Výsledky vyhledávání - "PHOSPHATASES"

Disruption of the Clock Component BMAL1 in HDM-induced Asthma Causes GC Resistance in Airway Epithelial Cells by Regulating GR Phosphorylation through the DUSP4-p38MAPK Pathway.

Autoři: Huang H Liao H Chen Y a další

Zdroj: International journal of biological sciences [Int J Biol Sci] 2025 Oct 10; Vol. 21 (14), pp. 6482-6500. Date of Electronic Publication: 2025 Oct 10 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: ARNTL Transcription Factors*/metabolism , ARNTL Transcription Factors*/genetics , Asthma*/metabolism , p38 Mitogen-Activated Protein Kinases*/metabolism , p38 Mitogen-Activated Protein Kinases*/genetics , Receptors, Glucocorticoid*/metabolism , Dual-Specificity Phosphatases*/metabolism , Glucocorticoids*/pharmacology , Mitogen-Activated Protein Kinase Phosphatases*/metabolism, Animals ; Phosphorylation ; Mice ; Epithelial Cells/metabolism ; Humans ; Mice, Inbred C57BL ; Protein Tyrosine Phosphatases

Mutational and expression analysis of classical protein tyrosine phosphatase genes in pancreatic ductal adenocarcinoma.

Autoři: Naeem M Ahmed K Sultan A

Zdroj: Computers in biology and medicine [Comput Biol Med] 2025 Jul; Vol. 193, pp. 110319. Date of Electronic Publication: 2025 May 21.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1250250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0534 (Electronic) Linking ISSN: 00104825 NLM ISO Abbreviation: Comput Biol Med Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/enzymology , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/enzymology , Gene Expression Regulation, Neoplastic* , Mutation* , Protein Tyrosine Phosphatases*/genetics , Neoplasm Proteins*/genetics , Neoplasm Proteins*/biosynthesis, Humans ; Male ; Female ; Middle Aged ; Aged ; Protein Tyrosine Phosphatase, Non-Receptor Type 12/genetics ; Exome Sequencing ; Receptor-Like Protein Tyrosine Phosphatases, Class 5/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 3/genetics ; Gene Expression Profiling ; Receptor-Like Protein Tyrosine Phosphatases, Class 2

The Protective Role of DUSP4 in Retinal Pigment Epithelium Senescence and Degeneration.

Autoři: Liu X Ni Z Zhang J a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Apr 15; Vol. 26 (8). Date of Electronic Publication: 2025 Apr 15.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Retinal Pigment Epithelium*/metabolism , Retinal Pigment Epithelium*/pathology , Dual-Specificity Phosphatases*/metabolism , Dual-Specificity Phosphatases*/genetics , Cellular Senescence*/genetics , Mitogen-Activated Protein Kinase Phosphatases*/metabolism , Mitogen-Activated Protein Kinase Phosphatases*/genetics , Macular Degeneration*/metabolism , Macular Degeneration*/pathology , Macular Degeneration*/genetics, Animals ; Mice ; Humans ; Disease Models, Animal ; Mice, Inbred C57BL ; Signal Transduction ; Mice, Knockout ; NF-kappa B/metabolism ; Cell Line ; Protein Tyrosine Phosphatases

Mitogen-Activated Protein Kinase Phosphatase-5 is Required for TGF-β Signaling Through a JNK-Dependent Pathway.

Autoři: Dorry S Perla S Bennett AM

Zdroj: Molecular and cellular biology [Mol Cell Biol] 2025 Jan; Vol. 45 (1), pp. 17-31. Date of Electronic Publication: 2024 Nov 28.

Způsob vydávání: Journal Article; Research Support, N.I.H., Extramural

Informace o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 8109087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5549 (Electronic) Linking ISSN: 02707306 NLM ISO Abbreviation: Mol Cell Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Transforming Growth Factor beta*/metabolism , Dual-Specificity Phosphatases*/metabolism , Dual-Specificity Phosphatases*/genetics , Fibroblasts*/metabolism , MAP Kinase Signaling System*, Animals ; Mice ; Phosphorylation ; Smad2 Protein/metabolism ; Signal Transduction ; JNK Mitogen-Activated Protein Kinases/metabolism ; Fibrosis/metabolism ; Humans ; Mitogen-Activated Protein Kinase Phosphatases/metabolism ; Mitogen-Activated Protein Kinase Phosphatases/genetics

A monoamine oxidase B inhibitor altered gene expression of catalytically active dual-specificity phosphatases in human oral gingival keratinocytes.

