Suchergebnisse - "PRO"

Highly Conserved STAT3 Motifs Present in the Neuronal Pomc Enhancer nPE1 are Critical for Maximal Hypothalamic Pomc Expression.

Autoren: Hael CE Low MJ Franchini LF et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Nov 15; Vol. 63 (1), pp. 51. Date of Electronic Publication: 2025 Nov 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Pro-Opiomelanocortin*/genetics , Pro-Opiomelanocortin*/metabolism , STAT3 Transcription Factor*/metabolism , STAT3 Transcription Factor*/genetics , STAT3 Transcription Factor*/chemistry , Hypothalamus*/metabolism , Neurons*/metabolism , Enhancer Elements, Genetic*/genetics , Conserved Sequence*, Animals ; Male ; Female ; Body Weight/genetics ; Eating/genetics ; Mice ; Mice, Inbred C57BL ; RNA, Messenger/metabolism ; RNA, Messenger/genetics

Magel2 in hypothalamic POMC neurons influences the impact of stress on anxiety-like behavior and spatial learning associated with a food reward in male mice.

Autoren: Lee S Jo YH

Quelle: Frontiers in neural circuits [Front Neural Circuits] 2025 Nov 14; Vol. 19, pp. 1690406. Date of Electronic Publication: 2025 Nov 14 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477940 Publication Model: eCollection Cited Medium: Internet ISSN: 1662-5110 (Electronic) Linking ISSN: 16625110 NLM ISO Abbreviation: Front Neural Circuits Subsets: MEDLINE

MeSH-Schlagworte: Anxiety*/metabolism , Anxiety*/genetics , Anxiety*/psychology , Neurons*/metabolism , Pro-Opiomelanocortin*/metabolism , Pro-Opiomelanocortin*/genetics , Reward* , Spatial Learning*/physiology , Hypothalamus*/metabolism , Stress, Psychological*/metabolism , Stress, Psychological*/genetics , Stress, Psychological*/psychology , Proteins*/genetics , Proteins*/metabolism, Animals ; Male ; Mice ; Female ; Mice, Knockout ; Mice, Transgenic ; Mice, Inbred C57BL ; Intracellular Signaling Peptides and Proteins ; Intrinsically Disordered Proteins

The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα.

Autoren: Xie Z Cheng L Hu Y et al.

Quelle: Cell metabolism [Cell Metab] 2025 Nov 04; Vol. 37 (11), pp. 2149-2166.e9. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE

MeSH-Schlagworte: ATP Citrate (pro-S)-Lyase*/antagonists & inhibitors , ATP Citrate (pro-S)-Lyase*/metabolism , Dicarboxylic Acids*/pharmacology , Dicarboxylic Acids*/therapeutic use , Fatty Liver*/drug therapy , Fatty Liver*/metabolism , PPAR alpha*/metabolism, Animals ; Humans ; Male ; Mice ; Disease Models, Animal ; Lipid Metabolism/drug effects ; Lipogenesis/drug effects ; Liver/metabolism ; Liver/drug effects ; Macaca fascicularis ; Mice, Inbred C57BL

ACLY regulates autolysosome acidification through tubulin acetylation-mediated assembly of V-ATPase subunits in Alzheimer's disease model mice.

Autoren: Lin A Dai X Chen J et al.

Quelle: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Nov; Vol. 21 (11), pp. e70919.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Lysosomes*/metabolism , Tubulin*/metabolism , ATP Citrate (pro-S)-Lyase*/metabolism , ATP Citrate (pro-S)-Lyase*/genetics , Vacuolar Proton-Translocating ATPases*/metabolism, Animals ; Mice ; Acetylation ; Disease Models, Animal ; Humans ; Hippocampus/metabolism ; Mice, Transgenic ; Neurons/metabolism ; Amyloid beta-Peptides/metabolism ; Microtubules/metabolism ; Male

ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation.

Autoren: Sohn H Kolicheski A Poursine-Laurent J et al.

Quelle: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2025 Nov 01; Vol. 214 (11), pp. 3100-3114.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

MeSH-Schlagworte: Killer Cells, Natural*/immunology , Killer Cells, Natural*/metabolism , Glycolysis*/immunology , Histones*/metabolism , ATP Citrate (pro-S)-Lyase*/genetics , ATP Citrate (pro-S)-Lyase*/metabolism , ATP Citrate (pro-S)-Lyase*/immunology, Animals ; Mice ; Acetylation ; Mice, Knockout ; Mice, Inbred C57BL ; Acetyl Coenzyme A/metabolism ; Lymphocyte Activation ; Interleukin-15/immunology

PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression.

