Suchergebnisse - "PYROPTOSIS"

Generation of personalized whole tumor cells vaccine for pyroptosis-enhanced anticancer immunity via Cu 2-x Se photothermal activation under NIR irradiation.

Autoren: Chang J Wang M Wang J et al.

Quelle: Journal of colloid and interface science [J Colloid Interface Sci] 2025 Dec 15; Vol. 700 (Pt 2), pp. 138488. Date of Electronic Publication: 2025 Jul 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis*/drug effects , Pyroptosis*/immunology , Cancer Vaccines*/immunology , Cancer Vaccines*/chemistry , Copper*/chemistry , Copper*/pharmacology , Photothermal Therapy*, Animals ; Mice ; Infrared Rays ; Female ; Mice, Inbred BALB C ; Cell Line, Tumor ; Nanoparticles/chemistry ; Particle Size ; Surface Properties

Ccn1 Mediates Pyroptosis and Purine Metabolism Pattern Shifts in a High-Uric Acid Microenvironment After Spinal Cord Injury.

Autoren: Zhang Z Xu N Tao Z et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Dec 01; Vol. 63 (1), pp. 229. Date of Electronic Publication: 2025 Dec 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/pathology , Pyroptosis*/physiology , Pyroptosis*/drug effects , Cysteine-Rich Protein 61*/metabolism , Cysteine-Rich Protein 61*/genetics , Uric Acid*/metabolism , Purines*/metabolism , Cellular Microenvironment*, Animals ; Rats, Sprague-Dawley ; PC12 Cells ; Rats ; Male ; Spinal Cord/metabolism ; Spinal Cord/pathology

The role of IL-18BP in alleviating anxiety-like behaviors after traumatic brain injury in rats by modulating astrocytic pyroptosis in amygdala.

Autoren: Wu D Li X Xing Y et al.

Quelle: Brain injury [Brain Inj] 2025 Dec; Vol. 39 (14), pp. 1348-1356. Date of Electronic Publication: 2025 Sep 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8710358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-301X (Electronic) Linking ISSN: 02699052 NLM ISO Abbreviation: Brain Inj Subsets: MEDLINE

MeSH-Schlagworte: Brain Injuries, Traumatic*/complications , Brain Injuries, Traumatic*/metabolism , Brain Injuries, Traumatic*/pathology , Brain Injuries, Traumatic*/psychology , Astrocytes*/metabolism , Astrocytes*/pathology , Astrocytes*/drug effects , Pyroptosis*/physiology , Pyroptosis*/drug effects , Anxiety*/etiology , Anxiety*/metabolism , Anxiety*/drug therapy , Amygdala*/metabolism , Amygdala*/pathology, Animals ; Rats, Sprague-Dawley ; Rats ; Male ; Interleukin-18/metabolism ; Interleukin-18/cerebrospinal fluid ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Disease Models, Animal ; Caspase 1/metabolism ; Intercellular Signaling Peptides and Proteins

Tanshinone IIA suppresses endoplasmic reticulum stress-mediated IRE1α/TXNIP/NLRP3 pathway to mitigate pyroptosis in type 2 diabetic osteoporosis.

Autoren: Jiang Z Zuo J Luo H et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 3), pp. 117356. Date of Electronic Publication: 2025 Sep 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/antagonists & inhibitors , Abietanes*/pharmacology , Abietanes*/therapeutic use , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Endoplasmic Reticulum Stress*/drug effects , Endoplasmic Reticulum Stress*/physiology , Endoribonucleases*/metabolism , Endoribonucleases*/antagonists & inhibitors , Pyroptosis*/drug effects , Pyroptosis*/physiology , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/complications , Osteoporosis*/drug therapy , Osteoporosis*/metabolism , Carrier Proteins*/metabolism , Carrier Proteins*/antagonists & inhibitors, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Dose-Response Relationship, Drug ; Cell Line ; Thioredoxins

Mechanism of glycolysis-pyrolysis crosstalk driving vicious circle of intervertebral disc degeneration.

Autoren: Gao S Liu T Hou X et al.

