Suchergebnisse - "PROTEIN stability"

Protein thermostabilization with Protposer: Pushing the stability limits and folding reversibility of a highly-stabilized apoflavodoxin.

Autoren: Hidalgo-Toledo A Bazco D Correa-Pérez V et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 331 (Pt 1), pp. 148333. Date of Electronic Publication: 2025 Oct 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Protein Stability* , Protein Folding* , Apoproteins*/chemistry , Apoproteins*/genetics , Flavodoxin*/chemistry , Flavodoxin*/genetics, Temperature ; Computational Biology/methods ; Hydrogen Bonding ; Mutation ; Protein Denaturation ; Protein Conformation

Prediction of protein biophysical traits from limited data: a case study on nanobody thermostability through NanoMelt.

Autoren: Ramon A Ni M Predeina O et al.

Quelle: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2442750. Date of Electronic Publication: 2025 Jan 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

MeSH-Schlagworte: Single-Domain Antibodies*/chemistry , Single-Domain Antibodies*/immunology , Protein Stability*, Humans ; Software ; Computer Simulation

Differences in Alzheimer's disease blood biomarker stability: Implications for the use of tau/amyloid ratios.

Autoren: Figdore DJ Schuder BJ Ashrafzadeh-Kian S et al.

Quelle: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Apr; Vol. 21 (4), pp. e70173.

Publikationsart: Comparative Study; Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

MeSH-Schlagworte: tau Proteins*/blood , Amyloid beta-Peptides*/blood , Peptide Fragments*/blood , Alzheimer Disease*/blood , Protein Stability*, Biomarkers/blood ; Humans ; Temperature ; Phosphorylation ; Time Factors

Exploring the impact of lipid nanoparticles on protein stability and cellular proteostasis.

Autoren: Gao Z Jing B Wang Y et al.

Quelle: Journal of colloid and interface science [J Colloid Interface Sci] 2025 Jan 15; Vol. 678 (Pt A), pp. 656-665. Date of Electronic Publication: 2024 Aug 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE

MeSH-Schlagworte: Proteostasis*/drug effects , Nanoparticles*/chemistry , Protein Stability*, Humans ; Hep G2 Cells ; Lipids/chemistry ; Polyethylene Glycols/chemistry ; Particle Size ; Cell Survival/drug effects ; Proteome/metabolism ; Surface Properties ; Protein Aggregates ; Liposomes

Protein stability models fail to capture epistatic interactions of double point mutations.

Autoren: Dieckhaus H Kuhlman B

Quelle: Protein science : a publication of the Protein Society [Protein Sci] 2025 Jan; Vol. 34 (1), pp. e70003.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

MeSH-Schlagworte: Protein Stability* , Point Mutation* , Epistasis, Genetic*, Proteins/chemistry ; Proteins/genetics ; Models, Molecular

Improved Prediction of Stabilizing Mutations in Proteins by Incorporation of Mutational Effects on Ligand Binding.

Autoren: Ganesan S Mittal N Bhat A et al.

Quelle: Proteins [Proteins] 2025 Jan; Vol. 93 (1), pp. 384-395. Date of Electronic Publication: 2024 Aug 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8700181 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0134 (Electronic) Linking ISSN: 08873585 NLM ISO Abbreviation: Proteins Subsets: MEDLINE

MeSH-Schlagworte: Mutation* , Protein Stability* , Protein Binding*, Ligands ; Thermodynamics ; Neuraminidase/genetics ; Neuraminidase/metabolism ; Neuraminidase/chemistry ; Computational Biology/methods ; Bacterial Toxins/genetics ; Bacterial Toxins/chemistry ; Bacterial Toxins/metabolism ; Models, Molecular

Predicting absolute protein folding stability using generative models.

Autoren: Cagiada M Ovchinnikov S Lindorff-Larsen K

Quelle: Protein science : a publication of the Protein Society [Protein Sci] 2025 Jan; Vol. 34 (1), pp. e5233.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

MeSH-Schlagworte: Protein Folding* , Protein Stability* , Proteins*/chemistry, Models, Molecular ; Thermodynamics ; Protein Conformation

Amino acid sequence encodes protein abundance shaped by protein stability at reduced synthesis cost.

Autoren: Buric F Viknander S Fu X et al.

Quelle: Protein science : a publication of the Protein Society [Protein Sci] 2025 Jan; Vol. 34 (1), pp. e5239.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

MeSH-Schlagworte: Protein Stability*, Humans ; Amino Acid Sequence ; Molecular Dynamics Simulation ; Animals ; Proteins/chemistry ; Proteins/genetics ; Proteins/metabolism ; Protein Biosynthesis ; Mice ; Mutation ; Hydrophobic and Hydrophilic Interactions

Microscopic Significance of Hydrophobic Residues for Protein Stability in Ionic Liquids.

