Search Results - "Pharmacology."

Deciphering the pharmacological mechanisms of Scutellariae Radix on hepatocellular carcinoma by combining network pharmacology, metabolomics and experimental evaluations.

Authors: Zhou R Li Y Luo L et al.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Dec 15; Vol. 792, pp. 152918. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Scutellaria baicalensis*/chemistry , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry, Humans ; Network Pharmacology ; Metabolomics ; Flavanones/pharmacology ; Flavanones/chemistry ; Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Molecular Docking Simulation ; Cell Movement/drug effects ; Mice, Nude ; Signal Transduction/drug effects ; Mice, Inbred BALB C ; Mice

Potential of Amaranthus tricolor Terpenoids in Managing Obesity by Modulating the PI3K/AKT Pathway: A Network Pharmacology Approach.

Authors: Khandelwal A Pande B Jyotsana et al.

Source: Cell biochemistry and biophysics [Cell Biochem Biophys] 2025 Dec; Vol. 83 (4), pp. 5255-5269. Date of Electronic Publication: 2025 Jul 28.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE

MeSH Terms: Terpenes*/pharmacology , Terpenes*/chemistry , Terpenes*/therapeutic use , Obesity*/drug therapy , Obesity*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Phosphatidylinositol 3-Kinases*/metabolism , Amaranthus*/chemistry , Amaranthus*/metabolism , Signal Transduction*/drug effects , Network Pharmacology*, Molecular Docking Simulation ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Animals ; Plant Leaves/chemistry ; Mice ; Gas Chromatography-Mass Spectrometry ; Humans

Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease.

Authors: Tusar MTT Munna MMR Ahmed MH et al.

Source: Cell biochemistry and biophysics [Cell Biochem Biophys] 2025 Dec; Vol. 83 (4), pp. 4623-4650. Date of Electronic Publication: 2025 Jun 04.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE

MeSH Terms: Molecular Docking Simulation* , Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism , Network Pharmacology* , Acetophenones*/chemistry , Acetophenones*/therapeutic use , Acetophenones*/pharmacology , Abietanes*/chemistry , Abietanes*/therapeutic use , Abietanes*/pharmacology , Anisoles*/chemistry , Anisoles*/therapeutic use , Anisoles*/pharmacology , Molecular Dynamics Simulation*, Humans ; Allylbenzene Derivatives ; Cymenes/chemistry ; Cymenes/therapeutic use ; Cymenes/pharmacology ; Monoterpenes/chemistry ; Monoterpenes/therapeutic use ; Monoterpenes/pharmacology ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Protein Interaction Maps

Bioactive components from Kaixin san alleviate bradyarrhythmia via modulation of the calcium signaling pathway: Integrated UPLC-Q-TOF/MS, network pharmacology, and experimental validation.

Authors: Ren Y Wang P Yang F et al.

Source: Fitoterapia [Fitoterapia] 2025 Dec; Vol. 187, pp. 106918. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

MeSH Terms: Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/chemistry , Bradycardia*/drug therapy , Bradycardia*/chemically induced , Calcium Signaling*/drug effects , Anti-Arrhythmia Agents*/pharmacology , Anti-Arrhythmia Agents*/isolation & purification, Animals ; Rats ; Network Pharmacology ; Rats, Sprague-Dawley ; Male ; Molecular Docking Simulation ; Phytochemicals/pharmacology ; Phytochemicals/isolation & purification ; Molecular Structure ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Chromatography, High Pressure Liquid

Mechanistic insights into Schisandrin C as the active anti-renal fibrosis ingredient of Schisandra chinensis: a network pharmacology analysis and transcriptomics integrated experimental verification.

Authors: Yang X Qiaolongbatu X Shen R et al.

Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Dec; Vol. 398 (12), pp. 17503-17523. Date of Electronic Publication: 2025 Jun 12.

Publication Type: Journal Article

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH Terms: Schisandra*/chemistry , Lignans*/pharmacology , Lignans*/therapeutic use , Polycyclic Compounds*/pharmacology , Polycyclic Compounds*/therapeutic use , Kidney*/drug effects , Kidney*/pathology , Kidney*/metabolism , Kidney Diseases*/drug therapy , Kidney Diseases*/pathology , Kidney Diseases*/genetics , Antifibrotic Agents*/pharmacology, Animals ; Zebrafish ; Fibrosis ; Network Pharmacology ; Cyclooctanes/pharmacology ; Cyclooctanes/therapeutic use ; Transcriptome/drug effects ; Humans ; Molecular Docking Simulation ; Signal Transduction/drug effects ; Disease Models, Animal

Integrating serum pharmacochemistry, network pharmacology, and metabolomics to explore the protective mechanism of Hua-Feng-Dan in ischemic stroke.

