Search Results - "PROTEOMICS"

Use of Synthetic Standard Peptides in Standardized Digests to Evaluate Both Sample and Instrument Suitability in Proteomics.

Authors: Collins LB Williams TI Sohn AL et al.

Source: Journal of proteome research [J Proteome Res] 2025 Dec 05; Vol. 24 (12), pp. 5995-6005. Date of Electronic Publication: 2025 Nov 13.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE

MeSH Terms: Proteomics*/methods , Proteomics*/standards , Proteomics*/instrumentation , Peptides*/chemistry , Proteome*, Humans ; HeLa Cells ; Tandem Mass Spectrometry/methods ; Tandem Mass Spectrometry/standards ; Chromatography, Liquid ; Reference Standards ; Reproducibility of Results

Spatial- and Phospho-Proteomic Profiling Reveals Pancreatic and Hepatic Dysfunction in a Rat Model of Lethal Insulin Overdose.

Authors: Zhang J Li S Kong Q et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 14; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 14.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Insulin*/adverse effects , Insulin*/toxicity , Liver*/metabolism , Liver*/pathology , Liver*/drug effects , Proteomics*/methods , Pancreas*/metabolism , Pancreas*/pathology , Pancreas*/drug effects , Drug Overdose*/metabolism , Drug Overdose*/pathology , Proteome*/metabolism , Phosphoproteins*/metabolism, Animals ; Rats ; Male ; Disease Models, Animal ; Rats, Sprague-Dawley

mzPeak: Designing a Scalable, Interoperable, and Future-Ready Mass Spectrometry Data Format.

Authors: Van Den Bossche T Alexandrov T Bilbao A et al.

Source: Journal of proteome research [J Proteome Res] 2025 Nov 07; Vol. 24 (11), pp. 5329-5335. Date of Electronic Publication: 2025 Oct 02.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE

MeSH Terms: Mass Spectrometry*/methods , Proteomics*/methods , Software*, Humans ; Metabolomics/methods ; Workflow

Evaluation of a Prototype Orbitrap Astral Zoom Mass Spectrometer for Quantitative Proteomics─Beyond Identification Lists.

Authors: Hsu C Shulman N Stewart HI et al.

Source: Journal of proteome research [J Proteome Res] 2025 Nov 07; Vol. 24 (11), pp. 5742-5754. Date of Electronic Publication: 2025 Oct 22.

Publication Type: Journal Article; Evaluation Study

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE

MeSH Terms: Proteomics*/methods , Proteomics*/instrumentation , Mass Spectrometry*/methods , Mass Spectrometry*/instrumentation, Peptides/analysis ; Humans

Protein Abundance of Clinically Relevant Drug-Metabolizing Hydrolases in Human Liver and Intestine by Targeted versus Global Proteomics Approaches: A Comparative Study.

Authors: Singh DK Ahire D Jones RS et al.

Source: Journal of proteome research [J Proteome Res] 2025 Nov 07; Vol. 24 (11), pp. 5683-5695. Date of Electronic Publication: 2025 Oct 13.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE

MeSH Terms: Proteomics*/methods , Liver*/enzymology , Intestines*/enzymology , Hydrolases*/metabolism , Intestinal Mucosa*/metabolism, Humans

Bacterial Proteomics and Antibiotic Resistance Identification: Is Single-Cell Analysis a Worthwhile Pursuit?

Authors: Ayon NJ; Analytical Development Laboratory, United States Pharmacopeia, Rockville, MD 20852, USA.

Source: Pathogens (Basel, Switzerland) [Pathogens] 2025 Nov 05; Vol. 14 (11). Date of Electronic Publication: 2025 Nov 05.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-0817 (Electronic) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: MEDLINE

MeSH Terms: Proteomics*/methods , Single-Cell Analysis*/methods , Bacteria*/drug effects , Bacteria*/metabolism , Bacteria*/genetics , Drug Resistance, Bacterial* , Bacterial Proteins*/metabolism , Bacterial Proteins*/analysis, Anti-Bacterial Agents/pharmacology ; Proteome/analysis ; Humans ; Mass Spectrometry

Longitudinal plasma proteomics: relation to incident Alzheimer's disease dementia and biomarkers.

Authors: Lee EH Huang YN Park T et al.

Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Nov; Vol. 21 (11), pp. e70900.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/blood , Alzheimer Disease*/diagnosis , Biomarkers*/blood , Proteomics* , Blood Proteins*/metabolism, Humans ; Male ; Female ; Longitudinal Studies ; Aged ; Disease Progression ; Aged, 80 and over

Evolving stratification and biomarker discovery in cancer research with technological advancement of proteomics: 35 years and counting.