Autoren: Lu RS Ren LK Fei XB et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (44), pp. e05762. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , ATP Citrate (pro-S)-Lyase*/metabolism , ATP Citrate (pro-S)-Lyase*/genetics , Lactate Dehydrogenase 5*/metabolism , Lactate Dehydrogenase 5*/genetics , Proteasome Endopeptidase Complex*/metabolism , Proteasome Endopeptidase Complex*/genetics, Humans ; Mice ; Animals ; Ubiquitination ; Cell Line, Tumor ; Disease Progression ; Lipid Metabolism/genetics ; Mice, Nude ; L-Lactate Dehydrogenase

Discovery of potent ATP citrate lyase inhibitors from Tripterygium wilfordii Hook. f.: a structural and bioactivity analysis.

Autoren: Qu B Wang J Li Y et al.

Quelle: Phytochemistry [Phytochemistry] 2025 Nov; Vol. 239, pp. 114581. Date of Electronic Publication: 2025 Jun 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE

MeSH-Schlagworte: Tripterygium*/chemistry , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/isolation & purification , ATP Citrate (pro-S)-Lyase*/antagonists & inhibitors , ATP Citrate (pro-S)-Lyase*/metabolism, Molecular Structure ; Structure-Activity Relationship ; Diterpenes/chemistry ; Diterpenes/isolation & purification ; Diterpenes/pharmacology ; Crystallography, X-Ray ; Molecular Conformation ; Triterpenes/chemistry ; Triterpenes/isolation & purification ; Triterpenes/pharmacology ; Drug Discovery

Preventing liver carcinogenesis through the use of inhibitors targeting metabolic enzymes ACLY, G6PD, and TYMS, combined with 9-cis retinoic acid.

Autoren: Chen A Yin K Cui Q et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 331 (Pt 1), pp. 148378. Date of Electronic Publication: 2025 Oct 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Tretinoin*/pharmacology , Glucosephosphate Dehydrogenase*/antagonists & inhibitors , Glucosephosphate Dehydrogenase*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/enzymology , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/genetics , ATP Citrate (pro-S)-Lyase*/antagonists & inhibitors , ATP Citrate (pro-S)-Lyase*/metabolism , Enzyme Inhibitors*/pharmacology , Carcinogenesis*/drug effects, Humans ; Cell Proliferation/drug effects ; Animals ; Cell Line, Tumor ; Mice ; Gene Expression Regulation, Neoplastic/drug effects

Reduced Availability of Essential Amino Acids Disrupts Differentiation of Anorexigenic POMC Neurons in the Fetal Rat Hypothalamus.

Autoren: Vancamp P Grit I Demonceaux M et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Nov; Vol. 62 (11), pp. 14261-14285. Date of Electronic Publication: 2025 Jul 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Neurons*/metabolism , Neurons*/pathology , Hypothalamus*/metabolism , Hypothalamus*/embryology , Hypothalamus*/pathology , Pro-Opiomelanocortin*/metabolism , Pro-Opiomelanocortin*/genetics , Cell Differentiation* , Fetus*/metabolism, Animals ; Female ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; TOR Serine-Threonine Kinases/metabolism ; Signal Transduction

ACLY facilitates alanine flux in the livers of db/db mice: a hyperpolarized [1-13C]pyruvate MRS study.

Autoren: Choi YS Song JE Lim SH et al.

Quelle: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2025 Oct 27; Vol. 16, pp. 1663958. Date of Electronic Publication: 2025 Oct 27 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE

MeSH-Schlagworte: Alanine*/metabolism , Liver*/metabolism , ATP Citrate (pro-S)-Lyase*/metabolism , ATP Citrate (pro-S)-Lyase*/antagonists & inhibitors , Pyruvic Acid*/metabolism , Diabetes Mellitus, Type 2*/metabolism , Non-alcoholic Fatty Liver Disease*/metabolism, Animals ; Mice ; Male ; Gluconeogenesis ; Mice, Inbred C57BL ; Carbon Isotopes ; Magnetic Resonance Spectroscopy/methods

Impact of Bariatric Surgery on the Expression of Fertility-Related Genes in Obese Women: A Systematic Review of LEP , LEPR , MC4R , FTO , and POMC .

