Výsledky vyhľadávania - "PYRAZINES"

The synthesis and evaluation of new N-(pyrazin-2-yl)-4-aminopyrimidine derivatives targeted EGFR and JAK.

Autori: Yao H Cao L Ma EE a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118120. Date of Electronic Publication: 2025 Sep 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Janus Kinase 2*/antagonists & inhibitors , Janus Kinase 2*/metabolism , Pyrimidines*/pharmacology , Pyrimidines*/chemistry , Pyrimidines*/chemical synthesis , Janus Kinase 3*/antagonists & inhibitors , Janus Kinase 3*/metabolism , Pyrazines*/pharmacology , Pyrazines*/chemistry , Pyrazines*/chemical synthesis, Humans ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Animals ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Drug Screening Assays, Antitumor ; Mice, Nude ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Neoplasms, Experimental/metabolism

Design, synthesis, and biological evaluation of (E)-3-amino-N'-substituted benzylidene-6-chloropyrazine-2-carbohydrazide derivatives as anti-mycobacterial agents.

Autori: Kumar BVS Bhardwaj P Chaudhari HS a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109206. Date of Electronic Publication: 2025 Nov 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mycobacterium tuberculosis*/drug effects , Drug Design* , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemical synthesis , Antitubercular Agents*/chemistry , Hydrazines*/pharmacology , Hydrazines*/chemistry , Hydrazines*/chemical synthesis , Pyrazines*/pharmacology , Pyrazines*/chemistry , Pyrazines*/chemical synthesis , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry, Microbial Sensitivity Tests ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Humans

Cerebral aspergillosis in a patient treated with acalabrutinib, a second generation Bruton's tyrosine kinase inhibitor.

Autori: Rezig S Talarmin JP Le Gal S a ďalší

Zdroj: Journal de mycologie medicale [J Mycol Med] 2025 Dec; Vol. 35 (4), pp. 101586. Date of Electronic Publication: 2025 Oct 20.

Spôsob vydávania: Case Reports; Journal Article

Informácie o časopise: Publisher: Masson Country of Publication: France NLM ID: 9425651 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1773-0449 (Electronic) Linking ISSN: 11565233 NLM ISO Abbreviation: J Mycol Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors , Pyrazines*/adverse effects , Pyrazines*/therapeutic use , Benzamides*/adverse effects , Benzamides*/therapeutic use , Protein Kinase Inhibitors*/adverse effects , Protein Kinase Inhibitors*/therapeutic use , Neuroaspergillosis*/chemically induced , Neuroaspergillosis*/diagnosis , Neuroaspergillosis*/microbiology, Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Male ; Fatal Outcome ; Aged ; Middle Aged ; Tyrosine Kinase Inhibitors

Gilteritinib maintenance after allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute myeloid leukemia with FLT3-internal tandem duplication mutation.

Autori: Liang C Yang D Pang A a ďalší

Zdroj: Hematology (Amsterdam, Netherlands) [Hematology] 2025 Dec; Vol. 30 (1), pp. 2509353. Date of Electronic Publication: 2025 Jun 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8454 (Electronic) Linking ISSN: 10245332 NLM ISO Abbreviation: Hematology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/therapy , Leukemia, Myeloid, Acute*/mortality , fms-Like Tyrosine Kinase 3*/genetics , Hematopoietic Stem Cell Transplantation*/methods , Pyrazines*/therapeutic use , Pyrazines*/administration & dosage , Pyrazines*/adverse effects , Pyrazines*/pharmacology , Mutation* , Aniline Compounds*/therapeutic use , Aniline Compounds*/administration & dosage , Aniline Compounds*/adverse effects , Aniline Compounds*/pharmacology, Humans ; Female ; Male ; Middle Aged ; Adult ; Retrospective Studies ; Transplantation, Homologous ; Recurrence ; Tandem Repeat Sequences ; Aged ; Young Adult

Exploring the pharmacological versatility of triazolopyrazine: A multi-target scaffold for drug development.

Autori: Mondal D Bisht P Kumari P a ďalší

Zdroj: Future medicinal chemistry [Future Med Chem] 2025 Dec; Vol. 17 (23), pp. 2863-2879. Date of Electronic Publication: 2025 Nov 01.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Triazoles*/chemistry , Triazoles*/pharmacology , Pyrazines*/chemistry , Pyrazines*/pharmacology , Pyrazines*/chemical synthesis , Drug Development*, Humans ; Structure-Activity Relationship ; Animals ; Molecular Structure ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology

Zanubrutinib versus acalabrutinib indirect treatment comparison in relapsed or refractory mantle cell lymphoma.

