Suchergebnisse - "Pharmacokinetics"

Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations.

Autoren: Ezuruike U Dinh J El-Khateeb E et al.

Quelle: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2025 Oct; Vol. 14 (10), pp. 1598-1615. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Models, Biological* , Pharmacokinetics*, Humans ; Drug Interactions ; Liver-Specific Organic Anion Transporter 1/genetics ; Liver-Specific Organic Anion Transporter 1/metabolism ; Computer Simulation ; White People/genetics ; Black or African American/genetics ; Male ; Hispanic or Latino/genetics ; Female ; Cytochrome P-450 CYP2C9/genetics ; Adult ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Asian/genetics ; Middle Aged ; Ethnicity ; North America ; Piperidines/pharmacokinetics ; Carbamates/pharmacokinetics ; White

Development, Verification, and Application of a Chinese Pediatric Physiologically Based Pharmacokinetic Model: Emphasis on CYP Metabolism and Renal Elimination.

Autoren: Southall RL Dinh J Pan X et al.

Quelle: The AAPS journal [AAPS J] 2025 Nov 10; Vol. 28 (1), pp. 17. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE

MeSH-Schlagworte: Models, Biological* , Pharmacokinetics* , Renal Elimination*/physiology, Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; China ; Cyclopropanes/pharmacokinetics ; Cytochrome P-450 CYP3A/metabolism ; Drug Development/methods ; Midazolam/pharmacokinetics ; Theophylline/pharmacokinetics ; East Asian People

Target-Mediated Drug Disposition (TMDD) Revisited: High Versus Low-Affinity Approximations of the TMDD Model.

Autoren: Straube R; Pioneering Medicines, Cambridge, Massachusetts, USA.

Quelle: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2025 Jul; Vol. 14 (7), pp. 1262-1272. Date of Electronic Publication: 2025 May 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Models, Biological* , Pharmacokinetics* , Drug Delivery Systems*, Humans ; Antibodies, Monoclonal/pharmacokinetics ; Pharmaceutical Preparations/metabolism

Comprehensive assessments of pharmacokinetics and immunogenicity of farletuzumab ecteribulin, a novel antibody-drug conjugate against tumors expressing folate receptor α, in monkeys.

Autoren: Fernando S Mano Y

Quelle: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Dec 15; Vol. 266, pp. 117084. Date of Electronic Publication: 2025 Jul 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH-Schlagworte: Immunoconjugates*/pharmacokinetics , Immunoconjugates*/immunology , Immunoconjugates*/administration & dosage , Antibodies, Monoclonal, Humanized*/pharmacokinetics , Antibodies, Monoclonal, Humanized*/immunology , Antibodies, Monoclonal, Humanized*/administration & dosage , Folate Receptor 1*/metabolism , Neoplasms*/drug therapy , Antineoplastic Agents*/pharmacokinetics, Animals ; Furans/pharmacokinetics ; Tandem Mass Spectrometry/methods ; Ketones/pharmacokinetics ; Macaca fascicularis ; Male ; Humans ; Chromatography, Liquid/methods ; Polyether Polyketides

Establishing a Quantitative Framework for Combined Oral Contraceptives: Evaluating the Impact of Drug-Drug Interactions on Exposure and Clinical (Surrogate) Efficacy Endpoints.

Autoren: Chun D Chen H Cicali B et al.

Quelle: Journal of clinical pharmacology [J Clin Pharmacol] 2025 Dec; Vol. 65 (12), pp. 1855-1863. Date of Electronic Publication: 2025 Jul 22.

Publikationsart: Journal Article; Meta-Analysis

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Contraceptives, Oral, Combined*/pharmacokinetics , Contraceptives, Oral, Combined*/pharmacology , Models, Biological*, Humans ; Female ; Drug Interactions ; Levonorgestrel/pharmacokinetics ; Levonorgestrel/pharmacology ; Androstenes/pharmacokinetics ; Androstenes/pharmacology ; Cytochrome P-450 CYP3A/metabolism ; Ovulation/drug effects ; Adult ; Progestins/pharmacology ; Progestins/pharmacokinetics ; Cytochrome P-450 CYP3A Inducers/pharmacology

Clinical pharmacokinetics and immunogenicity evaluation of a trophoblast cell surface antigen 2-targeted antibody-drug conjugate, FDA018, in patients with epithelial malignant solid tumors.

