Search Results - "PINOCYTOSIS"

LncRNA AFAP1-AS1 promoting residual tumor progression after insufficient radiofrequency ablation by up-regulating macropinocytosis in hepatocellular carcinoma.

Authors: Wei Q Xiong S Luo W et al.

Source: Cellular signalling [Cell Signal] 2025 Nov; Vol. 135, pp. 112031. Date of Electronic Publication: 2025 Jul 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/metabolism , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Pinocytosis*/genetics , Radiofrequency Ablation* , Neoplasm, Residual*/genetics , Neoplasm, Residual*/pathology, Humans ; Animals ; Mice ; Disease Progression ; Cell Line, Tumor ; Up-Regulation ; Mice, Nude ; Male ; Cell Proliferation ; Cell Movement ; Mice, Inbred BALB C ; Gene Expression Regulation, Neoplastic

CDC42 supports HBV entry by NTCP translocation to the plasma membrane and macropinocytosis.

Authors: Cui S Gao W Chen Y et al.

Source: EMBO reports [EMBO Rep] 2025 Nov; Vol. 26 (21), pp. 5239-5269. Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

MeSH Terms: cdc42 GTP-Binding Protein*/metabolism , cdc42 GTP-Binding Protein*/genetics , Hepatitis B virus*/physiology , Virus Internalization* , Organic Anion Transporters, Sodium-Dependent*/metabolism , Organic Anion Transporters, Sodium-Dependent*/genetics , Cell Membrane*/metabolism , Cell Membrane*/virology , Pinocytosis* , Symporters*/metabolism, Humans ; rab GTP-Binding Proteins/metabolism ; Hepatocytes/virology ; Hepatocytes/metabolism ; Protein Transport ; Signal Transduction ; Endocytosis ; Hep G2 Cells ; Hepatitis B/virology ; Hepatitis B/metabolism ; Endosomes/metabolism

Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance.

Authors: Wang Y Chai Y Liu Y et al.

Source: Immunity [Immunity] 2025 Oct 14; Vol. 58 (10), pp. 2456-2471.e6. Date of Electronic Publication: 2025 Aug 14.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

MeSH Terms: Pinocytosis*/immunology , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/metabolism , Programmed Cell Death 1 Receptor*/immunology , Drug Resistance, Neoplasm*/immunology , Oxidoreductases Acting on CH-CH Group Donors*/metabolism , Oxidoreductases Acting on CH-CH Group Donors*/genetics , Neoplasms*/immunology, Humans ; Animals ; Mice ; Dihydroorotate Dehydrogenase ; Cell Line, Tumor ; Female ; Neuropilin-1/metabolism ; Tumor Escape ; Immunotherapy/methods

Impairment of Hyaluronan-Related Glycocalyx Inhibits Macropinocytosis in Cancer Cells via p21 Upregulation.

Authors: Luan G Guo Q Liu Y et al.

Source: Biomacromolecules [Biomacromolecules] 2025 Oct 13; Vol. 26 (10), pp. 6586-6599. Date of Electronic Publication: 2025 Sep 03.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE

MeSH Terms: Hyaluronic Acid*/metabolism , Glycocalyx*/metabolism , Pinocytosis*/drug effects , Cyclin-Dependent Kinase Inhibitor p21*/metabolism , Cyclin-Dependent Kinase Inhibitor p21*/genetics , Neoplasms*/metabolism , Neoplasms*/pathology, Humans ; Cell Proliferation ; Up-Regulation ; Cell Line, Tumor

Methuosis caused by dysregulated macropinocytosis, a promising tumor therapeutic strategy.

Authors: Ji X Huang M Liu Q

Source: Pharmacological research [Pharmacol Res] 2025 Oct; Vol. 220, pp. 107945. Date of Electronic Publication: 2025 Sep 08.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

MeSH Terms: Pinocytosis*/drug effects , Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/metabolism , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/pharmacology , Vacuoles*/drug effects , Vacuoles*/pathology , Vacuoles*/metabolism, Humans ; Animals

Antidepressants stimulate lipoprotein(a) macropinocytosis via serotonin-enhanced cell surface binding.

