Search Results - "PHENYLALANINE AMMONIA-LYASE"

Optimizing germination to enhance antioxidant and nutritional quality of sunflower seed oil: Role of phenylalanine ammonia-lyase.

Authors: Lin Z Zhao Z Yao Z et al.

Source: Food chemistry [Food Chem] 2025 Nov 30; Vol. 493 (Pt 2), pp. 145773. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Phenylalanine Ammonia-Lyase*/metabolism , Phenylalanine Ammonia-Lyase*/chemistry , Seeds*/growth & development , Seeds*/enzymology , Seeds*/chemistry , Seeds*/metabolism , Antioxidants*/metabolism , Antioxidants*/chemistry , Antioxidants*/analysis , Helianthus*/growth & development , Helianthus*/enzymology , Helianthus*/chemistry , Plant Proteins*/metabolism , Plant Proteins*/chemistry , Plant Proteins*/genetics , Sunflower Oil*/chemistry , Sunflower Oil*/metabolism , Plant Oils*/chemistry , Plant Oils*/metabolism, Germination ; Nutritive Value ; Molecular Docking Simulation

Switching Enantioselectivity in Phenylalanine Ammonia Lyase for the Synthesis of Electron-Deficient Aromatic d-Amino Acids.

Authors: Buslov I Desmons S Wang W et al.

Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Oct 20; Vol. 64 (43), pp. e202511739. Date of Electronic Publication: 2025 Sep 12.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH Terms: Phenylalanine Ammonia-Lyase*/metabolism , Phenylalanine Ammonia-Lyase*/chemistry , Phenylalanine Ammonia-Lyase*/genetics , Amino Acids, Aromatic*/chemistry , Amino Acids, Aromatic*/chemical synthesis , Amino Acids, Aromatic*/metabolism , Amino Acids, Aromatic*/biosynthesis, Stereoisomerism ; Electrons ; Biocatalysis ; Catalytic Domain

The TaNAC29L-B-TaNAC1L-A module negatively regulates wheat sharp eyespot resistance by reducing lignin content though the phenylalanine ammonia-lyase gene TaPAL4-B.

Authors: Gao Z Sun M Shao C et al.

Source: The Plant journal : for cell and molecular biology [Plant J] 2025 Dec; Vol. 124 (5), pp. e70582.

Publication Type: Journal Article

Journal Info: Publisher: Blackwell Scientific Publishers and BIOS Scientific Publishers in association with the Society for Experimental Biology Country of Publication: England NLM ID: 9207397 Publication Model: Print Cited Medium: Internet ISSN: 1365-313X (Electronic) Linking ISSN: 09607412 NLM ISO Abbreviation: Plant J Subsets: MEDLINE

MeSH Terms: Triticum*/genetics , Triticum*/microbiology , Triticum*/metabolism , Triticum*/immunology , Lignin*/metabolism , Plant Diseases*/microbiology , Plant Diseases*/immunology , Plant Diseases*/genetics , Disease Resistance*/genetics , Plant Proteins*/genetics , Plant Proteins*/metabolism , Transcription Factors*/metabolism , Transcription Factors*/genetics , Phenylalanine Ammonia-Lyase*/genetics , Phenylalanine Ammonia-Lyase*/metabolism , Rhizoctonia*/physiology, Gene Expression Regulation, Plant

Alterations in carbon and nitrogen metabolism under phenylalanine ammonia-lyase inhibition in winter triticale seedlings.

Authors: Hura K Dziurka M Hura T et al.

Source: Scientific reports [Sci Rep] 2025 Nov 27; Vol. 15 (1), pp. 42482. Date of Electronic Publication: 2025 Nov 27.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Phenylalanine Ammonia-Lyase*/antagonists & inhibitors , Phenylalanine Ammonia-Lyase*/metabolism , Nitrogen*/metabolism , Seedlings*/metabolism , Seedlings*/drug effects , Carbon*/metabolism , Edible Grain*/metabolism , Edible Grain*/drug effects , Edible Grain*/growth & development , Edible Grain*/enzymology, Polyamines/metabolism ; Proline/metabolism ; Plant Leaves/metabolism ; Plant Leaves/drug effects ; Parabens/pharmacology

Genome-wide identification and expression analysis of Phenylalanine Ammonia-Lyase (PAL) in cucumber.

