Suchergebnisse - "Peptoids"

Design and evaluation of Ugi-derived peptoids as antibacterial and anticancer agents: experimental and computational insights.

Autoren: Meenakshi Brahma M Sudheer Babu Y et al.

Quelle: Future medicinal chemistry [Future Med Chem] 2025 Dec; Vol. 17 (23), pp. 2805-2819. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Peptoids*/pharmacology , Peptoids*/chemistry , Peptoids*/chemical synthesis , Drug Design*, Humans ; Molecular Docking Simulation ; Microbial Sensitivity Tests ; Staphylococcus aureus/drug effects ; Escherichia coli/drug effects ; Animals ; Structure-Activity Relationship ; Molecular Dynamics Simulation ; Chlorocebus aethiops ; Drug Screening Assays, Antitumor ; Vero Cells ; Cell Proliferation/drug effects ; Molecular Structure ; A549 Cells

Cell-Penetrating Peptoids: A Dual Functional Strategy for Upcoming Neuroregeneration Application.

Autoren: Paudel P Kaur R Gharai PK

Quelle: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Oct 01; Vol. 16 (19), pp. 3631-3633. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Peptoids*/pharmacology , Peptoids*/metabolism , Nerve Regeneration*/physiology , Nerve Regeneration*/drug effects , Mesenchymal Stem Cells*/drug effects , Mesenchymal Stem Cells*/metabolism , Cell-Penetrating Peptides*/metabolism , Cell-Penetrating Peptides*/pharmacology, Humans ; Animals ; Neurons/drug effects ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Mesenchymal Stem Cell Transplantation/methods

Antiparasitic effect of peptoids against Cryptosporidium parvum .

Autoren: Lamont B Russell BM Suwanarusk R et al.

Quelle: Microbiology (Reading, England) [Microbiology (Reading)] 2025 Oct; Vol. 171 (10).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Microbiology Society Country of Publication: England NLM ID: 9430468 Publication Model: Print Cited Medium: Internet ISSN: 1465-2080 (Electronic) Linking ISSN: 13500872 NLM ISO Abbreviation: Microbiology (Reading) Subsets: MEDLINE

MeSH-Schlagworte: Cryptosporidium parvum*/drug effects , Peptoids*/pharmacology , Peptoids*/chemistry , Peptoids*/chemical synthesis , Antiprotozoal Agents*/pharmacology , Antiprotozoal Agents*/chemistry , Antiparasitic Agents*/pharmacology, Humans ; Cryptosporidiosis/drug therapy ; Cryptosporidiosis/parasitology ; Animals ; Peptidomimetics/pharmacology

Local enhancement of cationic charge density via polyamine side chain incorporation improves the selectivity of antimicrobial peptoids.

Autoren: Oh J Choi SM Yun Y et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117920. Date of Electronic Publication: 2025 Jun 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Peptoids*/pharmacology , Peptoids*/chemistry , Peptoids*/chemical synthesis , Polyamines*/chemistry , Polyamines*/pharmacology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Gram-Positive Bacteria*/drug effects , Gram-Negative Bacteria*/drug effects, Structure-Activity Relationship ; Microbial Sensitivity Tests ; Molecular Structure ; Humans ; Dose-Response Relationship, Drug ; Cations/chemistry ; Cations/pharmacology

Structural Insights into Ice Recrystallization Activity of Helical Disubstituted Polypeptoids.

Autoren: Wang P Dong Y Deng X et al.

Quelle: ACS macro letters [ACS Macro Lett] 2025 Oct 21; Vol. 14 (10), pp. 1586-1593. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101574672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2161-1653 (Electronic) Linking ISSN: 21611653 NLM ISO Abbreviation: ACS Macro Lett Subsets: MEDLINE

MeSH-Schlagworte: Ice* , Cryoprotective Agents*/chemistry , Cryoprotective Agents*/pharmacology , Cryoprotective Agents*/chemical synthesis , Antifreeze Proteins*/chemistry , Peptoids*/chemistry , Peptoids*/chemical synthesis , Peptoids*/pharmacology, Crystallization ; Cryopreservation/methods ; Hydrophobic and Hydrophilic Interactions ; Humans

A Novel Peptoid Hybrid of Alpha-Calcitonin Gene-Related Peptide (α-CGRP) Ameliorates Cardiac Remodeling in Pressure Overload-Induced Heart Failure.

Autoren: Deloach S Kumar A Ruggiero E et al.

Quelle: Cells [Cells] 2025 Oct 11; Vol. 14 (20). Date of Electronic Publication: 2025 Oct 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH-Schlagworte: Heart Failure*/drug therapy , Heart Failure*/physiopathology , Heart Failure*/pathology , Ventricular Remodeling*/drug effects , Calcitonin Gene-Related Peptide*/pharmacology , Calcitonin Gene-Related Peptide*/chemistry , Calcitonin Gene-Related Peptide*/therapeutic use , Peptoids*/pharmacology , Peptoids*/chemistry , Peptoids*/therapeutic use, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Ventricular Dysfunction, Left/drug therapy ; Ventricular Dysfunction, Left/physiopathology ; Apoptosis/drug effects ; Disease Models, Animal

In Situ Click Chemistry Screen Facilitated by an On-Nanoparticle DNA-Encoded Library Identifies Highly Selective and Potent Peptoid Ligands for a Phosphatase.

