Search Results - "PLACEBOS"

A systematic qualitative review of ethical issues in open label placebo in published research.

Authors: Richard M Bernstein M Gaab J et al.

Source: Scientific reports [Sci Rep] 2025 Apr 10; Vol. 15 (1), pp. 12268. Date of Electronic Publication: 2025 Apr 10.

Publication Type: Journal Article; Systematic Review

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Placebos*, Humans ; Informed Consent/ethics ; Placebo Effect ; Qualitative Research

Specific effect of inserted sham acupuncture and its impact on the estimation of acupuncture treatment effect in randomized controlled trials: A systematic survey.

Authors: Luo XC Liu JL Yao MH et al.

Source: Journal of integrative medicine [J Integr Med] 2025 Nov; Vol. 23 (6), pp. 630-640. Date of Electronic Publication: 2025 Jul 30.

Publication Type: Journal Article; Systematic Review; Meta-Analysis; Review

Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101603118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2095-4964 (Print) NLM ISO Abbreviation: J Integr Med Subsets: MEDLINE

MeSH Terms: Acupuncture Therapy*/methods , Randomized Controlled Trials as Topic*, Humans ; Placebo Effect ; Placebos ; Treatment Outcome

Harms with placebo in trials of biological therapies and small molecules as induction therapy in inflammatory bowel disease: a systematic review and meta-analysis.

Authors: Din S Segal J Blackwell J et al.

Source: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2024 Nov; Vol. 9 (11), pp. 1020-1029. Date of Electronic Publication: 2024 Sep 20.

Publication Type: Journal Article; Systematic Review; Meta-Analysis

Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE

MeSH Terms: Colitis, Ulcerative*/drug therapy , Crohn Disease*/drug therapy , Placebos*/administration & dosage , Placebos*/adverse effects, Humans ; Biological Products/therapeutic use ; Biological Products/adverse effects ; Biological Therapy/methods ; Biological Therapy/adverse effects ; Randomized Controlled Trials as Topic ; Remission Induction

Harms with placebo in trials of biological therapies and small molecules as maintenance therapy in inflammatory bowel disease: a systematic review and meta-analysis.

Authors: Gros B Blackwell J Segal J et al.

Source: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2024 Nov; Vol. 9 (11), pp. 1030-1040. Date of Electronic Publication: 2024 Sep 20.

Publication Type: Journal Article; Systematic Review; Meta-Analysis

Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE

MeSH Terms: Colitis, Ulcerative*/drug therapy , Crohn Disease*/drug therapy , Maintenance Chemotherapy*/methods , Placebos*/administration & dosage , Placebos*/adverse effects, Humans ; Biological Products/therapeutic use ; Biological Products/adverse effects ; Biological Therapy/methods ; Biological Therapy/adverse effects ; Randomized Controlled Trials as Topic

Roles of administration route, expectation, and belief in placebos in a randomized controlled trial with open-label placebos.

Authors: Schaefer M Liedtke C Enge S

Source: Scientific reports [Sci Rep] 2025 Dec 02; Vol. 15 (1), pp. 42915. Date of Electronic Publication: 2025 Dec 02.

Publication Type: Journal Article; Randomized Controlled Trial

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Placebo Effect*, Humans ; Male ; Female ; Adult ; Placebos/administration & dosage ; Young Adult

Antifungal prophylaxis in patients with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD)-positive acute myeloid leukaemia receiving sorafenib during initial induction and consolidation treatment in ALLG AMLM16 trial.

Authors: Neoh CF Yong MK Rowley L et al.

Source: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Dec 02; Vol. 80 (12), pp. 3401-3406.

Publication Type: Journal Article; Randomized Controlled Trial

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH Terms: Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/complications , Leukemia, Myeloid, Acute*/genetics , fms-Like Tyrosine Kinase 3*/genetics , Antifungal Agents*/therapeutic use , Antifungal Agents*/administration & dosage , Antifungal Agents*/adverse effects , Phenylurea Compounds*/therapeutic use , Phenylurea Compounds*/adverse effects , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/adverse effects , Niacinamide*/analogs & derivatives , Niacinamide*/therapeutic use , Niacinamide*/adverse effects , Niacinamide*/administration & dosage , Invasive Fungal Infections*/prevention & control , Chemoprevention*/methods, Humans ; Sorafenib ; Middle Aged ; Male ; Female ; Adult ; Double-Blind Method ; Aged ; Amphotericin B/administration & dosage ; Amphotericin B/therapeutic use ; Amphotericin B/adverse effects ; Placebos/administration & dosage ; Young Adult ; Induction Chemotherapy ; Consolidation Chemotherapy

Safety and immunogenicity of a tetravalent dengue vaccine (CYD-TDV) in HIV-positive adults aged 18-50 years in Brazil: Results from a phase II, randomized, observer-blind, placebo-controlled trial.