Autoren: Cheng M Li X Li Y et al.

Quelle: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2025 Nov; Vol. 53 (11), pp. 100165. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article; Clinical Trial, Phase I

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

MeSH-Schlagworte: Immunoconjugates*/pharmacokinetics , Immunoconjugates*/administration & dosage , Immunoconjugates*/immunology , Antibodies, Monoclonal, Humanized*/pharmacokinetics , Antibodies, Monoclonal, Humanized*/administration & dosage , Antibodies, Monoclonal, Humanized*/immunology , Neoplasms*/drug therapy , Neoplasms*/immunology, Humans ; Female ; Adult ; Middle Aged ; Irinotecan/pharmacokinetics ; Male ; Dose-Response Relationship, Drug ; Camptothecin/analogs & derivatives ; Camptothecin/pharmacokinetics ; Camptothecin/administration & dosage ; Topoisomerase I Inhibitors/pharmacokinetics ; Topoisomerase I Inhibitors/administration & dosage ; Trophoblasts/metabolism ; Trophoblasts/immunology ; Aged

Methoxyethyl Etomidate Hydrochloride (ET-26): A Phase I Clinical Trial Assessing Drug-Drug Interactions in Healthy Subjects.

Autoren: Yang F Ye PP Lv WS et al.

Quelle: Journal of clinical pharmacology [J Clin Pharmacol] 2025 Nov; Vol. 65 (11), pp. 1443-1450. Date of Electronic Publication: 2025 Jul 03.

Publikationsart: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Etomidate*/pharmacokinetics , Etomidate*/analogs & derivatives , Etomidate*/pharmacology , Etomidate*/adverse effects , Etomidate*/administration & dosage , Anesthetics, Intravenous*/pharmacokinetics , Anesthetics, Intravenous*/adverse effects , Anesthetics, Intravenous*/pharmacology , Anesthetics, Intravenous*/administration & dosage, Humans ; Drug Interactions ; Male ; Adult ; Female ; Midazolam/pharmacokinetics ; Midazolam/pharmacology ; Omeprazole/pharmacokinetics ; Omeprazole/pharmacology ; Young Adult ; Rifampin/pharmacology ; Rifampin/pharmacokinetics ; Fluconazole/pharmacology ; Fluconazole/pharmacokinetics ; Fluconazole/administration & dosage ; Middle Aged ; Healthy Volunteers ; Cytochrome P-450 CYP2C19/metabolism ; Area Under Curve ; Cross-Over Studies

Influenza Antiviral Pharmacokinetic-Pharmacodynamic Relationships in Pregnancy, Infancy, and Early Childhood.

Autoren: Hastings LE Acosta EP Kimberlin DW

Quelle: The Journal of infectious diseases [J Infect Dis] 2025 Oct 17; Vol. 232 (Supplement_3), pp. S286-S298.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE

MeSH-Schlagworte: Antiviral Agents*/pharmacokinetics , Antiviral Agents*/pharmacology , Antiviral Agents*/therapeutic use , Influenza, Human*/drug therapy , Oseltamivir*/pharmacokinetics , Oseltamivir*/pharmacology , Oseltamivir*/therapeutic use , Pregnancy Complications, Infectious*/drug therapy, Humans ; Pregnancy ; Female ; Infant ; Child, Preschool ; Dibenzothiepins/pharmacokinetics ; Pyridones/pharmacokinetics ; Morpholines/pharmacokinetics ; Triazines/pharmacokinetics ; Triazines/pharmacology ; Triazines/therapeutic use ; Thiepins/pharmacokinetics ; Thiepins/pharmacology ; Thiepins/therapeutic use ; Pyridines/pharmacokinetics ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Infant, Newborn ; Neuraminidase/antagonists & inhibitors

Pharmacological evaluation on benzimidazole anthelmintics for eradication of the gill fluke Microcotyle sebastis infesting a black rockfish, Sebastes schlegelii.

Autoren: Yang CY Bae JS Kim GW et al.