Authors: Yuan X He X Shu Q et al.

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov 25; Vol. 148, pp. 157251. Date of Electronic Publication: 2025 Sep 10.

Publication Type: Journal Article

Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH Terms: Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/chemistry , Ischemic Stroke*/drug therapy , Ischemic Stroke*/metabolism , Neuroprotective Agents*/pharmacology, Animals ; Network Pharmacology ; Rats, Sprague-Dawley ; Male ; Metabolomics ; Rats ; Molecular Docking Simulation ; Infarction, Middle Cerebral Artery/drug therapy ; Signal Transduction/drug effects ; Oxidative Stress/drug effects ; Flavonoids/pharmacology ; Flavonoids/blood ; Apoptosis/drug effects ; Alkaloids/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Reperfusion Injury/drug therapy

GC-MS profiling and computational analysis of Balanites aegyptiaca phytoconstituents for antidiabetic activity: insights from network pharmacology and molecular docking.

Authors: Gautam SK Paul RK Jain S et al.

Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Nov; Vol. 398 (11), pp. 15413-15441. Date of Electronic Publication: 2025 May 06.

Publication Type: Journal Article

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH Terms: Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/pharmacokinetics , Hypoglycemic Agents*/isolation & purification , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Plant Extracts*/pharmacokinetics , Phytochemicals*/pharmacology, Molecular Docking Simulation ; Network Pharmacology ; Animals ; Gas Chromatography-Mass Spectrometry ; Antioxidants/pharmacology ; Molecular Dynamics Simulation ; Anti-Inflammatory Agents/pharmacology ; Male

Investigating the ameliorative effect of Kalanchoe pinnata on neuroinflammation-associated Alzheimer's disease using network pharmacology, molecular docking, and in vitro studies.

Authors: Khandayataray P Murthy MK

Source: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2025 Oct 24; Vol. 39 (2), pp. 105. Date of Electronic Publication: 2025 Oct 24.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 8710425 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4951 (Electronic) Linking ISSN: 0920654X NLM ISO Abbreviation: J Comput Aided Mol Des Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Kalanchoe*/chemistry, Molecular Docking Simulation ; Network Pharmacology ; Amyloid beta-Peptides/metabolism ; Humans ; Animals ; Signal Transduction/drug effects ; Mice ; Microglia/drug effects ; Microglia/metabolism ; Cell Line ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Phosphatidylinositol 3-Kinases/metabolism ; Cytokines/metabolism ; Proto-Oncogene Proteins c-akt/metabolism

Unraveling the active ingredients and molecular mechanisms of Buyi Xiaozheng decoction against ovarian cancer: An integrative approach combining UHPLC-QE-MS, network pharmacology, molecular docking, dynamics simulations, and experimental verification.

Authors: Ding C Guo J Wang C et al.

Source: Fitoterapia [Fitoterapia] 2025 Oct; Vol. 186, pp. 106819. Date of Electronic Publication: 2025 Aug 13.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

MeSH Terms: Ovarian Neoplasms*/drug therapy , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology, Humans ; Molecular Docking Simulation ; Network Pharmacology ; Female ; Cell Line, Tumor ; Molecular Dynamics Simulation ; Chromatography, High Pressure Liquid ; Molecular Structure ; Protein Interaction Maps ; Phytochemicals/pharmacology ; Signal Transduction/drug effects ; Cell Movement/drug effects

Untargeted Metabolomics Analysis Combined With Network Pharmacology Reveals Differences in Chemical Profiles and Activities of Different Processed Products of Clematis chinensis Osbeck.

Authors: Ke J Wang L Huang L et al.

Source: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2025 Dec 30; Vol. 39 (24), pp. e10143.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley And Sons Ltd Country of Publication: England NLM ID: 8802365 Publication Model: Print Cited Medium: Internet ISSN: 1097-0231 (Electronic) Linking ISSN: 09514198 NLM ISO Abbreviation: Rapid Commun Mass Spectrom Subsets: MEDLINE

MeSH Terms: Metabolomics*/methods , Clematis*/chemistry , Clematis*/metabolism , Drugs, Chinese Herbal*/chemistry , Drugs, Chinese Herbal*/pharmacology , Plant Extracts*/chemistry , Plant Extracts*/pharmacology, Network Pharmacology/methods ; Animals ; Metabolome/drug effects

Molecular insights into the anti-asthma potential of Zhimu-Chuanbeimu drug pair based on serum pharmacochemistry, network pharmacology and immune infiltration analysis.

