Suchergebnisse - "PROTEIN synthesis"

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum.

Autoren: Bravo P Diamanti E Hamed MM et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Dec 01; Vol. 64 (49), pp. e202514085. Date of Electronic Publication: 2025 Oct 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Plasmodium falciparum*/drug effects , Plasmodium falciparum*/metabolism , Antimalarials*/pharmacology , Antimalarials*/chemistry , Antimalarials*/chemical synthesis , Protein Biosynthesis*/drug effects , Protein Synthesis Inhibitors*/pharmacology , Protein Synthesis Inhibitors*/chemistry, Humans ; Molecular Structure ; Parasitic Sensitivity Tests

Structural insights into context-specific inhibition of bacterial translation by macrolides.

Autoren: Syroegin EA Aleksandrova EV Kruglov AA et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 03; Vol. 16 (1), pp. 9685. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Macrolides*/pharmacology , Macrolides*/chemistry , Ribosomes*/metabolism , Ribosomes*/drug effects , Ribosomes*/chemistry , Protein Biosynthesis*/drug effects , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Protein Synthesis Inhibitors*/pharmacology, RNA, Transfer, Amino Acyl/metabolism ; RNA, Transfer, Amino Acyl/chemistry ; Peptidyl Transferases/metabolism ; Peptidyl Transferases/chemistry ; Escherichia coli/metabolism ; Escherichia coli/drug effects ; Escherichia coli/genetics ; RNA, Transfer/metabolism

Sensitivity to an inhibitor of translation elongation in solid and hematologic cancers.

Autoren: Gomes N Frederick B Tentler J et al.

Quelle: Scientific reports [Sci Rep] 2025 Jul 01; Vol. 15 (1), pp. 21328. Date of Electronic Publication: 2025 Jul 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Hematologic Neoplasms*/drug therapy , Hematologic Neoplasms*/metabolism , Hematologic Neoplasms*/pathology , Hematologic Neoplasms*/genetics , Protein Biosynthesis*/drug effects , Protein Synthesis Inhibitors*/pharmacology , Antineoplastic Agents*/pharmacology, Humans ; Animals ; Cell Line, Tumor ; Mice ; Apoptosis/drug effects ; Xenograft Model Antitumor Assays ; Cell Proliferation/drug effects ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-myc/metabolism

Anisomycin selectively inhibits orientation tuning shifts in mouse visual cortex.

Autoren: Jain E Lussiez R Flouty O et al.

Quelle: Journal of neurophysiology [J Neurophysiol] 2025 Jul 01; Vol. 134 (1), pp. 372-381. Date of Electronic Publication: 2025 Jun 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE

MeSH-Schlagworte: Anisomycin*/pharmacology , Visual Cortex*/drug effects , Visual Cortex*/physiology , Protein Synthesis Inhibitors*/pharmacology , Neuronal Plasticity*/drug effects , Adaptation, Physiological*/drug effects, Animals ; Mice ; Mice, Inbred C57BL ; Male

Structure-function comparison of Arbekacin with other aminoglycosides elucidates its higher potency as bacterial translation inhibitor.

Autoren: Majumdar S Parajuli NP Ge X et al.

Quelle: Scientific reports [Sci Rep] 2025 May 25; Vol. 15 (1), pp. 18271. Date of Electronic Publication: 2025 May 25.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Aminoglycosides*/pharmacology , Aminoglycosides*/chemistry , Dibekacin*/analogs & derivatives , Dibekacin*/pharmacology , Dibekacin*/chemistry , Protein Biosynthesis*/drug effects , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Protein Synthesis Inhibitors*/pharmacology , Protein Synthesis Inhibitors*/chemistry, Structure-Activity Relationship ; Ribosomes/metabolism ; Ribosomes/drug effects ; Microbial Sensitivity Tests ; Cryoelectron Microscopy ; Kanamycin/pharmacology ; Kanamycin/chemistry ; Escherichia coli/drug effects ; Escherichia coli/metabolism

Macrolactin a is an inhibitor of protein biosynthesis in bacteria.

Autoren: Vasilchenko AS Lukyanov DA Dilbaryan DS et al.

