Výsledky vyhľadávania - "Peptide Synthases"

VyPAL2 peptide asparaginyl ligase enables versatile workflows for radiolabeling single-domain antibody-based theranostics.

Autori: Declercq S Chen WM El Sahili A a ďalší

Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 2), pp. 114361. Date of Electronic Publication: 2025 Oct 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

Výrazy zo slovníka MeSH: Peptide Synthases*/chemistry , Peptide Synthases*/isolation & purification , Peptide Synthases*/metabolism , Single-Domain Antibodies*/chemistry , Radiopharmaceuticals*/chemistry , Gallium Radioisotopes*/chemistry, Precision Medicine ; Viola/chemistry ; Viola/enzymology ; Radioligand Assay ; Mice, Inbred C57BL ; Humans ; Male ; Female ; Animals ; Mice ; Mice, Nude

High-Throughput Engineering and Modification of Non-Ribosomal Peptide Synthetases Based on Golden Gate Assembly.

Autori: Podolski A Lindeboom TA Präve L a ďalší

Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Dec 01; Vol. 64 (49), pp. e202508967. Date of Electronic Publication: 2025 Oct 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Výrazy zo slovníka MeSH: Peptide Synthases*/metabolism , Peptide Synthases*/genetics , Peptide Synthases*/chemistry , Protein Engineering*, Xenorhabdus/enzymology ; Xenorhabdus/genetics ; High-Throughput Screening Assays

Slow Dynamics Orchestrate Communication Between Binding Sites in the Condensation Domain of a Non-ribosomal Peptide Synthetase.

Autori: Karanth MN De D Kirkpatrick JP a ďalší

Zdroj: Journal of molecular biology [J Mol Biol] 2025 Dec 01; Vol. 437 (23), pp. 169484. Date of Electronic Publication: 2025 Oct 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Peptide Synthases*/chemistry , Peptide Synthases*/metabolism, Binding Sites ; Protein Domains ; Protein Binding ; Models, Molecular ; Protein Conformation

A single non-coding SNP in FPGS modulates folate drug efficacy in acute lymphoblastic leukemia: data-driven exploration and experimental validation.

Autori: Yu W Li C Meng Y a ďalší

Zdroj: Molecular biomedicine [Mol Biomed] 2025 Nov 21; Vol. 6 (1), pp. 114. Date of Electronic Publication: 2025 Nov 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE

Výrazy zo slovníka MeSH: Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy , Polymorphism, Single Nucleotide*/genetics , Methotrexate*/therapeutic use , Methotrexate*/pharmacology , Peptide Synthases*/genetics , Peptide Synthases*/metabolism , Folic Acid*/pharmacology , Folic Acid*/therapeutic use, Humans ; Animals ; Mice ; Cell Line, Tumor ; Genotype

In silico strategies for identifying therapeutic candidates against Acinetobacter baumannii : spotlight on the UDP-N-acetylmuramoyl-L-alanine-D-glutamate:meso-diaminopimelate ligase (MurE).

Autori: Kumar A Singh P Singh E a ďalší

Zdroj: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2025 Oct; Vol. 43 (16), pp. 8996-9010. Date of Electronic Publication: 2024 Mar 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

Výrazy zo slovníka MeSH: Acinetobacter baumannii*/enzymology , Acinetobacter baumannii*/drug effects , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Peptide Synthases*/chemistry , Peptide Synthases*/antagonists & inhibitors , Peptide Synthases*/metabolism , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Bacterial Proteins*/chemistry , Bacterial Proteins*/antagonists & inhibitors, Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Models, Molecular ; Amino Acid Sequence ; Computer Simulation

Potential Anti-Filarial Molecules Against ATP Binding Site of MurE Enzyme: A Molecular Docking and Dynamics Approach to Combat Lymphatic Filariasis.

