Suchergebnisse - "PROTEIN-tyrosine phosphatase"

The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR.

Autoren: Callahan A Mojumdar A Hu M et al.

Quelle: Scientific reports [Sci Rep] 2025 Jul 30; Vol. 15 (1), pp. 27747. Date of Electronic Publication: 2025 Jul 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Antigen, T-Cell*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 6*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 6*/genetics , T-Lymphocytes*/metabolism , T-Lymphocytes*/immunology , Protein Tyrosine Phosphatase, Non-Receptor Type 22*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 22*/genetics , Phosphotyrosine*/metabolism, Humans ; Jurkat Cells ; Feedback, Physiological ; Signal Transduction ; CRISPR-Cas Systems ; Protein Tyrosine Phosphatase, Non-Receptor Type 1

Pro-inflammatory cytokines as regulators of protein tyrosine phosphatases and insulin signaling in murine skeletal muscle cells.

Autoren: Stein V Geserick P Friedrich K et al.

Quelle: Cellular signalling [Cell Signal] 2025 Nov; Vol. 135, pp. 112037. Date of Electronic Publication: 2025 Jul 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH-Schlagworte: Signal Transduction*/drug effects , Insulin*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics , Cytokines*/metabolism , Cytokines*/pharmacology , Muscle, Skeletal*/metabolism , Muscle, Skeletal*/cytology , Protein Tyrosine Phosphatases*/metabolism, Animals ; Mice ; Cell Line ; Interleukin-1beta/pharmacology ; Interleukin-6/pharmacology ; Tumor Necrosis Factor-alpha/pharmacology ; Insulin Resistance

Impact of C18 Epimerization of Indole- and Pyrazole-Fused 18β-Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies.

Autoren: De-la-Cruz-Martínez L Martínez-Arellano R López-Sánchez M et al.

Quelle: ChemMedChem [ChemMedChem] 2025 Nov 18; Vol. 20 (22), pp. e202500350. Date of Electronic Publication: 2025 Sep 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Glycyrrhetinic Acid*/chemistry , Glycyrrhetinic Acid*/analogs & derivatives , Glycyrrhetinic Acid*/pharmacology , Glycyrrhetinic Acid*/chemical synthesis , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Indoles*/chemistry , Indoles*/pharmacology , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Molecular Structure ; Dose-Response Relationship, Drug

Enhancing the apo protein tyrosine phosphatase non-receptor type 2 crystal soaking strategy through inhibitor-accessible binding sites.

Autoren: Bester SM Linwood R Kataoka R et al.

Quelle: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2024 Sep 01; Vol. 80 (Pt 9), pp. 210-219. Date of Electronic Publication: 2024 Aug 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons Inc Country of Publication: United States NLM ID: 101620319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2053-230X (Electronic) Linking ISSN: 2053230X NLM ISO Abbreviation: Acta Crystallogr F Struct Biol Commun Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/chemistry , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics , Catalytic Domain*, Humans ; Crystallography, X-Ray ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Binding Sites ; Models, Molecular ; Protein Binding ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; Crystallization ; Apoenzymes/chemistry ; Apoenzymes/metabolism ; Apoenzymes/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism

PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression.

Autoren: Ross MO Xie Y Owyang RC et al.

Quelle: Nature communications [Nat Commun] 2024 Aug 13; Vol. 15 (1), pp. 6947. Date of Electronic Publication: 2024 Aug 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: ErbB Receptors*/metabolism , ErbB Receptors*/genetics , Copper*/metabolism , Cyclic AMP Response Element-Binding Protein*/metabolism , Signal Transduction* , Copper Transporter 1*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics, Humans ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; Transcription, Genetic/drug effects

Marine alkaloid rigidin analogues as potential selective inhibitors of SHP1, a new strategy for cancer immunotherapeutics.

Autoren: Bhasin S Das A

Quelle: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 Jul; Vol. 42 (11), pp. 5590-5606. Date of Electronic Publication: 2023 Jun 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 6*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 6*/antagonists & inhibitors , Molecular Dynamics Simulation* , Alkaloids*/chemistry , Alkaloids*/pharmacology, Humans ; Neoplasms/drug therapy ; Molecular Docking Simulation ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/antagonists & inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism ; Immunotherapy/methods ; Protein Binding ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Structure-Activity Relationship

Oral PTP1B siRNA Delivery Using Milk-Derived Extracellular Vesicles for Alleviation of Acute Kidney Injury.