Autori: Shah B Challagulla S Xu S a ďalší

Zdroj: Leukemia & lymphoma [Leuk Lymphoma] 2025 Dec; Vol. 66 (12), pp. 2238-2248. Date of Electronic Publication: 2025 Sep 01.

Spôsob vydávania: Journal Article; Comparative Study

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE

Výrazy zo slovníka MeSH: Lymphoma, Mantle-Cell*/drug therapy , Lymphoma, Mantle-Cell*/mortality , Lymphoma, Mantle-Cell*/pathology , Pyrazines*/therapeutic use , Pyrazines*/adverse effects , Pyrazines*/administration & dosage , Benzamides*/therapeutic use , Benzamides*/adverse effects , Benzamides*/administration & dosage , Pyrazoles*/therapeutic use , Piperidines*/therapeutic use , Pyrimidines*/therapeutic use , Neoplasm Recurrence, Local*/drug therapy , Neoplasm Recurrence, Local*/pathology, Humans ; Male ; Female ; Aged ; Middle Aged ; Drug Resistance, Neoplasm ; Treatment Outcome ; Aged, 80 and over

Tetramethylpyrazine Confers Protection Against Oxidative Stress and NLRP3-Dependent Pyroptosis in Rats with Endometriosis.

Autori: Xu K Zhang M Zou X a ďalší

Zdroj: Organogenesis [Organogenesis] 2025 Dec; Vol. 21 (1), pp. 2460261. Date of Electronic Publication: 2025 Feb 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101253266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-8592 (Electronic) Linking ISSN: 15476278 NLM ISO Abbreviation: Organogenesis Subsets: MEDLINE

Výrazy zo slovníka MeSH: Oxidative Stress*/drug effects , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Pyroptosis*/drug effects , Endometriosis*/drug therapy , Endometriosis*/metabolism , Endometriosis*/pathology , Pyrazines*/pharmacology , Pyrazines*/therapeutic use, Animals ; Female ; Rats ; Rats, Sprague-Dawley ; Inflammasomes/metabolism ; Inflammasomes/drug effects ; NF-E2-Related Factor 2/metabolism

Tetramethylpyrazine Promotes Functional Recovery after Spinal Cord Injury by Regulating 5-Methylcytosine RNA Modification via the NSUN2-XBP1 Axis.

Autori: Xiao Z Wang Z Jiang H a ďalší

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov 19; Vol. 63 (1), pp. 74. Date of Electronic Publication: 2025 Nov 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Spinal Cord Injuries*/drug therapy , Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/physiopathology , Pyrazines*/pharmacology , Pyrazines*/therapeutic use , Recovery of Function*/drug effects , X-Box Binding Protein 1*/metabolism , 5-Methylcytosine*/metabolism , Methyltransferases*/metabolism, Animals ; Rats ; Rats, Sprague-Dawley ; PC12 Cells ; Apoptosis/drug effects ; Male ; Signal Transduction/drug effects ; Oxidative Stress/drug effects ; Cytokines/metabolism

Distinct Target Site of Lenacapavir in Immature HIV-1 and Concurrent Binding with the Maturation Inhibitor Bevirimat.

Autori: Wu C Meuser ME Rey JS a ďalší

Zdroj: Journal of the American Chemical Society [J Am Chem Soc] 2025 Nov 19; Vol. 147 (46), pp. 42685-42700. Date of Electronic Publication: 2025 Nov 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

Výrazy zo slovníka MeSH: HIV-1*/drug effects , HIV-1*/chemistry , HIV-1*/metabolism , Anti-HIV Agents*/chemistry , Anti-HIV Agents*/pharmacology , Anti-HIV Agents*/metabolism , Succinates*/chemistry , Succinates*/pharmacology , Succinates*/metabolism , Pyrazines*/chemistry , Pyrazines*/pharmacology, Cryoelectron Microscopy ; Humans ; Cyclopropanes/chemistry ; Models, Molecular ; Binding Sites ; Acetamides ; Indazoles ; Pentacyclic Triterpenes

Tetramethylpyrazine-caffeic Acid Hybrid CT-011 Exerts Dopaminergic Neuroprotection Through Inhibiting Microglia-mediated Neuroinflammation.

