, Article, Islets of Langerhans, 03 medical and health sciences, Phosphorylation/drug effects [MeSH], Islets of Langerhans/drug effects [MeSH], Swine [MeSH], Humans [MeSH], Insulin Secretion/drug effects [MeSH], Adaptive proliferation, FOXM1, Functional maturity, Glucose Intolerance/metabolism [MeSH], Animals [MeSH], Fetuin-A, Islets of Langerhans/metabolism [MeSH], TGFBR–SMAD2/3, Signal Transduction/drug effects [MeSH], Smad Proteins/metabolism [MeSH], Gene Expression Profiling [MeSH], Diabetes Mellitus, Type 2/metabolism [MeSH], Cell Proliferation/drug effects [MeSH], alpha-2-HS-Glycoprotein/pharmacology [MeSH], Insulin/metabolism [MeSH], Glucose Intolerance, Insulin Secretion, Animals, Humans, Insulin, Phosphorylation, Cell Proliferation, 0303 health sciences, Gene Expression Profiling, Adaptive Proliferation, Foxm1, Fetuin-a, Functional Maturity, Pancreatic Beta Cells, Tgfbr–smad2/3, Diabetes Mellitus, Type 2, Signal Transduction

Dateibeschreibung: application/pdf

Zugangs-URL: https://link.springer.com/content/pdf/10.1007/s00125-021-05435-1.pdf
https://pubmed.ncbi.nlm.nih.gov/33765181
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099843
https://pubmed.ncbi.nlm.nih.gov/33765181/
http://pubmed.ncbi.nlm.nih.gov/33765181/
https://link.springer.com/article/10.1007/s00125-021-05435-1
https://link.springer.com/content/pdf/10.1007/s00125-021-05435-1.pdf
https://europepmc.org/article/PMC/PMC8099843
https://hdl.handle.net/20.500.11768/115647
https://doi.org/10.1007/s00125-021-05435-1
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=61684
https://repository.publisso.de/resource/frl:6451918

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors

Autoren: Lindsay C. Spender G. John Ferguson Gareth D. Hughes et al.

Quelle: Molecular Pharmacology. 95:222-234

Schlagwörter: 0301 basic medicine, Activin Receptors, Receptor, Transforming Growth Factor-beta Type I, Smad2 Protein, name=Pharmacology, Cell Line, Cell Proliferation/drug effects, Mice, 03 medical and health sciences, Signal Transduction/drug effects, name=Molecular Medicine, Animals, Transforming Growth Factor-beta Type I/metabolism, Neoplasm Metastasis, Phosphorylation, Protein Kinase Inhibitors, Cell Proliferation, 0303 health sciences, Bone Morphogenetic Proteins/metabolism, Neoplasm Metastasis/pathology, Phosphorylation/drug effects, Smad2 Protein/metabolism, 3. Good health, DNA-Binding Proteins, Protein Kinase Inhibitors/pharmacology, Bone Morphogenetic Proteins, NIH 3T3 Cells, Type I/metabolism, Activin Receptors, Type I, Receptor, Signal Transduction

Dateibeschreibung: application/pdf

Zugangs-URL: https://molpharm.aspetjournals.org/content/molpharm/95/2/222.full.pdf
https://pubmed.ncbi.nlm.nih.gov/30459156
https://molpharm.aspetjournals.org/content/molpharm/95/2/222.full.pdf
http://molpharm.aspetjournals.org/content/molpharm/early/2018/11/20/mol.118.112946.full.pdf
http://eprints.gla.ac.uk/202587/
http://europepmc.org/abstract/MED/30459156
https://www.ncbi.nlm.nih.gov/pubmed/30459156
https://pubmed.ncbi.nlm.nih.gov/30459156/

A drug discovery platform to identify compounds that inhibit EGFR triple mutants

Autoren: Konstantin Weiss Leanne E Wybenga-Groot Michael Prakesch et al.

Weitere Verfasser: Konstantin Weiss Leanne E Wybenga-Groot Michael Prakesch et al.

Quelle: Nature Chemical Biology. 16:577-586

Schlagwörter: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung/drug therapy, Drug Resistance, Drug Resistance, Neoplasm/genetics, Non-Small-Cell Lung/drug therapy, Cell Line, Small Molecule Libraries, Genes, Reporter, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Taverne, ErbB Receptors/antagonists & inhibitors, Small Molecule Libraries/pharmacology, Drug Discovery, High-Throughput Screening Assays/methods, Humans, Luciferases/genetics, Phosphorylation, Lung Neoplasms/drug therapy, Luciferases, Reporter, Protein Kinase Inhibitors, Tumor, Neoplasm/genetics, CHECKPOINT KINASE INHIBITOR, PHASE-I, PROTEIN, RESISTANCE, FLT3, AZD7762, AZD9291, Carcinoma, Phosphorylation/drug effects, Reproducibility of Results, Staurosporine, High-Throughput Screening Assays, 3. Good health, ErbB Receptors, Genes, Drug Resistance, Neoplasm, Protein Kinase Inhibitors/pharmacology, DNA Nucleotidyltransferases/genetics, DNA Nucleotidyltransferases, Mutation, Staurosporine/analogs & derivatives

