Suchergebnisse - "Peptides, Cyclic"

Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN.

Autoren: Fakhouri F Bomback AS Ariceta G et al.

Körperschaften: Fakhouri F Bomback AS Ariceta G et al.

Quelle: The New England journal of medicine [N Engl J Med] 2025 Dec 04; Vol. 393 (22), pp. 2210-2220.

Publikationsart: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study

Info zur Zeitschrift: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE

MeSH-Schlagworte: Complement C3*/analysis , Complement C3*/antagonists & inhibitors , Complement C3*/immunology , Glomerulonephritis, Membranoproliferative*/drug therapy , Glomerulonephritis, Membranoproliferative*/immunology , Glomerulonephritis, Membranoproliferative*/pathology , Glomerulonephritis, Membranoproliferative*/urine , Proteinuria*/drug therapy , Proteinuria*/immunology , Proteinuria*/pathology , Proteinuria*/urine , Peptides, Cyclic*/administration & dosage , Peptides, Cyclic*/adverse effects, Adolescent ; Adult ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Creatinine/urine ; Double-Blind Method ; Kidney Glomerulus/pathology ; Treatment Outcome

Somatostatin receptor 2 targeting peptide modifications for peptide-drug conjugate treatment of small cell lung cancer.

Autoren: Bo Q Zhang MG Yang F et al.

Quelle: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Dec; Vol. 46 (12), pp. 3291-3301. Date of Electronic Publication: 2025 Jun 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Somatostatin*/metabolism , Receptors, Somatostatin*/agonists , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Small Cell Lung Carcinoma*/drug therapy , Small Cell Lung Carcinoma*/pathology , Small Cell Lung Carcinoma*/metabolism , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Somatostatin*/analogs & derivatives , Somatostatin*/chemistry , Somatostatin*/therapeutic use , Somatostatin*/pharmacology , Maytansine*/chemistry , Maytansine*/analogs & derivatives , Maytansine*/therapeutic use , Maytansine*/pharmacology , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/therapeutic use , Peptides, Cyclic*/pharmacology, Humans ; Animals ; Mice, Nude ; Cell Line, Tumor ; Mice ; Mice, Inbred BALB C ; Xenograft Model Antitumor Assays

Identification of a novel and high-affinity cyclic peptide targeting Keap1 for inflammation treatment by a combined virtual screening strategy.

Autoren: Gao S Shi X Yang S et al.

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2574023. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Kelch-Like ECH-Associated Protein 1*/antagonists & inhibitors , Kelch-Like ECH-Associated Protein 1*/metabolism , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/chemical synthesis , Inflammation*/drug therapy , Inflammation*/metabolism , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemistry , Anti-Inflammatory Agents, Non-Steroidal*/chemical synthesis , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/chemical synthesis, Mice ; Animals ; RAW 264.7 Cells ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Molecular Structure ; Molecular Docking Simulation ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/antagonists & inhibitors ; Macrophages/drug effects ; Drug Evaluation, Preclinical

Exploring the reactivity landscape of bioactive peptides using conceptual DFT and molecular modeling tools.

Autoren: Flores-Holguín N Frau J Glossman-Mitnik D

Quelle: Computational biology and chemistry [Comput Biol Chem] 2025 Dec; Vol. 119, pp. 108571. Date of Electronic Publication: 2025 Jul 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101157394 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-928X (Electronic) Linking ISSN: 14769271 NLM ISO Abbreviation: Comput Biol Chem Subsets: MEDLINE

MeSH-Schlagworte: Density Functional Theory* , Peptides*/chemistry , Peptides*/pharmacokinetics , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/pharmacokinetics, Models, Molecular ; Humans

Macrocyclic peptides targeting human CD44 inhibit cell adhesion.

Autoren: Chatzopoulos A Kolliopoulos C Yin Y et al.

Quelle: Cellular signalling [Cell Signal] 2025 Dec; Vol. 136, pp. 112178. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH-Schlagworte: Hyaluronan Receptors*/metabolism , Cell Adhesion*/drug effects , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/chemistry , Peptides*/pharmacology , Peptides*/chemistry, Humans ; Hyaluronic Acid/metabolism ; Cell Line, Tumor ; ErbB Receptors/metabolism ; Signal Transduction/drug effects ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Glioma/metabolism ; Glioma/pathology ; Epidermal Growth Factor/pharmacology

Unlocking the Therapeutic Potential of Cyclic Peptide-Based Nanocarriers for Enhanced Colon Cancer Treatment.

Autoren: Souresh V Srikayalsamyukktha M Harini M et al.