Autoři: Ostadkarampour M Putnins EE

Zdroj: European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2024 Dec; Vol. 28 (24), pp. 4681-4690.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Verduci Country of Publication: Italy NLM ID: 9717360 Publication Model: Print Cited Medium: Internet ISSN: 2284-0729 (Electronic) Linking ISSN: 11283602 NLM ISO Abbreviation: Eur Rev Med Pharmacol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Gingiva*/metabolism , Gingiva*/cytology , Keratinocytes*/drug effects , Keratinocytes*/metabolism , Dual-Specificity Phosphatases*/genetics , Dual-Specificity Phosphatases*/metabolism , Monoamine Oxidase Inhibitors*/pharmacology, Humans ; Mitogen-Activated Protein Kinase Phosphatases/metabolism ; Mitogen-Activated Protein Kinase Phosphatases/genetics ; Cells, Cultured ; Lipopolysaccharides/pharmacology ; Dual Specificity Phosphatase 6/metabolism ; Dual Specificity Phosphatase 6/genetics ; Monoamine Oxidase/metabolism ; Monoamine Oxidase/genetics ; Porphyromonas gingivalis

Inhibiting TRIM8 alleviates adipocyte inflammation and insulin resistance by regulating the DUSP14/MAPKs pathway.

Autoři: Zhu M Pu J Zhang T a další

Zdroj: Adipocyte [Adipocyte] 2024 Dec; Vol. 13 (1), pp. 2381262. Date of Electronic Publication: 2024 Jul 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101567863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-397X (Electronic) Linking ISSN: 21623945 NLM ISO Abbreviation: Adipocyte Subsets: MEDLINE

Výrazy ze slovníku MeSH: Insulin Resistance* , Adipocytes*/metabolism , Inflammation*/metabolism , Dual-Specificity Phosphatases*/metabolism , Dual-Specificity Phosphatases*/genetics, Animals ; Mice ; MAP Kinase Signaling System ; 3T3-L1 Cells ; Signal Transduction ; Mitogen-Activated Protein Kinase Phosphatases/metabolism ; Mitogen-Activated Protein Kinase Phosphatases/genetics ; Mice, Inbred C57BL

Targeting DUSP26 to drive cardiac mitochondrial dynamics via FAK-ERK signaling in diabetic cardiomyopathy.

Autoři: Liu C Xu X Sun G a další

Zdroj: Free radical biology & medicine [Free Radic Biol Med] 2024 Nov 20; Vol. 225, pp. 856-870. Date of Electronic Publication: 2024 Nov 05.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

Výrazy ze slovníku MeSH: Diabetic Cardiomyopathies*/metabolism , Diabetic Cardiomyopathies*/pathology , Diabetic Cardiomyopathies*/genetics , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/pathology , Dual-Specificity Phosphatases*/metabolism , Dual-Specificity Phosphatases*/genetics , Mitochondrial Dynamics* , MAP Kinase Signaling System* , Focal Adhesion Kinase 1*/metabolism , Focal Adhesion Kinase 1*/genetics, Animals ; Mice ; Male ; Humans ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Experimental/complications ; Mitogen-Activated Protein Kinase Phosphatases/metabolism ; Mitogen-Activated Protein Kinase Phosphatases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Extracellular Signal-Regulated MAP Kinases/genetics ; Mitochondria, Heart/metabolism ; Mitochondria, Heart/pathology ; Mitochondria, Heart/genetics ; Mice, Inbred C57BL

An emerging role of STriatal-Enriched protein tyrosine Phosphatase in hyperexcitability-associated brain disorders.

Autoři: Walters JM Noblet HA Chung HJ

Zdroj: Neurobiology of disease [Neurobiol Dis] 2024 Oct 01; Vol. 200, pp. 106641. Date of Electronic Publication: 2024 Aug 17.