Authors: Zhang J Wang K Meng S et al.

Source: PloS one [PLoS One] 2025 Nov 06; Vol. 20 (11), pp. e0334923. Date of Electronic Publication: 2025 Nov 06 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Cucumis sativus*/genetics , Cucumis sativus*/enzymology , Phenylalanine Ammonia-Lyase*/genetics , Phenylalanine Ammonia-Lyase*/metabolism , Gene Expression Regulation, Plant* , Plant Proteins*/genetics , Plant Proteins*/metabolism , Genome, Plant*, Phylogeny ; Fruit/genetics ; Gene Expression Profiling

Salicylic acid biosynthesis via the PAL pathway requires benzaldehyde synthase and a benzyl salicylate-specific esterase.

Authors: Ma D Gordon H Nazir R et al.

Source: The Plant cell [Plant Cell] 2025 Oct 08; Vol. 37 (10).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9208688 Publication Model: Print Cited Medium: Internet ISSN: 1532-298X (Electronic) Linking ISSN: 10404651 NLM ISO Abbreviation: Plant Cell Subsets: MEDLINE

MeSH Terms: Salicylic Acid*/metabolism , Plant Proteins*/metabolism , Plant Proteins*/genetics , Phenylalanine Ammonia-Lyase*/metabolism , Phenylalanine Ammonia-Lyase*/genetics , Intramolecular Transferases*/metabolism , Intramolecular Transferases*/genetics, Salicylates/metabolism ; Nicotiana/metabolism ; Nicotiana/genetics ; Gene Expression Regulation, Plant ; Biosynthetic Pathways ; Benzoates/metabolism

A Blast-Resistant NLR Gene Confers Drought Resistance by Competitively Interacting with an E3 Ligase to Protect Phenylalanine Ammonia-Lyase in Rice.

Authors: Xiang D Tu H Yuan Y et al.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Oct; Vol. 12 (39), pp. e02662. Date of Electronic Publication: 2025 Jul 21.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Oryza*/genetics , Oryza*/metabolism , Phenylalanine Ammonia-Lyase*/metabolism , Phenylalanine Ammonia-Lyase*/genetics , Disease Resistance*/genetics , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics , Plant Proteins*/genetics , Plant Proteins*/metabolism , Plant Diseases*/genetics , NLR Proteins*/genetics , NLR Proteins*/metabolism, Droughts ; Gene Expression Regulation, Plant/genetics ; Genome-Wide Association Study ; Drought Resistance

Physiological and Molecular Responses of the Flag Leaf Under L -Phenylalanine Ammonia-Lyase Inhibition.

Authors: Hura K Dziurka M Hura T et al.

Source: Cells [Cells] 2025 Sep 02; Vol. 14 (17). Date of Electronic Publication: 2025 Sep 02.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH Terms: Phenylalanine Ammonia-Lyase*/antagonists & inhibitors , Phenylalanine Ammonia-Lyase*/metabolism , Plant Leaves*/drug effects , Plant Leaves*/physiology , Plant Leaves*/enzymology , Plant Leaves*/metabolism, Photosynthesis/drug effects ; Antioxidants/metabolism ; Chlorophyll/metabolism ; Hydroxybenzoates/pharmacology ; Parabens

[Cloning and functional analysis of the phenylalanine ammonia-lyase gene from Anthoceros angustus ].

Authors: Yu H Mo J Yang J et al.

Source: Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2025 Jul 25; Vol. 41 (7), pp. 2855-2870.

