Search Results - "PHYTOCHEMICALS"

Molecular Mechanisms Behind Organ-Related Aging and Regulatory Effects of Natural Therapeutics.

Authors: Abaidullah R Ali S Summer M et al.

Source: Cell biochemistry and biophysics [Cell Biochem Biophys] 2025 Dec; Vol. 83 (4), pp. 4047-4074. Date of Electronic Publication: 2025 Jun 17.

Publication Type: Journal Article; Review

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE

MeSH Terms: Aging*/drug effects , Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Phytochemicals*/therapeutic use, Humans ; Animals ; Antioxidants/pharmacology ; Oxidative Stress/drug effects ; Anti-Inflammatory Agents/pharmacology

Mitochondrial disease management through phytochemical interventions.

Authors: Ramya RP Megha KB Reshma S et al.

Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2025 Dec; Vol. 480 (12), pp. 5911-5940. Date of Electronic Publication: 2025 Aug 03.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE

MeSH Terms: Phytochemicals*/therapeutic use , Phytochemicals*/pharmacology , Mitochondrial Diseases*/drug therapy , Mitochondrial Diseases*/metabolism , Mitochondrial Diseases*/pathology , Mitochondria*/metabolism , Mitochondria*/pathology , Mitochondria*/drug effects, Humans ; Animals ; Oxidative Stress/drug effects ; Energy Metabolism/drug effects

Investigation of the potential of phytochemicals derived from citrus peels to inhibit digestive enzymes: an overture to the management of lifestyle diseases.

Authors: Moloi L Samson S Tshiyoyo K et al.

Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2564800. Date of Electronic Publication: 2025 Oct 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH Terms: Citrus*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Phytochemicals*/isolation & purification , Lipase*/antagonists & inhibitors , Lipase*/metabolism , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/isolation & purification , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/isolation & purification , Anti-Obesity Agents*/chemistry , Anti-Obesity Agents*/pharmacology , Anti-Obesity Agents*/isolation & purification, Humans ; alpha-Glucosidases/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Structure-Activity Relationship ; Obesity/drug therapy ; Molecular Structure ; Animals ; Molecular Docking Simulation

Targeting systemic lupus erythematosus (SLE) using Withania somnifera derived compounds: A network and molecular dynamics study.

Authors: Barik D Sarangi AK Mandal K et al.

Source: Lupus [Lupus] 2025 Dec; Vol. 34 (14), pp. 1491-1503. Date of Electronic Publication: 2025 Nov 07.

Publication Type: Journal Article

Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0962 (Electronic) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE

MeSH Terms: Withania*/chemistry , Lupus Erythematosus, Systemic*/drug therapy , Lupus Erythematosus, Systemic*/genetics , Phytochemicals*/pharmacology , Phytochemicals*/therapeutic use , Plant Extracts*/pharmacology , Plant Extracts*/therapeutic use , Plant Extracts*/chemistry, Humans ; Molecular Dynamics Simulation ; Molecular Docking Simulation ; Withanolides/pharmacology ; Protein Interaction Maps/drug effects

Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation.

Authors: Petersen C Satheesh Babu AK Della Lucia CM et al.

Source: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2446375. Date of Electronic Publication: 2025 Jan 06.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH Terms: Fragaria*/microbiology , Gastrointestinal Microbiome*/drug effects , Mice, Inbred C57BL* , Dysbiosis*/microbiology , Phytochemicals*/pharmacology , Phytochemicals*/metabolism , Diet, High-Fat*/adverse effects, Animals ; Mice ; Male ; Bacteria/classification ; Bacteria/metabolism ; Bacteria/drug effects ; Inflammation/metabolism ; Inflammation/drug therapy ; Propionates/metabolism ; Coumaric Acids/metabolism ; Coumaric Acids/pharmacology ; Anti-Bacterial Agents/pharmacology ; Humans

Molecular Insights into Phytochemicals Mediated Epigenetic Regulation in Preclinical Models of Breast Cancer.

Authors: Pandey P Alkhathami AG Saeed M et al.

Source: Drug design, development and therapy [Drug Des Devel Ther] 2025 Nov 27; Vol. 19, pp. 10589-10606. Date of Electronic Publication: 2025 Nov 27 (Print Publication: 2025).

Publication Type: Journal Article; Review

Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Epigenesis, Genetic*/drug effects , Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry, Humans ; Female ; Animals ; DNA Methylation/drug effects

Phytochemicals as modulators of Astrocytes in Alzheimer's disease: A therapeutic perspective.

Authors: Wang S Zhang Z Liu Y et al.

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov 25; Vol. 148, pp. 157347. Date of Electronic Publication: 2025 Sep 28.