Authors: Perroud A Madruga JVR Fernandes L et al.

Source: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2025 Dec; Vol. 21 (1), pp. 2582237. Date of Electronic Publication: 2025 Nov 10.

Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

MeSH Terms: Dengue Vaccines*/immunology , Dengue Vaccines*/adverse effects , Dengue Vaccines*/administration & dosage , Dengue*/prevention & control , HIV Infections*/complications , HIV Infections*/drug therapy , HIV Infections*/immunology , Immunogenicity, Vaccine*, Humans ; Adult ; Male ; Brazil ; Female ; Antibodies, Neutralizing/blood ; Young Adult ; Adolescent ; Antibodies, Viral/blood ; Middle Aged ; Placebos/administration & dosage ; Vaccines, Attenuated/immunology ; Vaccines, Attenuated/adverse effects ; Vaccines, Attenuated/administration & dosage ; Neutralization Tests ; Dengue Virus/immunology

Placebo is non-inferior to postoperative antimicrobial treatment in uncomplicated canine pyometra - A double-blinded randomized controlled trial.

Authors: Ylhäinen A Rantala M Thomson K et al.

Source: Veterinary journal (London, England : 1997) [Vet J] 2025 Dec; Vol. 314, pp. 106449. Date of Electronic Publication: 2025 Sep 23.

Publication Type: Journal Article; Randomized Controlled Trial, Veterinary; Randomized Controlled Trial

Journal Info: Publisher: Balliere Tindall Country of Publication: England NLM ID: 9706281 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2971 (Electronic) Linking ISSN: 10900233 NLM ISO Abbreviation: Vet J Subsets: MEDLINE

MeSH Terms: Dog Diseases*/drug therapy , Dog Diseases*/surgery , Surgical Wound Infection*/veterinary , Surgical Wound Infection*/prevention & control , Surgical Wound Infection*/epidemiology , Pyometra*/veterinary , Pyometra*/surgery , Pyometra*/drug therapy , Trimethoprim*/therapeutic use , Trimethoprim*/administration & dosage , Sulfadoxine*/therapeutic use , Sulfadoxine*/administration & dosage , Anti-Bacterial Agents*/therapeutic use , Antibiotic Prophylaxis*/veterinary, Animals ; Dogs ; Double-Blind Method ; Female ; Urinary Tract Infections/veterinary ; Urinary Tract Infections/prevention & control ; Placebos ; Sulfadiazine/therapeutic use ; Postoperative Care/veterinary ; Drug Combinations

A new frontier in oral care with proteins and peptide infused in orally disintegrating film to prevent early dental erosion in vivo.

Authors: Pelá VT da Silva GC de Brito MM et al.

Source: Journal of dentistry [J Dent] 2025 Dec; Vol. 163, pp. 106129. Date of Electronic Publication: 2025 Sep 23.

Publication Type: Journal Article; Randomized Controlled Trial

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 0354422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-176X (Electronic) Linking ISSN: 03005712 NLM ISO Abbreviation: J Dent Subsets: MEDLINE

MeSH Terms: Tooth Erosion*/prevention & control , Peptides*/administration & dosage , Peptides*/therapeutic use , Proteins*/administration & dosage, Humans ; Male ; Adult ; Female ; Cross-Over Studies ; Young Adult ; Citric Acid ; Sodium Fluoride/administration & dosage ; Calcium/analysis ; Dental Enamel/drug effects ; Dental Enamel/pathology ; Dental Pellicle/drug effects ; Placebos ; Patient Satisfaction ; Administration, Oral ; Double-Blind Method

Safety and immunogenicity of an mRNA-based RSV vaccine in seropositive children aged 12-59 months.

Authors: Schnyder Ghamloush S Fanning S Essink B et al.

Source: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2025 Dec; Vol. 21 (1), pp. 2557676. Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

MeSH Terms: Respiratory Syncytial Virus Infections*/prevention & control , Respiratory Syncytial Virus Infections*/immunology , Respiratory Syncytial Virus Vaccines*/immunology , Respiratory Syncytial Virus Vaccines*/adverse effects , Respiratory Syncytial Virus Vaccines*/administration & dosage , Respiratory Syncytial Virus, Human*/immunology , Immunogenicity, Vaccine*, Humans ; Infant ; Male ; Female ; Antibodies, Viral/blood ; Child, Preschool ; Antibodies, Neutralizing/blood ; Vaccines, Synthetic/immunology ; Vaccines, Synthetic/adverse effects ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/genetics ; RNA, Messenger/immunology ; RNA, Messenger/genetics ; RNA, Messenger/administration & dosage ; Viral Fusion Proteins/immunology ; Viral Fusion Proteins/genetics ; Placebos/administration & dosage ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/pathology

Safety and immunogenicity of a bivalent norovirus vaccine candidate in infants from 6 weeks to 5 months of age: A phase 2, randomized, double-blind trial.