Quelle: The protein journal [Protein J] 2025 Dec; Vol. 44 (6), pp. 691-716. Date of Electronic Publication: 2025 Oct 05.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 101212092 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8355 (Electronic) Linking ISSN: 15723887 NLM ISO Abbreviation: Protein J Subsets: MEDLINE

MeSH-Schlagworte: Peptides, Cyclic*/chemistry , Peptides, Cyclic*/therapeutic use , Peptides, Cyclic*/pharmacology , Colonic Neoplasms*/drug therapy , Colonic Neoplasms*/pathology , Drug Carriers*/chemistry , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/pharmacology , Nanoparticles*/chemistry, Humans ; Animals ; Drug Delivery Systems

Heterophyllin B enhances the benefits of intermittent fasting in the treatment of metabolic dysfunction‑associated steatotic liver disease via activation of GLP‑1R.

Autoren: Li K Deng L Xue L et al.

Quelle: International journal of molecular medicine [Int J Mol Med] 2025 Dec; Vol. 56 (6). Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE

MeSH-Schlagworte: Fasting* , Glucagon-Like Peptide-1 Receptor*/metabolism , Glucagon-Like Peptide-1 Receptor*/genetics , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/therapeutic use , Fatty Liver*/metabolism , Fatty Liver*/drug therapy, Animals ; Humans ; Mice ; Mice, Inbred C57BL ; Hep G2 Cells ; Male ; Lipid Metabolism/drug effects ; Diet, High-Fat/adverse effects ; Liver/metabolism ; Liver/pathology ; Liver/drug effects ; Intermittent Fasting

Stereoselective Synthesis and Antiproliferative Activity of Nemamide Analogs.

Autoren: Yu R Gonzalez MS Rakshit S et al.

Quelle: Journal of natural products [J Nat Prod] 2025 Nov 28; Vol. 88 (11), pp. 2596-2601. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/chemical synthesis, Animals ; Humans ; Stereoisomerism ; Caenorhabditis elegans/chemistry ; Cell Proliferation/drug effects ; Molecular Structure ; Drug Screening Assays, Antitumor ; Cell Line, Tumor

Backbone Alterations in Cyclic Peptides Influence Both Membrane Permeability and Biological Activity.

Autoren: Openy J Vega-Ces S Amrahova G et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24108-24126. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Peptides, Cyclic*/chemistry , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/metabolism , Cell Membrane Permeability*/drug effects, Humans ; Structure-Activity Relationship ; Magnetic Resonance Spectroscopy

Enabling the Identification of Dopamine Receptor Ligands from Complex Matrices Using a Cyclic Tetrapeptide.

Autoren: Wen H Lai Z Wang J et al.

Quelle: Analytical chemistry [Anal Chem] 2025 Nov 25; Vol. 97 (46), pp. 25623-25634. Date of Electronic Publication: 2025 Nov 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE

MeSH-Schlagworte: Peptides, Cyclic*/chemistry , Peptides, Cyclic*/metabolism , Receptors, Dopamine D1*/antagonists & inhibitors , Receptors, Dopamine D1*/metabolism, Ligands ; Humans

Phosphorylation of peptides by a kinase domain in cyanobactin pathways.

Autoren: Castelo-Branco R Ouyang X Reis JPA et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 21; Vol. 16 (1), pp. 10279. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Peptides, Cyclic*/metabolism , Peptides, Cyclic*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/chemistry , Peptides*/metabolism , Peptides*/chemistry, Phosphorylation ; Protein Processing, Post-Translational ; Multigene Family ; Protein Domains ; Cyanobacteria/genetics ; Cyanobacteria/metabolism ; Protein Kinases/metabolism ; Mutagenesis, Site-Directed

Chemokine-Binding All-D-CLIPS Peptides Identified Using Mirror-Image Phage Display.

Autoren: Denisov SS Bialek EL Beretta F et al.

Quelle: ACS chemical biology [ACS Chem Biol] 2025 Nov 21; Vol. 20 (11), pp. 2798-2807. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

MeSH-Schlagworte: Peptide Library* , Interleukin-8*/metabolism , Interleukin-8*/chemistry , Peptides*/chemistry , Peptides*/metabolism , Chemokines*/metabolism , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/metabolism, Humans ; Protein Binding ; Amino Acid Sequence

Synthesis of DNA-Encoded Bicyclic Peptides via Cysteine-Promoted Cyclization and Amide Condensation Reaction.

Autoren: Gan Y Zeng Y Guan H et al.

Quelle: Bioconjugate chemistry [Bioconjug Chem] 2025 Nov 19; Vol. 36 (11), pp. 2336-2341. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

MeSH-Schlagworte: Cysteine*/chemistry , Peptides, Cyclic*/chemical synthesis , Peptides, Cyclic*/chemistry , DNA*/chemistry , Amides*/chemistry, Cyclization ; Peptide Library

Tissue factor derived β-hairpin peptides that bind and inhibit FVII activity.