Authors: Deo N Siddiqui H Peppercorn K et al.

Source: Journal of lipid research [J Lipid Res] 2025 Oct; Vol. 66 (10), pp. 100889. Date of Electronic Publication: 2025 Aug 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE

MeSH Terms: Pinocytosis*/drug effects , Serotonin*/metabolism , Serotonin*/pharmacology , Cell Membrane*/metabolism , Cell Membrane*/drug effects , Lipoprotein(a)*/metabolism , Antidepressive Agents*/pharmacology, Humans ; Imipramine/pharmacology ; Selective Serotonin Reuptake Inhibitors/pharmacology ; Protein Binding/drug effects ; Citalopram/pharmacology ; rab GTP-Binding Proteins/metabolism

Macropinocytosis and Fast Endophilin-Mediated Endocytosis Mediate Absorption of Garlic Chive-Derived Vesicle-like Nanoparticles in Human Intestinal Epithelial Cells.

Authors: Nguyen PL Liu B Zhang S et al.

Source: Molecular pharmaceutics [Mol Pharm] 2025 Jul 07; Vol. 22 (7), pp. 3935-3948. Date of Electronic Publication: 2025 May 23.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

MeSH Terms: Nanoparticles*/chemistry , Nanoparticles*/metabolism , Garlic*/chemistry , Endocytosis*/physiology , Endocytosis*/drug effects , Pinocytosis*/physiology , Pinocytosis*/drug effects , Epithelial Cells*/metabolism , Intestinal Mucosa*/metabolism , Extracellular Vesicles*/metabolism, Humans ; Caco-2 Cells ; Animals ; Mice ; Mice, Inbred C57BL ; Intestinal Absorption ; Male

SFTSV utilizes AXL/GAS6 for entry via PI3K-PLC-dependent macropinocytosis activated by AXL-kinase.

Authors: Jin Z Taguwa S Hirano J et al.

Source: Journal of virology [J Virol] 2025 Sep 23; Vol. 99 (9), pp. e0022125. Date of Electronic Publication: 2025 Aug 25.

Publication Type: Journal Article

Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

MeSH Terms: Receptor Protein-Tyrosine Kinases*/metabolism , Receptor Protein-Tyrosine Kinases*/genetics , Virus Internalization* , Proto-Oncogene Proteins*/metabolism , Proto-Oncogene Proteins*/genetics , Pinocytosis* , Phlebovirus*/physiology , Intercellular Signaling Peptides and Proteins*/metabolism , Intercellular Signaling Peptides and Proteins*/genetics , Type C Phospholipases*/metabolism , Phosphatidylinositol 3-Kinases*/metabolism , Phosphatidylinositol 3-Kinase*/metabolism, Humans ; Axl Receptor Tyrosine Kinase ; Human Umbilical Vein Endothelial Cells/virology ; Animals ; Signal Transduction

Targeting and exploiting macropinocytosis in cancer therapy.

Authors: Moon HR Cho BK Kang SH et al.

Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Sep 10; Vol. 385, pp. 113962. Date of Electronic Publication: 2025 Jun 16.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH Terms: Pinocytosis*/drug effects , Neoplasms*/drug therapy , Neoplasms*/metabolism , Neoplasms*/pathology , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/therapeutic use , Drug Delivery Systems*/methods, Humans ; Animals ; Tumor Microenvironment ; Nanoparticles

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer.

Authors: Zhang Y Ling L Murad R et al.

Source: Cancer cell [Cancer Cell] 2025 Sep 08; Vol. 43 (9), pp. 1677-1696.e15. Date of Electronic Publication: 2025 Jul 24.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

MeSH Terms: Pinocytosis* , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/pathology , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Carcinoma, Pancreatic Ductal*/metabolism , Carcinoma, Pancreatic Ductal*/pathology , Stress, Physiological*, Animals ; Humans ; Tumor Microenvironment ; Mice ; Cell Line, Tumor ; Glutamine/metabolism ; Glutamine/deficiency ; MAP Kinase Signaling System

EIPA, A macropinocytosis blocking agent, inhibits Siniperca chuatsi rhabdovirus infection in vitro and in vivo.

