Suchergebnisse - "POLYKETIDE synthases"

Global profiling of polyketide synthases in facultative multicellular eukaryotes.

Autoren: Günther M Herbst R Ueberschaar N et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 11; Vol. 122 (45), pp. e2515852122. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Polyketide Synthases*/metabolism , Polyketide Synthases*/genetics , Dictyostelium*/genetics , Dictyostelium*/enzymology , Dictyostelium*/growth & development , Dictyostelium*/metabolism , Protozoan Proteins*/genetics , Protozoan Proteins*/metabolism, Polyketides/metabolism ; Bacterial Proteins ; Transferases (Other Substituted Phosphate Groups)

JBIR-160-166 Obtained from the Heterologous Expression of a Cryptic Gene Cluster in Kitasatospora setae .

Autoren: Nishimura T Kudo K Izumikawa M et al.

Quelle: Organic letters [Org Lett] 2025 Dec 05; Vol. 27 (48), pp. 13175-13180. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

MeSH-Schlagworte: Multigene Family* , Polyketide Synthases*/genetics , Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Streptomycetaceae*/genetics , Streptomycetaceae*/chemistry , Biological Products*/chemistry , Biological Products*/metabolism, Molecular Structure ; Acyltransferases/genetics ; Acyltransferases/metabolism ; Acyltransferases/chemistry

Engineering of FK520 polyketide synthase for rapid access to quality control reference standards.

Autoren: Žigart N Pivk Lukančič P Drčar T et al.

Quelle: Microbial cell factories [Microb Cell Fact] 2025 Nov 28; Vol. 24 (1), pp. 243. Date of Electronic Publication: 2025 Nov 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101139812 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2859 (Electronic) Linking ISSN: 14752859 NLM ISO Abbreviation: Microb Cell Fact Subsets: MEDLINE

MeSH-Schlagworte: Polyketide Synthases*/metabolism , Polyketide Synthases*/genetics , Tacrolimus*/analogs & derivatives , Tacrolimus*/metabolism , Protein Engineering*, Reference Standards ; Quality Control ; Chromatography, High Pressure Liquid ; Metabolic Engineering

Discovery of Cladoescherins, Unusual Hybrid Metabolites Derived from a Fungal PKS and a Bacterial NRPS by Co-cultivation.

Autoren: Li F Wang G Li S et al.

Quelle: Journal of natural products [J Nat Prod] 2025 Nov 28; Vol. 88 (11), pp. 2726-2735. Date of Electronic Publication: 2025 Nov 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

MeSH-Schlagworte: Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Peptide Synthases*/metabolism , Macrolides*/chemistry , Macrolides*/isolation & purification , Macrolides*/pharmacology, Escherichia coli/metabolism ; Escherichia coli/chemistry ; Molecular Structure ; Coculture Techniques ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/isolation & purification

Engineering Polyketide Stereocenters with Ketoreductase Domain Exchanges.

Autoren: Keiser LS Gatenil PP Zhu Y et al.

Quelle: Journal of the American Chemical Society [J Am Chem Soc] 2025 Nov 19; Vol. 147 (46), pp. 42237-42252. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH-Schlagworte: Polyketides*/chemistry , Polyketides*/metabolism , Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Polyketide Synthases*/genetics , Protein Engineering* , Alcohol Oxidoreductases*/chemistry , Alcohol Oxidoreductases*/metabolism , Alcohol Oxidoreductases*/genetics, Stereoisomerism ; Protein Domains ; Bacterial Proteins

Establishing Selectivity Trends with Reactions of Thioesterases and Semi-Synthetic Polyketides.

Autoren: Litman ZC Chen Y Sherman DH

Quelle: Journal of the American Chemical Society [J Am Chem Soc] 2025 Nov 05; Vol. 147 (44), pp. 40305-40318. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH-Schlagworte: Polyketides*/chemistry , Polyketides*/metabolism , Polyketides*/chemical synthesis , Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Thiolester Hydrolases*/metabolism , Thiolester Hydrolases*/chemistry , Thiolester Hydrolases*/genetics, Substrate Specificity

Synergizing a Metabolic Blockade and Non-reducing Polyketide Synthase Substrate Flexibility Expand Depsidone Diversity in a Marine-Derived Aspergillus Species.

Autoren: Liu Y Lin L Yang J et al.

