Výsledky vyhledávání - "PK–PD modeling"

Precision Dosing in Presence of Multiobjective Therapies by Integrating Reinforcement Learning and PK‐PD Models: Application to Givinostat Treatment of Polycythemia Vera

Autoři: Alessandro De Carlo Elena Maria Tosca Paolo Magni

Zdroj: CPT Pharmacometrics Syst Pharmacol
CPT: Pharmacometrics & Systems Pharmacology, Vol 14, Iss 6, Pp 1018-1031 (2025)

Témata: PK‐PD modeling, Research, adaptive dosing protocol, Givinostat, AI/ML, model‐informed precision dosing, Therapeutics. Pharmacology, RM1-950, pharmacometrics

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40325832
https://doaj.org/article/840b0288702c472ba639e9a8430ca3de

Population Pharmacokinetic and Pharmacodynamic Modeling Analysis of rhIL-7-hyFc, a Hybrid Fc-Fused Long-Acting Interleukin-7, to Support Optimal Dosing Regimens in Patients with Solid Cancer

Autoři: Park S Lee SM Pak KC a další

Zdroj: Drug Design, Development and Therapy, Vol 19, Iss Issue 1, Pp 9303-9320 (2025)

Témata: rhIL-7-hyFc, PK/PD modeling, ALC, Model-based exposure–response relationship, optimal dosing regimens, Therapeutics. Pharmacology, RM1-950

Popis souboru: electronic resource

Relation: https://www.dovepress.com/population-pharmacokinetic-and-pharmacodynamic-modeling-analysis-of-rh-peer-reviewed-fulltext-article-DDDT; https://doaj.org/toc/1177-8881

Přístupová URL adresa: https://doaj.org/article/a216b097ceb242f496a6851fde005a8f

Enhanced Sensitivity to Tramadol in Diabetic Neuropathic Pain Compared to Nerve Compression Neuropathies: A Population PK/PD Model Analysis

Autoři: Dain Chun Parsshava Mehta Serge Guzy a další

Zdroj: CPT Pharmacometrics Syst Pharmacol
CPT: Pharmacometrics & Systems Pharmacology, Vol 14, Iss 4, Pp 781-795 (2025)

Témata: neuropathic pain, Male, Adult, tramadol enantiomers, diabetes, Research, Nerve Compression Syndromes, fraction unbound, RM1-950, Middle Aged, Models, Biological, Analgesics, Opioid, Diabetes Mellitus, Type 1, Diabetic Neuropathies, Diabetes Mellitus, Type 2, Humans, Neuralgia, PK/PD modeling, Female, Therapeutics. Pharmacology, Tramadol, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39959991
https://doaj.org/article/92823537895c49cb99b5f5256118573f

Population Pharmacokinetics and Pharmacodynamics of Sotalol Following Expedited Intravenous Loading in Patients With Atrial Arrhythmias

Autoři: Venkata K. Yellepeddi Mohamed Ismail T. Jared Bunch a další

Zdroj: CPT Pharmacometrics Syst Pharmacol
CPT: Pharmacometrics & Systems Pharmacology, Vol 14, Iss 4, Pp 658-667 (2025)

Témata: Male, Adult, Aged, 80 and over, intravenous Sotalol, Research, Sotalol, Administration, Oral, QT prolongation, RM1-950, Middle Aged, Models, Biological, Atrial Flutter, population pharmacokinetics, Atrial Fibrillation, pharmacodynamics, Humans, atrial fibrillation, PK/PD modeling, Female, Administration, Intravenous, Therapeutics. Pharmacology, Prospective Studies, Anti-Arrhythmia Agents, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39749676
https://doaj.org/article/294d6bd72cc34c1f946f9c9a96022308

Pharmacokinetics, pharmacodynamic efficacy prediction indices, and Monte Carlo simulations of enrofloxacin for the treatment of colibacillosis in broiler chickens

Autoři: Larissa Alexsandra Felix Beatriz Monte Egito Diego Diaz David a další

Zdroj: Open Veterinary Journal, Vol 15, Iss 9, Pp 4454-4469 (2025)

Témata: antibiotic therapy, poultry farming, e. coli, pharmacometrics, pk/pd modeling, Zoology, QL1-991

Popis souboru: electronic resource

Relation: http://www.ejmanager.com/fulltextpdf.php?mno=242668; https://doaj.org/toc/2226-4485; https://doaj.org/toc/2218-6050