Quelle: Apoptosis : an international journal on programmed cell death [Apoptosis] 2025 Dec; Vol. 30 (11-12), pp. 3129-3148. Date of Electronic Publication: 2025 Oct 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE

MeSH-Schlagworte: Intervertebral Disc Degeneration*/metabolism , Intervertebral Disc Degeneration*/pathology , Intervertebral Disc Degeneration*/genetics , Glycolysis* , Pyroptosis*/genetics , Pyroptosis*/drug effects, Nucleus Pulposus/metabolism ; Nucleus Pulposus/pathology ; Animals ; Humans ; Interleukin-1beta/metabolism ; Interleukin-1beta/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Inflammasomes/metabolism ; Male ; Lactic Acid/metabolism ; Lactic Acid/pharmacology ; Rats

By inhibiting pyroptosis to reduce neuroinflammation, PEG-bHb may prevent the development of secondary injury after traumatic brain injury.

Autoren: Zeng Q You G Li W et al.

Quelle: Experimental neurology [Exp Neurol] 2025 Dec; Vol. 394, pp. 115447. Date of Electronic Publication: 2025 Aug 27.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

MeSH-Schlagworte: Brain Injuries, Traumatic*/metabolism , Brain Injuries, Traumatic*/complications , Brain Injuries, Traumatic*/drug therapy , Polyethylene Glycols*/pharmacology , Polyethylene Glycols*/therapeutic use , Pyroptosis*/drug effects , Pyroptosis*/physiology , Neuroinflammatory Diseases*/prevention & control , Neuroinflammatory Diseases*/etiology , Neuroinflammatory Diseases*/metabolism , Hemoglobins*/pharmacology , Hemoglobins*/therapeutic use, Animals ; Humans ; Cattle ; Blood-Brain Barrier/drug effects

ETV5 transcriptionally inhibits KIF23 to repress pyroptosis in aged mice with perioperative neurocognitive disorders.

Autoren: Tang S Bu X Yu X et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 3), pp. 117352. Date of Electronic Publication: 2025 Sep 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis*/physiology , Pyroptosis*/drug effects , Kinesins*/genetics , Kinesins*/antagonists & inhibitors , Kinesins*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/biosynthesis , Transcription Factors*/genetics , Transcription Factors*/metabolism , Transcription Factors*/biosynthesis , Neurocognitive Disorders*/metabolism , Neurocognitive Disorders*/genetics , Aging*/metabolism, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Hippocampus/metabolism ; Humans ; Cell Line ; Transcription, Genetic

Pyroptosis in cancer therapy: a double-edged sword for immune activation and tumor progression.

Autoren: Alishvandi A Aram C Shahrivar FF et al.

Quelle: Molecular cancer [Mol Cancer] 2025 Nov 25; Vol. 24 (1), pp. 297. Date of Electronic Publication: 2025 Nov 25.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis*/drug effects , Pyroptosis*/immunology , Neoplasms*/pathology , Neoplasms*/immunology , Neoplasms*/metabolism , Neoplasms*/therapy , Neoplasms*/etiology , Neoplasms*/drug therapy, Humans ; Disease Progression ; Tumor Microenvironment/immunology ; Animals ; Inflammasomes/metabolism ; Signal Transduction

Metal-Free Carbon Dots as Photon-Triggered Pyroptosis Inducers for Enhanced Cancer Immunotherapy.

Autoren: Cheng Q Wang Q Cheng H et al.

Quelle: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2025 Nov 06; Vol. 31 (62), pp. e02351. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis*/drug effects , Pyroptosis*/radiation effects , Neoplasms*/therapy , Neoplasms*/immunology , Carbon*/chemistry , Immunotherapy*/methods , Quantum Dots*/chemistry, Humans ; Photons ; Animals

HIFU-Driven Targeted Pyroptosis Therapy in Basal-Like Breast Cancer.

Autoren: Su X Wang Y Qin X et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (44), pp. e03830. Date of Electronic Publication: 2025 Sep 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis*/drug effects , Pyroptosis*/radiation effects , Pyroptosis*/genetics , Breast Neoplasms*/therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , High-Intensity Focused Ultrasound Ablation*/methods, Female ; Animals ; Mice ; Humans ; Mice, Inbred BALB C ; Cell Line, Tumor ; Liposomes

LPS-Induced Mitochondrial Damage via SLC41A1-Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells.