Quelle: Journal of natural products [J Nat Prod] 2025 Oct 24; Vol. 88 (10), pp. 2511-2519. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

MeSH-Schlagworte: Aspergillus*/chemistry , Aspergillus*/metabolism , Polyketide Synthases*/metabolism , Polyketide Synthases*/antagonists & inhibitors , Lactones*/chemistry , Lactones*/pharmacology , Lactones*/metabolism , Lactones*/isolation & purification , Depsides*/chemistry , Depsides*/pharmacology , Depsides*/metabolism, Molecular Structure ; Polyketides/chemistry ; Resorcinols

High polyketide synthase gene expression boosts pathogenicity of Klebsiella pneumoniae in the digestive infection.

Autoren: Luo C Huang W Shi Y et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 14; Vol. 15 (1), pp. 35839. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Klebsiella pneumoniae*/genetics , Klebsiella pneumoniae*/pathogenicity , Klebsiella pneumoniae*/enzymology , Polyketide Synthases*/genetics , Polyketide Synthases*/metabolism , Klebsiella Infections*/microbiology, Humans ; Virulence Factors/genetics ; Virulence/genetics ; Gene Expression Regulation, Bacterial ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism

Transformation of Alternaria dauci demonstrates the involvement of two polyketide synthase genes in aldaulactone production and fungal pathogenicity.

Autoren: Bernardino JM Neau E Kocuiba J et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 02; Vol. 15 (1), pp. 34418. Date of Electronic Publication: 2025 Oct 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Polyketide Synthases*/genetics , Polyketide Synthases*/metabolism , Alternaria*/genetics , Alternaria*/pathogenicity , Alternaria*/metabolism , Alternaria*/enzymology , Lactones*/metabolism, Plant Diseases/microbiology ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Daucus carota/microbiology ; Multigene Family ; Mycotoxins/biosynthesis ; Virulence ; Transformation, Genetic

Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi.

Autoren: Sokolova N Denisov SS Hackl T et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Oct; Vol. 64 (44), pp. e202514786. Date of Electronic Publication: 2025 Sep 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Polyketide Synthases*/genetics , Fungi*/enzymology, Substrate Specificity ; Machine Learning ; Catalytic Domain

Discovery of Tricyclic Aromatic Polyketides Reveals Hidden Chain-Length Flexibility in Type II Polyketide Synthases.

Autoren: Liu Y Wang L Wang H et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Aug 13; Vol. 26 (16). Date of Electronic Publication: 2025 Aug 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Polyketides*/metabolism , Polyketides*/chemistry , Polyketide Synthases*/metabolism , Polyketide Synthases*/genetics , Polyketide Synthases*/chemistry , Streptomyces*/genetics , Streptomyces*/enzymology , Streptomyces*/metabolism, Multigene Family ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics

Targeted Discovery and Characterization of Type-II PKS-NRPS Hybrid DNA-Alkylating Antibiotics.

Autoren: Nie QY Fang SQ Wu L et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Sep 22; Vol. 64 (39), pp. e202512820. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/metabolism , Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Peptide Synthases*/metabolism , Peptide Synthases*/chemistry , Drug Discovery* , DNA*/chemistry , DNA*/metabolism, Humans ; Streptomyces/chemistry ; Streptomyces/metabolism ; Microbial Sensitivity Tests ; Cell Line, Tumor ; Molecular Structure

Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications.

Autoren: Kim G Lee D Kim JH et al.

Quelle: Natural product reports [Nat Prod Rep] 2025 Sep 17; Vol. 42 (9), pp. 1489-1506. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 8502408 Publication Model: Electronic Cited Medium: Internet ISSN: 1460-4752 (Electronic) Linking ISSN: 02650568 NLM ISO Abbreviation: Nat Prod Rep Subsets: MEDLINE

MeSH-Schlagworte: Biological Products*/metabolism , Biological Products*/chemistry , Peptide Synthases*/metabolism , Peptide Synthases*/chemistry , Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Protein Engineering*/methods

Suppressing lipid biosynthesis in Mycobacterium tuberculosis through polyketide synthase 13 thioesterase inhibition: Insights from computational analysis.

Autoren: Alawi MM Gattan HS Alharbi AS et al.