Přístupová URL adresa: https://doaj.org/article/f41658f03f87418d85cc20fab75db1cd

Exposure–safety analysis of QTc interval and transaminase levels following bedaquiline administration in patients with drug‐resistant tuberculosis

Autoři: Tanneau, Lénaïg Svensson, Elin Rossenu, Stefaan a další

Zdroj: CPT. 10(12):1538-1549

Témata: tuberculosis, bedaquiline, QT interval prolongation, transaminase, PK/PD modeling, Pharmaceutical Science, Farmaceutisk vetenskap

Popis souboru: electronic

Přístupová URL adresa: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-466776
https://doi.org/10.1002/psp4.12722

First‐In‐Human, Randomized, Placebo‐Controlled, SAD and MAD Trial to Evaluate Safety, Tolerability, and PK/PD Modeling of Potravitug in Healthy Adults

Autoři: Marcus May Julia K. Bialek‐Waldmann Andrew Wright a další

Zdroj: Clinical and Translational Science, Vol 18, Iss 8, Pp n/a-n/a (2025)

Témata: BK polyomavirus, monoclonal antibody, phase I, PK/PD modeling, Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

Popis souboru: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Přístupová URL adresa: https://doaj.org/article/3e9b067469cf42e6b774773138c53c7c

Population pharmacokinetics/pharmacodynamics analysis confirming biosimilarity of SB16 to reference denosumab

Autoři: Seungchan Choi Suemin Park Jinah Jung a další

Zdroj: Frontiers in Pharmacology, Vol 16 (2025)

Témata: denosumab, biosimilar, target-mediated drug disposition, osteoporosis, PK/PD modeling and simulation, monolix, Therapeutics. Pharmacology, RM1-950

Popis souboru: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2025.1631034/full; https://doaj.org/toc/1663-9812

Přístupová URL adresa: https://doaj.org/article/e06b307b7222479d958bd6f1ff3cd0be

Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

Autoři: Sou, Tomás Kukavica-Ibrulj, Irena Soukarieh, Fadi a další

Zdroj: Journal of Pharmaceutical Sciences. 108(1):630-640

Témata: pulmonary drug delivery, pharmacometrics, PK/PD modeling, preclinical pharmacokinetics, absorption, solubility, metabolic clearance, distribution, disposition, simulations

Popis souboru: electronic

Přístupová URL adresa: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-377374
https://doi.org/10.1016/j.xphs.2018.09.017

Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies

Autoři: Apolline Lefèvre Zinnia P. Parra-Guillen Iñaki F. Trocóniz a další

Zdroj: Front Immunol
Frontiers in Immunology, Vol 15 (2025)

Témata: cancer immunotherapy (CIT), CD3 Complex, T-Lymphocytes, pharmacokinetics/pharmacodynamics (PK/PD) modeling, Immunology, Models, Immunological, RC581-607, effector T-cell dynamics, cytokine release, Neoplasms, T-cell engager (TCE), Humans, Cytokines, Immunotherapy, Immunologic diseases. Allergy, Cytokine Release Syndrome

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39896804
https://doaj.org/article/f5fbc9acd46b492697fde78dde486709

Proposed linezolid dosing strategies to minimize adverse events for treatment of extensively drug-resistant tuberculosis

Autoři: Imperial, Marjorie Z Nedelman, Jerry R Conradie, Francesca a další

Zdroj: Clinical Infectious Diseases. 74(10)

Témata: 32 Biomedical and Clinical Sciences (for-2020), 3202 Clinical Sciences (for-2020), Neurosciences (rcdc), Infectious Diseases (rcdc), Patient Safety (rcdc), Hematology (rcdc), Neurodegenerative (rcdc), Rare Diseases (rcdc), Tuberculosis (rcdc), Orphan Drug (rcdc), Emerging Infectious Diseases (rcdc), Peripheral Neuropathy (rcdc), Clinical Research (rcdc), Clinical Trials and Supportive Activities (rcdc), 6.1 Pharmaceuticals (hrcs-rac), 3 Good Health and Well Being (sdg), Adult (mesh), Anemia (mesh), Antitubercular Agents (mesh), Extensively Drug-Resistant Tuberculosis (mesh), Humans (mesh), Linezolid (mesh), Peripheral Nervous System Diseases (mesh), Prospective Studies (mesh), Thrombocytopenia (mesh), Treatment Outcome (mesh), Tuberculosis, Multidrug-Resistant (mesh), adverse events, drug-resistant tuberculosis, linezolid, PK-PD modeling, tuberculosis therapeutics, Humans (mesh), Tuberculosis, Multidrug-Resistant (mesh), Peripheral Nervous System Diseases (mesh), Anemia (mesh), Thrombocytopenia (mesh), Antitubercular Agents (mesh), Treatment Outcome (mesh), Prospective Studies (mesh), Adult (mesh), Extensively Drug-Resistant Tuberculosis (mesh), Linezolid (mesh), PK–PD modeling, adverse events, drug-resistant tuberculosis, linezolid, tuberculosis therapeutics, Adult (mesh), Anemia (mesh), Antitubercular Agents (mesh), Extensively Drug-Resistant Tuberculosis (mesh), Humans (mesh), Linezolid (mesh), Peripheral Nervous System Diseases (mesh), Prospective Studies (mesh), Thrombocytopenia (mesh), Treatment Outcome (mesh), Tuberculosis, Multidrug-Resistant (mesh), 06 Biological Sciences (for), 11 Medical and Health Sciences (for), Microbiology (science-metrix), 3202 Clinical sciences (for-2020)

Popis souboru: application/pdf

Přístupová URL adresa: https://escholarship.org/uc/item/59m21394
https://escholarship.org/content/qt59m21394/qt59m21394.pdf

Pharmacokinetic and Pharmacodynamic Modeling of Enrofloxacin and Its Metabolite Ciprofloxacin in Pregnant Goats.

Autoři: Ambros, Luis Adrian Kreil, Verónica Lucas Burneo, José Julio De a další

Témata: 636.09:615, Enrofloxacin, Ciprofloxacin, Goats, Gestation, PK/PD modeling, Farmacología veterinaria, 3109.08 Farmacología

Popis souboru: application/pdf

Relation: 20020220200090BA; Ambros, L. A., Kreil, V., de Lucas Burneo, J. J., Tinti, M. G., San Andrés Larrea, M. I., & Lorenzutti, A. M. (2025). Pharmacokinetic and Pharmacodynamic Modeling of Enrofloxacin and Its Metabolite Ciprofloxacin in Pregnant Goats. Veterinary Sciences, 12(6), 588. https://doi.org/10.3390/vetsci12060588; https://hdl.handle.net/20.500.14352/122764

Dostupnost: https://hdl.handle.net/20.500.14352/122764
https://doi.org/10.3390/vetsci12060588

Assessment of the Effects of Single-Domain Anti-Idiotypic Distribution Enhancers on the Disposition of Trastuzumab and on the Efficacy of a PE24-Trastuzumab Immunotoxin

Autoři: Ping Chen Yu Zhang Brandon M. Bordeau a další

Zdroj: Cancers ; Volume 17 ; Issue 9 ; Pages: 1468

Témata: binding-site barrier, anti-idiotypic distribution enhancers (AIDEs), immunotoxin, trastuzumab, PE24, pharmacokinetics/pharmacodynamics (PK/PD) modeling, antibody tumor distribution, antibody selectivity

Popis souboru: application/pdf

Relation: Cancer Drug Development; https://dx.doi.org/10.3390/cancers17091468

Dostupnost: https://doi.org/10.3390/cancers17091468

Translational Pharmacokinetic-Pharmacodynamic Modeling of a Novel Oral Dihydroorotate Dehydrogenase (DHODH) Inhibitor, HOSU-53 (JBZ-001)

Autoři: Joo Young Na Min Hai Kyeongmin Kim a další

Zdroj: Pharmaceutics ; Volume 17 ; Issue 4 ; Pages: 412

Témata: PK/PD modeling, PBPK modeling, first-in-human, HOSU-53, JBZ-001, DHODH inhibitor

Popis souboru: application/pdf

Relation: Clinical Pharmaceutics; https://dx.doi.org/10.3390/pharmaceutics17040412

Dostupnost: https://doi.org/10.3390/pharmaceutics17040412

Quantifying expression and metabolic activity of genes regulated by pregnane X receptor in primary human hepatocyte spheroids

Autoři: Lukáš Lochman Ellen Tanaka Kahiya Bechara Saade a další

Zdroj: PLoS Comput Biol

Témata: Receptors, Steroid, Pregnane X Receptor, CYP enzyme induction, Models, Biological, primary human hepatocyte spheroids, Gene Expression Regulation, Spheroids, Cellular, Hepatocytes, Humans, Cytochrome P-450 CYP3A, PK/PD modeling, mathematical biology, Rifampin, nuclear receptor activation, Cells, Cultured, Research Article

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40233301
https://hdl.handle.net/11104/0368211

Duchenne Muscular Dystrophy (DMD) Treatment via the ψ–Hamzah Model

Autoři: JALALI, SEYED RASOUL

Témata: Duchenne Muscular Dystrophy, DMD, ψ–Hamzah, Hamzah Equation, dystrophin, muscular dystrophy, muscle degeneration, muscle regeneration, genetic mutation, X-linked disorder, neuromuscular disease, fractional calculus, fractal theory, fractional derivatives, quantum biology, computational biology, mathematical modeling, advanced therapy, gene therapy alternatives, dystrophin restoration, peptide therapy, nanomedicine, nanoparticle carriers, RNA therapeutics, DNA therapy, epigenetic modulation, immune modulation, cellular memory, feedback loops, non-local interactions, fractal structures, tissue engineering, muscle mass restoration, chronic inflammation, fibrosis reduction, cardiomyopathy prevention, respiratory failure prevention, regenerative medicine, advanced drug delivery, bioinformatics, protein therapy, therapeutic peptides, quantum fields, biological oscillations, Bessel functions, immune response modulation, fractional dynamics, reaction–diffusion modeling, stochastic simulations, Green's functions, Python simulations, computational simulations, biological integration, clinical trials, preclinical testing, therapeutic vaccines, dystrophin protein repair, dystrophin peptide mimetics, dystrophin-like proteins, dystrophin pathway, dystrophin deficiency, nanoscience, biophysics, muscle fiber reconstruction, myopathy treatment, musculoskeletal disorders, immunotherapy, pharmacological innovations, biological engineering, epigenome reactivation, nano-fractal systems, peptide-based vaccines, synthetic biology, advanced biomaterials, nanogenomics, biopolymer scaffolds, exosome carriers, lipidoid nanoparticles, fractal nanoscaffolds, mitochondrial targeting, nano-capsules, oral drug formulations, injectable drug formulations, intravenous therapy, nanotechnology medicine, therapeutic nanostructures, adaptive therapy, systemic therapy, intelligent drug design, smart therapy, personalized medicine, targeted drug delivery, immune-safe therapy, immune engineering, peptide delivery, bio-computational models, dystrophin gene regulation, dystrophin synthesis, dystrophin repair, dystrophin stabilization, protein folding, protein expression, cell signaling, molecular biology, enzyme therapy, epigenetic therapy, gene regulation therapy, preclinical models, animal models, macaque models, bio-simulation, humanized models, WHO recommendations, FDA approval, EMA registration, Nature Medicine, NEJM publications, Cell Reports, JAMA Neurology, clinical feasibility, experimental therapy, phase 1 clinical trials, multicenter research, global collaboration, intellectual property, patent protection, biopharmaceuticals, drug development, vaccine development, biomedical engineering, computational medicine, translational research, biotechnology, life sciences, disease modeling, molecular dynamics, synthetic peptides, targeted therapy, protein repair therapy, non-invasive treatment, chronic illness management, systemic disease treatment, healthcare innovation, breakthrough therapy, rare disease therapy, orphan disease treatment, muscular rehabilitation, motor function recovery, skeletal muscle repair, cellular repair mechanisms, dystrophic tissue, myocyte regeneration, sarcolemma stability, muscle signaling chain, bioenergetics, mitochondrial function, therapeutic efficacy, pharmacokinetics, pharmacodynamics, absorption simulation, drug metabolism, drug clearance, immune response safety, cytokine regulation, non-toxic therapy, zero mortality, low side effects, nanotechnology applications, nanobiotechnology, molecular therapeutics, biomedical simulations, advanced Python code, Grünwald–Letnikov method, fractional order derivatives, immune feedback loops, fractal self-regulation, biological return point, oscillatory potential, complex integrals, computational innovations, advanced mathematics, medical breakthroughs, next-generation therapy, translational medicine, therapeutic development, regenerative drug therapy, protein therapy design, nanomedicine systems, tissue regeneration, molecular reprogramming, synthetic biology innovations, clinical applications, biomedical sciences, therapeutic pathway simulation, advanced biotechnology, future medicine, disease-resistant therapy, dystrophin-targeted drugs, biological response modeling, adaptive immune response, advanced drug formulations, dystrophin activation, dystrophin epigenetics, dystrophin nanotherapy, immune safe nanoparticles, fractionally derived models, advanced vaccine design, quantum-level interventions, bioreactor conditions, laboratory manufacturing, environmental standards, ADME simulation, PK/PD modeling, tissue distribution, immune system learning, cooperative multicellular response, fractional integral equation, dystrophin regeneration therapy, dystrophin repair modeling, DMD treatment strategies, genetic muscle disorders, orphan diseases, global health, translational biotechnology, experimental medicine, next-generation biopharma, disease progression modeling, dystrophin stabilization therapy, non-viral therapy, viral vector-free therapy, cost-effective treatment, scalable therapy, clinical-grade nanoparticles, bioethical considerations, humanitarian medicine, urgent therapy, medical innovation, scientific revolution, neuromuscular regeneration, tissue stabilization, fibrosis prevention, systemic inflammation control, smart nanomedicine, safe therapeutic peptides, clinical translation, dystrophin restoration pathways, bio-integrated systems, future of medicine, holistic therapy, complete treatment strategy