Autori: Xie M Cheng Y Yang L a ďalší

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov 15; Vol. 63 (1), pp. 44. Date of Electronic Publication: 2025 Nov 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Microglia*/drug effects , Microglia*/metabolism , Microglia*/pathology , Caffeic Acids*/pharmacology , Caffeic Acids*/chemistry , Dopaminergic Neurons*/drug effects , Dopaminergic Neurons*/metabolism , Dopaminergic Neurons*/pathology , Pyrazines*/pharmacology , Pyrazines*/chemistry , Neuroprotective Agents*/pharmacology , Neuroinflammatory Diseases*/drug therapy , Neuroinflammatory Diseases*/pathology , Neuroinflammatory Diseases*/metabolism , Neuroprotection*/drug effects , Dopamine*/metabolism, Animals ; Mice ; Lipopolysaccharides/pharmacology ; Cell Line ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Inflammasomes/metabolism ; Cytokines/metabolism

Unveiling the γ-carboxyl role of glutamic acid in pyrazine formation from N-(1-deoxy-α-d-ribulos-1-yl)-glutamic acid: Mechanistic insights via integrated experimental and density functional theory approaches.

Autori: Zhan H Zhang L Xu M a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Nov 15; Vol. 492 (Pt 3), pp. 145652. Date of Electronic Publication: 2025 Jul 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glutamic Acid*/chemistry , Pyrazines*/chemistry, Density Functional Theory ; Maillard Reaction ; Hydrogen-Ion Concentration ; Hot Temperature ; Molecular Structure ; Flavoring Agents/chemistry

Venetoclax plus gilteritinib is effective in preclinical models of FLT3-mutant BCL11B-a lineage-ambiguous leukemia.

Autori: Montefiori LE Iacobucci I Gao Q a ďalší

Zdroj: Blood [Blood] 2025 Nov 06; Vol. 146 (19), pp. 2350-2356.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

Výrazy zo slovníka MeSH: Sulfonamides*/pharmacology , Sulfonamides*/administration & dosage , Bridged Bicyclo Compounds, Heterocyclic*/pharmacology , Bridged Bicyclo Compounds, Heterocyclic*/administration & dosage , fms-Like Tyrosine Kinase 3*/genetics , fms-Like Tyrosine Kinase 3*/antagonists & inhibitors , Aniline Compounds*/pharmacology , Aniline Compounds*/administration & dosage , Pyrazines*/pharmacology , Pyrazines*/administration & dosage , Mutation* , Antineoplastic Combined Chemotherapy Protocols*/pharmacology , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Leukemia*/drug therapy , Leukemia*/genetics , Leukemia*/pathology, Animals ; Humans ; Mice ; Proto-Oncogene Proteins c-bcl-2/genetics ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Female

Tetramethylpyrazine ameliorates 5-fluorouracil-Induced cardiotoxicity by inhibiting PANoptosis and suppressing the p38 MAPK/JNK/ERK signaling pathway.

Autori: Xie Y Shen A Lin H a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 05; Vol. 1006, pp. 178180. Date of Electronic Publication: 2025 Sep 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fluorouracil*/adverse effects , Pyrazines*/pharmacology , Pyrazines*/therapeutic use , Cardiotoxicity*/drug therapy , Cardiotoxicity*/etiology , Cardiotoxicity*/pathology , Cardiotoxicity*/metabolism , p38 Mitogen-Activated Protein Kinases*/metabolism , MAP Kinase Signaling System*/drug effects , Cardiotonic Agents*/pharmacology , Cardiotonic Agents*/therapeutic use, Animals ; Male ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/metabolism ; Mice ; Rats

Selective RNA binding and imaging with imidazopyrazine-based fluorescent molecule.

Autori: Sevinçli ZŞ Amudi K Öncel BC a ďalší

Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2025 Nov 05; Vol. 340, pp. 126382. Date of Electronic Publication: 2025 May 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fluorescent Dyes*/chemistry , Fluorescent Dyes*/metabolism , Pyrazines*/chemistry , Pyrazines*/metabolism , RNA*/metabolism , RNA*/chemistry , Imidazoles*/chemistry , Imidazoles*/metabolism, Humans ; MCF-7 Cells ; Spectrometry, Fluorescence

Regulation of Autophagy by Tetramethylpyrazine Through the PI3K/AKT/mTOR Pathway to Treat Pulmonary Thromboembolism.

Autori: Long J Chen W Lin F a ďalší

Zdroj: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2025 Nov; Vol. 39 (11), pp. e70567.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

Výrazy zo slovníka MeSH: TOR Serine-Threonine Kinases*/metabolism , Pyrazines*/pharmacology , Pyrazines*/therapeutic use , Pulmonary Embolism*/drug therapy , Pulmonary Embolism*/metabolism , Pulmonary Embolism*/pathology , Proto-Oncogene Proteins c-akt*/metabolism , Autophagy*/drug effects , Phosphatidylinositol 3-Kinases*/metabolism , Signal Transduction*/drug effects, Animals ; Rats ; Male ; Rats, Sprague-Dawley

Development of a leucine aminopeptidase-activatable co-prodrug from CDDO-Me and ligustrazine for synergistic treatment of liver injury.

