Search Results - "PLATELET-derived growth factor"

Pdgfab/Pdgfra-mediated chemoattraction guides the migration of sclerotome-derived fibroblast precursors in zebrafish.

Authors: Méndez-Olivos EE Kocha KM Bloomekatz J et al.

Source: PLoS biology [PLoS Biol] 2025 Sep 02; Vol. 23 (9), pp. e3003365. Date of Electronic Publication: 2025 Sep 02 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

MeSH Terms: Zebrafish*/embryology , Zebrafish*/metabolism , Zebrafish*/genetics , Fibroblasts*/cytology , Fibroblasts*/metabolism , Receptor, Platelet-Derived Growth Factor alpha*/metabolism , Receptor, Platelet-Derived Growth Factor alpha*/genetics , Zebrafish Proteins*/metabolism , Zebrafish Proteins*/genetics , Proto-Oncogene Proteins c-sis*/metabolism , Proto-Oncogene Proteins c-sis*/genetics , Chemotaxis*, Animals ; Cell Movement ; Animal Fins/embryology ; Animal Fins/cytology ; Animal Fins/metabolism ; Tenocytes/metabolism ; Tenocytes/cytology ; Platelet-Derived Growth Factor/metabolism

Sorafenib inhibits ovarian inflammation and fibrosis in polycystic ovary syndrome by targeting the PDGFA/PDGFRα/NF-κB pathway in granulosa cells†.

Authors: Liu X Wang Y Bai Y et al.

Source: Biology of reproduction [Biol Reprod] 2025 Aug 13; Vol. 113 (2), pp. 423-435.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0207224 Publication Model: Print Cited Medium: Internet ISSN: 1529-7268 (Electronic) Linking ISSN: 00063363 NLM ISO Abbreviation: Biol Reprod Subsets: MEDLINE

MeSH Terms: Sorafenib*/pharmacology , Sorafenib*/therapeutic use , Polycystic Ovary Syndrome*/drug therapy , Polycystic Ovary Syndrome*/metabolism , Polycystic Ovary Syndrome*/pathology , NF-kappa B*/metabolism , Granulosa Cells*/drug effects , Granulosa Cells*/metabolism , Inflammation*/drug therapy , Inflammation*/metabolism , Receptor, Platelet-Derived Growth Factor alpha*/metabolism , Receptor, Platelet-Derived Growth Factor alpha*/genetics , Ovary*/drug effects , Ovary*/pathology, Female ; Animals ; Signal Transduction/drug effects ; Fibrosis ; Platelet-Derived Growth Factor/metabolism ; Humans ; Protein Kinase Inhibitors/pharmacology

Platelet-derived growth factor (PDGF) and its impact in fibroid pathogenesis: A narrative review.

Authors: Obeagu EI; Department of Biomedical Laboratory Science, Africa University, Mutare, Zimbabwe.

Source: Medicine [Medicine (Baltimore)] 2025 Jun 20; Vol. 104 (25), pp. e42995.

Publication Type: Journal Article; Review

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH Terms: Leiomyoma*/metabolism , Leiomyoma*/pathology , Leiomyoma*/etiology , Platelet-Derived Growth Factor*/metabolism , Platelet-Derived Growth Factor*/physiology , Uterine Neoplasms*/metabolism , Uterine Neoplasms*/pathology , Uterine Neoplasms*/etiology, Humans ; Female ; Signal Transduction ; Receptors, Platelet-Derived Growth Factor/metabolism

PDGFC secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and immunosuppression in lung adenocarcinoma.

Authors: Cui M Ding X Jiang Y et al.

Source: Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2025 Jun 11; Vol. 57 (10), pp. 1625-1635.