Autoren: Voros C Sapantzoglou I Koulakmanidis AM et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 23; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article; Systematic Review; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Receptor, Melanocortin, Type 4*/genetics , Receptor, Melanocortin, Type 4*/metabolism , Alpha-Ketoglutarate-Dependent Dioxygenase FTO*/genetics , Alpha-Ketoglutarate-Dependent Dioxygenase FTO*/metabolism , Bariatric Surgery* , Pro-Opiomelanocortin*/genetics , Pro-Opiomelanocortin*/metabolism , Leptin*/genetics , Leptin*/metabolism , Obesity*/genetics , Obesity*/surgery , Fertility*/genetics, Humans ; Receptors, Leptin/genetics ; Receptors, Leptin/metabolism ; Female

Generation of human induced pluripotent stem cell line from an obesity patient with POMC deficiency due to POMC:W84X mutation.

Autoren: Ludwik KA Jahn R Jyrch S et al.

Quelle: Stem cell research [Stem Cell Res] 2025 Oct; Vol. 88, pp. 103814. Date of Electronic Publication: 2025 Aug 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101316957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7753 (Electronic) Linking ISSN: 18735061 NLM ISO Abbreviation: Stem Cell Res Subsets: MEDLINE

MeSH-Schlagworte: Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/cytology , Mutation* , Obesity*/genetics , Obesity*/pathology , Obesity*/metabolism , Pro-Opiomelanocortin*/genetics , Pro-Opiomelanocortin*/deficiency, Humans ; Cell Differentiation ; Cell Line ; Fibroblasts/metabolism ; Fibroblasts/cytology

Identification of a novel ACLY inhibitor proanthocyanidin B2 from grape seeds with lipid-lowering effect in vitro.

Autoren: Wang Y Wang P Xu F et al.

Quelle: Fitoterapia [Fitoterapia] 2025 Dec; Vol. 187, pp. 106874. Date of Electronic Publication: 2025 Sep 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

MeSH-Schlagworte: Proanthocyanidins*/pharmacology , Proanthocyanidins*/isolation & purification , Vitis*/chemistry , ATP Citrate (pro-S)-Lyase*/antagonists & inhibitors , Hypolipidemic Agents*/pharmacology , Hypolipidemic Agents*/isolation & purification , Enzyme Inhibitors*/isolation & purification , Enzyme Inhibitors*/pharmacology, Seeds/chemistry ; Molecular Structure ; Molecular Dynamics Simulation ; Grape Seed Extract

Role and Mechanism of Arcuate Nucleus POMC Neurons in Depression-Like Behavior of Chronic Pain.

Autoren: Yang T Huang Y Zhang K et al.

Quelle: Journal of neurochemistry [J Neurochem] 2025 Nov; Vol. 169 (11), pp. e70249.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE

MeSH-Schlagworte: Arcuate Nucleus of Hypothalamus*/metabolism , Pro-Opiomelanocortin*/metabolism , Neurons*/metabolism , Chronic Pain*/psychology , Chronic Pain*/metabolism , Chronic Pain*/complications , Depression*/metabolism , Depression*/psychology , Depression*/etiology, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Neuralgia/metabolism ; Neuralgia/psychology ; Disease Models, Animal

Brain POMC Neurons: Comparative Aspects of Anatomy, Peptide Processing and Function.

Autoren: Carr JA; Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409-3131, USA. Electronic address: james.carr@ttu.edu.

Quelle: General and comparative endocrinology [Gen Comp Endocrinol] 2026 Jan; Vol. 375, pp. 114849. Date of Electronic Publication: 2025 Nov 08.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0370735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6840 (Electronic) Linking ISSN: 00166480 NLM ISO Abbreviation: Gen Comp Endocrinol Subsets: MEDLINE

MeSH-Schlagworte: Pro-Opiomelanocortin*/metabolism , Pro-Opiomelanocortin*/physiology , Neurons*/metabolism , Neurons*/cytology , Neurons*/physiology , Brain*/metabolism , Brain*/anatomy & histology , Brain*/cytology, Animals ; Humans ; Protein Processing, Post-Translational

POMC mediates orofacial hyperalgesia under hypoestrogenic conditions.