Quelle: Veterinary parasitology [Vet Parasitol] 2025 Oct; Vol. 339, pp. 110573. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7602745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2550 (Electronic) Linking ISSN: 03044017 NLM ISO Abbreviation: Vet Parasitol Subsets: MEDLINE

MeSH-Schlagworte: Anthelmintics*/pharmacokinetics , Anthelmintics*/pharmacology , Anthelmintics*/therapeutic use , Fish Diseases*/drug therapy , Fish Diseases*/parasitology , Trematode Infections*/veterinary , Trematode Infections*/drug therapy , Trematode Infections*/parasitology , Trematoda*/drug effects , Benzimidazoles*/pharmacokinetics , Benzimidazoles*/pharmacology , Benzimidazoles*/therapeutic use, Animals ; Gills/parasitology ; Albendazole/pharmacokinetics ; Albendazole/pharmacology ; Fishes ; Mebendazole/pharmacokinetics ; Mebendazole/pharmacology ; Fenbendazole/pharmacokinetics ; Fenbendazole/pharmacology

Pharmacokinetics and Penetration of a Novel Pharmacodynamically Optimized, Carbapenem-Sparing Antibiotic, WCK 4282 (Cefepime/Tazobactam), into Epithelial Lining Fluid of Healthy, Lung-, and Thigh-Infected Neutropenic Mice.

Autoren: Chavan R Zope V Patil K et al.

Quelle: Microbial drug resistance (Larchmont, N.Y.) [Microb Drug Resist] 2025 Oct; Vol. 31 (10), pp. 338-344. Date of Electronic Publication: 2025 Sep 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 9508567 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-8448 (Electronic) Linking ISSN: 10766294 NLM ISO Abbreviation: Microb Drug Resist Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/pharmacokinetics , Anti-Bacterial Agents*/pharmacology , Neutropenia*/microbiology , Neutropenia*/drug therapy , Neutropenia*/metabolism , Escherichia coli Infections*/drug therapy , Escherichia coli Infections*/microbiology , Cephalosporins*/pharmacokinetics , Cephalosporins*/pharmacology, Animals ; Mice ; Tazobactam/pharmacokinetics ; Thigh/microbiology ; Cefepime/pharmacokinetics ; Lung/microbiology ; Lung/metabolism ; Lung/drug effects ; Female ; Escherichia coli/drug effects ; Microbial Sensitivity Tests ; Carbapenems/pharmacology ; Disease Models, Animal

Piperacillin reaches high concentrations in bile and target tissues of the biliary system: an experimental study in pigs.

Autoren: Pontoppidan LL Bue M Houlind KC et al.

Quelle: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2025 Oct; Vol. 69 (10), pp. e0079225. Date of Electronic Publication: 2025 Aug 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

MeSH-Schlagworte: Bile*/metabolism , Anti-Bacterial Agents*/pharmacokinetics , Anti-Bacterial Agents*/pharmacology , Piperacillin*/pharmacokinetics , Piperacillin*/pharmacology , Biliary Tract*/metabolism , Biliary Tract*/drug effects, Animals ; Swine ; Microbial Sensitivity Tests ; Liver/metabolism ; Liver/drug effects ; Gallbladder/metabolism ; Gallbladder/drug effects ; Piperacillin, Tazobactam Drug Combination/pharmacokinetics ; Microdialysis ; Penicillanic Acid/analogs & derivatives ; Penicillanic Acid/pharmacokinetics ; Penicillanic Acid/pharmacology ; Common Bile Duct/metabolism ; Common Bile Duct/drug effects

Assessing Impact of Food on Oral Drug Bioequivalence Supporting ICH M13 A with the Advancements of Physiologically Based Pharmacokinetic Modeling.

Autoren: Pal A Alam K Stier E et al.

Quelle: Pharmaceutical research [Pharm Res] 2025 May; Vol. 42 (5), pp. 835-845. Date of Electronic Publication: 2025 Jun 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

MeSH-Schlagworte: Models, Biological* , Food-Drug Interactions* , Drugs, Generic*/pharmacokinetics , Drugs, Generic*/administration & dosage, Therapeutic Equivalency ; Humans ; Administration, Oral ; United States Food and Drug Administration ; United States ; Drug Development/methods ; Pharmacokinetics

Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling and its Regulatory Utility to Support Oral Drug Product Development and Harmonization.

Autoren: Cheng YH Thomas S Tsang YC et al.