Publication Type: Journal Article

Journal Info: Publisher: China Science Publishing & Media Ltd Country of Publication: China NLM ID: 101206716 Publication Model: Print Cited Medium: Internet ISSN: 1745-7270 (Electronic) Linking ISSN: 16729145 NLM ISO Abbreviation: Acta Biochim Biophys Sin (Shanghai) Subsets: MEDLINE

MeSH Terms: Epithelial-Mesenchymal Transition* , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Cancer-Associated Fibroblasts*/immunology , Adenocarcinoma of Lung*/pathology , Adenocarcinoma of Lung*/immunology , Adenocarcinoma of Lung*/metabolism , Adenocarcinoma of Lung*/genetics , Lung Neoplasms*/pathology , Lung Neoplasms*/immunology , Lung Neoplasms*/metabolism , Platelet-Derived Growth Factor*/metabolism , Lymphokines*/metabolism , Lymphokines*/genetics, Humans ; Tumor Microenvironment/immunology ; Cell Line, Tumor ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; Female ; Matrix Metalloproteinase 2/metabolism ; Male ; MAP Kinase Signaling System

PDGFRα inhibition reduces myofibroblast expansion in the fibrotic rim and enhances recovery after ischemic stroke.

Authors: Protzmann J Zeitelhofer M Stefanitsch C et al.

Source: The Journal of clinical investigation [J Clin Invest] 2025 Jan 14; Vol. 135 (5). Date of Electronic Publication: 2025 Jan 14.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

MeSH Terms: Receptor, Platelet-Derived Growth Factor alpha*/antagonists & inhibitors , Receptor, Platelet-Derived Growth Factor alpha*/genetics , Receptor, Platelet-Derived Growth Factor alpha*/metabolism , Myofibroblasts*/pathology , Myofibroblasts*/metabolism , Ischemic Stroke*/pathology , Ischemic Stroke*/metabolism , Ischemic Stroke*/genetics , Ischemic Stroke*/drug therapy, Animals ; Mice ; Fibrosis ; Male ; Platelet-Derived Growth Factor/metabolism ; Platelet-Derived Growth Factor/genetics ; Lymphokines/metabolism ; Lymphokines/genetics ; Recovery of Function ; Signal Transduction ; Mice, Inbred C57BL

Deletion of platelet-derived growth factor receptor β suppresses tumorigenesis in metabolic dysfunction-associated steatohepatitis (MASH) mice with diabetes.

Authors: Wada T Takeda Y Okekawa A et al.

Source: Scientific reports [Sci Rep] 2024 Oct 11; Vol. 14 (1), pp. 23829. Date of Electronic Publication: 2024 Oct 11.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Receptor, Platelet-Derived Growth Factor beta*/metabolism , Receptor, Platelet-Derived Growth Factor beta*/genetics , Carcinogenesis*/genetics , Carcinogenesis*/metabolism , Mice, Knockout*, Animals ; Mice ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Fatty Liver/metabolism ; Fatty Liver/genetics ; Fatty Liver/pathology ; Disease Models, Animal ; Male ; Platelet-Derived Growth Factor/metabolism ; Platelet-Derived Growth Factor/genetics ; Liver/metabolism ; Liver/pathology ; Hepatic Stellate Cells/metabolism ; Signal Transduction ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/genetics

Phase II trial of imatinib mesylate in patients with PDGFRA/B-negative hypereosinophilic syndrome.

Authors: Kim DH Kim S Park S et al.

Source: British journal of haematology [Br J Haematol] 2024 Dec; Vol. 205 (6), pp. 2305-2314. Date of Electronic Publication: 2024 Oct 10.

Publication Type: Journal Article; Clinical Trial, Phase II

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

MeSH Terms: Imatinib Mesylate*/therapeutic use , Hypereosinophilic Syndrome*/drug therapy , Hypereosinophilic Syndrome*/genetics , Receptor, Platelet-Derived Growth Factor alpha*/genetics, Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; Receptor, Platelet-Derived Growth Factor beta/genetics ; Exome Sequencing ; Mutation ; Treatment Outcome

Imatinib is effective in some PDGFRA/B-negative hypereosinophilic syndromes: A step closer to unveiling underlying mechanisms.