Authors: Mahajan D Kaushik S Srivastava T

Source: Bioscience reports [Biosci Rep] 2025 Oct 09; Vol. 45 (10). Date of Electronic Publication: 2025 Oct 09.

Publication Type: Journal Article; Review

Journal Info: Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE

MeSH Terms: Proteomics*/methods , Proteomics*/trends , Neoplasms*/metabolism , Neoplasms*/pathology , Neoplasms*/genetics , Neoplasms*/diagnosis , Neoplasms*/therapy , Biomarkers, Tumor*/metabolism , Proteome*/metabolism, Humans ; Mass Spectrometry/methods ; Protein Processing, Post-Translational ; Tumor Microenvironment ; Animals

Investigate the Insoluble Fraction in Heart Tissue Preparation after Deoxycholate for Potential Loss of Proteins in Heart Proteomics.

Authors: Torkamannejad S Yip HY Sun B

Source: Journal of proteome research [J Proteome Res] 2025 Oct 03; Vol. 24 (10), pp. 5046-5055. Date of Electronic Publication: 2025 Sep 18.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE

MeSH Terms: Deoxycholic Acid*/chemistry , Proteomics*/methods , Proteome*/analysis , Proteome*/chemistry , Myocardium*/chemistry , Myocardium*/metabolism, Humans ; Solubility ; Detergents/chemistry ; Sarcomeres/chemistry ; Heart Ventricles/chemistry

Brief Evaluation of Olink Reveal Proximity Extension Assay for High-Throughput Proteomics: A Case Study Using NIST SRM 1950 and Two Spike-In Protein Standards.

Authors: van der Burgt YEM de Meijer E Palmblad M

Source: Journal of proteome research [J Proteome Res] 2025 Oct 03; Vol. 24 (10), pp. 5292-5296. Date of Electronic Publication: 2025 Sep 08.

Publication Type: Journal Article; Evaluation Study

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE

MeSH Terms: Proteomics*/methods , Proteomics*/standards , Interleukin-10*/blood , High-Throughput Screening Assays*/methods , High-Throughput Screening Assays*/standards , Blood Proteins*/analysis, Humans ; Reference Standards ; Recombinant Proteins ; Mass Spectrometry

Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting.

Authors: Doncheva NT Schwämmle V Locard-Paulet M

Source: Journal of proteome research [J Proteome Res] 2025 Oct 03; Vol. 24 (10), pp. 4965-4976. Date of Electronic Publication: 2025 Sep 03.

Publication Type: Journal Article; Letter

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE

MeSH Terms: Proteomics*/methods , Proteomics*/standards , Mass Spectrometry*/methods , Data Analysis*, Workflow ; Quality Control ; Humans

State-of-the-Art and Future Directions in Structural Proteomics.

Authors: Happonen LJ Varjosalo M

Source: Molecular & cellular proteomics : MCP [Mol Cell Proteomics] 2025 Oct; Vol. 24 (10), pp. 101065. Date of Electronic Publication: 2025 Sep 03.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 101125647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-9484 (Electronic) Linking ISSN: 15359476 NLM ISO Abbreviation: Mol Cell Proteomics Subsets: MEDLINE

MeSH Terms: Proteomics*/methods , Proteomics*/trends, Humans ; Mass Spectrometry/methods ; Animals ; Protein Conformation

SLB-msSIM: A Spectral Library-Based Multiplex Segmented SIM Platform for Single-Cell Proteomic Analysis.

Authors: Senavirathna L Ma C Duong VA et al.

Source: Proteomics [Proteomics] 2025 Oct; Vol. 25 (19), pp. 50-61. Date of Electronic Publication: 2025 Sep 04.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101092707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-9861 (Electronic) Linking ISSN: 16159853 NLM ISO Abbreviation: Proteomics Subsets: MEDLINE

MeSH Terms: Single-Cell Analysis*/methods , Proteomics*/methods , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/pathology , Mass Spectrometry*/methods , Proteome*/analysis, Humans ; Cell Line, Tumor

New insights into clinical strategies for acute coronary syndrome based on biomarker-driven multiomics research.

Authors: Zhao Z Yu K Zhao Y et al.

Source: Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2025 Dec 31; Vol. 47 (1), pp. 2593619. Date of Electronic Publication: 2025 Dec 05.