Autoren: Jang H Park D Park B et al.

Quelle: ACS nano [ACS Nano] 2025 Nov 25; Vol. 19 (46), pp. 40085-40099. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE

MeSH-Schlagworte: Acute Kidney Injury*/therapy , Acute Kidney Injury*/pathology , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/genetics , Acute Kidney Injury*/drug therapy , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Extracellular Vesicles*/chemistry , Extracellular Vesicles*/metabolism , RNA, Small Interfering*/administration & dosage , RNA, Small Interfering*/genetics , Milk*/chemistry, Animals ; Mice ; Administration, Oral ; Humans ; Mice, Inbred C57BL ; Male ; Endoplasmic Reticulum Stress/drug effects

Development of Novel PTPN2/1 Inhibitors for the Treatment of Melanoma.

Autoren: Wang D Song M Tong C et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21917-21938. Date of Electronic Publication: 2025 Oct 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 2*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Melanoma*/drug therapy , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/therapeutic use, Animals ; Mice ; Humans ; Mice, Inbred C57BL ; Cell Line, Tumor ; Structure-Activity Relationship ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/pathology

PTPN2 acts as a tumor suppressor and therapeutic target in ovarian cancer.

Autoren: Sun X Zhang W Wang H et al.

Quelle: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Oct 20; Vol. 785, pp. 152704. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH-Schlagworte: Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/drug therapy , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/antagonists & inhibitors , Genes, Tumor Suppressor* , Tumor Suppressor Proteins*/metabolism , Tumor Suppressor Proteins*/genetics, Humans ; Female ; Cell Line, Tumor ; Cell Proliferation ; Cell Movement ; Gene Expression Regulation, Neoplastic ; Biomarkers, Tumor/metabolism ; Biomarkers, Tumor/genetics

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity.

Autoren: Allen B Dambuza IM Berry SH et al.

Quelle: MBio [mBio] 2025 Oct 08; Vol. 16 (10), pp. e0151625. Date of Electronic Publication: 2025 Aug 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 1*/deficiency , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/immunology , Candida albicans*/immunology , Candidiasis*/immunology , Candidiasis*/microbiology , Myeloid Cells*/immunology , Myeloid Cells*/microbiology, Animals ; Mice ; Macrophages/immunology ; Macrophages/microbiology ; Humans ; Mice, Knockout ; Neutrophils/immunology ; Disease Susceptibility ; Mice, Inbred C57BL ; Phagocytosis ; Disease Models, Animal

SCR Disease Name: Systemic candidiasis

Insights into PTP1B inhibitors as antidiabetic agents: Current research and future perspectives.

Autoren: Haider AS Ambatwar R Khatik GL

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Oct 05; Vol. 295, pp. 117791. Date of Electronic Publication: 2025 May 23.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology, Humans ; Structure-Activity Relationship ; Molecular Structure ; Animals ; Diabetes Mellitus, Type 2/drug therapy

Mechanism-Based Allosteric Inhibition of PTP1B by Prenylated Flavonoids from Glycyrrhiza echinata: In Vitro Experiments and in Silico Validation.

Autoren: Kamel EM Abdelrheem DA Ahmed NA et al.

Quelle: The protein journal [Protein J] 2025 Oct; Vol. 44 (5), pp. 526-549. Date of Electronic Publication: 2025 Jul 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 101212092 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8355 (Electronic) Linking ISSN: 15723887 NLM ISO Abbreviation: Protein J Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/chemistry , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Flavonoids*/chemistry , Flavonoids*/pharmacology , Glycyrrhiza*/chemistry , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology, Molecular Docking Simulation ; Humans ; Allosteric Regulation ; Prenylation ; Allosteric Site ; Kinetics

Novel azabicyclic series of potent SHP2 allosteric inhibitors.

Autoren: Sferrazza A Rossetti I Fabbrini D et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 15; Vol. 129, pp. 130383. Date of Electronic Publication: 2025 Aug 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Aza Compounds*/chemistry , Aza Compounds*/pharmacology , Aza Compounds*/chemical synthesis, Humans ; Structure-Activity Relationship ; Allosteric Regulation/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor

Phytochemical constituents of Hydrangea macrophylla var. acuminata leaves and their inhibitory activity against PTP1B and α-glucosidase.