Publication Type: Journal Article; Review

Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/drug therapy , Astrocytes*/drug effects , Astrocytes*/metabolism , Phytochemicals*/pharmacology , Phytochemicals*/therapeutic use, Humans ; Animals ; Signal Transduction/drug effects

Phytochemical diversity, antioxidant potential, antimicrobial activity, cytotoxicity, and genotoxicity analyses of unconventional food plants: Cymbopogon citratus (DC.) Stapf, Pereskia aculeata Mill., Portulaca oleracea L., and Talinum paniculatum (Jacq.) Gaertn.

Authors: Giuliani CDS Farias CAA Marquezan PK et al.

Source: Food chemistry [Food Chem] 2025 Nov 15; Vol. 492 (Pt 3), pp. 145526. Date of Electronic Publication: 2025 Jul 13.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/toxicity , Cymbopogon*/chemistry , Portulaca*/chemistry , Portulaca*/toxicity , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/toxicity , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Phytochemicals*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/toxicity , Plants, Edible*/chemistry, Humans ; Mutagenicity Tests ; Brazil ; Plant Leaves/chemistry ; Bacteria/drug effects ; Fibroblasts/drug effects

Decoding apoptosis-associated pathways in inflammatory and neurodegenerative diseases: A network pharmacology based drug discovery approach.

Authors: Alkhammash A Alotaibi G Algethami A et al.

Source: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 15; Vol. 1007, pp. 178231. Date of Electronic Publication: 2025 Oct 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH Terms: Network Pharmacology* , Drug Discovery*/methods , Apoptosis*/drug effects , Neurodegenerative Diseases*/drug therapy , Neurodegenerative Diseases*/metabolism , Neurodegenerative Diseases*/pathology , Phytochemicals*/pharmacology , Phytochemicals*/therapeutic use , Inflammation*/drug therapy , Inflammation*/metabolism , Neuroprotective Agents*/pharmacology, Humans ; Molecular Docking Simulation ; Protein Interaction Maps/drug effects ; Signal Transduction/drug effects ; Alzheimer Disease/drug therapy

Comparative analysis of solvent and advanced extraction techniques for optimizing phytochemical yield and bioactivity of Matthiola ovatifolia (Boiss.) Aerial parts.

Authors: Sharifi-Rad M Camele I Pohl P et al.

Source: Scientific reports [Sci Rep] 2025 Nov 14; Vol. 15 (1), pp. 39978. Date of Electronic Publication: 2025 Nov 14.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Plant Extracts*/isolation & purification , Phytochemicals*/pharmacology , Phytochemicals*/isolation & purification , Phytochemicals*/chemistry , Solvents*/chemistry , Plant Components, Aerial*/chemistry, Humans ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; MCF-7 Cells ; Phenols/chemistry ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Hep G2 Cells ; Flavonoids ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/chemistry

Phytonutrient Profiles of Mistletoe and Their Values and Potential Applications in Ethnopharmacology and Nutraceuticals: A Review.

Authors: Mopai MG Mpai S Van Staden J et al.

Source: Molecules (Basel, Switzerland) [Molecules] 2025 Nov 13; Vol. 30 (22). Date of Electronic Publication: 2025 Nov 13.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH Terms: Mistletoe*/chemistry , Phytochemicals*/chemistry , Phytochemicals*/pharmacology , Dietary Supplements*/analysis , Ethnopharmacology* , Plant Extracts*/chemistry , Plant Extracts*/pharmacology, Humans ; Medicine, Traditional

Phytochemicals as modulators of dendritic cell functions: implications for tolerogenic cell-based therapy.

Authors: Fekete T Pázmándi K

Source: Frontiers in immunology [Front Immunol] 2025 Nov 11; Vol. 16, pp. 1653803. Date of Electronic Publication: 2025 Nov 11 (Print Publication: 2025).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Phytochemicals*/pharmacology , Phytochemicals*/therapeutic use , Dendritic Cells*/immunology , Dendritic Cells*/drug effects , Dendritic Cells*/metabolism , Immune Tolerance*/drug effects, Humans ; Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy

Ayurvedic Phytochemicals in Oncology: ADP-Ribosylation as a Molecular Nexus.

Authors: Reddy GSVSR Nandy SK Cherukuri P et al.

Source: Cells [Cells] 2025 Nov 10; Vol. 14 (22). Date of Electronic Publication: 2025 Nov 10.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH Terms: Phytochemicals*/pharmacology , Phytochemicals*/therapeutic use , Medicine, Ayurvedic* , Neoplasms*/drug therapy , Neoplasms*/metabolism , ADP-Ribosylation*/drug effects, Humans ; Animals ; Poly(ADP-ribose) Polymerases/metabolism

Microbiological and pharmacological investigation of phytochemicals extracted from selected ethnomedicinal plants with their potential against food pathogen.

Authors: Gawad AMA Molham F Tagyan AI et al.