Authors: Sáez-Llorens X deAntonio R López-Medina E et al.

Source: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2025 Dec; Vol. 21 (1), pp. 2450878. Date of Electronic Publication: 2025 Jan 13.

Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

MeSH Terms: Norovirus*/immunology , Gastroenteritis*/prevention & control , Gastroenteritis*/virology , Caliciviridae Infections*/prevention & control , Viral Vaccines*/immunology , Viral Vaccines*/adverse effects , Viral Vaccines*/administration & dosage , Vaccines, Virus-Like Particle*/immunology , Vaccines, Virus-Like Particle*/adverse effects , Vaccines, Virus-Like Particle*/administration & dosage , Immunogenicity, Vaccine*, Humans ; Infant ; Double-Blind Method ; Antibodies, Viral/blood ; Female ; Male ; Colombia ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/pathology ; Placebos/administration & dosage

Impact of active placebo controls on estimated drug effects in randomized trials: a meta-epidemiological study.

Authors: Laursen DRT Broager MI Damkjær MW et al.

Source: Journal of clinical epidemiology [J Clin Epidemiol] 2025 Dec; Vol. 188, pp. 111998. Date of Electronic Publication: 2025 Sep 24.

Publication Type: Journal Article; Meta-Analysis

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8801383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5921 (Electronic) Linking ISSN: 08954356 NLM ISO Abbreviation: J Clin Epidemiol Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/statistics & numerical data , Randomized Controlled Trials as Topic*/methods, Humans ; Placebos ; Epidemiologic Studies

Biomarkers of Histological Response in Lanifibranor-treated Patients With Metabolic Dysfunction-associated Steatohepatitis.

Authors: Boursier J Hervé H Roux M et al.

Source: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2025 Dec; Vol. 23 (13), pp. 2499-2508.e8. Date of Electronic Publication: 2025 Mar 17.

Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial

Journal Info: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE

MeSH Terms: Biomarkers*/blood , Fatty Liver*/drug therapy , Fatty Liver*/pathology , Propionates*/therapeutic use , Propionates*/administration & dosage, Humans ; Male ; Female ; Middle Aged ; Treatment Outcome ; Biopsy ; Adult ; Liver/pathology ; Placebos/administration & dosage ; Aged ; Chalcones

Safety, Tolerability, and Pharmacokinetics of Once-Monthly Oral Islatravir: A Phase 2a Study in Participants at Low Risk for Acquiring Human Immunodeficiency Virus Type 1.

Authors: Hillier SL Bekker LG Riddler SA et al.

Source: The Journal of infectious diseases [J Infect Dis] 2025 Nov 14; Vol. 232 (5), pp. 1050-1060.

Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE

MeSH Terms: HIV-1*/drug effects , HIV Infections*/prevention & control , HIV Infections*/drug therapy , HIV Infections*/virology , Anti-HIV Agents*/pharmacokinetics , Anti-HIV Agents*/adverse effects , Anti-HIV Agents*/administration & dosage , Deoxyadenosines*/pharmacokinetics , Deoxyadenosines*/adverse effects , Deoxyadenosines*/administration & dosage, Humans ; Female ; Male ; Adult ; Double-Blind Method ; Middle Aged ; Administration, Oral ; Leukocytes, Mononuclear/chemistry ; Young Adult ; Nitriles ; Adolescent ; Placebos/administration & dosage

Why an Antibiotic That is Effective Against a Type of Bacteria May Not Work Better Than "Placebo" in a Randomized Controlled Clinical Trial: Understanding Placebo and Its Implications for Psychiatric Drug Development, Part 2.

Authors: Preskorn SH; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Kansas, Wichita, KS.

Source: Journal of psychiatric practice [J Psychiatr Pract] 2025 Nov 01; Vol. 31 (6), pp. 327-328. Date of Electronic Publication: 2025 Nov 01.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100901141 Publication Model: Electronic Cited Medium: Internet ISSN: 1538-1145 (Electronic) Linking ISSN: 15274160 NLM ISO Abbreviation: J Psychiatr Pract Subsets: MEDLINE

MeSH Terms: Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/pharmacology , Randomized Controlled Trials as Topic*/standards , Drug Development*/methods , Mental Disorders*/drug therapy, Humans ; Placebo Effect ; Double-Blind Method ; Placebos

Ethical issues and doubts surrounding the acceptability of sham surgery.

Authors: De Micco F Di Palma G Blandino A et al.

Source: La Clinica terapeutica [Clin Ter] 2025 Nov-Dec; Vol. 176 (6), pp. 826-829.

