Výsledky vyhledávání - "PROGRAMMED cell death 1 receptors"

Deep learning-guided rational engineering of synergistic PD-1 and LAG-3 blockade for enhanced tumor immunomodulation.

Autoři: Mazhar, Shanza Koser, Taskeen Khalid, Rana Rehan

Zdroj: Journal of Computer-Aided Molecular Design. 11/4/2025, Vol. 39 Issue 2, p1-28. 28p.

Témata: *PROGRAMMED cell death 1 receptors, *IMMUNE checkpoint inhibitors, *DEEP learning, *IMMUNOTHERAPY, *MOLECULAR dynamics, *TUMOR microenvironment, *PROTEIN expression, *MONOCLONAL antibodies

HBV Suppression by Nucleos(t)ide Analogues Reduces PD‐1 Expression on Liver‐Resident T Cells.

Autoři: García‐López, Mireia Lens, Sabela Pallett, Laura J. a další

Zdroj: Liver International. Nov2025, Vol. 45 Issue 11, p1-12. 12p.

Témata: *CHRONIC hepatitis B, *PROGRAMMED cell death 1 receptors, *VIRUS inhibitors, *IMMUNOTHERAPY, *HEPATITIS B virus, *LIVER, *NUCLEOSIDE derivatives, *T cells

p53 and PD-1/PD-L1 expression contribute to disease progression and are correlated to immune infiltrates in urothelial carcinoma.

Autoři: Zuo, Mingshun Liao, Yuanjian He, Pingang a další

Zdroj: Scientific Reports. 10/15/2025, Vol. 15 Issue 1, p1-20. 20p.

Témata: *P53 antioncogene, *PROGRAMMED cell death 1 receptors, *SOMATIC mutation, *IMMUNE response, *PROGRAMMED death-ligand 1, *IMMUNOTHERAPY, *PROGNOSIS, *TRANSITIONAL cell carcinoma

GFRAL-Fc disarms GDF15 to reprogram tumor immunity and amplify PD-1 efficacy in hepatocellular carcinoma.

Autoři: Shi, Gege Zhang, Wangqian Xie, Fei a další

Zdroj: Cell Communication & Signaling. 10/15/2025, Vol. 23 Issue 1, p1-17. 17p.

Témata: *HEPATOCELLULAR carcinoma, *PROGRAMMED cell death 1 receptors, *CYTOKINES, *CHIMERIC proteins, *CACHEXIA, *IMMUNOSUPPRESSION, *ANTINEOPLASTIC agents

A phase I study of the OX40 agonist BGB-A445 with or without tislelizumab, an anti–PD-1 monoclonal antibody, in patients with advanced solid tumors: dose-escalation results.

Autoři: Desai, Jayesh Deva, Sanjeev Gao, Bo a další

Zdroj: Cancer Chemotherapy & Pharmacology. 10/8/2025, Vol. 95 Issue 1, p1-15. 15p.

Témata: *PROGRAMMED cell death 1 receptors, *IMMUNE checkpoint inhibitors, *TUMORS, *CLINICAL trials, *IMMUNE response, *SAFETY, *TUMOR necrosis factors

Cellular expression of PD-1, PD-L1 and CTLA-4 in patients with JAK2^V617F mutated myeloproliferative disorders.

Autoři: Winkler, Christoph Anliker, Markus Schmidt, Stefan a další

Zdroj: Clinical Chemistry & Laboratory Medicine. Oct2025, Vol. 63 Issue 11, p2318-2329. 12p.

Témata: *MYELOPROLIFERATIVE neoplasms, *PROGRAMMED cell death 1 receptors, *GENETIC mutation, *JANUS kinases, *IMMUNE checkpoint proteins, *PROGRAMMED death-ligand 1, *CELLULAR immunity, *CYTOTOXIC T lymphocyte-associated molecule-4

Ivonescimab: The Two Pronged Attack.

Autoři: Vallathol, Dilip Harindran Menon, Abhinav Warrier, Arun R.