Autoren: Oliver A Iaccarino E Migliorini A et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 117987. Date of Electronic Publication: 2025 Jul 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Factor VII*/antagonists & inhibitors , Factor VII*/metabolism , Thromboplastin*/chemistry , Thromboplastin*/metabolism , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/chemical synthesis , Peptides*/chemistry , Peptides*/pharmacology, Humans ; Structure-Activity Relationship ; Protein Binding/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug ; Models, Molecular

Cyclic helix B peptide alleviates liver fibrosis via attenuating ROS-mediated pyroptosis.

Autoren: Yuan H Zhou N Li J et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Nov 14; Vol. 165, pp. 115439. Date of Electronic Publication: 2025 Sep 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/chemically induced , Liver Cirrhosis*/pathology , Liver Cirrhosis*/metabolism , Peptides, Cyclic*/therapeutic use , Peptides, Cyclic*/pharmacology, Animals ; Pyroptosis/drug effects ; Reactive Oxygen Species/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Mice ; Male ; Inflammasomes/metabolism ; Mice, Inbred C57BL ; Humans ; Carbon Tetrachloride ; Liver/pathology ; Liver/drug effects ; Oxidative Stress/drug effects ; Cell Line

Development of Ts-Protected Selenocysteine for Sec-Conjugate Arylation via a Reductive Coupling Approach.

Autoren: Zhang Q Zhai S Lu Q et al.

Quelle: Organic letters [Org Lett] 2025 Nov 14; Vol. 27 (45), pp. 12543-12548. Date of Electronic Publication: 2025 Nov 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

MeSH-Schlagworte: Peptides, Cyclic*/chemistry , Peptides, Cyclic*/chemical synthesis , Selenocysteine*/chemistry, Catalysis ; Molecular Structure ; Nickel/chemistry ; Oxidation-Reduction ; Phenanthrolines/chemistry ; Guanidines/chemistry

ClpC1 Modulating Ohmyungsamycin A and Ecumicin Natural Product Analogues are Potent Antimycobacterials.

Autoren: Hawkins PME Bedding MJ Hoi DM et al.

Quelle: ACS infectious diseases [ACS Infect Dis] 2025 Nov 14; Vol. 11 (11), pp. 3298-3309. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/enzymology , Bacterial Proteins*/metabolism , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemistry , Antitubercular Agents*/chemical synthesis , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/chemical synthesis , Depsipeptides*/pharmacology , Depsipeptides*/chemistry , Depsipeptides*/chemical synthesis , Biological Products*/pharmacology , Biological Products*/chemistry, Animals ; Microbial Sensitivity Tests ; Zebrafish ; Heat-Shock Proteins

In Vivo Atlas of Neuroprotective Cyclic Dipeptides Derived from Food Gelatin Using Peptidomics and Feature-Based Molecular Networking.

Autoren: Dong P Ao L Li Y et al.

Quelle: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Nov 12; Vol. 73 (45), pp. 28811-28822. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Neuroprotective Agents*/chemistry , Neuroprotective Agents*/metabolism , Neuroprotective Agents*/pharmacology , Gelatin*/chemistry , Gelatin*/metabolism , Dipeptides*/chemistry , Dipeptides*/metabolism , Dipeptides*/pharmacology , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/metabolism , Peptides, Cyclic*/pharmacology, Animals ; Mice ; Male ; Humans ; Metabolomics ; Cell Line ; Proteomics

Rapid Construction of a Tyr C6-Trp C5' Linkage: Application in the Total Synthesis of Micitide 982, a Noncanonical Cyclic Peptide.

Autoren: Ogawa H Nagata Y Chan TK et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Nov 10; Vol. 64 (46), pp. e202516053. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Peptides, Cyclic*/chemical synthesis , Peptides, Cyclic*/chemistry , Tyrosine*/chemistry , Tryptophan*/chemistry, Cyclization ; Catalysis ; Molecular Structure

In Vitro and In Silico Evaluation of a Novel Multifunctional Cyclic Peptide with Antioxidant, Tyrosinase-Inhibitory, and Extracellular Matrix-Modulating Activities.

Autoren: Kim GH Kim BM

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 09; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Monophenol Monooxygenase*/antagonists & inhibitors , Monophenol Monooxygenase*/metabolism , Monophenol Monooxygenase*/chemistry , Antioxidants*/pharmacology , Antioxidants*/chemistry , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/chemical synthesis , Extracellular Matrix*/drug effects , Extracellular Matrix*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry, Humans ; Molecular Docking Simulation ; Cell Survival/drug effects ; Matrix Metalloproteinase 1/metabolism