Autoren: Liu Y Song C Zhang L et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (42), pp. e05666. Date of Electronic Publication: 2025 Aug 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Magnesium*/metabolism , Pyroptosis*/drug effects , Pyroptosis*/physiology , Lipopolysaccharides*/pharmacology , Mitochondria*/metabolism , Mitochondria*/drug effects , Stem Cells*/metabolism , Stem Cells*/drug effects , Dental Pulp*/metabolism , Dental Pulp*/cytology , Cation Transport Proteins*/metabolism , Cation Transport Proteins*/genetics, Humans ; Reactive Oxygen Species/metabolism ; Cells, Cultured

Targeting STING alleviates pyroptosis of bladder epithelial cells and ameliorates bladder fibrosis in neurogenic bladder.

Autoren: Wang R Wang M Chen J et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Nov; Vol. 241, pp. 117177. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Urinary Bladder*/pathology , Urinary Bladder*/metabolism , Urinary Bladder*/drug effects , Pyroptosis*/drug effects , Pyroptosis*/physiology , Epithelial Cells*/metabolism , Epithelial Cells*/drug effects , Epithelial Cells*/pathology , Urinary Bladder, Neurogenic*/metabolism , Urinary Bladder, Neurogenic*/drug therapy , Urinary Bladder, Neurogenic*/pathology , Membrane Proteins*/metabolism , Membrane Proteins*/antagonists & inhibitors, Animals ; Rats ; Fibrosis/metabolism ; Rats, Sprague-Dawley ; Female ; Male

KIF23 inhibition protects against perioperative neurocognitive disorders by hindering ROS/caspase-3/GSDME-mediated pyroptosis.

Autoren: Tang S Yu X Zhang L et al.

Quelle: Experimental neurology [Exp Neurol] 2025 Nov; Vol. 393, pp. 115371. Date of Electronic Publication: 2025 Jul 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis*/physiology , Pyroptosis*/drug effects , Kinesins*/antagonists & inhibitors , Kinesins*/metabolism , Kinesins*/genetics , Reactive Oxygen Species*/metabolism , Caspase 3*/metabolism , Neurocognitive Disorders*/metabolism , Neurocognitive Disorders*/prevention & control , Phosphate-Binding Proteins*/metabolism, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Gasdermins

Ellagic acid mediated pyroptosis in hepatocellular carcinoma via the ESR1/G6PD pathway.

Autoren: Wang S Cai Y Zhou F et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Nov; Vol. 241, pp. 117178. Date of Electronic Publication: 2025 Jul 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Ellagic Acid*/pharmacology , Ellagic Acid*/therapeutic use , Pyroptosis*/drug effects , Pyroptosis*/physiology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Estrogen Receptor alpha*/metabolism , Estrogen Receptor alpha*/genetics , Glucosephosphate Dehydrogenase*/metabolism , Glucosephosphate Dehydrogenase*/genetics, Humans ; Animals ; Mice, Nude ; Mice ; Mice, Inbred BALB C ; Xenograft Model Antitumor Assays/methods ; Male ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Cell Line, Tumor ; Hep G2 Cells ; Female

Dnmt1 Alleviates S1PR1-Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression.

Autoren: Peng B Lin H Zhang M et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (42), pp. e07330. Date of Electronic Publication: 2025 Aug 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/genetics , Spinal Cord Injuries*/pathology , Pyroptosis*/genetics , Pyroptosis*/physiology , DNA (Cytosine-5-)-Methyltransferase 1*/metabolism , DNA (Cytosine-5-)-Methyltransferase 1*/genetics , Sphingosine-1-Phosphate Receptors*/metabolism , Sphingosine-1-Phosphate Receptors*/genetics, Animals ; Rats ; PC12 Cells ; Rats, Sprague-Dawley ; Autophagy ; Male ; Disease Models, Animal

Targeting ferroptosis, pyroptosis and necroptosis for cancer immunotherapy in melanoma: mechanistic insights and clinical perspectives.

Autoren: Shan Z Liu F

Quelle: Frontiers in immunology [Front Immunol] 2025 Oct 29; Vol. 16, pp. 1629620. Date of Electronic Publication: 2025 Oct 29 (Print Publication: 2025).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/drug effects , Ferroptosis*/immunology , Pyroptosis*/drug effects , Pyroptosis*/immunology , Melanoma*/immunology , Melanoma*/therapy , Melanoma*/pathology , Melanoma*/metabolism , Necroptosis*/drug effects , Necroptosis*/immunology , Immunotherapy*/methods, Humans ; Animals ; Tumor Microenvironment/immunology

Dihydroorotate dehydrogenase inhibition activates STING pathway and pyroptosis to enhance NK cell-dependent tumor immunotherapy.