Quelle: Biochimie [Biochimie] 2025 May; Vol. 232, pp. 25-34. Date of Electronic Publication: 2025 Jan 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1638-6183 (Electronic) Linking ISSN: 03009084 NLM ISO Abbreviation: Biochimie Subsets: MEDLINE

MeSH-Schlagworte: Macrolides*/pharmacology , Macrolides*/chemistry , Escherichia coli*/metabolism , Escherichia coli*/drug effects , Escherichia coli*/genetics , Protein Biosynthesis*/drug effects , Staphylococcus aureus*/metabolism , Staphylococcus aureus*/drug effects , Staphylococcus aureus*/genetics , Anti-Bacterial Agents*/pharmacology , Bacillus pumilus*/genetics , Bacillus pumilus*/metabolism , Bacillus pumilus*/drug effects , Protein Synthesis Inhibitors*/pharmacology, Peptide Elongation Factor Tu/genetics ; Peptide Elongation Factor Tu/metabolism ; Peptide Elongation Factor Tu/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/biosynthesis

Sporogen-AO1 inhibits eukaryotic translation elongation.

Autoren: Machida K Noseda S Miki S et al.

Quelle: The Journal of antibiotics [J Antibiot (Tokyo)] 2025 Apr; Vol. 78 (5), pp. 288-294. Date of Electronic Publication: 2025 Mar 26.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0151115 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-1469 (Electronic) Linking ISSN: 00218820 NLM ISO Abbreviation: J Antibiot (Tokyo) Subsets: MEDLINE

MeSH-Schlagworte: Protein Biosynthesis*/drug effects , Peptide Chain Elongation, Translational*/drug effects , Protein Synthesis Inhibitors*/pharmacology, Humans ; HeLa Cells ; Cell-Free System ; Ribosomes/drug effects ; Ribosomes/metabolism ; Cycloheximide/pharmacology ; Escherichia coli/metabolism

Structural insights into context-dependent inhibitory mechanisms of chloramphenicol in cells.

Autoren: Xue L Spahn CMT Schacherl M et al.

Quelle: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Feb; Vol. 32 (2), pp. 257-267. Date of Electronic Publication: 2024 Dec 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Chloramphenicol*/chemistry , Chloramphenicol*/pharmacology , Mycoplasma pneumoniae*/drug effects , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Protein Synthesis Inhibitors*/chemistry , Protein Synthesis Inhibitors*/pharmacology, Ribosomes ; Peptide Chain Elongation, Translational ; Protein Structure, Quaternary ; Protein Interaction Mapping

The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation.

Autoren: Safdari HA Morici M Sanchez-Castro A et al.

Quelle: Nature communications [Nat Commun] 2025 Mar 12; Vol. 16 (1), pp. 2470. Date of Electronic Publication: 2025 Mar 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Aminoglycosides*/pharmacology , Aminoglycosides*/chemistry , Ribosome Subunits, Small, Bacterial*/metabolism , Ribosome Subunits, Small, Bacterial*/drug effects , Ribosome Subunits, Small, Bacterial*/ultrastructure , Peptide Chain Initiation, Translational*/drug effects , Anti-Bacterial Agents*/pharmacology , Protein Synthesis Inhibitors*/pharmacology, Cryoelectron Microscopy ; Escherichia coli/metabolism ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Protein Biosynthesis/drug effects ; Codon, Initiator/metabolism

Combined use of vitamin C and antifolates induces cuproptosis-like bacterial death.

Autoren: Wen M Si L Gu J et al.

Quelle: Microbiological research [Microbiol Res] 2025 Dec; Vol. 301, pp. 128323. Date of Electronic Publication: 2025 Aug 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: G. Fischer Country of Publication: Germany NLM ID: 9437794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0623 (Electronic) Linking ISSN: 09445013 NLM ISO Abbreviation: Microbiol Res Subsets: MEDLINE

MeSH-Schlagworte: Ascorbic Acid*/pharmacology , Copper*/metabolism , Anti-Bacterial Agents*/pharmacology , Bacteria*/drug effects , Bacteria*/metabolism, Reactive Oxygen Species/metabolism ; Microbial Sensitivity Tests ; Drug Synergism ; DNA Damage/drug effects ; Protein Synthesis Inhibitors/pharmacology ; Microbial Viability/drug effects

The mechanisms of memory traces storage and interaction in snails: Role of DNA methylation and protein synthesis.

