Search Results - "PHOSPHORYLATION"

DYRK1A-TGF-β signaling axis determines sensitivity to OXPHOS inhibition in hepatocellular carcinoma.

Authors: Cao Y Qian R Yao R et al.

Source: Developmental cell [Dev Cell] 2025 May 19; Vol. 60 (10), pp. 1483-1497.e7. Date of Electronic Publication: 2025 Jan 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE

MeSH Terms: Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/genetics , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/genetics , Protein-Tyrosine Kinases*/metabolism , Protein-Tyrosine Kinases*/genetics , Protein-Tyrosine Kinases*/antagonists & inhibitors , Transforming Growth Factor beta*/metabolism , Oxidative Phosphorylation*/drug effects, Dyrk Kinases ; Humans ; Animals ; Signal Transduction/drug effects ; Mice ; Mitochondria/metabolism ; Mitochondria/drug effects ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Phosphorylation ; Pyrazoles ; Quinolines

A protet-based model that can account for energy coupling in oxidative and photosynthetic phosphorylation.

Authors: Kell DB; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, L69 7ZB, UK; The Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kgs Lyngby, Denmark; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, Private Bag X1, Matieland, 7602, South Africa. Electronic address: dbk@liv.ac.uk.

Source: Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2024 Nov 01; Vol. 1865 (4), pp. 149504. Date of Electronic Publication: 2024 Aug 15.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2650 (Electronic) Linking ISSN: 00052728 NLM ISO Abbreviation: Biochim Biophys Acta Bioenerg Subsets: MEDLINE

MeSH Terms: Photosynthesis* , Oxidative Phosphorylation*, Phosphorylation ; Electron Transport ; Models, Biological ; Energy Metabolism ; Proton-Motive Force

Androgen Receptors Promote Oxidative Phosphorylation and Resistance to Palmitate Lipotoxicity in ER-Mutant Breast Cancer.

Authors: Sessions DT Boulton DP Spoelstra NS et al.

Source: Endocrinology [Endocrinology] 2025 Dec 05; Vol. 167 (1).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

MeSH Terms: Receptors, Androgen*/metabolism , Receptors, Androgen*/genetics , Breast Neoplasms*/metabolism , Breast Neoplasms*/genetics , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Oxidative Phosphorylation*/drug effects , Receptors, Estrogen*/genetics , Receptors, Estrogen*/metabolism , Palmitates*/toxicity, Humans ; Female ; Cell Line, Tumor ; Nitriles ; Carnitine O-Palmitoyltransferase/metabolism ; Carnitine O-Palmitoyltransferase/genetics ; MCF-7 Cells ; Benzamides ; Drug Resistance, Neoplasm ; Mutation ; Mitochondria/metabolism ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/pharmacology ; Signal Transduction

SSR4 Promote Gastric Cancer Progression by Regulating Mitochondrial Oxidative Phosphorylation via NDUFB11 and ATP6AP1.

Authors: Li A Liao B Wu K et al.

Source: Molecular carcinogenesis [Mol Carcinog] 2025 Dec; Vol. 64 (12), pp. 2026-2036. Date of Electronic Publication: 2025 Sep 25.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8811105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2744 (Electronic) Linking ISSN: 08991987 NLM ISO Abbreviation: Mol Carcinog Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/pathology , Stomach Neoplasms*/metabolism , Stomach Neoplasms*/genetics , Oxidative Phosphorylation* , Mitochondria*/metabolism , Mitochondria*/genetics , Electron Transport Complex I*/metabolism , Electron Transport Complex I*/genetics , Mitochondrial Proton-Translocating ATPases*/metabolism , Mitochondrial Proton-Translocating ATPases*/genetics, Humans ; Animals ; Mice ; Gene Expression Regulation, Neoplastic ; Disease Progression ; Cell Line, Tumor ; Male ; Female ; Cell Proliferation ; Mice, Nude

Dual inhibition of oxidative phosphorylation and glycolysis using a hyaluronic acid nanoparticle NOX inhibitor enhanced response to radiotherapy in colorectal cancer.

Authors: Zhang L Liu T Chen M et al.

Source: Biomaterials [Biomaterials] 2025 Dec; Vol. 323, pp. 123437. Date of Electronic Publication: 2025 May 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

MeSH Terms: Hyaluronic Acid*/chemistry , Glycolysis*/drug effects , Glycolysis*/radiation effects , Colorectal Neoplasms*/radiotherapy , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/drug therapy , Nanoparticles*/chemistry , Oxidative Phosphorylation*/drug effects , NADPH Oxidases*/antagonists & inhibitors , NADPH Oxidases*/metabolism, Animals ; Humans ; Mice ; Cell Line, Tumor ; Reactive Oxygen Species/metabolism ; Cell Proliferation/drug effects ; Apoptosis/drug effects ; Mitochondria/metabolism ; Mitochondria/drug effects ; Pyridones ; Pyrazolones

Single-cell transcriptomics reveal oxidative phosphorylation and oxidative stress in the superior temporal plane of non-syndromic cleft lip and palate fetuses.

Authors: Fang C Huang X Wang Q et al.

Source: Life sciences [Life Sci] 2025 Nov 15; Vol. 381, pp. 123922. Date of Electronic Publication: 2025 Aug 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

MeSH Terms: Oxidative Stress*/genetics , Cleft Palate*/genetics , Cleft Palate*/metabolism , Cleft Palate*/pathology , Cleft Lip*/genetics , Cleft Lip*/metabolism , Cleft Lip*/pathology , Oxidative Phosphorylation* , Transcriptome*, Humans ; Female ; Pregnancy ; Single-Cell Analysis/methods ; Fetus/metabolism ; Brain/metabolism ; Brain/embryology

Metabolic Plasticity and Cancer Stem Cell Metabolism: Exploring the Glycolysis-OXPHOS Switch as a Mechanism for Resistance and Tumorigenesis.

Authors: Keoh LQ Chiu CF Ramasamy TS

Source: Stem cell reviews and reports [Stem Cell Rev Rep] 2025 Nov; Vol. 21 (8), pp. 2446-2468. Date of Electronic Publication: 2025 Aug 29.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101752767 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2629-3277 (Electronic) Linking ISSN: 26293277 NLM ISO Abbreviation: Stem Cell Rev Rep Subsets: MEDLINE

MeSH Terms: Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Glycolysis* , Oxidative Phosphorylation* , Drug Resistance, Neoplasm* , Carcinogenesis*/metabolism , Carcinogenesis*/pathology , Neoplasms*/metabolism , Neoplasms*/pathology, Humans ; Animals ; Tumor Microenvironment

OXPHOS complex deficiency in congenital myopathy: A systematic review.

Authors: du Preez MJ Schoonen M Williams ME et al.

Source: European journal of clinical investigation [Eur J Clin Invest] 2025 Nov; Vol. 55 (11), pp. e70114. Date of Electronic Publication: 2025 Sep 11.

Publication Type: Journal Article; Systematic Review; Review

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2362 (Electronic) Linking ISSN: 00142972 NLM ISO Abbreviation: Eur J Clin Invest Subsets: MEDLINE

MeSH Terms: Oxidative Phosphorylation* , Mitochondrial Diseases*/genetics , Myotonia Congenita*/genetics, Humans ; Ryanodine Receptor Calcium Release Channel/genetics

Apelin-13 treats postmenopausal osteoporosis by reducing mitochondrial oxidative phosphorylation and modulating the OPG/RANK/RANKL/IGF-1 pathway.

Authors: Meng X Meng D Xiang C et al.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Oct 30; Vol. 786, pp. 152738. Date of Electronic Publication: 2025 Sep 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Osteoporosis, Postmenopausal*/drug therapy , Osteoporosis, Postmenopausal*/metabolism , Osteoporosis, Postmenopausal*/pathology , Mitochondria*/metabolism , Mitochondria*/drug effects , Oxidative Phosphorylation*/drug effects , Intercellular Signaling Peptides and Proteins*/pharmacology , Intercellular Signaling Peptides and Proteins*/therapeutic use, Animals ; Mice ; RANK Ligand/metabolism ; Signal Transduction/drug effects ; Insulin-Like Growth Factor I/metabolism ; Female ; Osteoprotegerin/metabolism ; Receptor Activator of Nuclear Factor-kappa B/metabolism ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteogenesis/drug effects ; Cell Line ; Reactive Oxygen Species/metabolism ; Apoptosis/drug effects ; Humans ; Cell Proliferation/drug effects ; Dexamethasone/pharmacology

Quiescent OXPHOS-High Triple-Negative Breast Cancer Cells That Persist After Chemotherapy Depend on BCL-XL for Survival.

Authors: Andrzejewski S Winter M Encarnacao Garcia L et al.

Source: Cells [Cells] 2025 Oct 08; Vol. 14 (19). Date of Electronic Publication: 2025 Oct 08.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH Terms: Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/genetics , bcl-X Protein*/metabolism , bcl-X Protein*/genetics , Oxidative Phosphorylation*/drug effects, Humans ; Female ; Cell Line, Tumor ; Animals ; Mitochondria/metabolism ; Mitochondria/drug effects ; Cell Survival/drug effects ; Mice ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Xenograft Model Antitumor Assays ; Apoptosis/drug effects

Integrated transcriptomics unveils mitochondrial oxidative phosphorylation dysfunction as a shared mechanism in sarcopenia and obesity.

Authors: Yu R Miao L Wang J et al.

Source: Scientific reports [Sci Rep] 2025 Oct 06; Vol. 15 (1), pp. 34810. Date of Electronic Publication: 2025 Oct 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Sarcopenia*/genetics , Sarcopenia*/metabolism , Sarcopenia*/pathology , Obesity*/genetics , Obesity*/metabolism , Obesity*/pathology , Oxidative Phosphorylation* , Transcriptome* , Mitochondria*/metabolism , Mitochondria*/genetics, Humans ; Protein Interaction Maps ; Gene Expression Profiling ; Computational Biology/methods ; Gene Regulatory Networks ; Muscle, Skeletal/metabolism

Molecular Profiling of Belumosudil-Treated IOMM-Lee Meningioma Cells Reveals Repurposing Potential via Enhanced Oxidative Phosphorylation and ROS-Mediated Cell Death.

Authors: Halder A Maitra A Attrish D et al.

Source: Journal of proteome research [J Proteome Res] 2025 Oct 03; Vol. 24 (10), pp. 4935-4951. Date of Electronic Publication: 2025 Sep 13.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE

MeSH Terms: Reactive Oxygen Species*/metabolism , Drug Repositioning* , Oxidative Phosphorylation*/drug effects , Meningioma*/drug therapy , Meningioma*/metabolism , Meningioma*/pathology , 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine*/analogs & derivatives , 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine*/pharmacology , Meningeal Neoplasms*/metabolism , Meningeal Neoplasms*/drug therapy , Meningeal Neoplasms*/pathology, Humans ; Cell Line, Tumor ; Mitochondria/metabolism ; Mitochondria/drug effects ; Cell Death/drug effects ; Signal Transduction/drug effects ; rho-Associated Kinases/antagonists & inhibitors ; Cell Proliferation/drug effects

The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity-Induced Oocyte Maturation Arrest.

Authors: Ge L Gao Y Du F et al.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Oct; Vol. 12 (38), pp. e05570. Date of Electronic Publication: 2025 Jul 18.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Oocytes*/metabolism , Mitochondria*/metabolism , Weightlessness Simulation*/methods , Oxidative Phosphorylation*, Animals ; Mice ; Female ; Meiosis/physiology

Discovery and optimization of oxidative phosphorylation inhibitors from a phenotypic screen.

Authors: El Shemerly M Richalet F Robay D et al.

Source: Anti-cancer drugs [Anticancer Drugs] 2025 Oct 01; Vol. 36 (9), pp. 731-741. Date of Electronic Publication: 2025 Jun 20.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9100823 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5741 (Electronic) Linking ISSN: 09594973 NLM ISO Abbreviation: Anticancer Drugs Subsets: MEDLINE

MeSH Terms: Oxidative Phosphorylation*/drug effects , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacokinetics, Animals ; Humans ; Female ; Mice ; Drug Discovery ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Monocarboxylic Acid Transporters/metabolism ; Muscle Proteins/metabolism ; High-Throughput Screening Assays ; Mice, Nude ; Mitochondria/metabolism ; Mitochondria/drug effects ; Cell Proliferation/drug effects

Dominant negative ATP5F1A variants disrupt oxidative phosphorylation causing neurological disorders.

Authors: Fielder SM Friederich MW Hock DH et al.

Corporate Authors: Fielder SM Friederich MW Hock DH et al.

Source: EMBO molecular medicine [EMBO Mol Med] 2025 Oct; Vol. 17 (10), pp. 2562-2585. Date of Electronic Publication: 2025 Aug 26.