Autoren: Sun G Fang B Yang Y et al.

Quelle: The journal of physical chemistry. B [J Phys Chem B] 2025 Mar 27; Vol. 129 (12), pp. 3244-3252. Date of Electronic Publication: 2025 Mar 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5207 (Electronic) Linking ISSN: 15205207 NLM ISO Abbreviation: J Phys Chem B Subsets: MEDLINE

MeSH-Schlagworte: Ionic Liquids*/chemistry , Protein Stability*, Hydrophobic and Hydrophilic Interactions ; Molecular Docking Simulation ; Microfilament Proteins/chemistry ; Microfilament Proteins/metabolism ; Hydrogen Bonding ; Imidazoles/chemistry ; Imidazoles/metabolism ; Protein Conformation ; Protein Structural Elements

Survey of chemical unfolding complexity as a unique stability assessment assay for monoclonal antibodies.

Autoren: Floyd JA Shaver JM

Quelle: Analytical biochemistry [Anal Biochem] 2025 Mar; Vol. 698, pp. 115729. Date of Electronic Publication: 2024 Nov 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0309 (Electronic) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Monoclonal*/chemistry , Antibodies, Monoclonal*/immunology , Protein Stability* , Immunoglobulin G*/chemistry , Protein Unfolding*, Protein Denaturation ; Hydrogen-Ion Concentration ; Humans ; Immunoglobulin Variable Region/chemistry ; Temperature

Investigating binding mechanism between coconut globulin and tannic acid mediated by atmospheric cold plasma: Protein structure and stability.

Autoren: Chen Y Jiang L Wang J et al.

Quelle: Food chemistry [Food Chem] 2025 Feb 01; Vol. 464 (Pt 2), pp. 141670. Date of Electronic Publication: 2024 Oct 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Tannins*/chemistry , Cocos*/chemistry , Protein Stability* , Globulins*/chemistry , Globulins*/metabolism , Plant Proteins*/chemistry , Plant Proteins*/metabolism , Plasma Gases*/chemistry, Hydrophobic and Hydrophilic Interactions ; Protein Binding ; Solubility ; Viscosity ; Polyphenols

Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.

Autoren: Wang J Liao L Miao B et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jan 07; Vol. 122 (1), pp. e2419625121. Date of Electronic Publication: 2024 Dec 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/genetics , Ferroptosis*/genetics , Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein*/metabolism , Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein*/genetics , Protein Stability* , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics , Sorafenib*/pharmacology, Humans ; Cell Line, Tumor ; Ubiquitination ; Liver Neoplasms/metabolism ; Liver Neoplasms/genetics ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Phenylurea Compounds/pharmacology ; Gene Expression Regulation, Neoplastic ; Pyridines

HERC5/ISG15 Enhances Glioblastoma Stemness and Tumor Progression by mediating SERBP1protein stability.

Autoren: Li Z Qian R Li M et al.

Quelle: Neuromolecular medicine [Neuromolecular Med] 2025 Jan 07; Vol. 27 (1), pp. 7. Date of Electronic Publication: 2025 Jan 07.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 101135365 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1174 (Electronic) Linking ISSN: 15351084 NLM ISO Abbreviation: Neuromolecular Med Subsets: MEDLINE

MeSH-Schlagworte: Glioblastoma*/pathology , Glioblastoma*/metabolism , Glioblastoma*/genetics , Ubiquitins*/genetics , Ubiquitins*/metabolism , Neoplastic Stem Cells*/pathology , Neoplastic Stem Cells*/metabolism , Brain Neoplasms*/pathology , Brain Neoplasms*/metabolism , Brain Neoplasms*/genetics , Cytokines*/metabolism , RNA-Binding Proteins*/genetics , RNA-Binding Proteins*/metabolism , Protein Stability* , Mice, Nude* , Cell Proliferation*/drug effects, Humans ; Animals ; Mice ; Cell Line, Tumor ; Disease Progression ; Temozolomide/pharmacology ; Temozolomide/therapeutic use ; Gene Expression Regulation, Neoplastic ; Male ; Apoptosis ; Female ; Cell Movement/drug effects ; Xenograft Model Antitumor Assays ; Drug Resistance, Neoplasm ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Intracellular Signaling Peptides and Proteins

Mechanisms of p53 core tetramer stability mediated by multi-interface interactions: A molecular dynamics study.

