Suchergebnisse - "PLEIOTROPY"

Arabidopsis thaliana exhibits wide within-species variation in tolerance to boron limitation and root and shoot trait resilience associate with a pleiotropic locus.

Autoren: Alcock TD Bienert MD Junker A et al.

Quelle: The New phytologist [New Phytol] 2025 Dec; Vol. 248 (5), pp. 2444-2465. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley on behalf of New Phytologist Trust Country of Publication: England NLM ID: 9882884 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8137 (Electronic) Linking ISSN: 0028646X NLM ISO Abbreviation: New Phytol Subsets: MEDLINE

MeSH-Schlagworte: Boron*/deficiency , Boron*/metabolism , Boron*/pharmacology , Arabidopsis*/genetics , Arabidopsis*/physiology , Arabidopsis*/drug effects , Arabidopsis*/growth & development , Plant Roots*/genetics , Plant Roots*/drug effects , Plant Roots*/physiology , Plant Roots*/growth & development , Plant Shoots*/genetics , Plant Shoots*/drug effects , Plant Shoots*/physiology , Plant Shoots*/growth & development , Quantitative Trait Loci*/genetics , Adaptation, Physiological*/genetics , Adaptation, Physiological*/drug effects , Genetic Pleiotropy* , Quantitative Trait, Heritable*, Species Specificity ; Phylogeny ; Gene Expression Regulation, Plant/drug effects ; Genome-Wide Association Study ; Phenotype ; Biomass

Dissecting Schizophrenia Biology Using Pleiotropy With Cognitive Genomics.

Autoren: Bhattacharyya U John J Lencz T et al.

Quelle: Biological psychiatry [Biol Psychiatry] 2025 Nov 01; Vol. 98 (9), pp. 670-678. Date of Electronic Publication: 2025 Feb 22.

Publikationsart: Journal Article; Meta-Analysis

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE

MeSH-Schlagworte: Schizophrenia*/genetics , Genetic Pleiotropy* , Cognition*/physiology, Humans ; Polymorphism, Single Nucleotide/genetics ; Genome-Wide Association Study ; Genetic Predisposition to Disease ; Genomics ; Educational Status ; Phenotype ; Female

Mediated pleiotropy drives the negative correlation of total carotenoid and dry matter contents in cassava (Manihot esculenta).

Autoren: Villwock SS Parkes EY Mbanjo EGN et al.

Quelle: Genetics [Genetics] 2025 Oct 08; Vol. 231 (2).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE

MeSH-Schlagworte: Manihot*/genetics , Manihot*/metabolism , Carotenoids*/metabolism , Genetic Pleiotropy*, Genome-Wide Association Study ; Geranylgeranyl-Diphosphate Geranylgeranyltransferase/genetics ; Quantitative Trait Loci ; Polymorphism, Single Nucleotide ; Phenotype ; Plant Breeding ; Plant Proteins/genetics

Functional Determinants and Evolutionary Consequences of Pleiotropy in Complex and Mendelian Traits.

Autoren: Barbitoff YA Bogaichuk PM Pavlova NS et al.

Quelle: Molecular biology and evolution [Mol Biol Evol] 2025 Oct 01; Vol. 42 (10).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 8501455 Publication Model: Print Cited Medium: Internet ISSN: 1537-1719 (Electronic) Linking ISSN: 07374038 NLM ISO Abbreviation: Mol Biol Evol Subsets: MEDLINE

MeSH-Schlagworte: Genetic Pleiotropy* , Evolution, Molecular*, Animals ; Humans ; Mice ; Genome-Wide Association Study ; Selection, Genetic ; Phenotype ; Multifactorial Inheritance ; Biological Evolution

Deciphering the Impact of Temperature on Pleiotropic Consequences of RNA Polymerase Mutations.

Autoren: Ozbilek D Soley JK Gifford DR et al.

Quelle: Molecular biology and evolution [Mol Biol Evol] 2025 Oct 01; Vol. 42 (10).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 8501455 Publication Model: Print Cited Medium: Internet ISSN: 1537-1719 (Electronic) Linking ISSN: 07374038 NLM ISO Abbreviation: Mol Biol Evol Subsets: MEDLINE

MeSH-Schlagworte: Mutation* , DNA-Directed RNA Polymerases*/genetics , Genetic Pleiotropy*, Temperature ; Transcriptome

Unveiling the genetic pleiotropy between anxiety disorders and autoimmune diseases: insights from large-scale genome-wide cross-trait analysis.

Autoren: Lin H Xiao Y Liu Y et al.