Source: Scientific reports [Sci Rep] 2025 Nov 07; Vol. 15 (1), pp. 39017. Date of Electronic Publication: 2025 Nov 07.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Plants, Medicinal*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry, Humans ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Microbial Sensitivity Tests ; Origanum/chemistry ; Flavonoids/pharmacology ; Flavonoids/chemistry ; Zingiber officinale/chemistry ; HCT116 Cells ; Cell Line, Tumor ; Medicine, Traditional ; Phenols/pharmacology ; Phenols/chemistry ; Bacteria/drug effects ; Anti-Bacterial Agents/pharmacology ; Fungi/drug effects ; Ocimum basilicum/chemistry

Phytochemicals as Epigenetic Modulators in Chronic Diseases: Molecular Mechanisms.

Authors: Cord D Rîmbu MC Iordache MP et al.

Source: Molecules (Basel, Switzerland) [Molecules] 2025 Nov 06; Vol. 30 (21). Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH Terms: Phytochemicals*/pharmacology , Phytochemicals*/therapeutic use , Phytochemicals*/chemistry , Epigenesis, Genetic*/drug effects, Humans ; Chronic Disease ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Antioxidants/therapeutic use ; Animals ; Oxidative Stress/drug effects ; Signal Transduction/drug effects ; DNA Methylation/drug effects ; Anti-Inflammatory Agents/pharmacology

Exploring Cadaba fruticosa bioactive compounds for oral cancer an in silico and in vitro approach.

Authors: Selvan ST Venkateshkumar A Alagumuthu M et al.

Source: Scientific reports [Sci Rep] 2025 Nov 06; Vol. 15 (1), pp. 38953. Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Mouth Neoplasms*/drug therapy , Mouth Neoplasms*/metabolism , Mouth Neoplasms*/pathology , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/chemistry, Humans ; Molecular Docking Simulation ; Cell Line, Tumor ; Network Pharmacology ; Computer Simulation ; Apoptosis/drug effects

Therapeutic potential of medicinal plant sprouts: emerging opportunities and challenges in phytochemistry.

Authors: Melegova D Babelova A Selc M

Source: Planta [Planta] 2025 Nov 05; Vol. 262 (6), pp. 146. Date of Electronic Publication: 2025 Nov 05.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer-Verlag [etc.] Country of Publication: Germany NLM ID: 1250576 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-2048 (Electronic) Linking ISSN: 00320935 NLM ISO Abbreviation: Planta Subsets: MEDLINE

MeSH Terms: Plants, Medicinal*/chemistry , Plants, Medicinal*/growth & development , Phytochemicals*/therapeutic use , Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Seedlings*/chemistry , Seedlings*/growth & development, Germination ; Seeds/chemistry ; Seeds/growth & development ; Humans ; Phytotherapy

Comprehensive Analysis of Bioactive Phytoconstituents in Red Flesh of Dioscorea opposita Thunb. by UHPLC-Q-Orbitrap-HRMS.

Authors: Yang L Wang W Liu Z et al.

Source: Biomedical chromatography : BMC [Biomed Chromatogr] 2025 Nov; Vol. 39 (11), pp. e70232.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print Cited Medium: Internet ISSN: 1099-0801 (Electronic) Linking ISSN: 02693879 NLM ISO Abbreviation: Biomed Chromatogr Subsets: MEDLINE

MeSH Terms: Dioscorea*/chemistry , Phytochemicals*/analysis , Phytochemicals*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/analysis, Chromatography, High Pressure Liquid/methods ; Antioxidants/analysis ; Antioxidants/chemistry ; Mass Spectrometry/methods

Phytochemicals in overcoming venetoclax resistance in acute myeloid leukemia: mechanistic insights and therapeutic potential.

Authors: Prajapati S Patel M Jyotishi C et al.

Source: Annals of hematology [Ann Hematol] 2025 Nov; Vol. 104 (11), pp. 5573-5591. Date of Electronic Publication: 2025 Nov 07.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE

MeSH Terms: Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/metabolism , Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/pathology , Bridged Bicyclo Compounds, Heterocyclic*/therapeutic use , Bridged Bicyclo Compounds, Heterocyclic*/pharmacology , Phytochemicals*/therapeutic use , Phytochemicals*/pharmacology , Drug Resistance, Neoplasm*/drug effects , Sulfonamides*/therapeutic use , Sulfonamides*/pharmacology, Humans ; Animals ; Apoptosis/drug effects

Phytochemicals encouraging neurotrophic pathways: brain-derived neurotrophic factors as molecular targets in depression.

Authors: Karad V Gupta GL

Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Nov; Vol. 398 (11), pp. 15075-15094. Date of Electronic Publication: 2025 Jun 09.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH Terms: Brain-Derived Neurotrophic Factor*/metabolism , Phytochemicals*/therapeutic use , Phytochemicals*/pharmacology , Antidepressive Agents*/pharmacology , Antidepressive Agents*/therapeutic use , Depressive Disorder, Major*/drug therapy , Depressive Disorder, Major*/metabolism, Humans ; Animals ; Signal Transduction/drug effects