Quelle: Pharmaceutical research [Pharm Res] 2025 May; Vol. 42 (5), pp. 819-833. Date of Electronic Publication: 2025 Mar 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

MeSH-Schlagworte: Drug Development*/methods , Drug Development*/legislation & jurisprudence , Drugs, Generic*/pharmacokinetics , Drugs, Generic*/administration & dosage , Models, Biological*, Humans ; Administration, Oral ; Biological Availability ; Pharmaceutical Preparations/administration & dosage ; Pharmaceutical Preparations/metabolism ; Pharmacokinetics ; United States ; United States Food and Drug Administration

Patchouli alcohol as an effective adjuvant for artemisinin-based combination therapies: Metabolic profiling, pharmacokinetics and mechanistic validation.

Autoren: Li L Wang B Du X et al.

Quelle: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2025 Dec 15; Vol. 1267, pp. 124827. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

MeSH-Schlagworte: Artemisinins*/pharmacokinetics , Artemisinins*/pharmacology , Antimalarials*/pharmacokinetics , Antimalarials*/chemistry , Antimalarials*/pharmacology , Sesquiterpenes*/pharmacokinetics , Sesquiterpenes*/chemistry , Sesquiterpenes*/pharmacology , Sesquiterpenes*/analysis , Sesquiterpenes*/metabolism , Metabolome*/drug effects, Male ; Female ; Molecular Docking Simulation ; Animals ; Tandem Mass Spectrometry ; Gas Chromatography-Mass Spectrometry ; Rats ; Rats, Sprague-Dawley ; Humans ; Reproducibility of Results ; Chromatography, High Pressure Liquid ; Artesunate/pharmacokinetics ; Linear Models

Pharmacokinetics and tissue distribution of tripchlorolide in rodents using liquid chromatography tandem mass spectrometry.

Autoren: Deng Y Zhou L Gu Z et al.

Quelle: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2025 Dec 15; Vol. 1267, pp. 124805. Date of Electronic Publication: 2025 Oct 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

MeSH-Schlagworte: Tandem Mass Spectrometry*/methods , Diterpenes*/pharmacokinetics , Diterpenes*/chemistry , Diterpenes*/blood , Diterpenes*/analysis , Phenanthrenes*/pharmacokinetics , Phenanthrenes*/chemistry , Phenanthrenes*/analysis , Phenanthrenes*/blood, Animals ; Tissue Distribution ; Mice ; Rats ; Male ; Reproducibility of Results ; Rats, Sprague-Dawley ; Linear Models ; Chromatography, Liquid/methods ; Female ; Limit of Detection ; Epoxy Compounds/pharmacokinetics

Control of pharmacokinetics of radioimmunoconjugates using chelating agents containing poly(ethylene glycol).

Autoren: Nakashima K Jinda H Shimohara H et al.

Quelle: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 1), pp. 114293. Date of Electronic Publication: 2025 Oct 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH-Schlagworte: Polyethylene Glycols*/chemistry , Polyethylene Glycols*/pharmacokinetics , Chelating Agents*/chemistry , Chelating Agents*/pharmacokinetics , Chelating Agents*/administration & dosage , Immunoconjugates*/pharmacokinetics , Immunoconjugates*/administration & dosage , Immunoconjugates*/chemistry, Animals ; Humans ; Cell Line, Tumor ; Female ; Tissue Distribution ; Trastuzumab/pharmacokinetics ; Trastuzumab/administration & dosage ; Heterocyclic Compounds, 1-Ring/chemistry ; Heterocyclic Compounds, 1-Ring/pharmacokinetics ; Mice, Nude ; Mice ; Mice, Inbred BALB C ; Receptor, ErbB-2/metabolism ; Radioisotopes/pharmacokinetics ; Radioisotopes/administration & dosage ; Maleimides/chemistry

Association of SULT2A1 Locus With Abiraterone Clearance in the Alliance A031201: Randomized Phase III Study of Enzalutamide Compared With Enzalutamide Plus Abiraterone for Metastatic Castration-Resistant Prostate Cancer.

Autoren: Norton N Larson NB Jenkins GD et al.

Quelle: Clinical and translational science [Clin Transl Sci] 2025 Dec; Vol. 18 (12), pp. e70425.

