Suchergebnisse - "Phospholipases A2"

Varespladib Alleviates Colonic Inflammation Induced by High-Fat Diet via Downregulating the TGF-β/Smad Pathway and AA Pathway by Inhibiting sPLA 2 .

Autoren: Shirui M Yuanyuan L Linfeng W et al.

Quelle: Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2025 Dec; Vol. 40 (12), pp. 2933-2943. Date of Electronic Publication: 2025 Oct 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Blackwell Scientific Publications Country of Publication: Australia NLM ID: 8607909 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1746 (Electronic) Linking ISSN: 08159319 NLM ISO Abbreviation: J Gastroenterol Hepatol Subsets: MEDLINE

MeSH-Schlagworte: Diet, High-Fat*/adverse effects , Transforming Growth Factor beta*/metabolism , Signal Transduction*/drug effects , Smad Proteins*/metabolism , Arachidonic Acid*/metabolism , Colitis*/drug therapy , Colitis*/etiology , Colitis*/pathology , Colitis*/metabolism , Colitis*/genetics , Phospholipases A2, Secretory*/antagonists & inhibitors , Phospholipases A2, Secretory*/metabolism, Animals ; Mice, Inbred C57BL ; Down-Regulation/drug effects ; Male ; Disease Models, Animal ; Mice ; Colon/pathology

Deficiency of PLA2G6 Induces Ferroptosis in Dopaminergic Neurons and Contributes to Parkinson's Disease Pathogenesis via Disruption of PRDX6/FTH1/GPX4 Axis.

Autoren: Li T Liu J Huang X et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Dec; Vol. 62 (12), pp. 15916-15927. Date of Electronic Publication: 2025 Jul 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/physiology , Group VI Phospholipases A2*/deficiency , Group VI Phospholipases A2*/metabolism , Dopaminergic Neurons*/metabolism , Dopaminergic Neurons*/pathology , Parkinson Disease*/pathology , Parkinson Disease*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism , Peroxiredoxin VI*/metabolism , Ferritins*/metabolism, Animals ; Mice ; Mice, Inbred C57BL ; Iron/metabolism ; Lipid Peroxidation ; Mice, Knockout

Phospholipases A 2 (PLA 2 s) and Related Peptides from Bothrops Snake Venoms: History, Structure, Pharmacology, and Inhibitors.

Autoren: Santos ICD Romanazzi M Malachias-Pires GM et al.

Quelle: Biomolecules [Biomolecules] 2025 Nov 11; Vol. 15 (11). Date of Electronic Publication: 2025 Nov 11.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

MeSH-Schlagworte: Bothrops*/metabolism , Phospholipases A2*/chemistry , Phospholipases A2*/metabolism , Peptides*/chemistry , Peptides*/pharmacology , Crotalid Venoms*/chemistry , Crotalid Venoms*/enzymology , Phospholipase A2 Inhibitors*/pharmacology , Phospholipase A2 Inhibitors*/chemistry , Snake Venoms*/enzymology , Snake Venoms*/chemistry, Animals ; Humans

Therapeutic potential of Bothrops leucurus phospholipase A 2 in preventing dengue virus infection.

Autoren: Caldas S Faria G de Oliveira Silva F et al.

Quelle: Archives of virology [Arch Virol] 2025 Nov 10; Vol. 170 (12), pp. 246. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7506870 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-8798 (Electronic) Linking ISSN: 03048608 NLM ISO Abbreviation: Arch Virol Subsets: MEDLINE

MeSH-Schlagworte: Bothrops* , Dengue Virus*/drug effects , Dengue Virus*/physiology , Antiviral Agents*/pharmacology , Antiviral Agents*/isolation & purification , Phospholipases A2*/pharmacology , Phospholipases A2*/isolation & purification , Dengue*/prevention & control , Dengue*/virology , Dengue*/drug therapy , Crotalid Venoms*/enzymology, Animals ; Humans ; Cell Line ; Virus Internalization/drug effects ; Vero Cells ; RNA, Viral ; Virus Replication/drug effects

Unravelling homozygous PLA2G6 variants in Pakistani individuals with diverse clinical manifestations via whole exome sequencing.

Autoren: Khan H Zahid M Shabbir MI et al.