Publication Type: Journal Article; Review

Journal Info: Publisher: Societa Editrice Universo Country of Publication: Italy NLM ID: 0372604 Publication Model: Print Cited Medium: Internet ISSN: 1972-6007 (Electronic) Linking ISSN: 00099074 NLM ISO Abbreviation: Clin Ter Subsets: MEDLINE

MeSH Terms: Surgical Procedures, Operative*/ethics , Placebo Effect*, Humans ; Informed Consent/ethics ; Placebos

Modulating Placebo Effects in Clinical Trials: Study Team Briefing to Optimize Drug-Placebo Differences.

Authors: Coenen M Bingel U Soledad Berdaguer M et al.

Source: Clinical and translational science [Clin Transl Sci] 2025 Nov; Vol. 18 (11), pp. e70399.

Publication Type: Journal Article; Randomized Controlled Trial

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

MeSH Terms: Placebo Effect* , Oxycodone*/administration & dosage , Analgesics, Opioid*/administration & dosage , Pain*/drug therapy , Pain*/psychology , Pain*/diagnosis, Humans ; Male ; Female ; Adult ; Pain Measurement ; Young Adult ; Treatment Outcome ; Double-Blind Method ; Placebos/administration & dosage

Immediate postoperative anesthesia with either lidocaine or bupivacaine: A short-term clinical response.

Authors: Koster JD Deas DE Palaiologou A et al.

Source: Journal of periodontology [J Periodontol] 2025 Nov; Vol. 96 (11), pp. 1227-1235. Date of Electronic Publication: 2025 Mar 28.

Publication Type: Journal Article; Randomized Controlled Trial; Comparative Study

Journal Info: Publisher: American Academy of Periodontology Country of Publication: United States NLM ID: 8000345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-3670 (Electronic) Linking ISSN: 00223492 NLM ISO Abbreviation: J Periodontol Subsets: MEDLINE

MeSH Terms: Bupivacaine*/administration & dosage , Lidocaine*/administration & dosage , Anesthetics, Local*/administration & dosage , Pain, Postoperative*/prevention & control , Anesthesia, Dental*/methods , Anesthesia, Local*/methods, Humans ; Female ; Male ; Pain Measurement/methods ; Middle Aged ; Adult ; Ibuprofen/therapeutic use ; Ibuprofen/administration & dosage ; Acetaminophen/therapeutic use ; Acetaminophen/administration & dosage ; Double-Blind Method ; Analgesics, Non-Narcotic/therapeutic use ; Analgesics, Non-Narcotic/administration & dosage ; Surgical Flaps/surgery ; Follow-Up Studies ; Placebos ; Young Adult ; Injections ; Aged

Effect of fluoride gels supplemented with nano-sized sodium trimetaphosphate on enamel remineralization in situ.

Authors: Martins TP Báez-Quintero LC Gomes IMP et al.

Source: Journal of dentistry [J Dent] 2025 Nov; Vol. 162, pp. 105964. Date of Electronic Publication: 2025 Jul 08.

Publication Type: Journal Article; Randomized Controlled Trial

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 0354422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-176X (Electronic) Linking ISSN: 03005712 NLM ISO Abbreviation: J Dent Subsets: MEDLINE

MeSH Terms: Tooth Remineralization*/methods , Polyphosphates*/administration & dosage , Polyphosphates*/therapeutic use , Dental Enamel*/drug effects , Cariostatic Agents*/administration & dosage , Cariostatic Agents*/therapeutic use , Fluorides, Topical*/administration & dosage , Nanoparticles* , Fluorides*/administration & dosage, Animals ; Humans ; Cattle ; Double-Blind Method ; Gels ; Cross-Over Studies ; Calcium Fluoride/analysis ; Hardness ; Dental Caries/drug therapy ; Dental Caries/prevention & control ; Male ; Adult ; Placebos ; Female ; Young Adult

Effect and Safety of Phytosomal Curcumin Supplementation on Migraine Patients: A Randomized, Double-Blind and Placebo-Controlled Trial.

Authors: Shojaei M Khorvash F Sahebkar A et al.

Source: Chinese journal of integrative medicine [Chin J Integr Med] 2025 Nov; Vol. 31 (11), pp. 963-972. Date of Electronic Publication: 2025 Oct 24.

Publication Type: Journal Article; Randomized Controlled Trial

Journal Info: Publisher: Chinese Journal of Integrated Traditional and Western Medicine Press Country of Publication: China NLM ID: 101181180 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1993-0402 (Electronic) Linking ISSN: 16720415 NLM ISO Abbreviation: Chin J Integr Med Subsets: MEDLINE

MeSH Terms: Curcumin*/therapeutic use , Curcumin*/adverse effects , Dietary Supplements*/adverse effects , Migraine Disorders*/drug therapy, Humans ; Double-Blind Method ; Male ; Female ; Adult ; Quality of Life ; Middle Aged ; Placebos ; Treatment Outcome