Autori: Prabhu D Dharshini MKD Rajamanikandan S a ďalší

Zdroj: Biotechnology and applied biochemistry [Biotechnol Appl Biochem] 2025 Oct; Vol. 72 (5), pp. 1184-1194. Date of Electronic Publication: 2025 Feb 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8609465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1470-8744 (Electronic) Linking ISSN: 08854513 NLM ISO Abbreviation: Biotechnol Appl Biochem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Molecular Docking Simulation* , Adenosine Triphosphate*/metabolism , Adenosine Triphosphate*/chemistry , Elephantiasis, Filarial*/drug therapy , Peptide Synthases*/antagonists & inhibitors , Peptide Synthases*/metabolism , Peptide Synthases*/chemistry , Brugia malayi*/enzymology , Brugia malayi*/drug effects , Molecular Dynamics Simulation* , Filaricides*/chemistry , Filaricides*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology, Binding Sites/drug effects ; Animals ; Humans

Discovery of Cladoescherins, Unusual Hybrid Metabolites Derived from a Fungal PKS and a Bacterial NRPS by Co-cultivation.

Autori: Li F Wang G Li S a ďalší

Zdroj: Journal of natural products [J Nat Prod] 2025 Nov 28; Vol. 88 (11), pp. 2726-2735. Date of Electronic Publication: 2025 Nov 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

Výrazy zo slovníka MeSH: Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Peptide Synthases*/metabolism , Macrolides*/chemistry , Macrolides*/isolation & purification , Macrolides*/pharmacology, Escherichia coli/metabolism ; Escherichia coli/chemistry ; Molecular Structure ; Coculture Techniques ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/isolation & purification

NRPS gene dynamics in the wheat rhizoplane show increased proportion of viscosin NRPS genes of importance for root colonization during drought.

Autori: Guan Y Berne E Hennessy RC a ďalší

Zdroj: MSphere [mSphere] 2025 Oct 29; Vol. 10 (10), pp. e0085224. Date of Electronic Publication: 2025 Sep 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101674533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-5042 (Electronic) Linking ISSN: 23795042 NLM ISO Abbreviation: mSphere Subsets: MEDLINE

Výrazy zo slovníka MeSH: Triticum*/microbiology , Peptide Synthases*/genetics , Plant Roots*/microbiology , Droughts* , Rhizosphere* , Bacteria*/genetics , Bacteria*/classification , Bacteria*/enzymology, RNA, Ribosomal, 16S/genetics ; Soil Microbiology ; Siderophores/metabolism ; Secondary Metabolism ; Pseudomonas/genetics

Biosynthesis of Unnatural Cyclodipeptides through Genetic Code Expansion and Cyclodipeptide Synthase Evolution.

Autori: Hu Y Cheng L Liu Y a ďalší

Zdroj: Journal of the American Chemical Society [J Am Chem Soc] 2025 Sep 24; Vol. 147 (38), pp. 34517-34526. Date of Electronic Publication: 2025 Sep 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

Výrazy zo slovníka MeSH: Genetic Code* , Peptide Synthases*/genetics , Peptide Synthases*/metabolism , Peptide Synthases*/chemistry , Peptides, Cyclic*/biosynthesis , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/genetics , Directed Molecular Evolution*, Molecular Dynamics Simulation ; Protein Engineering ; Amino Acids/chemistry ; Amino Acids/genetics ; Amino Acids/metabolism

Targeted Discovery and Characterization of Type-II PKS-NRPS Hybrid DNA-Alkylating Antibiotics.

Autori: Nie QY Fang SQ Wu L a ďalší

Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Sep 22; Vol. 64 (39), pp. e202512820. Date of Electronic Publication: 2025 Aug 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/metabolism , Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Peptide Synthases*/metabolism , Peptide Synthases*/chemistry , Drug Discovery* , DNA*/chemistry , DNA*/metabolism, Humans ; Streptomyces/chemistry ; Streptomyces/metabolism ; Microbial Sensitivity Tests ; Cell Line, Tumor ; Molecular Structure

Revealing Diversity in NRPS Gene Clusters Across Six Pathogenic Colletotrichum Species.