Severe Neurodevelopmental Autism Spectrum Disorder Treatment via the ψ–Hamzah Approach: A Fractal–Fractional Neuropharmacological Framework

Autoři: JALALI, SEYED RASOUL

Témata: ψ–Hamzah model, autism spectrum disorder, severe ASD, autism treatment, neurodevelopmental disorders, neurobehavioral disorders, fractional calculus, fractal dynamics, neuropharmacology, nanovaccine, nanoimmunotherapy, BDNF, NGF, siRNA, DHA, Curcumin Phytosome, SHANK3, NRXN1, MECP2, CNTNAP2, SCN2A, synaptogenesis, neuroplasticity, gene expression modulation, personalized therapy, precision medicine, drug delivery, nanocarriers, nanoparticle stability, liposomal carriers, phytosomal carriers, PEGylation, PLGA, hyaluronic acid gel, slow-release injectables, dual-layer capsules, epigenetic modulation, histone reprogramming, gut–brain axis, IL-6 regulation, TNF-alpha inhibition, NF-κB suppression, PPARγ pathways, TrkB receptor agonist, 7,8-DHF, neuroinflammation control, oxidative stress reduction, antioxidant therapy, resveratrol, omega-3 DHA, probiotics, microbiome modulation, gut-brain interactions, cognitive restoration, synaptic repair, mirror neuron system, prefrontal cortex modeling, hippocampal pathways, amygdala regulation, neuronal oscillations, EEG dynamics, theta waves, alpha waves, synchronization, coherence, temporal memory, Caputo derivative, Riemann–Liouville integral, fractional Fourier transform, complex integrals, stochastic modeling, Gaussian noise, biological noise, fractal brain space, computational neuroscience, mathematical biology, pharmacokinetics, pharmacodynamics, ADME modeling, PK/PD modeling, nonlinear dynamics, chaos theory, time–fractional equations, brain fractals, multi-scale modeling, supraneuronal networks, topological analysis, social neural networks, computational simulations, Python modeling, code implementation, finite difference method, spectral analysis, memory-embedded dynamics, oscillatory stability, long-term neuronal memory, nonlinear damping, cubic damping, neuronal diffusivity, neurogenesis stimulation, axonal growth, synaptic regeneration, BDNF-mRNA, NGF peptides, siRNA-IL6, CpG-ODN, immunoactivator, PEG-5000, cholesterol nanolipids, Zn2+ crosslinkers, trehalose stabilizer, freeze-drying, lyophilization, GMP laboratory protocols, GLP compliance, FDA standards, EMA standards, WHO recommendations, clinical trial protocols, Phase I trials, Phase II trials, Phase III trials, translational medicine, neuroimmunology, neurogenetics, biomedical engineering, advanced therapeutics, regenerative medicine, behavioral restoration, psychiatric innovation, cognitive enhancement, neuronal recovery, neurorehabilitation, neuroprotective therapies, neuroregenerative strategies, molecular pharmacology, cellular pharmacology, drug metabolism, genetic variability, pharmacogenomics, personalized drug design, child neurology, pediatric psychiatry, child development, brain development, developmental delays, language delay, sensory processing disorder, repetitive behaviors, restrictive behaviors, emotional empathy deficits, social cognition, attention disorders, behavioral therapy limitations, ABA therapy, SSRIs, antipsychotics, TMS, dietary interventions, reductionist frameworks, nonlinear therapeutic pathways, fractal therapeutic framework, mathematical–biological integration, computational pharmacology, translational pharmacology, animal models, mouse models, chimpanzee models, human rescue protocol, synaptic plasticity enhancement, gene reprogramming, SHANK3 restoration, NRXN1 modulation, MECP2 function, CNTNAP2 role, SCN2A pathway, brain imaging, MRI, fMRI, PET, neuronal connectivity, prefrontal cortex, midbrain pathways, amygdala function, hippocampal memory, mirror neurons, synaptic desynchronization, gray matter volume, brain topology, cognitive scaling, nonlinear cognition, neurocognitive equilibrium, behavioral outcomes, clinical efficacy, clinical safety, side effect minimization, patient-specific therapy, neurochemical modulation, neuroimmune regulation, neurotherapeutics, chronic neurological diseases, neurodegenerative disease modeling, Alzheimer's therapy, Parkinson's models, epilepsy treatment, schizophrenia modeling, psychiatric innovations, biomedical modeling, interdisciplinary science, system biology, health innovation, therapeutic revolution, paradigm shift, life-saving protocol, global healthcare, translational neuroscience, medical nanotechnology, intelligent nanovaccine, nano-vectorized delivery, peptide carriers, DNA nanotherapy, immune regulation, Treg stimulation, cytokine pathways, IL-6 inhibition, TNF-alpha suppression, BDNF expression, synapse formation, axon function, neuronal stability, cognitive balance, neural-cognitive reset, scientific revolution, Seyed Rasoul Jalali, ψ–Hamzah framework, neurotherapy, pharmacological advancement, therapeutic innovation, biotechnological integration, drug optimization, child health, future clinical trials, global scientific adoption, personalized pharmacology, computational pharmacogenomics, advanced drug delivery, immune system regulation, brain therapeutic modeling, precision neurotherapy, health outcomes, healthcare transformation, neurological restoration, autism cure framework

The Role of Pharmacometrics in Advancing the Therapies for Autoimmune Diseases

Autoři: Artur Świerczek Dominika Batko Elżbieta Wyska

Zdroj: Pharmaceutics, Vol 16, Iss 12, p 1559 (2024)

Témata: pharmacometrics, autoimmune diseases, personalized medicine, PBPK modeling, PK/PD modeling, disease progression modeling, Pharmacy and materia medica, RS1-441

Popis souboru: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/12/1559; https://doaj.org/toc/1999-4923

Přístupová URL adresa: https://doaj.org/article/97ee800ee34c46878e8e266b87dc039d

Pharmacokinetics and Pharmacodynamics Evaluation of Amoxicillin Against Staphylococcus pseudintermedius in Dogs

Autoři: Ji-Soo Jeong Jeong-Won Kim Jin-Hwa Kim a další

Zdroj: Pathogens, Vol 13, Iss 12, p 1121 (2024)

Témata: antimicrobial, PK/PD modeling, dosing, drug exposure, antibiotic resistance, Medicine

Popis souboru: electronic resource

Relation: https://www.mdpi.com/2076-0817/13/12/1121; https://doaj.org/toc/2076-0817

Přístupová URL adresa: https://doaj.org/article/f76e90e2e0e64ae7b231cac47cf818b7

Improved Malaria Therapy with Cationic Nanocapsules Demonstrated in Plasmodium berghei-Infected Rodents Using Whole Blood Surrogate Population PK/PD Modeling

Autoři: Tamara Ramos Maciel Ana Claudia Funguetto-Ribeiro Laura Ben Olivo a další

Zdroj: Pharmaceutics, Vol 16, Iss 11, p 1369 (2024)

Témata: interspecies translation, whole blood, quinine, nanocapsules, malaria, PK/PD modeling, Pharmacy and materia medica, RS1-441

Popis souboru: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/11/1369; https://doaj.org/toc/1999-4923

Přístupová URL adresa: https://doaj.org/article/9f8eb09493d145a2b3a73912f8ad4f0c