Authors: Loscocco GG Helbig G

Source: British journal of haematology [Br J Haematol] 2024 Dec; Vol. 205 (6), pp. 2136-2138. Date of Electronic Publication: 2024 Oct 28.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

MeSH Terms: Hypereosinophilic Syndrome*/drug therapy , Hypereosinophilic Syndrome*/genetics , Imatinib Mesylate*/therapeutic use , Receptor, Platelet-Derived Growth Factor alpha*/genetics, Humans ; Receptor, Platelet-Derived Growth Factor beta/genetics ; Male

Platelet-derived growth factor is increased with cognitive fluctuations and hallucinations in Lewy Body disease.

Authors: Youssef P Chua M Andersson L et al.

Source: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2025 Dec; Vol. 141, pp. 108094. Date of Electronic Publication: 2025 Oct 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE

MeSH Terms: Hallucinations*/etiology , Hallucinations*/blood , Lewy Body Disease*/blood , Lewy Body Disease*/complications , Platelet-Derived Growth Factor*/metabolism , Receptor, Platelet-Derived Growth Factor beta*/blood , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/blood, Humans ; Male ; Female ; Aged ; Aged, 80 and over ; Middle Aged

Haploinsufficiency of Runx2 restores the cranial sutures in a mouse model of Pdgfrb-related craniosynostosis.

Authors: Ogawa E Oikawa T Ayabe S et al.

Source: Human molecular genetics [Hum Mol Genet] 2025 Nov 02; Vol. 34 (22), pp. 1856-1864.

Publication Type: Journal Article

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

MeSH Terms: Craniosynostoses*/genetics , Craniosynostoses*/pathology , Craniosynostoses*/metabolism , Haploinsufficiency*/genetics , Receptor, Platelet-Derived Growth Factor beta*/genetics , Receptor, Platelet-Derived Growth Factor beta*/metabolism , Core Binding Factor Alpha 1 Subunit*/genetics , Core Binding Factor Alpha 1 Subunit*/metabolism , Cranial Sutures*/metabolism , Cranial Sutures*/pathology, Animals ; Mice ; Disease Models, Animal ; Humans ; Osteogenesis/genetics ; Phenotype ; Signal Transduction

A Comparative Study of Neural and Connective Tissue Markers in Pediatric and Adult Cases With Ureteropelvic Junction Obstruction.

Authors: Dirik A Demirci D Baydilli N et al.

Source: Journal of pediatric surgery [J Pediatr Surg] 2025 Dec; Vol. 60 (12), pp. 162663. Date of Electronic Publication: 2025 Sep 11.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Saunders Country of Publication: United States NLM ID: 0052631 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-5037 (Electronic) Linking ISSN: 00223468 NLM ISO Abbreviation: J Pediatr Surg Subsets: MEDLINE

MeSH Terms: Ureteral Obstruction*/surgery , Ureteral Obstruction*/metabolism , Ureteral Obstruction*/pathology , Ureteral Obstruction*/etiology , S100 Proteins*/metabolism , S100 Proteins*/analysis , Synaptophysin*/metabolism , Synaptophysin*/analysis , Kidney Pelvis*/surgery , Connective Tissue*/metabolism , Connective Tissue*/pathology , Receptor, Platelet-Derived Growth Factor alpha*/metabolism , Receptor, Platelet-Derived Growth Factor alpha*/analysis, Humans ; Child ; Male ; Biomarkers/metabolism ; Biomarkers/analysis ; Female ; Adult ; Adolescent ; Child, Preschool ; Infant ; Young Adult ; Age Factors ; Immunohistochemistry ; Middle Aged ; Retrospective Studies

Variable response of germline activating PDGFRB variants to receptor tyrosine kinase inhibitors: implications for treatment.

Authors: Cristea I Mehrasa R Gladkauskas T et al.

Source: European journal of human genetics : EJHG [Eur J Hum Genet] 2025 Dec; Vol. 33 (12), pp. 1668-1676. Date of Electronic Publication: 2025 Oct 15.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5438 (Electronic) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE

MeSH Terms: Receptor, Platelet-Derived Growth Factor beta*/genetics , Receptor, Platelet-Derived Growth Factor beta*/antagonists & inhibitors , Receptor, Platelet-Derived Growth Factor beta*/metabolism , Germ-Line Mutation* , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/pharmacology, Humans ; Tyrosine Kinase Inhibitors

Hyperactive PDGFRβ signaling induces cataractogenesis via TGFβ and STAT5-IGF1.