Autoren: Chen C Zhang L Wang W et al.

Quelle: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2026 Jan; Vol. 255, pp. 106861. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Country of Publication: England NLM ID: 9015483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1220 (Electronic) Linking ISSN: 09600760 NLM ISO Abbreviation: J Steroid Biochem Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Pro-Opiomelanocortin*/metabolism , Pro-Opiomelanocortin*/genetics , Hyperalgesia*/metabolism , Hyperalgesia*/genetics , Trigeminal Ganglion*/metabolism , Estrogens*/metabolism , Facial Pain*/metabolism, Animals ; Female ; Rats ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor alpha/genetics ; Estradiol/pharmacology ; Rats, Sprague-Dawley ; Ovariectomy ; Promoter Regions, Genetic

Macrophage ATP citrate lyase aggravates acetaminophen-induced acute liver injury via TWEAK/FN14 signaling in mice.

Autoren: Yan X Ding QZ Gao GL et al.

Quelle: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Sep 15; Vol. 303, pp. 119036. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/toxicity , Chemical and Drug Induced Liver Injury*/metabolism , Cytokine TWEAK*/metabolism , Macrophages*/metabolism , Macrophages*/drug effects , ATP Citrate (pro-S)-Lyase*/metabolism , ATP Citrate (pro-S)-Lyase*/genetics , TWEAK Receptor*/metabolism, Animals ; Mice ; Signal Transduction ; Male ; Mice, Inbred C57BL

The potential role of hypothalamic POMC ^TRPM2 in interscapular BAT thermogenesis.

Autoren: Yang JH Halanobis ABBI Byeon EH et al.

Quelle: Experimental & molecular medicine [Exp Mol Med] 2025 Sep; Vol. 57 (9), pp. 2040-2051. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9607880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2092-6413 (Electronic) Linking ISSN: 12263613 NLM ISO Abbreviation: Exp Mol Med Subsets: MEDLINE

MeSH-Schlagworte: Thermogenesis* , Adipose Tissue, Brown*/metabolism , Adipose Tissue, Brown*/physiology , Hypothalamus*/metabolism , Pro-Opiomelanocortin*/metabolism , Pro-Opiomelanocortin*/genetics , TRPM Cation Channels*/metabolism , TRPM Cation Channels*/genetics, Animals ; Mice ; Neurons/metabolism ; Male ; Mice, Inbred C57BL

Generation of an isogenic iPSC line via CRISPR correction of the POMC:W84X mutation for monogenic obesity modeling.

Autoren: Ludwik KA Valone VF Jahn R et al.

Quelle: Stem cell research [Stem Cell Res] 2025 Sep; Vol. 87, pp. 103786. Date of Electronic Publication: 2025 Jul 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101316957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7753 (Electronic) Linking ISSN: 18735061 NLM ISO Abbreviation: Stem Cell Res Subsets: MEDLINE

MeSH-Schlagworte: Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/cytology , Pro-Opiomelanocortin*/genetics , Pro-Opiomelanocortin*/metabolism , Obesity*/genetics , Obesity*/pathology , Obesity*/metabolism , CRISPR-Cas Systems*/genetics , Mutation*/genetics, Humans ; Cell Line ; Gene Editing ; Cell Differentiation

ACLY inhibition promotes tumour immunity and suppresses liver cancer.

Autoren: Gautam J Wu J Lally JSV et al.

Quelle: Nature [Nature] 2025 Sep; Vol. 645 (8080), pp. 507-517. Date of Electronic Publication: 2025 Jul 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

MeSH-Schlagworte: Liver Neoplasms*/immunology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/enzymology , Liver Neoplasms*/genetics , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/enzymology , Carcinoma, Hepatocellular*/genetics , ATP Citrate (pro-S)-Lyase*/antagonists & inhibitors , ATP Citrate (pro-S)-Lyase*/genetics , ATP Citrate (pro-S)-Lyase*/metabolism , ATP Citrate (pro-S)-Lyase*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/therapeutic use, Animals ; Mice ; Humans ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Male ; Female ; Disease Models, Animal ; Liver/metabolism ; Liver/drug effects ; Liver/pathology ; Hepatocytes/drug effects ; Hepatocytes/enzymology ; Hepatocytes/metabolism