Výsledky vyhľadávania - "Phenotype"

A Targeting Senescence and Recycling Intracellular Nicotinamide Adenine Dinucleotide Strategy for Attenuation of Senescence-Associated Phenotypes.

Autori: Liu J Rong M Liu C a ďalší

Zdroj: ACS nano [ACS Nano] 2025 Sep 16; Vol. 19 (36), pp. 32131-32144. Date of Electronic Publication: 2025 Sep 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE

Výrazy zo slovníka MeSH: NAD*/metabolism , NAD*/chemistry , NAD*/pharmacology , Cellular Senescence*/drug effects , Senescence-Associated Secretory Phenotype*/drug effects , Copper*/chemistry , Copper*/pharmacology, Animals ; Mice ; Humans ; Doxorubicin/pharmacology ; Atherosclerosis/drug therapy ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Galactose ; Phenotype ; Mice, Inbred C57BL

Extracellular Vesicles of Adipose Multipotent Mesenchymal Stromal Cells Propagate Senescent Phenotype by Affecting PTEN Nuclear Import.

Autori: Chechekhina E Kamenkov S Chechekhin V a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Jul 24; Vol. 26 (15). Date of Electronic Publication: 2025 Jul 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/cytology , Extracellular Vesicles*/metabolism , PTEN Phosphohydrolase*/metabolism , PTEN Phosphohydrolase*/genetics , Cellular Senescence* , Adipose Tissue*/cytology , Adipose Tissue*/metabolism , Senescence-Associated Secretory Phenotype*, Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Active Transport, Cell Nucleus ; Cell Nucleus/metabolism ; Cell Differentiation ; Cells, Cultured ; Phenotype ; Signal Transduction

Propagation of senescent phenotypes by extracellular HMGB1 is dependent on its redox state.

Autori: Shin JW Jang DH Kim SY a ďalší

Zdroj: Metabolism: clinical and experimental [Metabolism] 2025 Jul; Vol. 168, pp. 156259. Date of Electronic Publication: 2025 Apr 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE

Výrazy zo slovníka MeSH: HMGB1 Protein*/metabolism , HMGB1 Protein*/pharmacology , Cellular Senescence*/physiology , Senescence-Associated Secretory Phenotype*/physiology, Animals ; Oxidation-Reduction ; Mice ; Humans ; Phenotype ; Mice, Inbred C57BL ; Male

Multiplexed single-cell imaging reveals diverging subpopulations with distinct senescence phenotypes during long-term senescence induction.

Autori: Sessions GA Loops MV Diekman BO a ďalší

Zdroj: GeroScience [Geroscience] 2025 Jun; Vol. 47 (3), pp. 3891-3905. Date of Electronic Publication: 2025 Jan 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

Výrazy zo slovníka MeSH: Single-Cell Analysis*/methods , Senescence-Associated Secretory Phenotype*/physiology , Cellular Senescence*/physiology , Epithelial Cells*/metabolism, Humans ; Proteomics/methods ; Phenotype ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Tumor Suppressor Protein p53/metabolism ; Etoposide/pharmacology

Functional diversity of senescent cells in driving ageing phenotypes and facilitating tissue regeneration.

Autori: Nakano Y Johmura Y

Zdroj: Journal of biochemistry [J Biochem] 2025 Mar 04; Vol. 177 (3), pp. 189-195.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376600 Publication Model: Print Cited Medium: Internet ISSN: 1756-2651 (Electronic) Linking ISSN: 0021924X NLM ISO Abbreviation: J Biochem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cellular Senescence* , Aging*/pathology , Aging*/metabolism , Senescence-Associated Secretory Phenotype* , Regeneration*, Humans ; Animals ; Phenotype ; Inflammation/metabolism ; Inflammation/pathology

Senescent myoblasts exhibit an altered exometabolome that is linked to senescence-associated secretory phenotype signaling.

Autori: Kamal M Shanmuganathan M Kroezen Z a ďalší

Zdroj: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2025 Feb 01; Vol. 328 (2), pp. C440-C451. Date of Electronic Publication: 2024 Dec 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cellular Senescence*/physiology , Cellular Senescence*/drug effects , Senescence-Associated Secretory Phenotype*/physiology , Myoblasts*/metabolism , Myoblasts*/drug effects , Metabolome*, Animals ; Mice ; Signal Transduction/physiology ; Cell Line ; Bleomycin/pharmacology ; DNA Damage ; Phenotype

The senescence-associated secretory phenotype and its physiological and pathological implications.

Autori: Wang B Han J Elisseeff JH a ďalší

Zdroj: Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2024 Dec; Vol. 25 (12), pp. 958-978. Date of Electronic Publication: 2024 Apr 23.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0080 (Electronic) Linking ISSN: 14710072 NLM ISO Abbreviation: Nat Rev Mol Cell Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Senescence-Associated Secretory Phenotype*/genetics , Cellular Senescence*/genetics , Neoplasms*/genetics , Neoplasms*/metabolism , Neoplasms*/pathology, Humans ; Animals ; Aging/metabolism ; Aging/genetics ; Biomarkers/metabolism ; DNA Damage ; Phenotype

Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging.