Authors: Reardon JJ Ma Y Grabinski NS et al.

Source: Developmental biology [Dev Biol] 2025 Dec; Vol. 528, pp. 228-238. Date of Electronic Publication: 2025 Sep 13.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372762 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-564X (Electronic) Linking ISSN: 00121606 NLM ISO Abbreviation: Dev Biol Subsets: MEDLINE

MeSH Terms: Cataract*/metabolism , Cataract*/pathology , Cataract*/genetics , Receptor, Platelet-Derived Growth Factor beta*/metabolism , Receptor, Platelet-Derived Growth Factor beta*/genetics , Transforming Growth Factor beta*/metabolism , Insulin-Like Growth Factor I*/metabolism, Animals ; Mice ; Signal Transduction ; Lens, Crystalline/metabolism ; Lens, Crystalline/pathology ; S100 Calcium-Binding Protein A4/metabolism ; S100 Calcium-Binding Protein A4/genetics ; Epithelial Cells/metabolism ; Fibrosis ; Mice, Transgenic

Comparison of growth factor concentrations in platelet-rich fibrin biomaterial in different systemic diseases.

Authors: Kuybu İ Alan H Şimşek MS

Source: Clinical oral investigations [Clin Oral Investig] 2025 Nov 28; Vol. 29 (12), pp. 588. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9707115 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-3771 (Electronic) Linking ISSN: 14326981 NLM ISO Abbreviation: Clin Oral Investig Subsets: MEDLINE

MeSH Terms: Platelet-Rich Fibrin*/chemistry , Platelet-Rich Fibrin*/metabolism , Vascular Endothelial Growth Factor A*/analysis , Vascular Endothelial Growth Factor A*/metabolism , Platelet-Derived Growth Factor*/analysis , Platelet-Derived Growth Factor*/metabolism , Intercellular Signaling Peptides and Proteins*/analysis , Biocompatible Materials*, Humans ; Male ; Female ; Middle Aged ; Enzyme-Linked Immunosorbent Assay ; Adult ; Aged ; Case-Control Studies ; Diabetes Mellitus/metabolism

Design, synthesis and biological evaluation of novel platelet-derived growth factor receptor-α (PDGFR-α) inhibitors based on 4-anilinoquinoline and 4-anilinoquinazoline scaffolds.

Authors: Wang R Yao SX Pang YW et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 118015. Date of Electronic Publication: 2025 Jul 28.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Drug Design* , Quinazolines*/chemistry , Quinazolines*/pharmacology , Quinazolines*/chemical synthesis , Quinolines*/chemistry , Quinolines*/pharmacology , Quinolines*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Receptor, Platelet-Derived Growth Factor alpha*/antagonists & inhibitors , Receptor, Platelet-Derived Growth Factor alpha*/metabolism , Aniline Compounds*/chemistry , Aniline Compounds*/pharmacology , Aniline Compounds*/chemical synthesis, Humans ; Zebrafish ; Structure-Activity Relationship ; Animals ; Molecular Structure ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; HT29 Cells

Ethanol-mediated one-pot synthesis of 3-phenyl-3,4,5,12-tetrahydrobenzo[4,5]imidazo[2,1-b]quinazolin-1(2H)-ones as PDGFRA inhibitors.

Authors: Parmar MP Kashyap S Vala DP et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117914. Date of Electronic Publication: 2025 Jul 04.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Ethanol*/chemistry , Receptor, Platelet-Derived Growth Factor alpha*/antagonists & inhibitors , Receptor, Platelet-Derived Growth Factor alpha*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemical synthesis , Quinazolinones*/chemistry, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Cell Line, Tumor

A New Approach for Achieving Earlier and More Accurate Diagnosis of Connective Tissue Disease-Related Interstitial Lung Disease: TGFB and PDGFA as Novel Promising Biomarkers.