Authors: Zhang C Tian X Zhang H et al.

Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Dec 15; Vol. 266, pp. 117077. Date of Electronic Publication: 2025 Jul 23.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH Terms: Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/chemistry , Asthma*/drug therapy , Asthma*/immunology , Anti-Asthmatic Agents*/pharmacology , Anti-Asthmatic Agents*/chemistry, Animals ; Molecular Docking Simulation/methods ; Network Pharmacology/methods ; Rats ; Molecular Dynamics Simulation ; Male ; Rats, Sprague-Dawley ; Medicine, Chinese Traditional/methods ; Chromatography, High Pressure Liquid/methods ; Disease Models, Animal ; Lung/drug effects ; Lung/immunology ; Ovalbumin

A study on the mechanism of action of Syringin in the treatment of type 2 diabetes by integrating metabolomics, network pharmacology, molecular docking technology and experimental validation.

Authors: Wan C Sun S Du Y et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115716. Date of Electronic Publication: 2025 Oct 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Glucosides*/therapeutic use , Glucosides*/pharmacology , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Phenylpropionates*/therapeutic use , Phenylpropionates*/pharmacology , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/pharmacology, Animals ; Molecular Docking Simulation ; Network Pharmacology ; Male ; Mice ; Metabolomics ; Humans ; Diet, High-Fat ; Mice, Inbred C57BL ; Blood Glucose/drug effects ; Streptozocin

Network pharmacology reveals Ficus. Carica. L latex as a potential therapeutic agent for gastric ulcers by modulating inflammation and promoting repair.

Authors: Shady NH Hisham M Abdullah HS et al.

Source: PloS one [PLoS One] 2025 Dec 02; Vol. 20 (12), pp. e0333777. Date of Electronic Publication: 2025 Dec 02 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Ficus*/chemistry , Stomach Ulcer*/drug therapy , Stomach Ulcer*/chemically induced , Stomach Ulcer*/pathology , Stomach Ulcer*/metabolism , Network Pharmacology* , Latex*/pharmacology , Latex*/chemistry , Latex*/therapeutic use , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Plant Extracts*/therapeutic use , Inflammation*/drug therapy , Anti-Ulcer Agents*/pharmacology, Animals ; Rats ; Male ; Molecular Docking Simulation ; Indomethacin ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Wound Healing/drug effects

Network Pharmacology Approach to Explore the Skin-Lightening Compounds and Potential Mechanisms of Chinese Herbal Medicines.

Authors: Liang Y Chen J Fu C et al.

Source: Journal of cosmetic dermatology [J Cosmet Dermatol] 2025 Dec; Vol. 24 (12), pp. e70562.

Publication Type: Journal Article

Journal Info: Publisher: Blackwell Science Country of Publication: England NLM ID: 101130964 Publication Model: Print Cited Medium: Internet ISSN: 1473-2165 (Electronic) Linking ISSN: 14732130 NLM ISO Abbreviation: J Cosmet Dermatol Subsets: MEDLINE

MeSH Terms: Drugs, Chinese Herbal*/pharmacology , Skin Lightening Preparations*/pharmacology , Skin Pigmentation*/drug effects, Humans ; Network Pharmacology ; Protein Interaction Maps/drug effects ; Skin/drug effects ; Skin/metabolism ; Skin/cytology ; Molecular Docking Simulation ; Signal Transduction/drug effects ; Keratinocytes/drug effects ; Medicine, Chinese Traditional ; NF-kappa B/metabolism

Therapeutic Potential of 6-Gingerol in Glioma: Mechanistic Insights and Experimental Validation.

Authors: Miao S Hua W Wang J et al.

Source: Chemical biology & drug design [Chem Biol Drug Des] 2025 Dec; Vol. 106 (6), pp. e70217.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Internet ISSN: 1747-0285 (Electronic) Linking ISSN: 17470277 NLM ISO Abbreviation: Chem Biol Drug Des Subsets: MEDLINE

MeSH Terms: Glioma*/drug therapy , Glioma*/pathology , Glioma*/metabolism , Catechols*/pharmacology , Catechols*/chemistry , Catechols*/therapeutic use , Catechols*/metabolism , Fatty Alcohols*/pharmacology , Fatty Alcohols*/chemistry , Fatty Alcohols*/therapeutic use , Fatty Alcohols*/metabolism, Humans ; Molecular Docking Simulation ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Apoptosis/drug effects ; Signal Transduction/drug effects ; Network Pharmacology ; Cell Movement/drug effects

Alpinetin Targets Mitophagy Pathways to Mitigate Parkinson's Disease Progression.