Publikationsart: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Comparative Study

Info zur Zeitschrift: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

MeSH-Schlagworte: Phenylthiohydantoin*/analogs & derivatives , Phenylthiohydantoin*/pharmacokinetics , Phenylthiohydantoin*/administration & dosage , Phenylthiohydantoin*/therapeutic use , Prostatic Neoplasms, Castration-Resistant*/drug therapy , Prostatic Neoplasms, Castration-Resistant*/genetics , Prostatic Neoplasms, Castration-Resistant*/pathology , Androstenes*/pharmacokinetics , Androstenes*/administration & dosage , Antineoplastic Combined Chemotherapy Protocols*/pharmacokinetics , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Sulfotransferases*/genetics , Sulfotransferases*/metabolism, Humans ; Male ; Nitriles ; Benzamides/pharmacokinetics ; Polymorphism, Single Nucleotide ; Aged ; Middle Aged ; Genome-Wide Association Study

Population Pharmacokinetics and Dosing Optimization of Piperacillin in Elderly Patients with Pneumonia in the Intensive Care Unit.

Autoren: Sun J Yang C Tang BH et al.

Quelle: Journal of clinical pharmacology [J Clin Pharmacol] 2025 Dec; Vol. 65 (12), pp. 1767-1776. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/pharmacokinetics , Anti-Bacterial Agents*/administration & dosage , Anti-Bacterial Agents*/blood , Models, Biological* , Piperacillin*/pharmacokinetics , Piperacillin*/administration & dosage , Piperacillin*/blood , Pneumonia*/drug therapy , Pneumonia, Bacterial*/drug therapy, Humans ; Aged ; Male ; Female ; Intensive Care Units ; Aged, 80 and over ; Prospective Studies ; Monte Carlo Method ; Piperacillin, Tazobactam Drug Combination/pharmacokinetics ; Piperacillin, Tazobactam Drug Combination/administration & dosage ; Microbial Sensitivity Tests ; Dose-Response Relationship, Drug ; Middle Aged

Pharmacokinetic Study and Bioequivalence Evaluation of Two Sustained-Release Tablets of Tamsulosin in Healthy Chinese Subjects Under Fasting and Postprandial Conditions.

Autoren: Wang J Yao F Lu P et al.

Quelle: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2025 Dec; Vol. 14 (12), pp. 971-976. Date of Electronic Publication: 2025 Sep 09.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 101572899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2160-7648 (Electronic) Linking ISSN: 2160763X NLM ISO Abbreviation: Clin Pharmacol Drug Dev Subsets: MEDLINE

MeSH-Schlagworte: Adrenergic alpha-1 Receptor Antagonists*/pharmacokinetics , Adrenergic alpha-1 Receptor Antagonists*/administration & dosage , Adrenergic alpha-1 Receptor Antagonists*/adverse effects , Adrenergic alpha-1 Receptor Antagonists*/blood , Tamsulosin*/pharmacokinetics , Tamsulosin*/administration & dosage , Tamsulosin*/adverse effects , Tamsulosin*/blood, Adult ; Humans ; Male ; Young Adult ; Administration, Oral ; Area Under Curve ; Cross-Over Studies ; Delayed-Action Preparations/pharmacokinetics ; Fasting ; Healthy Volunteers ; Postprandial Period ; Tablets ; Therapeutic Equivalency ; East Asian People

Pharmacokinetics and postoperative analgesic efficacy of intravenous acetaminophen in dogs undergoing laparoscopic ovariohysterectomy.

Autoren: Del Mar Granados M Mengual C Medina-Bautista F et al.

Quelle: Research in veterinary science [Res Vet Sci] 2025 Dec; Vol. 197, pp. 105792. Date of Electronic Publication: 2025 Jul 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: British Veterinary Association Country of Publication: England NLM ID: 0401300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2661 (Electronic) Linking ISSN: 00345288 NLM ISO Abbreviation: Res Vet Sci Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/pharmacokinetics , Acetaminophen*/administration & dosage , Acetaminophen*/therapeutic use , Hysterectomy*/veterinary , Pain, Postoperative*/veterinary , Pain, Postoperative*/drug therapy , Ovariectomy*/veterinary , Analgesics, Non-Narcotic*/pharmacokinetics , Analgesics, Non-Narcotic*/administration & dosage , Analgesics, Non-Narcotic*/therapeutic use, Animals ; Dogs/surgery ; Female ; Laparoscopy/veterinary ; Pain Measurement/veterinary ; Administration, Intravenous/veterinary ; Buprenorphine/therapeutic use ; Buprenorphine/pharmacokinetics ; Buprenorphine/administration & dosage