Publication Type: English Abstract; Journal Article

Journal Info: Publisher: Ke xue chu ban she Country of Publication: China NLM ID: 9426463 Publication Model: Print Cited Medium: Internet ISSN: 1872-2075 (Electronic) Linking ISSN: 10003061 NLM ISO Abbreviation: Sheng Wu Gong Cheng Xue Bao Subsets: MEDLINE

MeSH Terms: Phenylalanine Ammonia-Lyase*/genetics , Phenylalanine Ammonia-Lyase*/metabolism , Plant Proteins*/genetics , Plant Proteins*/metabolism, Cloning, Molecular ; Cinnamates/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/metabolism ; Rosmarinic Acid ; Depsides/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Amino Acid Sequence ; Phylogeny ; Acetates/pharmacology ; Cyclopentanes ; Oxylipins

Trans-cinnamic acid coordinates PAL repression and C4H induction to modulate lignification in bamboo.

Authors: Wang Q Li H Di X et al.

Source: Plant physiology [Plant Physiol] 2025 Sep 30; Vol. 199 (2).

Publication Type: Journal Article

Journal Info: Publisher: American Society of Plant Biologists Country of Publication: United States NLM ID: 0401224 Publication Model: Print Cited Medium: Internet ISSN: 1532-2548 (Electronic) Linking ISSN: 00320889 NLM ISO Abbreviation: Plant Physiol Subsets: MEDLINE

MeSH Terms: Lignin*/metabolism , Lignin*/biosynthesis , Phenylalanine Ammonia-Lyase*/metabolism , Phenylalanine Ammonia-Lyase*/genetics , Cinnamates*/metabolism , Trans-Cinnamate 4-Monooxygenase*/metabolism , Trans-Cinnamate 4-Monooxygenase*/genetics , Sasa*/metabolism , Sasa*/genetics, Gene Expression Regulation, Plant ; Plant Proteins/metabolism ; Plant Proteins/genetics ; Cell Wall/metabolism

Long-term management strategies for pegvaliase use in phenylketonuria: Lessons learned from the phase-3 PRISM open-label extension study.

Authors: Harding CO Whitehall KB Lilienstein J et al.

Source: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2025 Aug; Vol. 27 (8), pp. 101459. Date of Electronic Publication: 2025 May 20.

Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 9815831 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0366 (Electronic) Linking ISSN: 10983600 NLM ISO Abbreviation: Genet Med Subsets: MEDLINE

MeSH Terms: Enzyme Replacement Therapy*/methods , Phenylalanine Ammonia-Lyase*/therapeutic use , Phenylalanine Ammonia-Lyase*/pharmacokinetics , Phenylalanine Ammonia-Lyase*/administration & dosage , Phenylketonurias*/drug therapy , Phenylketonurias*/blood, Adolescent ; Adult ; Child ; Female ; Humans ; Male ; Phenylalanine/blood ; Recombinant Proteins/pharmacokinetics ; Recombinant Proteins/therapeutic use ; Recombinant Proteins/administration & dosage

Establishing an Artificial Old Yellow Enzyme (OYE)-Mediated Pathway in Escherichia coli for Efficient Synthesis of 3-Phenyl-1-propanol.

Authors: Zhao M Wu X Zhang M et al.

Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Jul 16; Vol. 73 (28), pp. 17730-17738. Date of Electronic Publication: 2025 Jul 07.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH Terms: Escherichia coli*/genetics , Escherichia coli*/metabolism , Escherichia coli*/enzymology , Oxidoreductases*/metabolism , Oxidoreductases*/genetics , Phenylalanine Ammonia-Lyase*/metabolism , Phenylalanine Ammonia-Lyase*/genetics , Propanols*/metabolism , Escherichia coli Proteins*/genetics , Escherichia coli Proteins*/metabolism , Fungal Proteins*/genetics , Fungal Proteins*/metabolism, Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae/genetics ; Rhodotorula/enzymology ; Rhodotorula/genetics ; Fermentation ; Metabolic Engineering ; Glucose/metabolism ; Phenylalanine/metabolism

Genome-wide identification, transcriptome dynamics, and expression regulation of the key lignin biosynthesis gene families PAL and CAD in black walnut shell.

Authors: Zhou H Liu H Ma J et al.