Autoren: Kim M Kim J Wang HM et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Oct 06; Vol. 64 (41), pp. e202511606. Date of Electronic Publication: 2025 Aug 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Peptoids*/chemistry , Peptoids*/metabolism , DNA*/chemistry , Nanoparticles*/chemistry , Phosphoric Monoester Hydrolases*/metabolism , Phosphoric Monoester Hydrolases*/antagonists & inhibitors , Phosphoric Monoester Hydrolases*/chemistry, Click Chemistry ; Ligands ; Humans ; Peptide Library

Structure-function relationship within helical peptoids for Cu ²⁺ chelation in the context of Alzheimer's disease.

Autoren: Behar AE Maayan G

Quelle: Journal of inorganic biochemistry [J Inorg Biochem] 2025 Oct; Vol. 271, pp. 112961. Date of Electronic Publication: 2025 May 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE

MeSH-Schlagworte: Copper*/chemistry , Copper*/metabolism , Peptoids*/chemistry , Peptoids*/pharmacology , Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Chelating Agents*/chemistry , Chelating Agents*/pharmacology, Humans ; Structure-Activity Relationship ; Reactive Oxygen Species/metabolism

Multi-stimuli responsive nanomaterials assembled from spiropyran-containing peptoids.

Autoren: Chakma P Harris BS Shi C et al.

Quelle: Nanoscale [Nanoscale] 2025 Dec 04; Vol. 17 (47), pp. 27350-27361. Date of Electronic Publication: 2025 Dec 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: RSC Pub Country of Publication: England NLM ID: 101525249 Publication Model: Electronic Cited Medium: Internet ISSN: 2040-3372 (Electronic) Linking ISSN: 20403364 NLM ISO Abbreviation: Nanoscale Subsets: MEDLINE

MeSH-Schlagworte: Benzopyrans*/chemistry , Indoles*/chemistry , Nitro Compounds*/chemistry , Nanostructures*/chemistry , Peptoids*/chemistry, Density Functional Theory

Specific and non-specific interactions of fibronectin with zwitterionic peptoid brushes studied by molecular dynamics simulation.

Autoren: Cheung DL Messersmith PB Lau KHA

Quelle: Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2025 Nov 26; Vol. 27 (46), pp. 25116-25126. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 100888160 Publication Model: Electronic Cited Medium: Internet ISSN: 1463-9084 (Electronic) Linking ISSN: 14639076 NLM ISO Abbreviation: Phys Chem Chem Phys Subsets: MEDLINE

MeSH-Schlagworte: Molecular Dynamics Simulation* , Fibronectins*/chemistry , Fibronectins*/metabolism , Peptoids*/chemistry, Protein Binding ; Sarcosine/analogs & derivatives ; Sarcosine/chemistry ; Peptides

The Effects of Chirality and Salt Addition on Phase Separation and Complexation Morphology in Mixtures of Polypeptides and Polypeptoids.

Autoren: Mirlohi K Thapa A Zhang D et al.

Quelle: Biomacromolecules [Biomacromolecules] 2025 Nov 10; Vol. 26 (11), pp. 7646-7655. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE

MeSH-Schlagworte: Peptides*/chemistry , Peptoids*/chemistry , Polymers*/chemistry, Stereoisomerism ; Salts/chemistry ; Osmolar Concentration ; Phase Separation

Cationic Peptoids for Systemic In Vivo Cartilage-Targeting.

Autoren: Zhang C Qiu R Huang Y et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (43), pp. e02781. Date of Electronic Publication: 2025 Aug 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Peptoids*/chemistry , Cartilage*/metabolism , Drug Delivery Systems*/methods, Animals ; Mice ; Zebrafish ; Cations ; Humans

Synthesis of Heterotelechelic Poly(N-ethylglycine) Polymers: from Polypeptoid Lipid Conjugates to Protein-Polymer Conjugates.

Autoren: Buijs E Nagorna Z Van Guyse JFR et al.

Quelle: Macromolecular rapid communications [Macromol Rapid Commun] 2025 Oct; Vol. 46 (20), pp. e00422. Date of Electronic Publication: 2025 Jul 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9888239 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3927 (Electronic) Linking ISSN: 10221336 NLM ISO Abbreviation: Macromol Rapid Commun Subsets: MEDLINE

MeSH-Schlagworte: Polymers*/chemistry , Polymers*/chemical synthesis , Lipids*/chemistry , Serum Albumin, Human*/chemistry , Peptoids*/chemistry, Humans ; Polymerization ; Molecular Structure ; Hydrophobic and Hydrophilic Interactions

Bioactive peptoids against vector-borne parasitic diseases.