Autori: Sayari M Sharifi-Tehrani M Shabani L a ďalší

Zdroj: Current microbiology [Curr Microbiol] 2025 Sep 20; Vol. 82 (11), pp. 515. Date of Electronic Publication: 2025 Sep 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer International Country of Publication: United States NLM ID: 7808448 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0991 (Electronic) Linking ISSN: 03438651 NLM ISO Abbreviation: Curr Microbiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Peptide Synthases*/genetics , Peptide Synthases*/metabolism , Colletotrichum*/genetics , Colletotrichum*/enzymology , Colletotrichum*/classification , Colletotrichum*/pathogenicity , Multigene Family* , Fungal Proteins*/genetics , Fungal Proteins*/metabolism , Genetic Variation*, Phylogeny ; Secondary Metabolism ; Genome, Fungal ; Plant Diseases/microbiology ; Evolution, Molecular

Characterizing the Biochemical Role of an Unusual Fatty Acyl-AMP Ligase from a Hybrid PKS-NRPS Pathway in Nematodes.

Autori: Gordon MT Gonzalez MS Priya a ďalší

Zdroj: ACS chemical biology [ACS Chem Biol] 2025 Sep 19; Vol. 20 (9), pp. 2095-2104. Date of Electronic Publication: 2025 Aug 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Caenorhabditis elegans*/enzymology , Caenorhabditis elegans*/metabolism , Caenorhabditis elegans Proteins*/metabolism , Caenorhabditis elegans Proteins*/genetics , Caenorhabditis elegans Proteins*/chemistry , Ligases*/metabolism , Nematoda*/enzymology , Peptide Synthases*/metabolism , Peptide Synthases*/chemistry , Peptide Synthases*/genetics , Polyketide Synthases*/metabolism, Animals ; Phylogeny ; Polyketides/metabolism ; Substrate Specificity ; Amines/chemistry

Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications.

Autori: Kim G Lee D Kim JH a ďalší

Zdroj: Natural product reports [Nat Prod Rep] 2025 Sep 17; Vol. 42 (9), pp. 1489-1506. Date of Electronic Publication: 2025 Sep 17.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 8502408 Publication Model: Electronic Cited Medium: Internet ISSN: 1460-4752 (Electronic) Linking ISSN: 02650568 NLM ISO Abbreviation: Nat Prod Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Biological Products*/metabolism , Biological Products*/chemistry , Peptide Synthases*/metabolism , Peptide Synthases*/chemistry , Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Protein Engineering*/methods

NRPStransformer, an Accurate Adenylation Domain Specificity Prediction Algorithm for Genome Mining of Nonribosomal Peptides.

Autori: Zhang Z Zhou Y Xie S a ďalší

Zdroj: Journal of the American Chemical Society [J Am Chem Soc] 2025 Sep 10; Vol. 147 (36), pp. 32662-32670. Date of Electronic Publication: 2025 Aug 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

Výrazy zo slovníka MeSH: Peptide Synthases*/metabolism , Peptide Synthases*/chemistry , Peptide Synthases*/genetics , Algorithms* , Peptides*/chemistry , Peptides*/metabolism , Peptides*/genetics, Substrate Specificity ; Protein Domains ; Prediction Algorithms

Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases.

Autori: Diecker J Hermanns B Rüschenbaum J a ďalší

Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Sep 01; Vol. 64 (36), pp. e202506621. Date of Electronic Publication: 2025 Jul 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Výrazy zo slovníka MeSH: Peptide Synthases*/chemistry , Peptide Synthases*/genetics , Multienzyme Complexes*/chemistry , Multienzyme Complexes*/genetics, Protein Domains/genetics ; Mutagenesis ; Crystallization ; Catalytic Domain

Biosynthesis of Antituberculosis Antibiotic Capreomycin Involves a trans -Iterative Adenylation Domain within the Nonribosomal Peptide Synthetase Machinery.