Způsob vydávání: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Informace o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

Výrazy ze slovníku MeSH: Protein Tyrosine Phosphatases, Non-Receptor*/metabolism , Protein Tyrosine Phosphatases, Non-Receptor*/genetics, Animals ; Humans ; Brain Diseases/metabolism ; Brain Diseases/physiopathology ; Synaptic Transmission/physiology ; Seizures/metabolism ; Seizures/physiopathology ; Neurons/metabolism ; Protein Tyrosine Phosphatases/metabolism ; Protein Tyrosine Phosphatases/genetics

Regulatory roles of MKP7/DUSP16 in cancer.

Autoři: Chen S Karekad MMA Yan J a další

Zdroj: Medical oncology (Northwood, London, England) [Med Oncol] 2025 Dec 01; Vol. 43 (1), pp. 28. Date of Electronic Publication: 2025 Dec 01.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Neoplasms*/pathology , Neoplasms*/metabolism , Dual-Specificity Phosphatases*/metabolism , Dual-Specificity Phosphatases*/genetics , Mitogen-Activated Protein Kinase Phosphatases*/metabolism, Humans ; Animals ; Cell Proliferation ; Apoptosis ; MAP Kinase Signaling System

Atypical phosphatase DUSP11 inhibition promotes nc886 expression and potentiates gemcitabine-mediated cell death through NF-kB modulation.

Autoři: Santos VS Vieira GM Ruckert MT a další

Zdroj: Cancer gene therapy [Cancer Gene Ther] 2024 Sep; Vol. 31 (9), pp. 1402-1411. Date of Electronic Publication: 2024 Jul 24.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9432230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5500 (Electronic) Linking ISSN: 09291903 NLM ISO Abbreviation: Cancer Gene Ther Subsets: MEDLINE

Výrazy ze slovníku MeSH: Deoxycytidine*/analogs & derivatives , Deoxycytidine*/pharmacology , Dual-Specificity Phosphatases*/genetics , Dual-Specificity Phosphatases*/metabolism , Gemcitabine* , NF-kappa B*/metabolism , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/pathology, Humans ; Apoptosis/drug effects ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Death/drug effects ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects ; Mitogen-Activated Protein Kinase Phosphatases/metabolism ; Mitogen-Activated Protein Kinase Phosphatases/genetics

Let-7c-5p Down Regulates the Proliferation of Colorectal Cancer Through the MAPK-ERK-Signaling Pathway.

Autoři: Fu J Zhou L Li S a další

Zdroj: Biochemical genetics [Biochem Genet] 2024 Aug; Vol. 62 (4), pp. 3231-3243. Date of Electronic Publication: 2023 Dec 14.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4927 (Electronic) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE

Výrazy ze slovníku MeSH: Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , MicroRNAs*/genetics , MicroRNAs*/metabolism , Cell Proliferation* , MAP Kinase Signaling System* , Dual-Specificity Phosphatases*/genetics , Dual-Specificity Phosphatases*/metabolism, Humans ; Gene Expression Regulation, Neoplastic ; Down-Regulation ; Female ; Cell Line, Tumor ; Prognosis ; Mitogen-Activated Protein Kinase Phosphatases/metabolism ; Mitogen-Activated Protein Kinase Phosphatases/genetics ; Male

Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer.

Autoři: Zhou X Wang G Tian C a další

Zdroj: Nature communications [Nat Commun] 2024 Jul 12; Vol. 15 (1), pp. 5851. Date of Electronic Publication: 2024 Jul 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/pathology , Cholesterol*/biosynthesis , Cholesterol*/metabolism , Dual-Specificity Phosphatases*/genetics , Dual-Specificity Phosphatases*/metabolism , Dual-Specificity Phosphatases*/antagonists & inhibitors , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/drug effects, Animals ; Mice ; Humans ; Cell Line, Tumor ; Tumor Microenvironment/immunology ; Tumor Microenvironment/drug effects ; Mitogen-Activated Protein Kinase Phosphatases/genetics ; Mitogen-Activated Protein Kinase Phosphatases/metabolism ; Tumor Escape/drug effects ; Tumor Escape/genetics ; Female

The E3 ligase tripartite motif 7 drives the progression of non-alcoholic fatty liver disease by targeting DUSP10 degradation in male mice.