Dateibeschreibung: application/pdf

Zugangs-URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123931
https://pubmed.ncbi.nlm.nih.gov/32094923
https://research-portal.uu.nl/en/publications/8c84db43-d226-43a0-8d45-c8c22e72ac39
https://doi.org/10.1038/s41589-020-0484-2
https://research.unipg.it/handle/11391/1469224
https://pubmed.ncbi.nlm.nih.gov/32094923/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123931/
https://www.nature.com/articles/s41589-020-0484-2.pdf
https://www.nature.com/articles/s41589-020-0484-2
https://pure.mpg.de/pubman/faces/ViewItemOverviewPage.jsp?itemId=item_3323730
https://hdl.handle.net/11391/1469224
https://www.nature.com/articles/s41589-020-0484-2
https://doi.org/10.1038/s41589-020-0484-2
https://dspace.library.uu.nl/handle/1874/410302

Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin

Autoren: Mehra, Anupriya Guérit, Sylvaine Macrez, Richard et al.

Weitere Verfasser: Mehra, Anupriya Guérit, Sylvaine Macrez, Richard et al.

Quelle: Mehra, A, Guérit, S, Macrez, R, Gosselet, F, Sevin, E, Lebas, H, Maubert, E, De Vries, H E, Bardou, I, Vivien, D & Docagne, F 2020, 'Nonionotropic Action of Endothelial NMDA Receptors on Blood-Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin', Journal of Neuroscience, vol. 40, no. 8, pp. 1778-1787. https://doi.org/10.1523/JNEUROSCI.0969-19.2019

Schlagwörter: Male, rho GTP-Binding Proteins, 0301 basic medicine, Cerebral Cortex/drug effects, N-Methylaspartate, [SDV]Life Sciences [q-bio], N-Methyl-D-Aspartate/agonists, Myosins, blood–brain barrier, Receptors, N-Methyl-D-Aspartate, Permeability, neuroinflammation, Cell Line, Mice, 03 medical and health sciences, rho GTP-Binding Proteins/metabolism, Signal Transduction/drug effects, Receptors, Excitatory Amino Acid Agonists, Animals, N-Methylaspartate/pharmacology, Phosphorylation, Endothelial Cells/drug effects, Cerebral Cortex, Neurons, rho-Associated Kinases, 0303 health sciences, Tumor Necrosis Factor-alpha, Phosphorylation/drug effects, Endothelial Cells, Excitatory Amino Acid Agonists/pharmacology, Neurons/drug effects, endothelial cells, [SDV] Life Sciences [q-bio], NMDA, Myosins/metabolism, Tumor Necrosis Factor-alpha/pharmacology, Blood-Brain Barrier, Tissue Plasminogen Activator, rho-Associated Kinases/metabolism, permeability, Tissue Plasminogen Activator/pharmacology, Blood-Brain Barrier/drug effects, signal transduction, Signal Transduction

Dateibeschreibung: application/pdf

Zugangs-URL: https://www.jneurosci.org/content/jneuro/40/8/1778.full.pdf
https://pubmed.ncbi.nlm.nih.gov/31953371
https://www.jneurosci.org/content/jneuro/40/8/1778.full.pdf
https://www.jneurosci.org/content/early/2020/01/15/JNEUROSCI.0969-19.2019
https://research.vumc.nl/en/publications/nonionotropic-action-of-endothelial-nmda-receptors-on-blood-brain
https://pubmed.ncbi.nlm.nih.gov/31953371/
https://www.ncbi.nlm.nih.gov/pubmed/31953371
https://www.jneurosci.org/content/40/8/1778
https://research.vumc.nl/en/publications/a4a26411-b4b2-4bc7-9be7-ff9cfeca3476
https://pure.amsterdamumc.nl/en/publications/a75652f0-b3bd-4441-8a45-b68cc5036bf6
https://doi.org/10.1523/JNEUROSCI.0969-19.2019

Metformin inhibits adenosine 5'-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hypothalamic neurons

Autoren: Chau-Van, C. Gamba, M. Salvi, R. et al.

Schlagwörter: Animals Cells, Cultured Dose-Response Relationship, Drug Enzyme Activation/drug effects Gene Expression/drug effects Glucose/administration & dosage/pharmacology Hypoglycemic Agents/*pharmacology Hypothalamus/cytology/drug effects/*metabolism Metformin/*pharmacology Multienzyme Complexes/*antagonists & inhibitors/metabolism Neurons/drug effects/*metabolism Neuropeptide Y/*antagonists & inhibitors/genetics/metabolism Osmolar Concentration Phosphorylation/drug effects Pro-Opiomelanocortin/antagonists & inhibitors/genetics/metabolism Protein-Serine-Threonine Kinases/*antagonists & inhibitors/metabolism Rats

Relation: Endocrinology; https://iris.unil.ch/handle/iris/83524; serval:BIB_2249C6A6C51C; 000243520500006

Verfügbarkeit: https://iris.unil.ch/handle/iris/83524
https://doi.org/10.1210/en.2006-1237