Autori: Lai YT Peng CY Liao HT a ďalší

Zdroj: Organic letters [Org Lett] 2025 Aug 29; Vol. 27 (34), pp. 9553-9558. Date of Electronic Publication: 2025 Aug 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: Peptide Synthases*/metabolism , Peptide Synthases*/chemistry , Capreomycin*/chemistry , Capreomycin*/biosynthesis , Antibiotics, Antitubercular*/chemistry , Antibiotics, Antitubercular*/biosynthesis , Antitubercular Agents*/chemistry, Molecular Structure

Mechanistic insights into TTLL11 polyglutamylase-mediated primary tubulin chain elongation.

Autori: Campbell J Vosahlikova M Ismail S a ďalší

Zdroj: Science advances [Sci Adv] 2025 Aug 22; Vol. 11 (34), pp. eadw1561. Date of Electronic Publication: 2025 Aug 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Výrazy zo slovníka MeSH: Tubulin*/metabolism , Tubulin*/chemistry , Peptide Synthases*/metabolism , Peptide Synthases*/chemistry , Peptide Synthases*/genetics, Humans ; Microtubules/metabolism ; Protein Binding ; Cryoelectron Microscopy ; Protein Processing, Post-Translational ; Models, Molecular

Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein.

Autori: Yang R Wang Y Kong M a ďalší

Zdroj: Nature communications [Nat Commun] 2025 Aug 14; Vol. 16 (1), pp. 7540. Date of Electronic Publication: 2025 Aug 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Energy Metabolism* , Escherichia coli*/metabolism , Escherichia coli*/genetics , Escherichia coli*/enzymology , Lipoylation* , Peptide Synthases*/metabolism , Peptide Synthases*/genetics , Escherichia coli Proteins*/metabolism , Escherichia coli Proteins*/genetics, Animals ; CHO Cells ; Cricetulus ; Protein Processing, Post-Translational ; Fatty Acids/biosynthesis ; Diatoms/metabolism ; Ketoglutarate Dehydrogenase Complex/metabolism ; Humans ; Pyruvate Dehydrogenase Complex/metabolism

Genome Mining-Based Discovery of Pyrano[2,3- c ]pyrrole Type Natural Products Possessing Alkyl Side Chain with Branched Methyl Groups.

Autori: Shi Y Ozaki T Morishita Y a ďalší

Zdroj: Organic letters [Org Lett] 2025 Aug 08; Vol. 27 (31), pp. 8580-8585. Date of Electronic Publication: 2025 Jul 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: Biological Products*/chemistry , Pyrroles*/chemistry , Peptide Synthases*/metabolism , Peptide Synthases*/chemistry , Peptide Synthases*/genetics , Ascomycota*/chemistry , Ascomycota*/genetics , Pyrans*/chemistry, Polyketide Synthases/metabolism ; Polyketide Synthases/chemistry ; Polyketide Synthases/genetics ; Molecular Structure

Tubulin tyrosine ligase variant perturbs microtubule tyrosination, causing hypertrophy in patient-specific and CRISPR gene-edited iPSC-cardiomyocytes.

Autori: Jain PK Mahanty S Chittora H a ďalší

Zdroj: JCI insight [JCI Insight] 2025 Aug 08; Vol. 10 (15). Date of Electronic Publication: 2025 Aug 08 (Print Publication: 2025).

Spôsob vydávania: Journal Article; Case Reports

Informácie o časopise: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cardiomyopathy, Hypertrophic*/genetics , Cardiomyopathy, Hypertrophic*/pathology , Microtubules*/metabolism , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/pathology , Peptide Synthases*/genetics , Peptide Synthases*/metabolism, Humans ; CRISPR-Cas Systems ; Gene Editing ; Induced Pluripotent Stem Cells/metabolism ; Mutation, Missense ; Tubulin/metabolism