Publication Type: Journal Article; Review

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9305929 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6006 (Electronic) Linking ISSN: 10641963 NLM ISO Abbreviation: Clin Exp Hypertens Subsets: MEDLINE

MeSH Terms: Acute Coronary Syndrome*/diagnosis , Acute Coronary Syndrome*/genetics , Acute Coronary Syndrome*/metabolism , Acute Coronary Syndrome*/therapy , Metabolomics*/methods , Proteomics*/methods , Genomics*/methods, Humans ; Biomarkers/metabolism ; Transcriptome ; Multiomics

Global immunostimulatory mechanisms of a high-branched glycogen from Glyptocidaris crenularis eggs in RAW264.7 macrophages via BONCAT-based nascent proteomics.

Authors: Wang Q Luo Y Xin Y et al.

Source: Carbohydrate polymers [Carbohydr Polym] 2025 Dec 15; Vol. 370, pp. 124473. Date of Electronic Publication: 2025 Sep 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE

MeSH Terms: Proteomics*/methods , Macrophages*/drug effects , Macrophages*/metabolism , Macrophages*/immunology , Glycogen*/chemistry , Glycogen*/pharmacology , Glycogen*/isolation & purification , Sea Urchins*/chemistry , Ovum*/chemistry , Adjuvants, Immunologic*/pharmacology , Adjuvants, Immunologic*/chemistry , Adjuvants, Immunologic*/isolation & purification, Animals ; Mice ; RAW 264.7 Cells ; Signal Transduction/drug effects ; Proteome

Comparative proteomics and metabolomics unveil regional variations in Dendrobium officinale.

Authors: Guan S Jin G Zhang X et al.

Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Dec 15; Vol. 266, pp. 117087. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH Terms: Dendrobium*/metabolism , Dendrobium*/chemistry , Metabolomics*/methods , Proteomics*/methods , Plant Proteins*/metabolism, China ; Plants, Medicinal/metabolism ; Flavonoids/biosynthesis ; Metabolome

Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics.

Authors: Scalvini L Tagliazucchi L Elisi GM et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118056. Date of Electronic Publication: 2025 Aug 12.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Proteomics* , Transcription Factors*/metabolism , Transcription Factors*/antagonists & inhibitors , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/antagonists & inhibitors , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/antagonists & inhibitors , Muscle Proteins*/metabolism , Muscle Proteins*/antagonists & inhibitors, Humans ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; TEA Domain Transcription Factors ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Mass Spectrometry ; YAP-Signaling Proteins ; Cell Line, Tumor

Mediating role of proteomics in the association between per- and polyfluoroalkyl substance exposure and blood pressure in youth.

Authors: Chen JC Goodrich JA Liao J et al.

Source: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2025 Dec 15; Vol. 387, pp. 127336. Date of Electronic Publication: 2025 Oct 31.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE

MeSH Terms: Fluorocarbons* , Proteomics* , Blood Pressure*/drug effects , Environmental Exposure*/statistics & numerical data , Environmental Pollutants* , Persistent Organic Pollutants*, Humans ; Adolescent ; Male ; Female ; Young Adult ; Child

Spermidine Prevents Polarity Loss of Absorptive Enterocytes in Jejunum of Lipopolysaccharide-Challenged Mice via 4D-DIA Proteomics Analysis.

Authors: Zheng P Tian S Chen Z et al.

Source: Journal of proteome research [J Proteome Res] 2025 Dec 05; Vol. 24 (12), pp. 6067-6078. Date of Electronic Publication: 2025 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE

MeSH Terms: Lipopolysaccharides*/toxicity , Jejunum*/drug effects , Jejunum*/metabolism , Jejunum*/pathology , Jejunum*/cytology , Proteomics*/methods , Enterocytes*/drug effects , Enterocytes*/metabolism , Enterocytes*/pathology , Cell Polarity*/drug effects , Spermidine*/pharmacology, Animals ; Mice ; Humans ; Caco-2 Cells ; Male

Alternative Ion-Pairing Modifiers Should Be Investigated in Low-Input and Single-Cell Proteomics.

Authors: Eberhard CD Braswell C Orsburn BC

Source: Journal of proteome research [J Proteome Res] 2025 Dec 05; Vol. 24 (12), pp. 6338-6343. Date of Electronic Publication: 2025 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE

MeSH Terms: Proteomics*/methods , Single-Cell Analysis*/methods , Proteome*/analysis, Humans ; Acetic Acid/chemistry ; Peptides/chemistry ; Peptides/analysis ; Formates/chemistry