Authors: Pulito-Cueto V Atienza-Mateo B Batista-Liz JC et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 04; Vol. 26 (21). Date of Electronic Publication: 2025 Nov 04.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Lung Diseases, Interstitial*/diagnosis , Lung Diseases, Interstitial*/blood , Lung Diseases, Interstitial*/etiology , Platelet-Derived Growth Factor*/metabolism , Platelet-Derived Growth Factor*/genetics , Connective Tissue Diseases*/complications , Connective Tissue Diseases*/diagnosis , Connective Tissue Diseases*/blood , Transforming Growth Factor beta1*/blood , Transforming Growth Factor beta1*/genetics , Transforming Growth Factor beta2*/blood , Transforming Growth Factor beta2*/genetics, Humans ; Biomarkers/blood ; Female ; Male ; Middle Aged ; Aged ; Adult ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/blood ; Transforming Growth Factor beta3/blood ; Early Diagnosis ; Scleroderma, Systemic/complications

Targeted Delivery of Anti-TGF-β 1 -siRNA Using PDGFR-β Peptide-Modified Chitosan Nanoparticles for the Treatment of Liver Fibrosis.

Authors: Mostafa S Shetab Boushehri MA Ezzat AA et al.

Source: Molecular pharmaceutics [Mol Pharm] 2025 Nov 03; Vol. 22 (11), pp. 6741-6758. Date of Electronic Publication: 2025 Sep 27.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

MeSH Terms: Chitosan*/chemistry , RNA, Small Interfering*/administration & dosage , RNA, Small Interfering*/genetics , Nanoparticles*/chemistry , Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/therapy , Liver Cirrhosis*/metabolism , Receptor, Platelet-Derived Growth Factor beta*/chemistry , Receptor, Platelet-Derived Growth Factor beta*/metabolism , Transforming Growth Factor beta1*/genetics , Transforming Growth Factor beta1*/antagonists & inhibitors , Transforming Growth Factor beta1*/metabolism , Peptides*/chemistry, Animals ; Mice ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/drug effects ; Male ; Drug Delivery Systems/methods ; Humans ; Liver/metabolism

Interactive effects of blood-brain barrier breakdown and Alzheimer's disease biomarker status on cognitive decline in older adults without dementia.

Authors: Edwards L Gonzalez AI Thomas KR et al.

Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Nov; Vol. 21 (11), pp. e70910.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

MeSH Terms: Blood-Brain Barrier*/metabolism , Cognitive Dysfunction*/cerebrospinal fluid , Alzheimer Disease*/cerebrospinal fluid , Receptor, Platelet-Derived Growth Factor beta*/cerebrospinal fluid, Humans ; Biomarkers/cerebrospinal fluid ; Male ; Female ; Aged ; Neuropsychological Tests ; Cross-Sectional Studies ; Aged, 80 and over ; Longitudinal Studies ; Apolipoproteins E/genetics ; Apolipoprotein E4/genetics

PDGFRA in paediatric high-grade glioma - target or distraction?

Authors: Le N Chen J Ekert PG et al.

Source: Neoplasia (New York, N.Y.) [Neoplasia] 2025 Nov; Vol. 69, pp. 101231. Date of Electronic Publication: 2025 Sep 22.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE

MeSH Terms: Glioma*/drug therapy , Glioma*/genetics , Glioma*/metabolism , Glioma*/pathology , Receptor, Platelet-Derived Growth Factor alpha*/genetics , Receptor, Platelet-Derived Growth Factor alpha*/antagonists & inhibitors , Receptor, Platelet-Derived Growth Factor alpha*/metabolism , Brain Neoplasms*/drug therapy , Brain Neoplasms*/genetics , Brain Neoplasms*/metabolism , Brain Neoplasms*/pathology, Humans ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Child ; Neoplasm Grading ; Drug Resistance, Neoplasm/genetics ; Molecular Targeted Therapy ; Mutation ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology