Search Results - "PLACEBO-CONTROLLED TRIAL"

NSGO-FANDANGO/ENGOT-EN1: A randomized phase II study of first-line combination chemotherapy with nintedanib/placebo in advanced/recurrent endometrial cancer: A randomized phase II study of first-line combination chemotherapy with nintedanib/placebo in advanced/recurrent endometrial cancer

Authors: Lindemann, Kristina Berton, Dominique Sehouli, Jalid et al.

Source: Gynecologic Oncology. 199:79-87

Subject Terms: Endometrial cancer, Nintedanib, Phase 3 placebo-controlled trial, VEGF receptor, Chemotherapy, Angiokinase inhibitor

Access URL: https://portal.findresearcher.sdu.dk/da/publications/3cfaffa1-7562-4189-98fd-13b0da4e1275
https://doi.org/10.1016/j.ygyno.2025.06.008

Camlipixant in Refractory Chronic Cough: A Phase 2b, Randomized, Placebo-controlled Trial (SOOTHE)

Authors: Jaclyn A. Smith Surinder S. Birring Michael S. Blaiss et al.

Source: Am J Respir Crit Care Med
Smith, J A, Birring, S S, Blaiss, M S, McGarvey, L, Morice, A H, Sher, M, Carroll, K J, Garin, M, Lanouette, S, Shaw, J, Yang, R & Bonuccelli, C M 2025, 'Camlipixant in refractory chronic cough: A Phase 2b, randomized, placebo-controlled trial (SOOTHE)', American Journal of Respiratory and Critical Care Medicine, vol. 211, no. 6, pp. 1038-1048. https://doi.org/10.1164/rccm.202409-1752OC

Subject Terms: refractory chronic cough, placebo-controlled trial, Camlipixant, Original Articles

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40043302
https://pure.qub.ac.uk/en/publications/6cf6c46f-4e7b-4f69-9b63-163a945e2e6a

Efficacy, safety, and immunogenicity of the AS01E-adjuvanted respiratory syncytial virus prefusion F protein vaccine (RSVPreF3 OA) in older adults over three respiratory syncytial virus seasons (AReSVi-006): a multicentre, randomised, observer-blinded, placebo-controlled, phase 3 trial

Authors: Michael G Ison Alberto Papi Eugene Athan et al.

Contributors: Michael G Ison Alberto Papi Eugene Athan et al.

Source: The Lancet. Respiratory medicine, Vol. 13, no.6, p. 517-529 (2025)

Subject Terms: Male, Aged, 80 and over, Respiratory syncytial virus, protein vaccine, placebo-controlled trial, Vaccine Efficacy, Respiratory Syncytial Virus Infections, Middle Aged, Immunogenicity, Vaccine, Adjuvants, Immunologic, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Vaccines, Humans, Female, Seasons, Viral Fusion Proteins, Aged

Access URL: https://pubmed.ncbi.nlm.nih.gov/40245915
https://hdl.handle.net/2078.1/302295
https://hdl.handle.net/11392/2590412
https://doi.org/10.1016/S2213-2600(25)00048-7

Tezepelumab can Restore Normal Lung Function in Patients with Severe, Uncontrolled Asthma: Pooled Results from the PATHWAY and NAVIGATOR Studies

Authors: Pavord, ID Brightling, CE Korn, S et al.

Source: Pulm Ther
Pulmonary Therapy, Vol 11, Iss 2, Pp 315-325 (2025)

Subject Terms: Severe asthma, Tezepelumab, Diseases of the respiratory system, Biologic, RC705-779, Brief Report, Pre-bronchodilator percent predicted normal, Randomized placebo-controlled trial, Lung function

Access URL: https://pubmed.ncbi.nlm.nih.gov/40285963
https://doaj.org/article/47b70f153f1a480d85c44e48c480c668
https://ora.ox.ac.uk/objects/uuid:7a5ed7d3-7ae7-40f2-bedf-508d3f7cc92e
https://doi.org/10.1007/s41030-025-00294-2

A randomized placebo-controlled trial in healthy volunteers examining the effects of acetaminophen and NO-acetaminophen NCX 701 in human endotoxemia

Authors: Sophie Brunner-Ziegler Moritz Staudacher Christian Schörgenhofer et al.

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)

Subject Terms: Nitric oxide (NO)-acetaminophen, Human endotoxemia, Randomized trial, Placebo-controlled trial, Healthy volunteers, Inflammation, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/951c5c4c6b2f45b9a1aac5e810ccb459

Effectiveness of cladribine compared to fingolimod, natalizumab, ocrelizumab and alemtuzumab in relapsing-remitting multiple sclerosis

Authors: Roos, Izanne Sharmin, Sifat Malpas, Charles et al.

Contributors: Roos, Izanne Sharmin, Sifat Malpas, Charles et al.

Source: MULTIPLE SCLEROSIS JOURNAL
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)
Multiple sclerosis : clinical and laboratory research

Subject Terms: Male, Adult, REVISIONS, comparative effectiveness, PLACEBO-CONTROLLED TRIAL, multiple sclerosis, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, Multiple Sclerosis, Relapsing-Remitting, 0302 clinical medicine, Medicine and Health Sciences, IMPUTATION, Humans, Immunologic Factors, observational studies, Alemtuzumab, Fingolimod Hydrochloride, Natalizumab, Middle Aged, 3. Good health, Cladribine, Treatment Outcome, Female, Human medicine, Immunosuppressive Agents

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39087208
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15078
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12804
https://hdl.handle.net/10067/2077130151162165141
https://hdl.handle.net/11697/240740
https://doi.org/10.1177/13524585241267211
http://doi.org/10.1177/13524585241267211
http://hdl.handle.net/1854/LU-01J718CWEDY10V27REV8X98XD6
https://biblio.ugent.be/publication/01J718CWEDY10V27REV8X98XD6
https://biblio.ugent.be/publication/01J718CWEDY10V27REV8X98XD6/file/01J718J26X7GRQNGSPZ4DT56HB

2024 European guidelines for the management of genital herpes

Authors: Patel, Rajul Moran, Benjamin Clarke, Emily et al.

Contributors: Patel, Rajul Moran, Benjamin Clarke, Emily et al.

Source: J Eur Acad Dermatol Venereol
Journal of the European Academy of Dermatology and Venereology

Subject Terms: Male, 0301 basic medicine, PLASMA HIV-1 RNA, HIV Infections, Dermatology, Guidelines, PLACEBO-CONTROLLED TRIAL, Antiviral Agents, DOUBLE-BLIND, 03 medical and health sciences, 0302 clinical medicine, QUALITY-OF-LIFE, Pregnancy, Recurrence, Humans, Settore MEDS-10/B - Malattie infettive, Pregnancy Complications, Infectious, Science & Technology, Herpes Genitalis, Coinfection, Dermatology & Venereal Diseases, 3202 Clinical sciences, 1103 Clinical Sciences, RECONSTITUTION INFLAMMATORY SYNDROME, SEXUALLY-TRANSMITTED DISEASES, Europe, LINKED IMMUNOSORBENT ASSAYS, INITIATED FAMCICLOVIR THERAPY, SIMPLEX-VIRUS TYPE-2, HUMAN-IMMUNODEFICIENCY-VIRUS, Practice Guidelines as Topic, Female, Human medicine, Life Sciences & Biomedicine

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39620271
https://lirias.kuleuven.be/handle/20.500.12942/768626
https://doi.org/10.1111/jdv.20450
https://hdl.handle.net/10067/2110890151162165141
https://repository.uantwerpen.be/docstore/d:irua:27283

Immune-related microRNAs in breast milk and their relation to regulatory T cells in breastfed children

Authors: Ahlberg, Emelie Martí, Magalí Govindaraj, Dhanapal et al.

Source: Pediatric Allergy and Immunology. 34(4)

Subject Terms: Limosilactobacillus reuteri, breast milk, microRNA, omega-3 polyunsaturated fatty acids, randomized placebo-controlled trial, regulatory T cell

File Description: print

Access URL: https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-105774
https://doi.org/10.1111/pai.13952

Why Consider Aspirin for the Treatment of Vestibular Schwannoma? A Brief Review and Randomized, Double‐Blind, Placebo‐Controlled Study Proposal

Authors: D. Bradley Welling Brian A. Neff Fred F. Telischi et al.

Source: Laryngoscope Investig Otolaryngol
Laryngoscope Investigative Otolaryngology, Vol 10, Iss 2, Pp n/a-n/a (2025)

Subject Terms: vestibular schwannoma, Otorhinolaryngology, RF1-547, RD1-811, aspirin, review, Surgery, double‐blinded prospective randomized placebo controlled trial, Review

Access URL: https://pubmed.ncbi.nlm.nih.gov/40171318
https://doaj.org/article/71c9a2281c30499390af33b924a2d765

Longitudinal outcomes of obeticholic acid therapy in ursodiol‐nonresponsive primary biliary cholangitis: Stratifying the impact of add‐on fibrates in real‐world practice

Authors: E. Gómez J. L. Montero E. Molina et al.

Contributors: E. Gómez J. L. Montero E. Molina et al.

Source: BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
Universidad Rey Juan Carlos
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Instituto de Investigación Sanitaria La Fe (IIS La Fe)
Digital.CSIC. Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)

Subject Terms: Male, Adult, Cholagogues and Choleretics, Liver Cirrhosis, Biliary, Ursodeoxycholic Acid, Fibric Acids, Bilirubin, Middle Aged, PLACEBO-CONTROLLED TRIAL, Chenodeoxycholic Acid, Alkaline Phosphatase, BEZAFIBRATE, URSODEOXYCHOLIC ACID, 3. Good health, Treatment Outcome, Spain, SURVIVAL, Humans, BIOCHEMICAL RESPONSE, Female, Drug Therapy, Combination, Longitudinal Studies, CIRRHOSIS, Aged

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38690746
https://hdl.handle.net/10115/35624
https://incliva.fundanetsuite.com/publicaciones/ProdCientif/PublicacionFrw.aspx?id=19054
http://zaguan.unizar.es/record/135354
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=20854
http://hdl.handle.net/10261/368571
https://api.elsevier.com/content/abstract/scopus_id/85192139777
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14854
https://ddd.uab.cat/record/301946

Predictive factors for decompensating events in patients with cirrhosis with primary biliary cholangitis under different lines of therapy

Authors: Ampuero, Javier Lucena-Valera, Ana Berenguer, Marina et al.

Contributors: Ampuero, Javier Lucena-Valera, Ana Berenguer, Marina et al.

Source: HEPATOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Instituto de Investigación Sanitaria La Fe (IIS La Fe)
Digital.CSIC. Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)

Subject Terms: Male, Liver Cirrhosis, Cholagogues and Choleretics, Liver Cirrhosis, Biliary, Ursodeoxycholic Acid, Fibric Acids, PROGRESSION, Middle Aged, PLACEBO-CONTROLLED TRIAL, Chenodeoxycholic Acid, BEZAFIBRATE, 3. Good health, Risk Factors, Spain, ACID, Hypertension, Portal, SURVIVAL, Humans, Female, Registries, Aged

Access URL: https://pubmed.ncbi.nlm.nih.gov/38447019
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=20659
http://hdl.handle.net/10261/387010
https://api.elsevier.com/content/abstract/scopus_id/85192189022

Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis

Authors: Kowdley, Kris V. Bowlus, Christopher L. Levy, Cynthia et al.

Source: The New England journal of medicine

Subject Terms: Cholagogues and Choleretics, Obeticholic Acid, Peroxisome Proliferator-Activated Receptors, Placebo-Controlled Trial, Administration, Oral, Quality-Of-Life, Chalcones, Double-Blind Method, Gastrointestinal Agents, 03 Salud y bienestar, Humans, PPAR alpha, PPAR delta, Cholestasis, Liver Cirrhosis, Biliary, Pruritus, Ursodeoxycholic Acid, Bilirubin, Alkaline Phosphatase, 3. Good health, Management, PPAR, PBC, Treatment Outcome, 03 Good Health and Well-being, Human medicine, Propionates

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/37962077
https://hdl.handle.net/10067/2039150151162165141
https://hdl.handle.net/10447/641403
https://doi.org/10.1056/nejmoa2306185

Thromboxane biosynthesis and future events in diabetes: the ASCEND trial

Authors: Giovanna Petrucci Georgina A Buck Bianca Rocca et al.

Contributors: Giovanna Petrucci Georgina A Buck Bianca Rocca et al.

Source: Eur Heart J

Subject Terms: Aspirin, Daily low-dose aspirin, Urinary 11-dehydro-thromboxane B 2, Diabetes, Thromboxanes, Randomized placebo-controlled trial, Thrombosis, 3. Good health, Thromboxane B2, Thromboxane A2, 03 medical and health sciences, 0302 clinical medicine, Diabetes Mellitus, Type 2, Clinical Research, Neoplasms, Humans, Female, Platelet activation, aspirin, platelets,diabetes, thromboxane

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38385506
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85190549103&origin=inward
https://hdl.handle.net/10576/54423

Evolution of patient demographics, baseline clinical characteristics and outcomes in Phase 3 trials of biologics (TNFi, IL12/23i, IL17i, IL23i), PDE4i and TYK2i for psoriasis

Authors: Peeters, Sara De Vlam, Kurt Boonen, Hugo et al.

Source: JEADV Clinical Practice, Vol 3, Iss 2, Pp 547-564 (2024)

Subject Terms: Science & Technology, disease characteristics, psoriasis, Dermatology, SEVERE PLAQUE PSORIASIS, RANDOMIZED CONTROLLED-TRIAL, PLACEBO-CONTROLLED TRIAL, EFFICACY, patient population characteristics, Diseases of the genitourinary system. Urology, systemic therapy, 3. Good health, DOUBLE-BLIND, 03 medical and health sciences, 0302 clinical medicine, SAFETY, RL1-803, TO-SEVERE PSORIASIS, MODERATE, CHINESE PATIENTS, biologics, RC870-923, Life Sciences & Biomedicine, disease activity, INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY

Access URL: https://doaj.org/article/08fc66fd6dfa49bebc68b3e59ddcb913
https://lirias.kuleuven.be/handle/20.500.12942/746639
https://doi.org/10.1002/jvc2.355

Treatments for hyperemesis gravidarum: A systematic review

Authors: Vinnars, M. T. Forslund, Maria Claesson, I. M. et al.

Source: Acta Obstetricia et Gynecologica Scandinavica. 103(1):13-29

Subject Terms: Gynaecology, Obstetrics and Reproductive Medicine, Gynekologi, obstetrik och reproduktionsmedicin, hyperemesis gravidarum, intervention, nausea, PUQE, quality of life, systematic review, treatment, vomiting, placebo-controlled trial, double-blind, inpatient management, early-pregnancy, women, metoclopramide, ondansetron, acupressure, corticosteroids, Obstetrics & Gynecology

Access URL: https://gup.ub.gu.se/publication/332218

An adjudication algorithm for respiratory-related hospitalisation in idiopathic pulmonary fibrosis

Authors: Ford, Paul Kreuter, Michael Brown, Kevin K. et al.

Source: ERJ Open Res
ERJ Open Research, Vol 10, Iss 1 (2024)

Subject Terms: Science & Technology, BOSENTAN, Respiratory System, PIRFENIDONE, PLACEBO-CONTROLLED TRIAL, DIAGNOSIS, EFFICACY, 16. Peace & justice, ACUTE EXACERBATIONS, RANDOMIZED-TRIAL, 3. Good health, DOUBLE-BLIND, ACETYLCYSTEINE, 03 medical and health sciences, 0302 clinical medicine, 3211 Oncology and carcinogenesis, Original Research Articles, Medicine, COHORT, 3201 Cardiovascular medicine and haematology, Life Sciences & Biomedicine

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38288082
https://doaj.org/article/dd10a57961ca4f14aca9968ef542372a
https://lirias.kuleuven.be/handle/20.500.12942/739943
https://doi.org/10.1183/23120541.00636-2023

Clinical guidelines for managing menopausal symptoms in women with (a history of) breast cancer

Authors: Servayge, Jonathan Verduyn, A. C. Page, Annelies et al.

Source: Facts Views Vis Obgyn
Facts, views & vision in obgyn : issues in obstetrics, gynaecology and reproductive health
FACTS VIEWS AND VISION IN OBGYN

Subject Terms: Review Paper, VULVO-VAGINAL ATROPHY, tamoxifen, HORMONE REPLACEMENT THERAPY, HOT FLASHES, INTERNATIONAL SOCIETY, PLACEBO-CONTROLLED TRIAL, 3. Good health, aromatase inhibitors, VASOMOTOR SYMPTOMS, DOUBLE-BLIND, hormone replacement therapy, breast cancer, QUALITY-OF-LIFE, menopausal symptoms, Medicine and Health Sciences, symptoms, INHIBITOR-INDUCED ARTHRALGIA, Human medicine, Menopause, GENITOURINARY SYNDROME

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/37963326
https://hdl.handle.net/10067/2027900151162165141
https://repository.uantwerpen.be/docstore/d:irua:21798
https://biblio.ugent.be/publication/01HPP74D1VMJJABTFX6S6FNG46
http://hdl.handle.net/1854/LU-01HPP74D1VMJJABTFX6S6FNG46
http://doi.org/10.52054/FVVO.15.4.102
https://biblio.ugent.be/publication/01HPP74D1VMJJABTFX6S6FNG46/file/01HR9ZQE7SX53MA0TZNZN0DQMR

Effect of Shi-Style Steaming and Bathing Decoction in Patients with Knee Osteoarthritis: Study Protocol for a Randomized Placebo-Controlled Trial

Authors: Zhang R Lei YJ Wen SY et al.

Source: Journal of Pain Research, Vol 17, Pp 2851-2860 (2024)

Subject Terms: balneotherapy, traditional chinese medicine, complementary and integrative medicine, randomized placebo-controlled trial, knee osteoarthritis, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/effect-of-shi-style-steaming-and-bathing-decoction-in-patients-with-kn-peer-reviewed-fulltext-article-JPR; https://doaj.org/toc/1178-7090

Access URL: https://doaj.org/article/f39656173eca44f58f9a8213b5afd85a

Novel active-feedback device improves sleep quality in insomnia disorder: a randomized placebo-controlled trial

Authors: Antonia Ypsilanti Maan van de Werken Anna Robson et al.

Subject Terms: C840 - Psychology in health & medicine, C841 - Health psychology, C848 - Psychology of mental health, C850 - Cognitive & affective psychology, C856 - Experimental psychology, Sleep, insomnia experience, randomised placebo-controlled trial

Relation: 10779/lincoln.29150573.v1

Availability: https://figshare.com/articles/journal_contribution/Novel_active-feedback_device_improves_sleep_quality_in_insomnia_disorder_a_randomized_placebo-controlled_trial/29150573

Harms of Morphine for Chronic Breathlessness in Relation to Dose, Duration and Titration Phase

Authors: Ekström, Magnus Alameri, Fatima Chang, Sungwon et al.

Subject Terms: Opioids, Breathlessness, COPD, Adverse events, Randomized controlled trial, Placebo controlled trial

Relation: https://hull-repository.worktribe.com/output/5078647; Journal of Pain and Symptom Management

Availability: https://hull-repository.worktribe.com/file/5078647/1/Article%20in%20press
https://hull-repository.worktribe.com/output/5078647
https://doi.org/10.1016/j.jpainsymman.2025.02.020