Publication Type: Journal Article

Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE

MeSH Terms: Oxidative Phosphorylation* , Mitochondrial Proton-Translocating ATPases*/genetics , Mitochondrial Proton-Translocating ATPases*/metabolism , Nervous System Diseases*/genetics , Nervous System Diseases*/pathology, Humans ; Male ; Female ; Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Mutation, Missense ; Child ; Mitochondria/metabolism ; Child, Preschool

NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis.

Authors: Fu H Zhang J Chen H et al.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Oct; Vol. 12 (37), pp. e03233. Date of Electronic Publication: 2025 Jun 20.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/metabolism , Stomach Neoplasms*/pathology , Stomach Neoplasms*/genetics , Lipolysis*/genetics , Lipolysis*/physiology , Oxidative Phosphorylation* , Mitochondria*/metabolism , Mitochondria*/genetics , Receptors, Atrial Natriuretic Factor*/metabolism , Receptors, Atrial Natriuretic Factor*/genetics , Lipid Droplets*/metabolism, Humans ; Mice ; Cell Line, Tumor ; Animals ; Male ; Lymphatic Metastasis ; Female

Gene therapy and mRNA drugs approach for mitochondrial OXPHOS deficiencies.

Authors: Garone C Sabeni S Carli S

Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Dec 03; Vol. 33 (12), pp. 5996-6024. Date of Electronic Publication: 2025 Sep 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH Terms: Mitochondrial Diseases*/therapy , Mitochondrial Diseases*/genetics , Mitochondrial Diseases*/metabolism , Genetic Therapy*/methods , Oxidative Phosphorylation*/drug effects , Mitochondria*/metabolism , Mitochondria*/genetics , RNA, Messenger*/genetics , RNA, Messenger*/therapeutic use, Humans ; Animals ; DNA, Mitochondrial/genetics ; Gene Editing

SQLE drives bladder cancer progression by boosting mitochondrial oxidative phosphorylation.

Authors: Dong Y Jiang X Yang X et al.

Source: Oncogene [Oncogene] 2025 Dec; Vol. 44 (49), pp. 4796-4813. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

MeSH Terms: Urinary Bladder Neoplasms*/pathology , Urinary Bladder Neoplasms*/metabolism , Urinary Bladder Neoplasms*/genetics , Mitochondria*/metabolism , Mitochondria*/pathology , Oxidative Phosphorylation*/drug effects , Squalene Monooxygenase*/metabolism , Squalene Monooxygenase*/genetics, Animals ; Humans ; Mice ; Disease Progression ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Reactive Oxygen Species/metabolism ; Cell Line, Tumor ; Mitochondrial Proteins/metabolism ; Mitochondrial Proteins/genetics ; Mice, Transgenic ; DNA-Binding Proteins/metabolism ; Female

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early-Onset of Breast Cancer.

Authors: Hu DW Huang CH He YH et al.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Dec; Vol. 12 (45), pp. e10811. Date of Electronic Publication: 2025 Sep 17.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/metabolism , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Oxidative Phosphorylation*/drug effects , Mitochondrial Dynamics*/genetics , Mitochondrial Dynamics*/drug effects , Neoplastic Stem Cells*/metabolism, Humans ; Female ; Animals ; Mice ; Diethylhexyl Phthalate ; Mitochondria/metabolism ; Cell Line, Tumor

Nucleoside diphosphate kinase strongly promotes GDP and ADP metabolism in the cell and affects endogenous proton leak in mitochondria - the kinase is hampered by oxidative phosphorylation inhibitors.

Authors: Woyda-Ploszczyca AM; Department of Bioenergetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland.

Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2520611. Date of Electronic Publication: 2025 Jul 17.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH Terms: Oxidative Phosphorylation*/drug effects , Mitochondria*/metabolism , Mitochondria*/drug effects , Nucleoside-Diphosphate Kinase*/metabolism , Nucleoside-Diphosphate Kinase*/antagonists & inhibitors , Adenosine Diphosphate*/metabolism , Guanosine Diphosphate*/metabolism , Saccharomyces cerevisiae*/metabolism , Saccharomyces cerevisiae*/drug effects , Saccharomyces cerevisiae*/enzymology , Protons*, Molecular Structure ; Dose-Response Relationship, Drug ; Structure-Activity Relationship