Zdroj: Indian Journal of Medical & Paediatric Oncology. Oct2025, Vol. 46 Issue 5, p499-502. 4p.

Témata: *BISPECIFIC antibodies, *PROGRAMMED cell death 1 receptors, *CANCER treatment, *INDIVIDUALIZED medicine, *IMMUNOTHERAPY, *CLINICAL trials, *VASCULAR endothelial growth factor antagonists

Geografický termín: CHINA

LncRNA RMRP knockdown upregulates PD-1 expression in natural killer cells.

Autoři: Abouhegaziah, Sarah Urlaub, Doris Moustafa, Ahmed a další

Zdroj: Scientific Reports. 10/3/2025, Vol. 15 Issue 1, p1-9. 9p.

Témata: *PROGRAMMED cell death 1 receptors, *KILLER cells, *LINCRNA, *GENE expression, *CYTOKINES, *IMMUNE checkpoint proteins, *IMMUNOTHERAPY

Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/Akt/mTOR and RAS/MEK/ERK signalling pathways.

Autoři: Fu, Shulin Li, Jingyang You, Jiarui a další

Zdroj: Veterinary Research. 7/29/2024, Vol. 55 Issue 1, p1-17. 17p.

Témata: Cell populations, Programmed cell death 1 receptors, Blood cells, Programmed death-ligand 1, Hepatitis A virus cellular receptors

高糖微环境中程序性细胞死亡受体 1 抑制大鼠骨髓间充质干细胞的成骨分化.

Alternate Title: Programmed cell death receptor-1 suppresses osteogenic differentiation of rat bone marrow mesenchymal stem cells in a high-glucose microenvironment.

Autoři: 韩念荣 黄异飞 艾克热木·吾斯曼 a další

Zdroj: Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu. 3/8/2026, Vol. 30 Issue 7, p1649-1657. 9p.

Témata: *PROGRAMMED cell death 1 receptors, *MESENCHYMAL stem cells, *PI3K/AKT pathway, *IMMUNOPRECIPITATION, *UBIQUITIN ligases, *TANDEM mass spectrometry, *OSSIFICATION

PD-1/PD-L1 axis induced host immunosuppression via PI3K/Akt/mTOR signalling pathway in piglets infected by Glaesserella Parasuis.

Autoři: Li, Jingyang Liu, Siyu Dong, Qiaoli a další

Zdroj: BMC Veterinary Research. 4/6/2024, Vol. 20 Issue 1, p1-14. 14p.

Témata: Programmed cell death 1 receptors, Programmed death-ligand 1, Cellular signal transduction, T cell differentiation, Immunosuppression, Proteomics

Influence of PD‐1 and PD‐1L Immune Exhaustion Receptors on Immune Reconstruction in People Living With HIV.

Autoři: Aksak-Wąs, Bogusz Skonieczna-Żydecka, Karolina Parczewski, Miłosz a další

Zdroj: Journal of Immunology Research. 9/30/2025, Vol. 2025, p1-10. 10p.

Témata: *HIV, *PROGRAMMED cell death 1 receptors, *PRINCIPAL components analysis, *ANTIRETROVIRAL agents, *T-cell exhaustion, *T cells, *IMMUNE reconstitution inflammatory syndrome, *PROGRAMMED death-ligand 1

PD‐1‐Cis IL‐2R Agonism Determines the Predicted Pharmacological Dose Range for the Immunocytokine Eciskafusp Alfa (PD1‐IL2v)

Autoři: Hutchinson, Lucy G. Lewin, Thomas D. Lauener, Laura a další

Zdroj: CPT: Pharmacometrics & Systems Pharmacology. Sep2025, p1. 11p. 5 Illustrations.

Témata: *PROGRAMMED cell death 1 receptors, *DOSE-effect relationship in pharmacology, *CYTOKINES, *T-cell exhaustion, *INTERLEUKIN-2, *MATHEMATICAL models, *NEUROCHEMISTRY

Molecular dynamics insights into the redox effects on PD-1/PD-L1 and PD-1/PD-L2 interactions.