Source: BMC plant biology [BMC Plant Biol] 2025 Jul 03; Vol. 25 (1), pp. 859. Date of Electronic Publication: 2025 Jul 03.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967807 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2229 (Electronic) Linking ISSN: 14712229 NLM ISO Abbreviation: BMC Plant Biol Subsets: MEDLINE

MeSH Terms: Juglans*/genetics , Juglans*/metabolism , Juglans*/enzymology , Juglans*/growth & development , Lignin*/biosynthesis , Gene Expression Regulation, Plant* , Transcriptome* , Phenylalanine Ammonia-Lyase*/genetics , Phenylalanine Ammonia-Lyase*/metabolism , Alcohol Oxidoreductases*/genetics , Alcohol Oxidoreductases*/metabolism , Plant Proteins*/genetics , Plant Proteins*/metabolism, Multigene Family ; Genome, Plant ; Gene Expression Profiling

Regulation of APX, SOD, and PAL genes by chitosan under salt stress in rapeseed (Brassica napus L.).

Authors: Bigham Soostani S Ranjbar M Memarian A et al.

Source: BMC plant biology [BMC Plant Biol] 2025 Jul 02; Vol. 25 (1), pp. 824. Date of Electronic Publication: 2025 Jul 02.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967807 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2229 (Electronic) Linking ISSN: 14712229 NLM ISO Abbreviation: BMC Plant Biol Subsets: MEDLINE

MeSH Terms: Chitosan*/pharmacology , Brassica napus*/genetics , Brassica napus*/drug effects , Brassica napus*/physiology , Brassica napus*/enzymology , Brassica napus*/metabolism , Superoxide Dismutase*/genetics , Superoxide Dismutase*/metabolism , Salt Stress*/drug effects , Phenylalanine Ammonia-Lyase*/genetics , Phenylalanine Ammonia-Lyase*/metabolism , Ascorbate Peroxidases*/genetics , Ascorbate Peroxidases*/metabolism , Plant Proteins*/genetics , Plant Proteins*/metabolism, Gene Expression Regulation, Plant/drug effects ; Antioxidants/metabolism ; Photosynthesis/drug effects

U-box E3 ubiquitin ligase OsPUB41 represses rice blast resistance by promoting degradation of OsPALs.

Authors: Xu L Tang Y Wang M et al.

Source: The New phytologist [New Phytol] 2025 Sep; Vol. 247 (5), pp. 2312-2327. Date of Electronic Publication: 2025 Jul 03.

Publication Type: Journal Article

Journal Info: Publisher: Wiley on behalf of New Phytologist Trust Country of Publication: England NLM ID: 9882884 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8137 (Electronic) Linking ISSN: 0028646X NLM ISO Abbreviation: New Phytol Subsets: MEDLINE

MeSH Terms: Oryza*/microbiology , Oryza*/genetics , Oryza*/enzymology , Oryza*/immunology , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics , Disease Resistance*/genetics , Plant Proteins*/metabolism , Plant Proteins*/genetics , Plant Diseases*/microbiology , Plant Diseases*/immunology , Plant Diseases*/genetics , Phenylalanine Ammonia-Lyase*/metabolism , Proteolysis* , Magnaporthe*/physiology, Gene Expression Regulation, Plant ; Lignin/metabolism ; Plants, Genetically Modified ; Gene Knockout Techniques ; Cell Wall/metabolism ; Ascomycota

SCR Organism: Pyricularia oryzae

Plasma-activated water modulates taxanes production and phenylalanineammonia-lyase activity in Taxus baccata cell culture.

Authors: Fathali Tehrani MH Mahmoudieh M Zargar M et al.

Source: PloS one [PLoS One] 2025 Jul 29; Vol. 20 (7), pp. e0325518. Date of Electronic Publication: 2025 Jul 29 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Taxus*/metabolism , Taxus*/cytology , Taxus*/drug effects , Phenylalanine Ammonia-Lyase*/metabolism , Taxoids*/metabolism , Water*/pharmacology , Water*/chemistry , Paclitaxel*/biosynthesis , Paclitaxel*/metabolism , Plasma Gases*/pharmacology, Cell Survival/drug effects ; Cell Culture Techniques

Deep learning-driven semi-rational design in phenylalanine ammonia-lyase for enhanced catalytic efficiency.