Quelle: BMC medical genomics [BMC Med Genomics] 2025 Nov 07; Vol. 18 (1), pp. 178. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101319628 Publication Model: Electronic Cited Medium: Internet ISSN: 1755-8794 (Electronic) Linking ISSN: 17558794 NLM ISO Abbreviation: BMC Med Genomics Subsets: MEDLINE

MeSH-Schlagworte: Group VI Phospholipases A2*/genetics , Group VI Phospholipases A2*/chemistry , Exome Sequencing* , Homozygote*, Humans ; Pakistan ; Male ; Female ; Mutation ; Child ; Phenotype ; Adolescent ; Adult ; Neurodevelopmental Disorders/genetics ; Child, Preschool

Decanoic acid extends lifespan and modulates metabolism in models of PLA2G6-associated neurodegeneration.

Autoren: Zhang B Dunn E Williams RSB et al.

Quelle: Disease models & mechanisms [Dis Model Mech] 2025 Nov 01; Vol. 18 (11). Date of Electronic Publication: 2025 Dec 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101483332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-8411 (Electronic) Linking ISSN: 17548403 NLM ISO Abbreviation: Dis Model Mech Subsets: MEDLINE

MeSH-Schlagworte: Drosophila melanogaster*/drug effects , Drosophila melanogaster*/genetics , Drosophila melanogaster*/metabolism , Longevity*/drug effects , Longevity*/genetics , Group VI Phospholipases A2*/metabolism , Group VI Phospholipases A2*/genetics , Decanoic Acids*/pharmacology , Decanoic Acids*/therapeutic use , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Neurodegenerative Diseases*/drug therapy , Neurodegenerative Diseases*/metabolism , Neurodegenerative Diseases*/genetics , Nerve Degeneration*, Animals ; Disease Models, Animal ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Metabolome/drug effects ; Heat-Shock Response/drug effects ; Mitochondria/metabolism ; Mitochondria/drug effects ; Transcription, Genetic/drug effects ; Gene Expression Regulation/drug effects

Exploring the antiangiogenic effects of Phospholipases A 2 from Bothrops diporus venom.

Autoren: Sasovsky DJ Olea GB Ojeda G et al.

Quelle: Cell and tissue research [Cell Tissue Res] 2025 Nov; Vol. 402 (2), pp. 189-199. Date of Electronic Publication: 2025 Sep 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0878 (Electronic) Linking ISSN: 0302766X NLM ISO Abbreviation: Cell Tissue Res Subsets: MEDLINE

MeSH-Schlagworte: Bothrops*/metabolism , Angiogenesis Inhibitors*/pharmacology , Phospholipases A2*/pharmacology , Crotalid Venoms*/enzymology, Animals ; Chorioallantoic Membrane/drug effects ; Chorioallantoic Membrane/blood supply ; Apoptosis/drug effects ; Humans ; Neovascularization, Physiologic/drug effects ; Human Umbilical Vein Endothelial Cells/drug effects

Histopathological alterations, local hemorrhage and myotoxic effects induced by Bothrops mattogrossensis venom and an acidic isolated phospholipase A₂.

Autoren: Eulálio MMC Bariani CO Ferreira E Ferreira AA et al.

Quelle: Acta tropica [Acta Trop] 2025 Nov; Vol. 271, pp. 107891. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6254 (Electronic) Linking ISSN: 0001706X NLM ISO Abbreviation: Acta Trop Subsets: MEDLINE

MeSH-Schlagworte: Bothrops* , Phospholipases A2*/toxicity , Phospholipases A2*/isolation & purification , Crotalid Venoms*/toxicity , Hemorrhage*/chemically induced , Hemorrhage*/pathology , Myotoxicity*/pathology, Animals ; Mice ; Male ; Creatine Kinase ; Histocytochemistry ; Muscle, Skeletal/pathology ; Muscle, Skeletal/drug effects ; Animal Structures/pathology ; Animal Structures/drug effects ; Lung/pathology

Cytosolic phospholipase A2 as a therapeutic target for degenerative joint diseases.

Autoren: Huang G He C Fu W et al.