Autoren: Bolt HL Kaiser M Luo Y et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2026 Feb 01; Vol. 131, pp. 130457. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Peptoids*/pharmacology , Peptoids*/chemistry , Peptoids*/chemical synthesis , Antiprotozoal Agents*/pharmacology , Antiprotozoal Agents*/chemistry , Antiprotozoal Agents*/chemical synthesis, Humans ; Plasmodium falciparum/drug effects ; Structure-Activity Relationship ; Parasitic Sensitivity Tests ; Animals ; Molecular Structure ; Dose-Response Relationship, Drug

Facile Synthesis of Thioether-Functionalized N -Substituted Glycine N -Thiocarboxyanhydride toward Well-Defined Thiopolypeptoids.

Autoren: Ding Y Feng C Jin S et al.

Quelle: Biomacromolecules [Biomacromolecules] 2025 Sep 08; Vol. 26 (9), pp. 5694-5704. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE

MeSH-Schlagworte: Sulfides*/chemistry , Peptoids*/chemistry , Peptoids*/chemical synthesis , Anhydrides*/chemistry , Anhydrides*/chemical synthesis , Glycine*/chemistry , Glycine*/analogs & derivatives , N-substituted Glycines*/chemistry , N-substituted Glycines*/chemical synthesis, Polymerization

NMR-Guided Studies to Establish the Binding Interaction between a Peptoid and Protein.

Autoren: Muli CS Xie D Post CB et al.

Quelle: Journal of the American Chemical Society [J Am Chem Soc] 2025 Aug 06; Vol. 147 (31), pp. 27403-27412. Date of Electronic Publication: 2025 Jul 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH-Schlagworte: Peptoids*/chemistry , Peptoids*/metabolism, Protein Binding ; Molecular Dynamics Simulation ; Binding Sites ; Nuclear Magnetic Resonance, Biomolecular

Exploration of Fluorinated Peptoid-Based Histone Deacetylase Inhibitors as Dual-Stage Antiplasmodial Agents.

Autoren: Reßing N Stopper D Schäfer TM et al.

Quelle: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2025 Aug; Vol. 358 (8), pp. e70071.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

MeSH-Schlagworte: Plasmodium falciparum*/drug effects , Antimalarials*/pharmacology , Antimalarials*/chemistry , Antimalarials*/chemical synthesis , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/chemical synthesis , Plasmodium berghei*/drug effects , Peptoids*/pharmacology , Peptoids*/chemistry , Peptoids*/chemical synthesis, Structure-Activity Relationship ; Parasitic Sensitivity Tests ; Molecular Structure ; Dose-Response Relationship, Drug ; Humans ; Halogenation ; Animals

Co-assembly of antimicrobial polypeptoids/carbon dots for internal-external cooperated sterilization.

Autoren: Wang S Huang C Gong Y et al.

Quelle: Journal of colloid and interface science [J Colloid Interface Sci] 2025 Jul 15; Vol. 690, pp. 137292. Date of Electronic Publication: 2025 Mar 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE

MeSH-Schlagworte: Escherichia coli*/drug effects , Staphylococcus aureus*/drug effects , Carbon*/chemistry , Carbon*/pharmacology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Peptoids*/chemistry , Peptoids*/pharmacology , Antimicrobial Peptides*/pharmacology , Antimicrobial Peptides*/chemistry , Quantum Dots*/chemistry, Animals ; Microbial Sensitivity Tests ; Mice ; Particle Size ; Reactive Oxygen Species/metabolism ; Surface Properties ; Iron/chemistry ; Iron/pharmacology ; Humans

Water-Soluble Peptoids with Two Different Binding Sites for Strong ATP Chelation.

Autoren: Vorobyov N Maayan G

Quelle: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2025 Sep 11; Vol. 31 (51), pp. e202500693. Date of Electronic Publication: 2025 Aug 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE

MeSH-Schlagworte: Peptoids*/chemistry , Adenosine Triphosphate*/chemistry , Adenosine Triphosphate*/metabolism , Chelating Agents*/chemistry, Binding Sites ; Water/chemistry ; Zinc/chemistry ; Ligands ; Solubility ; Pyridines/chemistry ; Boronic Acids/chemistry ; Coordination Complexes/chemistry

Crystalline Peptoid Nanofibers with a Single-Unit Cell Cross Section.

Autoren: Lee YJ Seidler M Luo X et al.

Quelle: Journal of the American Chemical Society [J Am Chem Soc] 2025 Aug 06; Vol. 147 (31), pp. 27390-27402. Date of Electronic Publication: 2025 Jun 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH-Schlagworte: Nanofibers*/chemistry , Peptoids*/chemistry, Molecular Dynamics Simulation ; Crystallization