Autoren: Nikitin VP Solntseva SV Nikitin PV

Quelle: Neurobiology of learning and memory [Neurobiol Learn Mem] 2025 Dec; Vol. 222, pp. 108105. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 9508166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9564 (Electronic) Linking ISSN: 10747427 NLM ISO Abbreviation: Neurobiol Learn Mem Subsets: MEDLINE

MeSH-Schlagworte: DNA Methylation*/physiology , DNA Methylation*/drug effects , Conditioning, Classical*/physiology , Conditioning, Classical*/drug effects , Memory Consolidation*/physiology , Memory Consolidation*/drug effects , Protein Biosynthesis*/physiology , Protein Biosynthesis*/drug effects , Memory*/physiology , Memory*/drug effects , Memory, Long-Term*/physiology , Memory, Long-Term*/drug effects, Animals ; Protein Synthesis Inhibitors/pharmacology ; Helix, Snails ; Snails

Fear generalization modulated by shock intensity and protein synthesis inhibitor.

Autoren: Dong X Wang Y Liu Y et al.

Quelle: Psychopharmacology [Psychopharmacology (Berl)] 2024 Dec; Vol. 241 (12), pp. 2627-2637. Date of Electronic Publication: 2024 Aug 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE

MeSH-Schlagworte: Fear* , Protein Synthesis Inhibitors*/pharmacology , Generalization, Psychological*/physiology , Electroshock* , Mice, Inbred C57BL* , Cycloheximide*/pharmacology , Cycloheximide*/administration & dosage, Animals ; Mice ; Male ; Conditioning, Classical ; Acoustic Stimulation ; Cues ; Stress, Psychological/psychology

Memory reconsolidation and amnesia induction: Separate processes dependent on specific protein and RNA synthesis.

Autoren: Nikitin VP Solntseva SV Nikitin PV

Quelle: Behavioral neuroscience [Behav Neurosci] 2024 Dec; Vol. 138 (6), pp. 441-455. Date of Electronic Publication: 2024 Sep 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Psychological Association Country of Publication: United States NLM ID: 8302411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-0084 (Electronic) Linking ISSN: 07357044 NLM ISO Abbreviation: Behav Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Receptors, N-Methyl-D-Aspartate*/antagonists & inhibitors , Receptors, N-Methyl-D-Aspartate*/metabolism , Memory Consolidation*/drug effects , Memory Consolidation*/physiology , Amnesia*/chemically induced , Amnesia*/metabolism , Protein Synthesis Inhibitors*/pharmacology, Animals ; Helix, Snails/physiology ; RNA/biosynthesis ; Excitatory Amino Acid Antagonists/pharmacology ; Memory/physiology ; Memory/drug effects ; Protein Biosynthesis/drug effects ; Protein Biosynthesis/physiology ; Avoidance Learning/drug effects ; Avoidance Learning/physiology ; Mental Recall/drug effects ; Mental Recall/physiology

Translation elongation inhibitors stabilize select short-lived transcripts.

Autoren: Rosa-Mercado NA Buskirk AR Green R

Quelle: RNA (New York, N.Y.) [RNA] 2024 Nov 18; Vol. 30 (12), pp. 1572-1585. Date of Electronic Publication: 2024 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE

MeSH-Schlagworte: RNA, Messenger*/genetics , RNA, Messenger*/metabolism , Peptide Chain Elongation, Translational*/drug effects , Emetine*/pharmacology , RNA Stability*/drug effects , Ribosomes*/metabolism , Ribosomes*/genetics , Ribosomes*/drug effects , Protein Synthesis Inhibitors*/pharmacology, Humans ; Protein Biosynthesis/drug effects

The translational inhibitor and amnestic agent emetine also suppresses ongoing hippocampal neural activity similarly to other blockers of protein synthesis.

Autoren: Al-Smadi S Padros A Goss GG et al.

Quelle: Hippocampus [Hippocampus] 2024 Aug; Vol. 34 (8), pp. 380-392. Date of Electronic Publication: 2024 May 24.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 9108167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-1063 (Electronic) Linking ISSN: 10509631 NLM ISO Abbreviation: Hippocampus Subsets: MEDLINE

MeSH-Schlagworte: Emetine*/pharmacology , Protein Synthesis Inhibitors*/pharmacology , Hippocampus*/drug effects , Hippocampus*/metabolism , Hippocampus*/physiology, Animals ; Male ; Protein Biosynthesis/drug effects ; Protein Biosynthesis/physiology ; Rats ; Neurons/drug effects ; Action Potentials/drug effects ; Action Potentials/physiology ; Rats, Sprague-Dawley

The role of retinoids in memory reconsolidation and extinction following appetitive conditioning.

