Suchergebnisse - "PHASE separation"

Engineering sequential liquid-liquid phase separation and affinity partitioning for compartmentalization and functionalization of all-aqueous emulsion drops.

Autoren: Wang W Sun W Du F et al.

Quelle: Journal of colloid and interface science [J Colloid Interface Sci] 2025 Nov 15; Vol. 698, pp. 138136. Date of Electronic Publication: 2025 Jun 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE

MeSH-Schlagworte: Emulsions*/chemistry , Phase Separation*, Particle Size ; Surface Properties ; Water/chemistry

ricePSP: a database of rice phase separation-associated proteins.

Autoren: Gao R Guo M Luan S et al.

Quelle: Genome biology [Genome Biol] 2025 Nov 17; Vol. 26 (1), pp. 390. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE

MeSH-Schlagworte: Oryza*/genetics , Oryza*/metabolism , Plant Proteins*/chemistry , Plant Proteins*/metabolism , Plant Proteins*/genetics , Databases, Protein*, Flowers/genetics ; Intrinsically Disordered Proteins/chemistry ; Phase Separation

Shining light on liquid-liquid phase separation in chronic liver disease.

Autoren: Li MH Yang Y Dong QQ et al.

Quelle: Drug discovery today [Drug Discov Today] 2025 Oct; Vol. 30 (10), pp. 104464. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Ltd. Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE

MeSH-Schlagworte: Liver Diseases*/therapy , Liver Diseases*/metabolism, Humans ; Animals ; Chronic Disease ; Genetic Therapy/methods ; Drug Development ; Lipid Metabolism ; Immunotherapy/methods ; Phase Separation

Phosphorylation-Induced Self-Coacervation versus RNA-Assisted Complex Coacervation of Tau Proteins.

Autoren: Allahyartorkaman M Chan TH Chen EH et al.

Quelle: Journal of the American Chemical Society [J Am Chem Soc] 2025 Mar 26; Vol. 147 (12), pp. 10172-10187. Date of Electronic Publication: 2025 Mar 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH-Schlagworte: Phase Separation* , tau Proteins*/chemistry , tau Proteins*/metabolism , RNA*/chemistry , RNA*/metabolism, Phosphorylation ; Temperature ; Hydrophobic and Hydrophilic Interactions ; Static Electricity ; Phosphates/chemistry ; Mass Spectrometry ; Humans ; Cell Line ; Kidney ; Epithelial Cells ; Alzheimer Disease/metabolism ; Brain/metabolism

Interactions-driven structural morphology and motion in two-dimensional active Brownian systems.

Autoren: Li, Minna Yang, Guangcan Wang, Yanwei et al.

Quelle: Journal of Chemical Physics. 11/21/2025, Vol. 163 Issue 19, p1-10. 10p.

Schlagwörter: *PHASE separation, *PARTICLE motion, *TOPOLOGICAL defects (Physics), *STATISTICAL mechanics, *THERMODYNAMICS

Effect of spatial dimensionality on the interplay between spinodal decomposition and wetting in multicomponent mixtures.

Autoren: Kumar, Sandeep Douglas, Jack F. Ghosh, Supriyo

Quelle: Journal of Chemical Physics. 11/7/2025, Vol. 163 Issue 17, p1-17. 17p.

Schlagwörter: *PHASE separation, *BINARY mixtures, *WETTING, *QUENCHING (Chemistry), *COMPOSITE materials

Targeting Liquid-Liquid Phase Separation and Autophagy in Alzheimer's Disease: Insights into Molecular Mechanisms and Therapeutic Potential.

Autoren: Li X Liu Y Hu H et al.

Quelle: Neurochemical research [Neurochem Res] 2025 Dec 04; Vol. 51 (1), pp. 9. Date of Electronic Publication: 2025 Dec 04.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6903 (Electronic) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/metabolism , Alzheimer Disease*/drug therapy , Alzheimer Disease*/pathology , Autophagy*/physiology , Autophagy*/drug effects, Humans ; Animals ; Amyloid beta-Peptides/metabolism ; tau Proteins/metabolism ; Phase Separation

Phase Separation of PHLDB2 Drives EMT and Tumor Progression in Triple-Negative Breast Cancer.