Autoři: Yan FJ Ding H Zhang N a další

Zdroj: Nature communications [Nat Commun] 2025 Nov 25; Vol. 16 (1), pp. 10437. Date of Electronic Publication: 2025 Nov 25.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Non-alcoholic Fatty Liver Disease*/metabolism , Non-alcoholic Fatty Liver Disease*/pathology , Non-alcoholic Fatty Liver Disease*/genetics , Dual-Specificity Phosphatases*/metabolism , Dual-Specificity Phosphatases*/genetics , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics , Mitogen-Activated Protein Kinase Phosphatases*/metabolism , Mitogen-Activated Protein Kinase Phosphatases*/genetics , Tripartite Motif Proteins*/metabolism , Tripartite Motif Proteins*/genetics, Animals ; Male ; Mice ; Humans ; Liver/pathology ; Liver/metabolism ; Ubiquitination ; Mice, Inbred C57BL ; Disease Models, Animal ; Disease Progression ; Mice, Knockout ; Proteolysis ; Insulin Resistance ; Hepatocytes/metabolism ; Diet, High-Fat/adverse effects

Targeting Protein Tyrosine Phosphatases via PROteolysis-TArgeting Chimeras (PROTACs): Current Developments and Prospects.

Autoři: Maccari R; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.

Zdroj: Molecules (Basel, Switzerland) [Molecules] 2025 Nov 18; Vol. 30 (22). Date of Electronic Publication: 2025 Nov 18.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Výrazy ze slovníku MeSH: Proteolysis*/drug effects , Protein Tyrosine Phosphatases*/antagonists & inhibitors , Protein Tyrosine Phosphatases*/metabolism , Protein Tyrosine Phosphatases*/chemistry , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology, Humans ; Animals ; Proteolysis Targeting Chimera

DUSP11 is an Intracellular Innate Immune Checkpoint in Lung Adenocarcinoma.

Autoři: Thomas BJ Bai X Cryer BJ a další

Zdroj: Cancer immunology research [Cancer Immunol Res] 2025 Nov 03; Vol. 13 (11), pp. 1798-1815.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Immunity, Innate* , Lung Neoplasms*/immunology , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Lung Neoplasms*/genetics , Dual-Specificity Phosphatases*/metabolism , Dual-Specificity Phosphatases*/genetics , Dual-Specificity Phosphatases*/immunology , Adenocarcinoma of Lung*/immunology , Adenocarcinoma of Lung*/pathology , Adenocarcinoma of Lung*/metabolism , Adenocarcinoma of Lung*/genetics , Mitogen-Activated Protein Kinase Phosphatases*/metabolism , Mitogen-Activated Protein Kinase Phosphatases*/genetics, Humans ; Animals ; Mice ; Cell Line, Tumor ; Apoptosis ; Female

Plumbagin activates NLRP3/caspase-1/GSDMD-mediated pyroptosis by decreasing DUSP4 expression to exhibit anticancer property in cholangiocarcinoma.

Autoři: Song F Wei L Wu J a další

Zdroj: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2025 Nov; Vol. 504, pp. 117492. Date of Electronic Publication: 2025 Jul 29.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pyroptosis*/drug effects , Cholangiocarcinoma*/drug therapy , Cholangiocarcinoma*/pathology , Cholangiocarcinoma*/metabolism , Cholangiocarcinoma*/enzymology , Caspase 1*/metabolism , Naphthoquinones*/pharmacology , Naphthoquinones*/therapeutic use , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/genetics , Bile Duct Neoplasms*/drug therapy , Bile Duct Neoplasms*/pathology , Bile Duct Neoplasms*/enzymology , Mitogen-Activated Protein Kinase Phosphatases*/metabolism , Mitogen-Activated Protein Kinase Phosphatases*/genetics , Dual-Specificity Phosphatases*/metabolism , Dual-Specificity Phosphatases*/genetics , Phosphate-Binding Proteins*/metabolism , Phosphate-Binding Proteins*/genetics , Intracellular Signaling Peptides and Proteins*/metabolism , Intracellular Signaling Peptides and Proteins*/genetics , Antineoplastic Agents, Phytogenic*/pharmacology, Animals ; Humans ; Cell Line, Tumor ; Mice ; Male ; Gasdermins

The novel role of DUSP4 in suppressing ferroptosis and promoting cytotoxicity of CD8 ⁺ T cells in MSI colorectal cancer.