Quelle: Bone research [Bone Res] 2025 Oct 15; Vol. 13 (1), pp. 86. Date of Electronic Publication: 2025 Oct 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE

MeSH-Schlagworte: Osteoarthritis*/drug therapy , Osteoarthritis*/pathology , Osteoarthritis*/enzymology , Phospholipases A2, Cytosolic*/metabolism , Phospholipases A2, Cytosolic*/antagonists & inhibitors , Intervertebral Disc Degeneration*/drug therapy , Intervertebral Disc Degeneration*/enzymology , Intervertebral Disc Degeneration*/pathology , Joint Diseases*/drug therapy , Joint Diseases*/enzymology , Molecular Targeted Therapy*, Animals ; Chondrocytes/pathology ; Chondrocytes/metabolism ; Chondrocytes/drug effects ; Chondrocytes/enzymology ; Mice ; Humans ; Mice, Inbred C57BL ; Disease Models, Animal ; Male

Secretory phospholipase A 2 -IIA targets bacterial extracellular vesicles to modulate immune signaling.

Autoren: Doré E Bérubé È Greffard K et al.

Quelle: Communications biology [Commun Biol] 2025 Nov 21; Vol. 8 (1), pp. 1634. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Vesicles*/metabolism , Extracellular Vesicles*/immunology , Extracellular Vesicles*/enzymology , Staphylococcus aureus*/immunology , Staphylococcus aureus*/metabolism , Signal Transduction* , Escherichia coli*/immunology , Escherichia coli*/metabolism , Group II Phospholipases A2*/metabolism, Humans ; Animals ; Mice

cPLA2α-driven Cox-2/PGE2 axis promotes hypoxia-induced senescence in Jurkat T cells.

Autoren: Jung JH Yang Y Kim Y

Quelle: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Nov 19; Vol. 790, pp. 152894. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH-Schlagworte: Cellular Senescence* , Cyclooxygenase 2*/metabolism , Dinoprostone*/metabolism , Group IV Phospholipases A2*/metabolism, Humans ; Jurkat Cells ; Cell Hypoxia ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/immunology

The impact of experimental variables in twitch tension recording on triphasic action of phospholipase A 2 neurotoxins at the neuromuscular junction and acetylcholine release.

Autoren: Fathi Hafshejani B Harvey AL Rowan EG et al.

Quelle: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2025 Nov; Vol. 266, pp. 108512. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE

MeSH-Schlagworte: Neuromuscular Junction*/drug effects , Phospholipases A2*/toxicity , Acetylcholine*/metabolism , Neurotoxins*/toxicity, Animals ; Male ; Calcium ; Magnesium ; Rats ; Amifampridine/pharmacology ; Elapid Venoms ; Temperature

Myotoxin II, a snake venom Lys49 phospholipase A 2 homolog, induces activation of the ryanodine receptor in artificial bilayers.

Autoren: Szentesi P Magyar ZÉ Fernández J et al.

Quelle: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2025 Nov; Vol. 267, pp. 108590. Date of Electronic Publication: 2025 Sep 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE

MeSH-Schlagworte: Ryanodine Receptor Calcium Release Channel*/metabolism , Ryanodine Receptor Calcium Release Channel*/drug effects , Lipid Bilayers* , Crotalid Venoms*/toxicity , Group II Phospholipases A2*/toxicity , Reptilian Proteins*/toxicity, Animals ; Bothrops ; Mice ; Calcium/metabolism

Molecular dynamics of Lys49 PLA 2 -like toxins: Insights into solution and membrane-bound conformations.

Autoren: Rachão R Coimbra JTS Ramos MJ et al.

Quelle: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2025 Nov; Vol. 267, pp. 108581. Date of Electronic Publication: 2025 Sep 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE

MeSH-Schlagworte: Molecular Dynamics Simulation* , Phospholipases A2*/chemistry , Crotalid Venoms*/chemistry, Bothrops ; Animals ; Protein Conformation ; Amino Acid Sequence ; Crystallography, X-Ray

PLA2 driven lipid signaling drives ARMS tumorigenic cell properties.

Autoren: Gupta A Ramanathan B Das D et al.

Quelle: Cell communication and signaling : CCS [Cell Commun Signal] 2025 Oct 01; Vol. 23 (1), pp. 404. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE

MeSH-Schlagworte: Lipid Metabolism* , Signal Transduction* , Phospholipases A2*/metabolism , Carcinogenesis*/pathology , Carcinogenesis*/metabolism, Humans ; Animals ; Cell Line, Tumor ; Mice ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology

Sex and dietary ALA and DHA effects on rat heart phospholipase A 2 activity mediating fatty acid release and oxylipin formation have cardiovascular implications.