Quelle: Journal of affective disorders [J Affect Disord] 2025 Dec 15; Vol. 391, pp. 119984. Date of Electronic Publication: 2025 Jul 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

MeSH-Schlagworte: Genetic Pleiotropy*/genetics , Autoimmune Diseases*/genetics , Autoimmune Diseases*/immunology , Anxiety Disorders*/genetics , Anxiety Disorders*/immunology, Humans ; Genome-Wide Association Study ; Genetic Predisposition to Disease/genetics ; Polymorphism, Single Nucleotide

Adaptive tracking with antagonistic pleiotropy results in seemingly neutral molecular evolution.

Autoren: Song S Chen P Shen X et al.

Quelle: Nature ecology & evolution [Nat Ecol Evol] 2025 Dec; Vol. 9 (12), pp. 2358-2373. Date of Electronic Publication: 2025 Nov 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Nature Country of Publication: England NLM ID: 101698577 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2397-334X (Electronic) Linking ISSN: 2397334X NLM ISO Abbreviation: Nat Ecol Evol Subsets: MEDLINE

MeSH-Schlagworte: Evolution, Molecular* , Genetic Pleiotropy* , Adaptation, Physiological*/genetics, Mutation ; Amino Acid Substitution ; Models, Genetic

Decoding missense variants pleiotropy in the immune GPCR P2RY8.

Autoren: Shen S Luo R Shao Z

Quelle: Cell genomics [Cell Genom] 2025 Nov 12; Vol. 5 (11), pp. 101063.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: Print Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: MEDLINE

MeSH-Schlagworte: Mutation, Missense*/genetics , Genetic Pleiotropy* , Receptors, G-Protein-Coupled*/genetics, Humans

Phenotypic pleiotropy of missense variants in human B cell confinement receptor P2RY8.

Autoren: LaFlam TN Billesbølle CB Dinh T et al.

Quelle: Cell genomics [Cell Genom] 2025 Nov 12; Vol. 5 (11), pp. 100981. Date of Electronic Publication: 2025 Sep 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: MEDLINE

MeSH-Schlagworte: Mutation, Missense*/genetics , B-Lymphocytes*/metabolism , Genetic Pleiotropy*, Humans ; Phenotype ; Cell Proliferation/genetics ; Cell Movement/genetics ; Cryoelectron Microscopy

Accelerated Biological Aging and Genetic Pleiotropy in Age-Related Eye Diseases: A Population-Based Cohort and Integrative Genetic Analysis.

Autoren: Gao Y Wang Y Zhang Y et al.

Quelle: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2025 Nov 03; Vol. 66 (14), pp. 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

MeSH-Schlagworte: Aging*/genetics , Aging*/physiology , Genetic Pleiotropy* , Eye Diseases*/genetics , Eye Diseases*/epidemiology, Humans ; Male ; Female ; Aged ; Cross-Sectional Studies ; Middle Aged ; Prospective Studies ; Genetic Predisposition to Disease ; United Kingdom/epidemiology ; Aged, 80 and over ; Risk Factors ; Polymorphism, Single Nucleotide

Pleiotropic Effects of Polymorphisms in the BCL11A Gene on Laboratory Parameters in Sickle Cell Anemia.

Autoren: Oliveira AM Fiuza L Figueiredo C et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 28; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Anemia, Sickle Cell*/genetics , Anemia, Sickle Cell*/blood , Polymorphism, Single Nucleotide* , Genetic Pleiotropy*, Humans ; Fetal Hemoglobin/metabolism ; Fetal Hemoglobin/genetics ; Male ; Female ; Adult ; Repressor Proteins ; Young Adult ; Adolescent ; Genetic Predisposition to Disease ; Biomarkers/blood ; Middle Aged ; Genotype

Genome-Wide Pleiotropy Analysis Identifies Shared and Opposing Pathways Influencing Coronary Artery Disease and Cancer.

Autoren: Yarmolinsky J Lau E Koskeridis F et al.

Quelle: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2025 Oct; Vol. 45 (10), pp. 1945-1956. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE

MeSH-Schlagworte: Coronary Artery Disease*/genetics , Coronary Artery Disease*/epidemiology , Genetic Pleiotropy* , Neoplasms*/genetics , Neoplasms*/epidemiology , Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/epidemiology , Breast Neoplasms*/genetics , Breast Neoplasms*/epidemiology , Lung Neoplasms*/genetics , Lung Neoplasms*/epidemiology, Humans ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide ; Male ; Genetic Predisposition to Disease ; Female ; Risk Factors ; Phenotype ; Risk Assessment ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/epidemiology

RMR-ICP: robust Mendelian randomization method accounting for idiosyncratic and correlated pleiotropy with applications to stroke outcomes.

Autoren: Cheng Q Xu W Wang C et al.