Autoři: Zhang D Yang S Xu H a další

Zdroj: British journal of cancer [Br J Cancer] 2025 Nov; Vol. 133 (8), pp. 1096-1110. Date of Electronic Publication: 2025 Aug 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE

Výrazy ze slovníku MeSH: Ferroptosis*/immunology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , CD8-Positive T-Lymphocytes*/immunology , Mitogen-Activated Protein Kinase Phosphatases*/metabolism , Mitogen-Activated Protein Kinase Phosphatases*/genetics , Dual-Specificity Phosphatases*/metabolism , Dual-Specificity Phosphatases*/genetics , Microsatellite Instability*, Humans ; Animals ; Mice ; Cell Line, Tumor ; Female ; Male ; Gene Expression Regulation, Neoplastic

Structural analysis of dual specificity phosphatases, the only type of protein tyrosine phosphatases found in humans and across diverse microorganisms.

Autoři: Ku B; Orphan Disease Therapeutic Target Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.

Zdroj: Journal of microbiology (Seoul, Korea) [J Microbiol] 2025 Oct; Vol. 63 (10), pp. e2506006. Date of Electronic Publication: 2025 Oct 31.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Microbiological Society Of Korea Country of Publication: Korea (South) NLM ID: 9703165 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1976-3794 (Electronic) Linking ISSN: 12258873 NLM ISO Abbreviation: J Microbiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Bacteria*/enzymology , Bacteria*/genetics , Dual-Specificity Phosphatases*/chemistry , Dual-Specificity Phosphatases*/metabolism , Dual-Specificity Phosphatases*/genetics , Viruses*/enzymology , Viruses*/genetics , Protein Tyrosine Phosphatases*/chemistry , Protein Tyrosine Phosphatases*/metabolism , Protein Tyrosine Phosphatases*/genetics, Humans ; Archaea/enzymology ; Archaea/genetics ; Catalytic Domain ; Substrate Specificity ; Amino Acid Sequence ; Protein Conformation

Bta-miR-25 alleviates lipopolysaccharide-induced endometritis in cows by targeting DUSP10 to inhibit MAPK signaling.

Autoři: Zhang Z Wang X Shi QT a další

Zdroj: Molecular immunology [Mol Immunol] 2025 Oct; Vol. 186, pp. 39-47. Date of Electronic Publication: 2025 Aug 14.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol Immunol Subsets: MEDLINE

Výrazy ze slovníku MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , Endometritis*/chemically induced , Endometritis*/genetics , Endometritis*/veterinary , Endometritis*/metabolism , Endometritis*/immunology , MAP Kinase Signaling System*/genetics , MAP Kinase Signaling System*/immunology , Dual-Specificity Phosphatases*/genetics , Dual-Specificity Phosphatases*/metabolism , Cattle Diseases*/genetics , Cattle Diseases*/immunology , Mitogen-Activated Protein Kinase Phosphatases*/genetics , Mitogen-Activated Protein Kinase Phosphatases*/metabolism, Animals ; Cattle ; Female ; Lipopolysaccharides ; Cytokines/metabolism

Mycobacterial Tyrosine Phosphatase PtpB Affects Host Cytokine Expression by Dephosphorylating ERK1/2 and STAT3.

Autoři: Liu T Fan Y Chen Y a další

Zdroj: Molecular & cellular proteomics : MCP [Mol Cell Proteomics] 2025 Oct; Vol. 24 (10), pp. 101067. Date of Electronic Publication: 2025 Sep 09.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 101125647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-9484 (Electronic) Linking ISSN: 15359476 NLM ISO Abbreviation: Mol Cell Proteomics Subsets: MEDLINE

Výrazy ze slovníku MeSH: STAT3 Transcription Factor*/metabolism , Protein Tyrosine Phosphatases*/metabolism , Protein Tyrosine Phosphatases*/genetics , Mycobacterium tuberculosis*/enzymology , Mitogen-Activated Protein Kinase 3*/metabolism , Cytokines*/metabolism , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Mitogen-Activated Protein Kinase 1*/metabolism, Phosphorylation ; Animals ; Mice ; Humans ; Host-Pathogen Interactions ; Interleukin-1beta/metabolism