Authors: Liang H Luo X Lin Q et al.

Source: Microbial pathogenesis [Microb Pathog] 2025 Sep; Vol. 206, pp. 107751. Date of Electronic Publication: 2025 May 26.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH Terms: Amiloride*/analogs & derivatives , Amiloride*/pharmacology , Fish Diseases*/drug therapy , Fish Diseases*/virology , Pinocytosis*/drug effects , Antiviral Agents*/pharmacology , Rhabdoviridae Infections*/drug therapy , Rhabdoviridae Infections*/veterinary , Rhabdoviridae Infections*/virology , Rhabdoviridae*/drug effects , Rhabdoviridae*/physiology, Animals ; Virus Replication/drug effects ; Cell Line ; Bass/virology ; Perciformes/virology ; Virus Internalization/drug effects

Lipoprotein-Based Nanocatalyst Enables Targeted Treatment of APAP-Induced Liver Injury via Enhanced Macropinocytosis.

Authors: Chen Y Jiang G Huang Y et al.

Source: Advanced healthcare materials [Adv Healthc Mater] 2025 Sep; Vol. 14 (25), pp. e2500507. Date of Electronic Publication: 2025 May 24.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE

MeSH Terms: Cerium*/chemistry , Cerium*/pharmacology , Chemical and Drug Induced Liver Injury*/drug therapy , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/pathology , Acetaminophen*/adverse effects , Pinocytosis*/drug effects , Nanoparticles*/chemistry , Lipoproteins, HDL*/chemistry , Lipoproteins, HDL*/pharmacology, Animals ; Mice ; Reactive Oxygen Species/metabolism ; Acetylcysteine/pharmacology ; Humans ; Hepatocytes/metabolism ; Hepatocytes/drug effects ; Male ; Mice, Inbred C57BL ; Liver/metabolism ; Liver/drug effects

Novel macropinocytosis inducers selectively modulate intracellular delivery of small and macromolecules in cancer cells.

Authors: Neupane R Karthikeyan C Piedra V et al.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Sep; Vol. 322 (Pt 3), pp. 146366. Date of Electronic Publication: 2025 Jul 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Pinocytosis*/drug effects , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Macromolecular Substances*/metabolism, Humans ; Cell Line, Tumor ; HCT116 Cells ; Paclitaxel/pharmacology

AntimiR uptake by human proximal tubule epithelial cells is predominantly by macropinocytosis.

Authors: Glover EK Berlinguer-Palmini R Thompson ER et al.

Source: Scientific reports [Sci Rep] 2025 Aug 29; Vol. 15 (1), pp. 31799. Date of Electronic Publication: 2025 Aug 29.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Kidney Tubules, Proximal*/metabolism , Kidney Tubules, Proximal*/cytology , Pinocytosis*/drug effects , MicroRNAs*/antagonists & inhibitors , MicroRNAs*/metabolism , MicroRNAs*/genetics , Epithelial Cells*/metabolism, Humans ; Endocytosis ; Cells, Cultured ; Low Density Lipoprotein Receptor-Related Protein-2/metabolism ; Low Density Lipoprotein Receptor-Related Protein-2/antagonists & inhibitors

Pinocytosis inhibitory nanoparticles enhance aPD-1 antibody delivery and efficacy while avoiding toxicity in the treatment of solid tumors.

Authors: Zelenetz SR Park H Qiang W et al.

Source: Nanoscale horizons [Nanoscale Horiz] 2025 Aug 21; Vol. 10 (9), pp. 2003-2016. Date of Electronic Publication: 2025 Aug 21.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101712576 Publication Model: Electronic Cited Medium: Internet ISSN: 2055-6764 (Electronic) Linking ISSN: 20556756 NLM ISO Abbreviation: Nanoscale Horiz Subsets: MEDLINE

MeSH Terms: Nanoparticles*/chemistry , Pinocytosis*/drug effects , Antibodies, Monoclonal* , Programmed Cell Death 1 Receptor*/immunology , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Colonic Neoplasms*/drug therapy , Colonic Neoplasms*/pathology , Neoplasms*/drug therapy, Animals ; Mice ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Humans ; Cell Line, Tumor ; Thiazolidines/chemistry ; Thiazolidines/pharmacology ; Tissue Distribution ; Female ; Tumor Microenvironment/drug effects ; Melanoma/drug therapy

Macropinocytosis: Molecular mechanisms and regulation.

Authors: Tu H Wang H Cai H

Source: Current opinion in cell biology [Curr Opin Cell Biol] 2025 Aug; Vol. 95, pp. 102563. Date of Electronic Publication: 2025 Jun 17.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 8913428 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0410 (Electronic) Linking ISSN: 09550674 NLM ISO Abbreviation: Curr Opin Cell Biol Subsets: MEDLINE

MeSH Terms: Pinocytosis*, Humans ; Animals ; Dictyostelium/metabolism ; Cell Movement ; Signal Transduction

Corneal epithelial cells upregulate macropinocytosis to engulf metabolically active axonal mitochondria released by injured axons.

Authors: Pal-Ghosh S Datta-Majumdar H Datta S et al.

Source: The ocular surface [Ocul Surf] 2025 Jul; Vol. 37, pp. 173-188. Date of Electronic Publication: 2025 Apr 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101156063 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-5913 (Electronic) Linking ISSN: 15420124 NLM ISO Abbreviation: Ocul Surf Subsets: MEDLINE

MeSH Terms: Mitochondria*/metabolism , Pinocytosis*/physiology , Epithelium, Corneal*/metabolism , Epithelium, Corneal*/pathology , Epithelium, Corneal*/injuries , Axons*/metabolism , Axons*/pathology , Corneal Injuries*/metabolism , Corneal Injuries*/pathology, Animals ; Mice ; Female ; Male ; Humans ; Mice, Inbred C57BL ; Disease Models, Animal ; Cells, Cultured

KRAS mutation-driven enhanced macropinocytosis: using albumin as a trojan horse for delivering nanomedicine.

Authors: Rathod D Vats M Gawali P et al.

Source: Nanomedicine (London, England) [Nanomedicine (Lond)] 2025 Jul; Vol. 20 (14), pp. 1759-1773. Date of Electronic Publication: 2025 Jul 02.

Publication Type: Journal Article; Review; Research Support, N.I.H., Extramural

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-6963 (Electronic) Linking ISSN: 17435889 NLM ISO Abbreviation: Nanomedicine (Lond) Subsets: MEDLINE

MeSH Terms: Pinocytosis*/genetics , Proto-Oncogene Proteins p21(ras)*/genetics , Albumins*/chemistry , Neoplasms*/genetics , Neoplasms*/drug therapy, Humans ; Mutation ; Animals ; Nanomedicine/methods ; Nanoparticles/chemistry ; Drug Delivery Systems/methods

EGF-Induced Macropinocytosis Promotes NAV1-Dependent Internalization of Occludin in Keratinocytes.

Authors: Taira H Li L Koyama A et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Apr 30; Vol. 39 (8), pp. e70564.

Publication Type: Journal Article

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Keratinocytes*/metabolism , Keratinocytes*/drug effects , Epidermal Growth Factor*/metabolism , Epidermal Growth Factor*/pharmacology , Pinocytosis*/drug effects , Pinocytosis*/physiology , Occludin*/metabolism, Humans ; Animals ; Mice ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; HaCaT Cells

Macropinocytosis: Both a Target and a Tool for Cancer Therapy.

Authors: Zhao M Zhou L Zhai Y et al.

Source: Biomolecules [Biomolecules] 2025 Jun 26; Vol. 15 (7). Date of Electronic Publication: 2025 Jun 26.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

MeSH Terms: Pinocytosis*/drug effects , Neoplasms*/drug therapy , Neoplasms*/metabolism , Neoplasms*/pathology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Humans ; Animals ; Drug Delivery Systems