Autoren: Pham TL Nguyen VP Nguyen TTA et al.

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2584940. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , alpha-Glucosidases*/metabolism , Plant Leaves*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Phytochemicals*/isolation & purification , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/isolation & purification , Hydrangea*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/isolation & purification, Molecular Docking Simulation ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Humans

The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2.

Autoren: van Vlimmeren AE Jiang Z Karandur D et al.

Quelle: Protein science : a publication of the Protein Society [Protein Sci] 2025 Dec; Vol. 34 (12), pp. e70373.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/chemistry , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism, Humans ; Molecular Dynamics Simulation ; src Homology Domains ; Mutation ; Models, Molecular ; Catalytic Domain

Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses.

Autoren: Chatterjee P Spalinger MR Acevedo C et al.

Quelle: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2559029. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/immunology , Intestinal Mucosa*/microbiology , Intestinal Mucosa*/immunology , Epithelial Cells*/microbiology , Epithelial Cells*/immunology , Escherichia coli*/immunology , Escherichia coli*/growth & development , Escherichia coli Infections*/immunology , Escherichia coli Infections*/microbiology , Escherichia coli Infections*/genetics, Animals ; Mice, Knockout ; Mice ; Humans ; Cytokines/metabolism ; Mice, Inbred C57BL ; Gastrointestinal Microbiome ; Female ; Male

DARPP-32 is a novel regulator of M2-macrophage polarization: Sustains STAT6 phosphorylation by directly binding and inhibiting tyrosine phosphatase SHP-1.

Autoren: Chowdhury S Sethi A Srivastava S et al.

Quelle: Oncogene [Oncogene] 2025 Dec; Vol. 44 (47), pp. 4639-4656. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 6*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 6*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 6*/genetics , STAT6 Transcription Factor*/metabolism , STAT6 Transcription Factor*/genetics , Macrophages*/metabolism , Macrophages*/immunology , Dopamine and cAMP-Regulated Phosphoprotein 32*/metabolism , Dopamine and cAMP-Regulated Phosphoprotein 32*/genetics, Humans ; Animals ; Phosphorylation ; Mice ; Macrophage Activation ; Signal Transduction ; Janus Kinase 1/metabolism ; F-Box-WD Repeat-Containing Protein 7/genetics ; THP-1 Cells ; Cell Polarity

The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis.

Autoren: Chatterjee P Canale V King SJ et al.

Quelle: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2526136. Date of Electronic Publication: 2025 Jul 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Inflammatory Bowel Diseases*/genetics , Inflammatory Bowel Diseases*/microbiology , Cell Adhesion Molecules*/metabolism , Cell Adhesion Molecules*/genetics , Antigens, CD*/metabolism , Antigens, CD*/genetics, Humans ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Animals ; Mice ; Janus Kinases/metabolism ; Janus Kinases/genetics ; Alleles ; HT29 Cells ; Signal Transduction ; Mice, Knockout ; STAT Transcription Factors/metabolism ; STAT Transcription Factors/genetics ; Intestinal Mucosa/microbiology ; Epithelial Cells/microbiology ; GPI-Linked Proteins

Targeting Protein Tyrosine Phosphatase Nonreceptor Type 2 with a Novel Inhibitor for the Treatment of Melanoma.

Autoren: Kuang W Li Q Wang W et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24649-24671. Date of Electronic Publication: 2025 Nov 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 2*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Melanoma*/drug therapy , Melanoma*/pathology , Melanoma*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/therapeutic use, Animals ; Humans ; Mice ; Cell Line, Tumor ; Structure-Activity Relationship ; Cell Proliferation/drug effects

Bioactivity-based molecular networking-guided identification of methyl rosmarinate from Orthosiphon aristatus as a PTP1B inhibitor that improves insulin sensitivity in diabetic mice.

Autoren: Xie B Zhu D Li L et al.

Quelle: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov 25; Vol. 148, pp. 157444. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Insulin Resistance* , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Type 2*/drug therapy , Hypoglycemic Agents*/pharmacology, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Cell Line ; Diet, High-Fat ; Muscle Fibers, Skeletal/drug effects