Autoren: Manson A Winter T Aukema HM

Quelle: Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2025 Oct; Vol. 206, pp. 102697. Date of Electronic Publication: 2025 Jun 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 8802730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2823 (Electronic) Linking ISSN: 09523278 NLM ISO Abbreviation: Prostaglandins Leukot Essent Fatty Acids Subsets: MEDLINE

MeSH-Schlagworte: Oxylipins*/metabolism , Docosahexaenoic Acids*/pharmacology , Docosahexaenoic Acids*/administration & dosage , Docosahexaenoic Acids*/metabolism , alpha-Linolenic Acid*/pharmacology , alpha-Linolenic Acid*/administration & dosage , Myocardium*/enzymology , Myocardium*/metabolism , Phospholipases A2*/metabolism , Fatty Acids*/metabolism, Animals ; Male ; Female ; Rats, Sprague-Dawley ; Rats ; Sex Factors ; Arachidonic Acid/metabolism ; Diet

Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells.

Autoren: Torres-Velarde JM Allen KN Salvador-Pascual A et al.

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2024 Jun; Vol. 218, pp. 82-93. Date of Electronic Publication: 2024 Apr 03.

Publikationsart: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/genetics , Peroxiredoxin VI*/metabolism , Peroxiredoxin VI*/genetics , Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/genetics , Lung*/metabolism , Lung*/pathology , Endothelial Cells*/metabolism , Lipid Peroxidation* , Piperazines* , Group VI Phospholipases A2*, Animals ; Mice ; Humans ; Phospholipases A2/metabolism ; Phospholipases A2/genetics ; Mice, Knockout

Detoxification of Insect-Derived Allergen PLA2 via Quercetin Modification: Molecular Simulation and Animal Validation.

Autoren: Li F Wu L Wang M et al.

Quelle: Nutrients [Nutrients] 2025 Sep 04; Vol. 17 (17). Date of Electronic Publication: 2025 Sep 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

MeSH-Schlagworte: Quercetin*/chemistry , Quercetin*/metabolism , Allergens*/chemistry , Allergens*/immunology , Allergens*/metabolism , Phospholipases A2*/chemistry , Phospholipases A2*/immunology , Phospholipases A2*/metabolism , Insect Proteins*/chemistry , Insect Proteins*/immunology , Insect Proteins*/metabolism, Animals ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mice ; Immunoglobulin E/blood ; Female ; Bees ; Mice, Inbred BALB C ; Food Hypersensitivity/immunology ; Food Hypersensitivity/prevention & control

Suppression of Cytosolic Phospholipase A2 in the Ventromedial Hypothalamus Induces Hyperphagia and Obesity in Male Mice.

Autoren: Abe T Ishimoto T Araki Y et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Aug 04; Vol. 26 (15). Date of Electronic Publication: 2025 Aug 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Obesity*/metabolism , Obesity*/genetics , Obesity*/etiology , Hyperphagia*/metabolism , Hyperphagia*/genetics , Hyperphagia*/etiology , Ventromedial Hypothalamic Nucleus*/metabolism , Group IV Phospholipases A2*/genetics , Group IV Phospholipases A2*/metabolism , Phospholipases A2, Cytosolic*/metabolism , Phospholipases A2, Cytosolic*/genetics, Animals ; Male ; Mice ; Energy Metabolism ; Oxygen Consumption ; Body Weight ; Mice, Inbred C57BL ; Eating ; Insulin Resistance ; RNA, Small Interfering/genetics

Specificity mechanism of Group VIA calcium-independent phospholipase A 2 toward truncated-oxidized phospholipids and its application for specific inhibitor design.

Autoren: Hayashi D Batsika CS Bourboula A et al.

Quelle: Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2025 Aug; Vol. 1870 (6), pp. 159655. Date of Electronic Publication: 2025 Jun 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731727 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2618 (Electronic) Linking ISSN: 13881981 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Biol Lipids Subsets: MEDLINE

MeSH-Schlagworte: Phospholipids*/metabolism , Phospholipids*/chemistry , Phospholipase A2 Inhibitors*/pharmacology , Phospholipase A2 Inhibitors*/chemistry , Phospholipases A2, Calcium-Independent*/metabolism , Phospholipases A2, Calcium-Independent*/antagonists & inhibitors , Phospholipases A2, Calcium-Independent*/chemistry , Group VI Phospholipases A2*/metabolism , Group VI Phospholipases A2*/antagonists & inhibitors, Humans ; Oxidation-Reduction ; Molecular Dynamics Simulation ; Drug Design ; Substrate Specificity ; Calcium/metabolism