Quelle: Journal of infection and public health [J Infect Public Health] 2025 Sep; Vol. 18 (9), pp. 102835. Date of Electronic Publication: 2025 May 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101487384 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-035X (Electronic) Linking ISSN: 18760341 NLM ISO Abbreviation: J Infect Public Health Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/enzymology , Mycobacterium tuberculosis*/metabolism , Polyketide Synthases*/antagonists & inhibitors , Polyketide Synthases*/metabolism , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry, Molecular Dynamics Simulation ; Molecular Docking Simulation ; Humans ; Bacterial Proteins

Plug-and-play engineering of modular polyketide synthases.

Autoren: Huang Z Xie S Liu RZ et al.

Quelle: Nature chemical biology [Nat Chem Biol] 2025 Sep; Vol. 21 (9), pp. 1361-1367. Date of Electronic Publication: 2025 Apr 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

MeSH-Schlagworte: Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Polyketide Synthases*/genetics , Protein Engineering*/methods, Polyketides/metabolism ; Polyketides/chemistry

Expanding catalytic versatility of modular polyketide synthases for alcohol biosynthesis.

Autoren: Yao S Xie S Liu RZ et al.

Quelle: Nature chemical biology [Nat Chem Biol] 2025 Sep; Vol. 21 (9), pp. 1368-1375. Date of Electronic Publication: 2025 Apr 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

MeSH-Schlagworte: Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Polyketide Synthases*/genetics , Alcohols*/metabolism , Alcohols*/chemistry, Biocatalysis ; Catalytic Domain ; Catalysis

Physiological drivers of pks+ E. coli in colorectal cancer.

Autoren: Jans M Vereecke L

Quelle: Trends in microbiology [Trends Microbiol] 2025 Sep; Vol. 33 (9), pp. 1003-1017. Date of Electronic Publication: 2025 May 06.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 9310916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4380 (Electronic) Linking ISSN: 0966842X NLM ISO Abbreviation: Trends Microbiol Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/microbiology , Polyketides*/metabolism , Polyketides*/toxicity , Escherichia coli*/genetics , Escherichia coli*/enzymology , Escherichia coli*/metabolism , Escherichia coli*/physiology , Polyketide Synthases*/metabolism , Polyketide Synthases*/genetics, Humans ; Gastrointestinal Microbiome ; DNA Damage ; Peptides/metabolism ; Mutation ; Animals

Visualizing acyl carrier protein interactions within a crosslinked type I polyketide synthase.

Autoren: Jiang Z Heberlig GW Chen JA et al.

Quelle: Nature communications [Nat Commun] 2025 Aug 21; Vol. 16 (1), pp. 7798. Date of Electronic Publication: 2025 Aug 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Acyl Carrier Protein*/metabolism , Acyl Carrier Protein*/chemistry , Acyl Carrier Protein*/ultrastructure , Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Polyketide Synthases*/ultrastructure , Mycobacterium tuberculosis*/enzymology , Mycobacterium tuberculosis*/metabolism , Bacterial Proteins*/metabolism , Bacterial Proteins*/chemistry, Cryoelectron Microscopy ; Catalytic Domain ; Models, Molecular ; Cross-Linking Reagents/chemistry

Seven Cyclization Patterns of Type II PKS Yield Fluorescent Compounds, Including Fungal-Type Folded Globismycin A.

Autoren: Ding W Dong Y Xu R et al.

Quelle: ACS chemical biology [ACS Chem Biol] 2025 Aug 15; Vol. 20 (8), pp. 1916-1927. Date of Electronic Publication: 2025 Jul 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

MeSH-Schlagworte: Polyketide Synthases*/metabolism , Polyketide Synthases*/chemistry , Fluorescent Dyes*/chemistry , Fluorescent Dyes*/metabolism , Polyketides*/chemistry , Polyketides*/metabolism , Benzopyrans*/chemistry , Benzopyrans*/metabolism, Humans ; Cyclization ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry

Structural insights and rational engineering strategies for modular polyketide synthases: A review.

Autoren: Yu W Rao J Zong G et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Aug; Vol. 319 (Pt 3), pp. 145299. Date of Electronic Publication: 2025 Jun 16.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Polyketide Synthases*/chemistry , Polyketide Synthases*/metabolism , Polyketide Synthases*/genetics , Protein Engineering*/methods, Polyketides/chemistry ; Polyketides/metabolism ; Substrate Specificity ; Catalytic Domain ; Acyltransferases/chemistry ; Acyltransferases/metabolism ; Acyltransferases/genetics