Authors: Shen Z Shan X Zhang S et al.

Source: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2025 Dec; Vol. 31 (12), pp. e70676.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE

MeSH Terms: Mitophagy*/drug effects , Mitophagy*/physiology , Flavanones*/pharmacology , Flavanones*/therapeutic use , Flavanones*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism, Animals ; Molecular Docking Simulation ; Male ; Disease Progression ; Mice ; Humans ; Mice, Inbred C57BL ; Network Pharmacology ; Oxidopamine/toxicity

Dihydromyricetin ameliorates vascular dementia by promoting angiogenesis via the VEGFR2 pathway: Network pharmacology, molecular docking and experimental validation.

Authors: Zhou SY Zhang GM Wang K et al.

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Dec; Vol. 149, pp. 157593. Date of Electronic Publication: 2025 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH Terms: Flavonols*/pharmacology , Vascular Endothelial Growth Factor Receptor-2*/metabolism , Dementia, Vascular*/drug therapy, Molecular Docking Simulation ; Animals ; Male ; Mice ; Network Pharmacology ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Molecular Dynamics Simulation ; Neuroprotective Agents/pharmacology ; Humans ; Angiogenesis

Clinical Pharmacology Approaches to Predict Efficacy of Monoclonal Antibodies Against Emerging SARS-CoV-2 Variants.

Authors: Wang Q Nader A Peppercorn A et al.

Source: Clinical and translational science [Clin Transl Sci] 2025 Dec; Vol. 18 (12), pp. e70421.

Publication Type: Journal Article; Review

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

MeSH Terms: SARS-CoV-2*/drug effects , SARS-CoV-2*/immunology , SARS-CoV-2*/genetics , Antibodies, Monoclonal*/pharmacology , Antibodies, Monoclonal*/therapeutic use , Antibodies, Monoclonal*/administration & dosage , COVID-19 Drug Treatment* , COVID-19*/virology , COVID-19*/immunology , Antibodies, Viral*/administration & dosage , Antibodies, Viral*/therapeutic use , Antibodies, Viral*/immunology , Antibodies, Viral*/pharmacology, Humans ; Pharmacology, Clinical/methods ; Antibodies, Neutralizing

SCR Organism: SARS-CoV-2 variants

Tanshinone IIA attenuates cerebral-ischemia-reperfusion-induced neuroinflammation by inhibiting the TLR4/NF-κB signaling cascade: A study integrating network pharmacology, bioinformatics, and experimental validation.

Authors: Zhou C Yu Z Chen T et al.

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Dec; Vol. 149, pp. 157548. Date of Electronic Publication: 2025 Nov 12.

Publication Type: Journal Article

Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH Terms: Abietanes*/pharmacology , Toll-Like Receptor 4*/metabolism , Reperfusion Injury*/drug therapy , NF-kappa B*/metabolism , Brain Ischemia*/drug therapy , Neuroinflammatory Diseases*/drug therapy, Animals ; Signal Transduction/drug effects ; Male ; Network Pharmacology ; Rats ; Rats, Sprague-Dawley ; Molecular Docking Simulation ; Humans ; Computational Biology ; Neuroprotective Agents/pharmacology ; Human Umbilical Vein Endothelial Cells ; Anti-Inflammatory Agents/pharmacology

Integrative Network Pharmacology and Proteomics Decipher the Immunomodulatory Mechanism of Sulforaphane Against Intrinsic Skin Aging.

Authors: Du X Yang X Zhang C et al.

Source: Molecular nutrition & food research [Mol Nutr Food Res] 2025 Dec; Vol. 69 (23), pp. e70281. Date of Electronic Publication: 2025 Oct 02.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101231818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-4133 (Electronic) Linking ISSN: 16134125 NLM ISO Abbreviation: Mol Nutr Food Res Subsets: MEDLINE

MeSH Terms: Isothiocyanates*/pharmacology , Skin Aging*/drug effects , Sulfoxides*/pharmacology, Animals ; Proteomics/methods ; Mice ; Network Pharmacology ; Skin/drug effects ; Mice, Inbred C57BL ; Male ; Signal Transduction/drug effects