Autoren: Hai Y Lin R Liao W et al.

Quelle: Molecular biomedicine [Mol Biomed] 2025 Oct 27; Vol. 6 (1), pp. 87. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE

MeSH-Schlagworte: Dihydroorotate Dehydrogenase*/antagonists & inhibitors , Killer Cells, Natural*/immunology , Killer Cells, Natural*/drug effects , Killer Cells, Natural*/metabolism , Pyroptosis*/drug effects , Pyroptosis*/immunology , Membrane Proteins*/metabolism , Immunotherapy*/methods , Signal Transduction*/drug effects , Neoplasms*/therapy , Neoplasms*/immunology , Oxidoreductases Acting on CH-CH Group Donors*/antagonists & inhibitors , Enzyme Inhibitors*/pharmacology, Humans ; Animals ; Mice ; Cell Line, Tumor ; Mitochondria/metabolism ; Tumor Microenvironment ; Mice, Inbred C57BL

Single-cell and machine learning-based pyroptosis-related gene signature predicts prognosis and immunotherapy response in glioblastoma.

Autoren: Fang L Wang D Meng F et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Oct 24; Vol. 16, pp. 1693940. Date of Electronic Publication: 2025 Oct 24 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis*/genetics , Pyroptosis*/immunology , Glioblastoma*/genetics , Glioblastoma*/therapy , Glioblastoma*/immunology , Glioblastoma*/mortality , Glioblastoma*/pathology , Machine Learning* , Immunotherapy*/methods , Transcriptome* , Brain Neoplasms*/genetics , Brain Neoplasms*/therapy , Brain Neoplasms*/immunology , Brain Neoplasms*/pathology , Biomarkers, Tumor*/genetics, Humans ; Prognosis ; Single-Cell Analysis/methods ; Tumor Microenvironment/immunology ; Tumor Microenvironment/genetics ; Gene Expression Regulation, Neoplastic ; Gene Expression Profiling ; Gene Regulatory Networks

Nicotinamide riboside attenuates radiation-induced intestinal injury by suppressing gasdermin E-mediated pyroptosis in intestinal epithelial cells.

Autoren: Zhou Q Liu L Lin X et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Oct 17; Vol. 23 (1), pp. 1126. Date of Electronic Publication: 2025 Oct 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Niacinamide*/analogs & derivatives , Niacinamide*/pharmacology , Niacinamide*/therapeutic use , Pyroptosis*/drug effects , Pyroptosis*/radiation effects , Intestinal Mucosa*/pathology , Intestinal Mucosa*/drug effects , Intestinal Mucosa*/radiation effects , Epithelial Cells*/drug effects , Epithelial Cells*/pathology , Epithelial Cells*/metabolism , Epithelial Cells*/radiation effects , Radiation Injuries*/drug therapy , Radiation Injuries*/pathology , Intestines*/pathology , Intestines*/radiation effects , Intestines*/drug effects, Animals ; Mice, Inbred C57BL ; Mice ; Cell Line ; Organoids/drug effects ; Organoids/pathology ; Sirtuin 1/metabolism ; Male ; Pyridinium Compounds

A Photon-Driven Unimolecular Immunostimulant for Self-Amplified Pyroptosis and cGAS-STING Pathway by Destroying the Pyroptosis Checkpoint.

Autoren: Zeng S Chen C Guo Z et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Oct 06; Vol. 64 (41), pp. e202513815. Date of Electronic Publication: 2025 Aug 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis*/drug effects , Nucleotidyltransferases*/metabolism , Membrane Proteins*/metabolism , Photosensitizing Agents*/pharmacology , Photosensitizing Agents*/chemistry , Adjuvants, Immunologic*/pharmacology , Adjuvants, Immunologic*/chemistry, Humans ; Animals ; Mice ; Immunity, Innate/drug effects ; Signal Transduction/drug effects ; Reactive Oxygen Species/metabolism