Autoři: Mashalov, Rasulbek Toshpulatova, Zulfizar Chen, Zhitong a další

Zdroj: Scientific Reports. 9/25/2025, Vol. 15 Issue 1, p1-9. 9p.

Témata: *PROGRAMMED cell death 1 receptors, *PROGRAMMED death-ligand 1, *IMMUNOTHERAPY, *MOLECULAR dynamics, *IMMUNOREGULATION, *OXIDATION-reduction reaction, *COLD atmospheric plasmas

Targeting the Exon2 splice cis-element in PD-1 and its effects on lymphocyte function.

Autoři: Tan, Yuto Kumagai-Takei, Naoko Shimizu, Yurika a další

Zdroj: PLoS ONE. 9/8/2025, Vol. 20 Issue 9, p1-11. 11p.

Témata: *PROGRAMMED cell death 1 receptors, *CYTOKINES, *CHIMERIC antigen receptors, *LYMPHOCYTE transformation, *RNA editing

Activation of PD-1/PD-L1 immune checkpoint by Zika virus.

Autoři: Wang, Chenxi Xie, Yubin Li, Weixin a další

Zdroj: PLoS Pathogens. 9/8/2025, Vol. 21 Issue 9, p1-22. 22p.

Témata: *ZIKA virus, *PROGRAMMED cell death 1 receptors, *PROGRAMMED death-ligand 1, *IMMUNE checkpoint proteins, *ANTIVIRAL agents, *VIRAL proteins, *VIRUS diseases, *T cells

PD‐1 Regulates the Glycolytic Pathway to Reverse Abnormal CD4⁺ T Cell Differentiation and Alleviate Hashimoto's Thyroiditis.

Autoři: Jiang, Xiao Luo, Tao Zhao, Xinyu a další

Zdroj: Immunology. Sep2025, Vol. 176 Issue 1, p132-144. 13p.

Témata: *PROGRAMMED cell death 1 receptors, *AUTOIMMUNE thyroiditis, *AUTOIMMUNE diseases, *GLUCOSE, *LACTATES, *LACTIC acid fermentation, *T helper cells

Assessing the Pharmacological and Pharmacogenomic Data of PD-1/PD-L1 Inhibitors to Enhance Cancer Immunotherapy Outcomes in the Clinical Setting.

Autoři: Zervanos, Damianos-Ioannis Galatou, Eleftheria Miliotou, Androulla N. a další

Zdroj: Future Pharmacology. Sep2025, Vol. 5 Issue 3, p43. 42p.

Témata: *PROGRAMMED cell death 1 receptors, *PROGRAMMED death-ligand 1, *BIOMARKERS, *INDIVIDUALIZED medicine, *PHARMACOGENOMICS, *CHEMICAL inhibitors, *IMMUNOTHERAPY

PD-1⁺ NK cell subsets in high grade serous ovarian cancer: an indicator of disease severity and a target for combined immune-checkpoint blockade.

Autoři: Greppi, Marco Tabellini, Giovanna Patrizi, Ornella a další

Zdroj: Journal of Experimental & Clinical Cancer Research (17569966). 8/29/2025, Vol. 44 Issue 1, p1-20. 20p.

Témata: *PROGRAMMED cell death 1 receptors, *KILLER cells, *TUMOR microenvironment, *OVARIAN tumors, *DISEASE progression, *CELL-mediated cytotoxicity, *IMMUNOTHERAPY, *IMMUNE checkpoint inhibitors

Impacts of immune checkpoint inhibitors use on the HIV reservoir are linked to provirus sequences but not integration sites.

Autoři: Guiraud, Vincent Fauchois, Antoine Soulie, Cathia a další

Zdroj: Scientific Reports. 8/28/2025, Vol. 15 Issue 1, p1-9. 9p.

Témata: *IMMUNE checkpoint inhibitors, *PROGRAMMED cell death 1 receptors, *CELL death, *VIRUS reactivation, *CYTOTOXIC T lymphocyte-associated molecule-4, *VIRAL genomes