Authors: Lü X Fan S Lü R et al.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 May; Vol. 305 (Pt 2), pp. 141024. Date of Electronic Publication: 2025 Feb 19.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Phenylalanine Ammonia-Lyase*/chemistry , Phenylalanine Ammonia-Lyase*/genetics , Phenylalanine Ammonia-Lyase*/metabolism , Deep Learning* , Protein Engineering*/methods , Anabaena variabilis*/enzymology , Anabaena variabilis*/genetics, Molecular Dynamics Simulation ; Biocatalysis ; Kinetics ; Catalysis ; Mutation

Continuous Engineering of Phenylalanine Ammonia Lyase from Lettuce ( Lactuca sativa L.) for Efficient Synthesis of 3,4-Substituted Phenylalanine.

Authors: Zhu BF Fatmi MQ Pei XQ et al.

Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Apr 30; Vol. 73 (17), pp. 10358-10368. Date of Electronic Publication: 2025 Apr 20.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH Terms: Phenylalanine Ammonia-Lyase*/genetics , Phenylalanine Ammonia-Lyase*/chemistry , Phenylalanine Ammonia-Lyase*/metabolism , Phenylalanine*/chemistry , Phenylalanine*/biosynthesis , Lactuca*/enzymology , Lactuca*/genetics , Lactuca*/chemistry , Plant Proteins*/genetics , Plant Proteins*/chemistry , Plant Proteins*/metabolism, Protein Engineering ; Enzyme Stability ; Biocatalysis ; Kinetics ; Molecular Dynamics Simulation ; Molecular Docking Simulation ; Catalytic Domain

Overexpression of the Glycyrrhiza uralensis Phenylalanine Ammonia-Lyase Gene GuPAL1 Promotes Flavonoid Accumulation in Arabidopsis thaliana .

Authors: Chen X Jiang C Long M et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Apr 25; Vol. 26 (9). Date of Electronic Publication: 2025 Apr 25.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Flavonoids*/metabolism , Flavonoids*/biosynthesis , Arabidopsis*/genetics , Arabidopsis*/metabolism , Glycyrrhiza uralensis*/genetics , Glycyrrhiza uralensis*/enzymology , Phenylalanine Ammonia-Lyase*/genetics , Phenylalanine Ammonia-Lyase*/metabolism , Plant Proteins*/genetics , Plant Proteins*/metabolism, Gene Expression Regulation, Plant ; Phylogeny ; Plants, Genetically Modified/genetics ; Plant Roots/genetics ; Plant Roots/metabolism ; Promoter Regions, Genetic ; Gene Expression Profiling

Pegvaliase therapy for phenylketonuria: Real-world safety, efficacy, and medication access outcomes in a pharmacist-led pegvaliase program.

Authors: Shrestha S Zagel AL Pillai NR et al.

Source: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2025 Jun; Vol. 27 (6), pp. 101405. Date of Electronic Publication: 2025 Mar 13.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 9815831 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0366 (Electronic) Linking ISSN: 10983600 NLM ISO Abbreviation: Genet Med Subsets: MEDLINE

MeSH Terms: Phenylketonurias*/drug therapy , Phenylalanine Ammonia-Lyase*/therapeutic use , Phenylalanine Ammonia-Lyase*/adverse effects , Phenylalanine Ammonia-Lyase*/administration & dosage , Recombinant Fusion Proteins*/therapeutic use , Recombinant Fusion Proteins*/adverse effects, Humans ; Female ; Male ; Adolescent ; Child ; Phenylalanine/blood ; Pharmacists ; Treatment Outcome ; Biopterins/analogs & derivatives ; Biopterins/therapeutic use ; Biopterins/adverse effects ; Biopterins/administration & dosage ; Child, Preschool ; Adult ; Recombinant Proteins/therapeutic use ; Recombinant Proteins/adverse effects ; Young Adult ; Infant