Autori: Afzal M Rekha MM Sahoo S a ďalší

Zdroj: Inflammopharmacology [Inflammopharmacology] 2025 Nov; Vol. 33 (11), pp. 6555-6575. Date of Electronic Publication: 2025 Oct 11.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Osteoarthritis*/drug therapy , Osteoarthritis*/metabolism , Osteoarthritis*/pathology , Aging*/metabolism , Aging*/pathology , Senescence-Associated Secretory Phenotype*/physiology , Senescence-Associated Secretory Phenotype*/drug effects, Humans ; Chondrocytes/metabolism ; Chondrocytes/drug effects ; Animals ; Senotherapeutics/pharmacology ; Oxidative Stress/physiology ; Oxidative Stress/drug effects ; Cellular Senescence/physiology ; Cellular Senescence/drug effects ; Biomarkers/metabolism

The prognostic significance of stress-phenotyping for stroke incidence: the Malmö Diet and Cancer Study.

Autori: Holm H Jujic A Nilsson PM a ďalší

Zdroj: Stress (Amsterdam, Netherlands) [Stress] 2025 Dec; Vol. 28 (1), pp. 2443980. Date of Electronic Publication: 2024 Dec 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9617529 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8888 (Electronic) Linking ISSN: 10253890 NLM ISO Abbreviation: Stress Subsets: MEDLINE

Výrazy zo slovníka MeSH: Stroke*/epidemiology , Stress, Psychological*/epidemiology , Phenotype*, Humans ; Male ; Female ; Sweden/epidemiology ; Aged ; Incidence ; Prognosis ; Risk Factors ; Biomarkers/blood ; Aged, 80 and over

Expansion of the phenotype in ZFX neurodevelopmental disorder in a family.

Autori: van der Tol L de Jong M Alders M a ďalší

Zdroj: European journal of medical genetics [Eur J Med Genet] 2025 Dec; Vol. 78, pp. 105053. Date of Electronic Publication: 2025 Oct 10.

Spôsob vydávania: Case Reports; Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101247089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0849 (Electronic) Linking ISSN: 17697212 NLM ISO Abbreviation: Eur J Med Genet Subsets: MEDLINE

Výrazy zo slovníka MeSH: Phenotype* , Neurodevelopmental Disorders*/genetics , Neurodevelopmental Disorders*/pathology, Humans ; Male ; Female ; Pedigree ; Adult

Exploring senescence markers as potential drivers of osteoarthritis pain in aging adults.

Autori: Abbas M Cruz CJ Tamargo JA a ďalší

Zdroj: Experimental gerontology [Exp Gerontol] 2025 Dec; Vol. 212, pp. 112950. Date of Electronic Publication: 2025 Oct 30.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0047061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6815 (Electronic) Linking ISSN: 05315565 NLM ISO Abbreviation: Exp Gerontol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Aging*/pathology , Osteoarthritis*/physiopathology , Osteoarthritis*/metabolism , Senescence-Associated Secretory Phenotype* , Cellular Senescence* , Chronic Pain*/etiology , Chronic Pain*/physiopathology, Humans ; Biomarkers/metabolism ; Aged ; Inflammation

Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues.

Autori: Saul D Jurk D Doolittle ML a ďalší

Zdroj: The EMBO journal [EMBO J] 2025 Dec; Vol. 44 (23), pp. 7295-7325. Date of Electronic Publication: 2025 Oct 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cyclin-Dependent Kinase Inhibitor p21*/genetics , Cyclin-Dependent Kinase Inhibitor p21*/metabolism , Cyclin-Dependent Kinase Inhibitor p16*/metabolism , Cyclin-Dependent Kinase Inhibitor p16*/genetics , Aging*/genetics , Aging*/metabolism , Cellular Senescence*/genetics , Senescence-Associated Secretory Phenotype*/genetics, Humans ; Animals ; Mice ; Single-Cell Analysis

cGAS/STING Pathway Mediates Accelerated Intestinal Cell Senescence and SASP After GCR Exposure in Mice.

Autori: Kumar S Kumar K Angdisen J a ďalší

Zdroj: Cells [Cells] 2025 Nov 11; Vol. 14 (22). Date of Electronic Publication: 2025 Nov 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cellular Senescence*/radiation effects , Membrane Proteins*/metabolism , Signal Transduction*/radiation effects , Cosmic Radiation*/adverse effects , Nucleotidyltransferases*/metabolism , Senescence-Associated Secretory Phenotype*/radiation effects , Intestines*/radiation effects , Intestines*/pathology, Animals ; Mice ; Mice, Inbred C57BL ; Male ; Oxidative Stress/radiation effects ; Intestinal Mucosa/metabolism ; DNA Breaks, Double-Stranded/radiation effects

The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy.