Autori: Chen F Zheng J Xu K a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109177. Date of Electronic Publication: 2025 Oct 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Pyrazines*/chemistry , Pyrazines*/pharmacology , Leucyl Aminopeptidase*/metabolism , Prodrugs*/pharmacology , Prodrugs*/chemistry , Prodrugs*/chemical synthesis , Prodrugs*/metabolism , Chemical and Drug Induced Liver Injury*/drug therapy , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/pathology, Animals ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Mice ; Dose-Response Relationship, Drug ; Apoptosis/drug effects ; Male ; Reactive Oxygen Species/metabolism ; Drug Synergism ; Leucine/analogs & derivatives ; Oleanolic Acid/analogs & derivatives

Tetramethylpyrazine protects against myocardial ischemia/reperfusion injury via regulating Myl2-mediated NLRP3 signaling pathway inhibition.

Autori: Li Y Chen X Yang M a ďalší

Zdroj: Cellular signalling [Cell Signal] 2025 Nov; Vol. 135, pp. 112045. Date of Electronic Publication: 2025 Aug 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

Výrazy zo slovníka MeSH: Pyrazines*/pharmacology , Pyrazines*/therapeutic use , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Myocardial Reperfusion Injury*/metabolism , Myocardial Reperfusion Injury*/drug therapy , Myocardial Reperfusion Injury*/pathology , Myocardial Reperfusion Injury*/prevention & control , Signal Transduction*/drug effects , Myosin Light Chains*/metabolism , Cardiotonic Agents*/pharmacology , Cardiac Myosins*/metabolism, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Inflammasomes/metabolism ; Inflammasomes/drug effects ; Cell Line ; Apoptosis/drug effects ; Pyroptosis/drug effects ; Myocardium/pathology ; Myocardium/metabolism

Design, synthesis and evaluation of novel UDCA-tetrahydropyrazine triazole hybrids for the treatment of pulmonary fibrosis.

Autori: Hu Y Zeng S Tang J a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109064. Date of Electronic Publication: 2025 Oct 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/metabolism , Pulmonary Fibrosis*/pathology , Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis , Drug Design* , Pyrazines*/chemistry , Pyrazines*/pharmacology , Ursodeoxycholic Acid*/chemistry , Ursodeoxycholic Acid*/pharmacology, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Movement/drug effects ; Cell Line ; Fibroblasts/drug effects ; Transforming Growth Factor beta1/antagonists & inhibitors ; Transforming Growth Factor beta1/metabolism

Porphyrin-ligustrazine conjugates: Dual-mode therapeutic agents combining photodynamic and chemotherapy for enhanced antitumor activity.

Autori: Shi L Liu Y Tian Z a ďalší

Zdroj: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2025 Nov; Vol. 272, pp. 113282. Date of Electronic Publication: 2025 Oct 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Sequoia Country of Publication: Switzerland NLM ID: 8804966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2682 (Electronic) Linking ISSN: 10111344 NLM ISO Abbreviation: J Photochem Photobiol B Subsets: MEDLINE

Výrazy zo slovníka MeSH: Porphyrins*/chemistry , Porphyrins*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Pyrazines*/chemistry , Pyrazines*/pharmacology , Photosensitizing Agents*/chemistry , Photosensitizing Agents*/pharmacology, Humans ; Photochemotherapy ; Cell Line, Tumor ; Reactive Oxygen Species/metabolism ; Cell Survival/drug effects

Cardiac Events in Three Phase 3 Randomized Trials Including Acalabrutinib in Chronic Lymphocytic Leukemia.

Autori: O'Quinn R Corry AJ Bajwa N a ďalší

Zdroj: Clinical lymphoma, myeloma & leukemia [Clin Lymphoma Myeloma Leuk] 2025 Nov; Vol. 25 (11), pp. 819-828.e5. Date of Electronic Publication: 2025 Apr 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 101525386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2152-2669 (Electronic) Linking ISSN: 21522669 NLM ISO Abbreviation: Clin Lymphoma Myeloma Leuk Subsets: MEDLINE

Výrazy zo slovníka MeSH: Benzamides*/therapeutic use , Benzamides*/adverse effects , Benzamides*/pharmacology , Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy , Leukemia, Lymphocytic, Chronic, B-Cell*/complications , Pyrazines*/therapeutic use , Pyrazines*/adverse effects , Pyrazines*/pharmacology, Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Adenine/analogs & derivatives ; Adenine/analogs & derivatives ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Piperidines ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Clinical Trials, Phase III as Topic ; Randomized Controlled Trials as Topic