Autoren: Zhou H Yan S

Quelle: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2025 Jan; Vol. 763, pp. 110210. Date of Electronic Publication: 2024 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0384 (Electronic) Linking ISSN: 00039861 NLM ISO Abbreviation: Arch Biochem Biophys Subsets: MEDLINE

MeSH-Schlagworte: Tumor Suppressor Protein p53*/chemistry , Tumor Suppressor Protein p53*/metabolism , Molecular Dynamics Simulation* , Protein Stability* , Protein Multimerization*, Humans ; Hydrogen Bonding ; Protein Binding ; DNA/chemistry ; DNA/metabolism

The lack of trade-off between conformational stability and binding affinity in a nanobody with therapeutic potential for a misfolding disease.

Autoren: Gómez-Mulas A Naganathan AN Pey AL

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Jan; Vol. 284 (Pt 1), pp. 138046. Date of Electronic Publication: 2024 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Single-Domain Antibodies*/chemistry , Single-Domain Antibodies*/pharmacology , Protein Binding* , Protein Stability*, Thermodynamics ; Humans ; Mutation ; Protein Conformation ; Proteostasis Deficiencies/metabolism ; Proteostasis Deficiencies/drug therapy ; Models, Molecular

Prediction of the Stability of Protein Substructures Using AI/ML Techniques.

Autoren: Gala M Paul ED Čekan P et al.

Quelle: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2870, pp. 153-182.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: HSP70 Heat-Shock Proteins*/chemistry , HSP70 Heat-Shock Proteins*/metabolism , Protein Stability*, Support Vector Machine ; Computational Biology/methods ; Machine Learning ; Proteins/chemistry ; Protein Conformation ; Models, Molecular

Adaptation of protein stability to thermally heterogeneous environments.

Autoren: Priklopil T Bomblies K Widmer A

Quelle: Journal of theoretical biology [J Theor Biol] 2025 Dec 07; Vol. 615, pp. 112252. Date of Electronic Publication: 2025 Aug 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 0376342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8541 (Electronic) Linking ISSN: 00225193 NLM ISO Abbreviation: J Theor Biol Subsets: MEDLINE

MeSH-Schlagworte: Temperature* , Adaptation, Physiological* , Proteins*/chemistry , Proteins*/genetics, Protein Stability ; Thermodynamics ; Protein Folding ; Mutation ; Evolution, Molecular ; Models, Genetic

Unraveling the impact of VHL exon 2 mutations in erythrocytosis or von Hippel-Lindau disease identified RNA-binding proteins involved in VHL splicing.

Autoren: Karaghiannis V Schmitt L Chesnel F et al.

Quelle: American journal of human genetics [Am J Hum Genet] 2025 Nov 06; Vol. 112 (11), pp. 2591-2604. Date of Electronic Publication: 2025 Sep 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6605 (Electronic) Linking ISSN: 00029297 NLM ISO Abbreviation: Am J Hum Genet Subsets: MEDLINE

MeSH-Schlagworte: Von Hippel-Lindau Tumor Suppressor Protein*/genetics , Von Hippel-Lindau Tumor Suppressor Protein*/metabolism , Polycythemia*/genetics , von Hippel-Lindau Disease*/genetics , RNA Splicing*/genetics , Exons*/genetics , Mutation*/genetics , RNA-Binding Proteins*/genetics , RNA-Binding Proteins*/metabolism, Humans ; Protein Stability ; Mutation, Missense ; Heterogeneous-Nuclear Ribonucleoprotein Group F-H/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group F-H/metabolism

Role of EZH2 in regulating c-Myc stability through the E3 ubiquitin ligase HUWE1 in heart failure and its mechanisms.

Autoren: Yan L Xie D Huang T et al.

Quelle: Cellular signalling [Cell Signal] 2025 Nov; Vol. 135, pp. 111968. Date of Electronic Publication: 2025 Jun 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH-Schlagworte: Enhancer of Zeste Homolog 2 Protein*/metabolism , Enhancer of Zeste Homolog 2 Protein*/genetics , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Heart Failure*/metabolism , Heart Failure*/pathology , Heart Failure*/genetics , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics , Tumor Suppressor Proteins*/metabolism , Tumor Suppressor Proteins*/genetics, Animals ; Mice ; Ubiquitination ; Male ; Humans ; Protein Stability ; Mice, Inbred C57BL ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Histones/metabolism ; Promoter Regions, Genetic

Molecular and functional characterization of the retinitis pigmentosa G90V mutation in a conformationally stabilized rhodopsin background.

Autoren: Fernandez-Gonzalez P Jencz S Smith SO et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 330 (Pt 2), pp. 148078. Date of Electronic Publication: 2025 Oct 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Rhodopsin*/genetics , Rhodopsin*/chemistry , Rhodopsin*/metabolism , Retinitis Pigmentosa*/genetics , Retinitis Pigmentosa*/metabolism , Mutation*, Protein Stability ; Models, Molecular ; Disulfides/chemistry ; Animals ; Humans ; Protein Conformation ; Retinaldehyde/metabolism ; Retinaldehyde/chemistry