Autori: Cao L Li K Li Q a ďalší

Zdroj: Molecular cancer [Mol Cancer] 2025 Nov 07; Vol. 24 (1), pp. 283. Date of Electronic Publication: 2025 Nov 07.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE

Výrazy zo slovníka MeSH: Neoplasms*/metabolism , Neoplasms*/pathology , Neoplasms*/drug therapy , Neoplasms*/etiology , Neoplasms*/therapy , Senescence-Associated Secretory Phenotype*/drug effects , Cellular Senescence*/drug effects, Humans ; Tumor Microenvironment/drug effects ; Animals ; Senotherapeutics/therapeutic use ; Senotherapeutics/pharmacology

Generative Models and Sentence Transformers for the Recognition and Normalization of Continuous and Discontinuous Phenotype Mentions: Model Development and Evaluation.

Autori: Alhassan A Schlegel V Aloud M a ďalší

Zdroj: JMIR medical informatics [JMIR Med Inform] 2025 Nov 05; Vol. 13, pp. e68558. Date of Electronic Publication: 2025 Nov 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: JMIR Publications Country of Publication: Canada NLM ID: 101645109 Publication Model: Electronic Cited Medium: Internet ISSN: 2291-9694 (Electronic) Linking ISSN: 22919694 NLM ISO Abbreviation: JMIR Med Inform Subsets: MEDLINE

Výrazy zo slovníka MeSH: Phenotype* , Natural Language Processing* , Data Mining*/methods, Humans

Phenotyping Chronic Pain and Neuropathic Pain in Population Studies.

Autori: Liang IJ Senaratne DNS Smith BH

Zdroj: European journal of pain (London, England) [Eur J Pain] 2025 Nov; Vol. 29 (10), pp. e70146.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Wiley Country of Publication: England NLM ID: 9801774 Publication Model: Print Cited Medium: Internet ISSN: 1532-2149 (Electronic) Linking ISSN: 10903801 NLM ISO Abbreviation: Eur J Pain Subsets: MEDLINE

Výrazy zo slovníka MeSH: Chronic Pain*/epidemiology , Chronic Pain*/diagnosis , Neuralgia*/epidemiology , Neuralgia*/diagnosis , Phenotype*, Humans ; Pain Measurement

A review of genetic variation underlying chicken phenotypic diversity.

Autori: Fulton JE McCarron AM Mullen A a ďalší

Zdroj: Poultry science [Poult Sci] 2025 Nov; Vol. 104 (11), pp. 105761. Date of Electronic Publication: 2025 Sep 01.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 0401150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3171 (Electronic) Linking ISSN: 00325791 NLM ISO Abbreviation: Poult Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Chickens*/genetics , Genetic Variation* , Phenotype*, Animals

Computable Phenotyping: Disease-Agnostic Translational Methods to Puberty and Diabetes in Adolescent Males.

Autori: Schnabel DJ Jr Dorn L

Zdroj: Nursing research [Nurs Res] 2025 Nov-Dec 01; Vol. 74 (6), pp. 460-466. Date of Electronic Publication: 2025 Jul 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 0376404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-9847 (Electronic) Linking ISSN: 00296562 NLM ISO Abbreviation: Nurs Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Phenotype* , Diabetes Mellitus, Type 2* , Puberty*/physiology, Humans ; Male ; Adolescent ; Pilot Projects ; Translational Research, Biomedical/methods ; Child

Equivalence of Type 2 Diabetes Prevalence Estimates: Comparative Study of Similar Phenotyping Algorithms Using Electronic Health Record Data.

Autori: Wandai ME Allen KS Wiensch A a ďalší

Zdroj: JMIR public health and surveillance [JMIR Public Health Surveill] 2025 Oct 27; Vol. 11, pp. e79653. Date of Electronic Publication: 2025 Oct 27.

Spôsob vydávania: Journal Article; Comparative Study

Informácie o časopise: Publisher: JMIR Publications Country of Publication: Canada NLM ID: 101669345 Publication Model: Electronic Cited Medium: Internet ISSN: 2369-2960 (Electronic) Linking ISSN: 23692960 NLM ISO Abbreviation: JMIR Public Health Surveill Subsets: MEDLINE

Výrazy zo slovníka MeSH: Electronic Health Records*/statistics & numerical data , Diabetes Mellitus, Type 2*/epidemiology , Phenotype* , Algorithms*, Humans ; Prevalence ; Adult ; Male ; Adolescent ; Female ; Young Adult ; Indiana/epidemiology

MLDAAPP: machine learning data acquisition for assessing population phenotypes.

Autori: Gabidulin AR Rudman SM

Zdroj: G3 (Bethesda, Md.) [G3 (Bethesda)] 2025 Oct 08; Vol. 15 (10).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Machine Learning* , Phenotype* , Software*, Animals ; Drosophila/genetics ; Reproducibility of Results