Quelle: Briefings in bioinformatics [Brief Bioinform] 2025 Aug 31; Vol. 26 (5).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 100912837 Publication Model: Print Cited Medium: Internet ISSN: 1477-4054 (Electronic) Linking ISSN: 14675463 NLM ISO Abbreviation: Brief Bioinform Subsets: MEDLINE

MeSH-Schlagworte: Mendelian Randomization Analysis*/methods , Genetic Pleiotropy* , Stroke*/genetics, Humans ; Linkage Disequilibrium ; Risk Factors

A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density.

Autoren: Han T Qu Y Zhu J et al.

Quelle: Bone [Bone] 2026 Feb; Vol. 203, pp. 117719. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE

MeSH-Schlagworte: Bone Density*/genetics , Genetic Pleiotropy* , Coronary Artery Disease*/genetics , Vascular Calcification*/genetics , Coronary Vessels*/pathology, Humans ; Polymorphism, Single Nucleotide/genetics ; Male ; Female ; Genome-Wide Association Study ; Middle Aged ; Aged

Exploring the pleiotropic effects of lncRNA in different repeat expansion disorders.

Autoren: Das S Khandelwal S Shukla S et al.

Quelle: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2026 Feb; Vol. 1872 (2), pp. 168089. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE

MeSH-Schlagworte: RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Genetic Pleiotropy* , DNA Repeat Expansion*/genetics, Humans ; Animals ; Epigenesis, Genetic

Pleiotropic effects of red and purple pericarp genes on seed coating patterns, flavonoids, dormancy, and germination in rice.

Autoren: Tang W Guo M Zhu Y et al.

Quelle: G3 (Bethesda, Md.) [G3 (Bethesda)] 2025 Sep 03; Vol. 15 (9).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE

MeSH-Schlagworte: Oryza*/genetics , Oryza*/metabolism , Oryza*/physiology , Germination*/genetics , Seeds*/genetics , Seeds*/metabolism , Flavonoids*/metabolism , Plant Dormancy*/genetics , Genetic Pleiotropy* , Genes, Plant* , Pigmentation*/genetics, Epistasis, Genetic ; Quantitative Trait Loci ; Phenotype ; Alleles

Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures.

Autoren: Kang M Ang TFA Devine SA et al.

Quelle: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Sep; Vol. 21 (9), pp. e70681.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study* , Blood Pressure*/genetics , Alzheimer Disease*/genetics , Cognition*/physiology , Genetic Pleiotropy* , Hypertension*/genetics , Cognitive Dysfunction*/genetics, Humans ; Male ; Female ; Aged ; Longitudinal Studies ; Polymorphism, Single Nucleotide ; Prospective Studies ; Middle Aged

Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans.

Autoren: Xiang Y Tanwar V Singh P et al.

Quelle: ELife [Elife] 2025 Aug 12; Vol. 13. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

MeSH-Schlagworte: Menarche*/genetics , Aging*/genetics , Parturition* , Genetic Pleiotropy*, Humans ; Female ; Mendelian Randomization Analysis ; Polymorphism, Single Nucleotide ; Middle Aged ; Adult ; Pregnancy ; Aged

Developmental rewiring of the NGAL/CUC/KLU network associated with pleiotropic roles of NGAL genes.

Autoren: Nicolas A Papadopoulos P Caroulle M et al.

Quelle: The Plant journal : for cell and molecular biology [Plant J] 2025 Jul; Vol. 123 (1), pp. e70321.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Blackwell Scientific Publishers and BIOS Scientific Publishers in association with the Society for Experimental Biology Country of Publication: England NLM ID: 9207397 Publication Model: Print Cited Medium: Internet ISSN: 1365-313X (Electronic) Linking ISSN: 09607412 NLM ISO Abbreviation: Plant J Subsets: MEDLINE

MeSH-Schlagworte: Arabidopsis*/genetics , Arabidopsis*/growth & development , Arabidopsis*/metabolism , Gene Regulatory Networks*/genetics , Arabidopsis Proteins*/genetics , Arabidopsis Proteins*/metabolism , Genetic Pleiotropy*/genetics, Gene Expression Regulation, Plant/genetics ; Plant Leaves/growth & development ; Plant Leaves/genetics

Drosophila Col4a1 Glycine mutations highlight allelic heterogeneity and mechanistic pleiotropy.

Autoren: Nichols A Sánchez-Sánchez BJ Marcotti S et al.

Quelle: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2025 Sep; Vol. 140, pp. 113-122. Date of Electronic Publication: 2025 Jul 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9432592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-1802 (Electronic) Linking ISSN: 0945053X NLM ISO Abbreviation: Matrix Biol Subsets: MEDLINE

MeSH-Schlagworte: Collagen Type IV*/genetics , Collagen Type IV*/metabolism , Collagen Type IV*/chemistry , Glycine*/genetics , Mutation* , Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism , Genetic Pleiotropy* , Drosophila melanogaster*/genetics , Drosophila melanogaster*/metabolism, Animals ; Alleles ; Phenotype ; Genetic Heterogeneity