Autoren: Wimmer J Ibrahim Z Spencer GE

Quelle: Neurobiology of learning and memory [Neurobiol Learn Mem] 2025 Sep; Vol. 221, pp. 108079. Date of Electronic Publication: 2025 Jul 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 9508166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9564 (Electronic) Linking ISSN: 10747427 NLM ISO Abbreviation: Neurobiol Learn Mem Subsets: MEDLINE

MeSH-Schlagworte: Extinction, Psychological*/drug effects , Extinction, Psychological*/physiology , Conditioning, Classical*/physiology , Conditioning, Classical*/drug effects , Memory Consolidation*/drug effects , Memory Consolidation*/physiology , Tretinoin*/pharmacology , Appetitive Behavior*/physiology , Appetitive Behavior*/drug effects , Retinoids*/physiology , Memory, Long-Term*/physiology , Memory, Long-Term*/drug effects, Animals ; Lymnaea ; Protein Synthesis Inhibitors/pharmacology

Involvement of serotonin receptors in destabilization and re-stabilization of retrieved context and food-aversion memory in terrestrial snail Helix lucorum.

Autoren: Zuzina AB Vinarskaya AK Balaban PM

Quelle: Neurobiology of learning and memory [Neurobiol Learn Mem] 2025 Sep; Vol. 221, pp. 108090. Date of Electronic Publication: 2025 Aug 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 9508166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9564 (Electronic) Linking ISSN: 10747427 NLM ISO Abbreviation: Neurobiol Learn Mem Subsets: MEDLINE

MeSH-Schlagworte: Helix, Snails*/physiology , Helix, Snails*/drug effects , Receptors, Serotonin*/physiology , Receptors, Serotonin*/metabolism , Memory Consolidation*/drug effects , Memory Consolidation*/physiology , Mental Recall*/drug effects , Mental Recall*/physiology , Memory*/drug effects , Memory*/physiology, Animals ; Methiothepin/pharmacology ; Serotonin Antagonists/pharmacology ; Anisomycin/pharmacology ; Protein Synthesis Inhibitors/pharmacology ; Cues

Memory persistence enhancement by post-learning moderate exercise requires de novo protein synthesis in the dorsal hippocampus.

Autoren: Inoue K Okamoto M Fukuie T et al.

Quelle: PloS one [PLoS One] 2025 Jul 18; Vol. 20 (7), pp. e0328128. Date of Electronic Publication: 2025 Jul 18 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Hippocampus*/metabolism , Hippocampus*/physiology , Hippocampus*/drug effects , Physical Conditioning, Animal*/physiology , Protein Biosynthesis*/drug effects , Memory Consolidation*/physiology , Memory Consolidation*/drug effects , Memory*/physiology , Memory*/drug effects , Learning*/physiology, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Anisomycin/pharmacology ; Protein Synthesis Inhibitors/pharmacology

Loss of the yeast transporter Agp2 upregulates the pleiotropic drug-resistant pump Pdr5 and confers resistance to the protein synthesis inhibitor cycloheximide.

Autoren: Manzoor Y Aouida M Ramadoss R et al.

Quelle: PloS one [PLoS One] 2024 May 22; Vol. 19 (5), pp. e0303747. Date of Electronic Publication: 2024 May 22 (Print Publication: 2024).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Cycloheximide*/pharmacology , Protein Synthesis Inhibitors*/pharmacology , Saccharomyces cerevisiae Proteins*/metabolism , Saccharomyces cerevisiae Proteins*/genetics , ATP-Binding Cassette Transporters*/metabolism , ATP-Binding Cassette Transporters*/genetics , Saccharomyces cerevisiae*/metabolism , Saccharomyces cerevisiae*/drug effects , Saccharomyces cerevisiae*/genetics, Up-Regulation/drug effects ; Drug Resistance, Fungal/genetics ; Drug Resistance, Fungal/drug effects ; Gene Expression Regulation, Fungal/drug effects

Efficient selenite reduction and chromium resistance by multiple pathways in Bacillus wiedmannii ES2-45 and Se-biofortification in rice by foliar application.

Autoren: Ma, Fang Zhao, Tiantian Guo, Jiayi et al.

Quelle: Journal of Environmental Sciences (Elsevier). Oct2025, Vol. 156, p660-670. 11p.

Schlagwörter: BACILLUS (Bacteria), PROTEIN synthesis, HEAVY metals, REDUCTASES, PROTEOMICS