Autoren: Zhang M Liang C Chen T et al.

Quelle: Cancer medicine [Cancer Med] 2025 Dec; Vol. 14 (23), pp. e71308.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE

MeSH-Schlagworte: Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/genetics , Triple Negative Breast Neoplasms*/metabolism , Epithelial-Mesenchymal Transition*/genetics, Humans ; Animals ; Female ; Mice ; Cell Proliferation ; Disease Progression ; Cell Line, Tumor ; Cell Movement ; Gene Expression Regulation, Neoplastic ; Lung Neoplasms/secondary ; Lung Neoplasms/genetics ; Gene Expression Profiling ; Xenograft Model Antitumor Assays ; Phase Separation

Nuclear lamina phase separation orchestrates stress-induced transcriptional responses in plants.

Autoren: Tang Y Liu X Fang Y et al.

Quelle: Developmental cell [Dev Cell] 2025 Dec 01; Vol. 60 (23), pp. 3156-3166.e8. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE

MeSH-Schlagworte: Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Arabidopsis*/genetics , Arabidopsis*/metabolism , Gene Expression Regulation, Plant* , Stress, Physiological*/genetics , Nuclear Lamina*/metabolism , Nuclear Lamina*/genetics , Transcription, Genetic*, Transcription Factors/metabolism ; Transcription Factors/genetics ; Heat-Shock Response ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Phase Separation

Potential prognostic value and immune landscape of lactylation and liquid-liquid phase separation related genes in acute myeloid leukemia.

Autoren: Jiang T Chen H Qin C et al.

Quelle: Hematology (Amsterdam, Netherlands) [Hematology] 2025 Dec; Vol. 30 (1), pp. 2548073. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8454 (Electronic) Linking ISSN: 10245332 NLM ISO Abbreviation: Hematology Subsets: MEDLINE

MeSH-Schlagworte: Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/immunology , Leukemia, Myeloid, Acute*/diagnosis , Leukemia, Myeloid, Acute*/mortality , Gene Expression Regulation, Leukemic*, Humans ; Prognosis ; Tumor Microenvironment/immunology ; Male ; Female ; HL-60 Cells ; Biomarkers, Tumor/genetics ; Chaperonin Containing TCP-1/genetics ; Middle Aged ; Apoptosis ; Phase Separation

Plectin promotes bone formation via phase separation and sequestering annexin A2.

Autoren: Zheng K He X Yu Y et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 4), pp. 117403. Date of Electronic Publication: 2025 Oct 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Plectin*/metabolism , Plectin*/pharmacology , Plectin*/genetics , Osteogenesis*/physiology , Osteogenesis*/drug effects , Osteoblasts*/metabolism , Osteoblasts*/drug effects , Annexin A2*/metabolism, Animals ; Mice ; Humans ; Cell Differentiation/physiology ; Cell Differentiation/drug effects ; Mice, Inbred C57BL ; Osteoporosis/metabolism ; Osteoporosis/drug therapy ; Male ; Phase Separation

Impact of liquid-liquid phase separation- and immune-related gene signatures on multiple myeloma prognosis: focus on DDX21 and EZH2.

Autoren: Wang F Shen C

Quelle: Hematology (Amsterdam, Netherlands) [Hematology] 2025 Dec; Vol. 30 (1), pp. 2445403. Date of Electronic Publication: 2024 Dec 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8454 (Electronic) Linking ISSN: 10245332 NLM ISO Abbreviation: Hematology Subsets: MEDLINE

MeSH-Schlagworte: Multiple Myeloma*/genetics , Multiple Myeloma*/mortality , Multiple Myeloma*/immunology , Multiple Myeloma*/pathology , Enhancer of Zeste Homolog 2 Protein*/genetics , DEAD-box RNA Helicases*/genetics, Humans ; Prognosis ; Gene Expression Regulation, Neoplastic ; Biomarkers, Tumor/genetics ; Transcriptome ; Cell Proliferation ; Male ; Female ; Phase Separation

Temperature and cosolute regulate the liquid-liquid phase separation in BSA solutions.

Autoren: Merino Naranjo B Fuoco E Bartucci R et al.

Quelle: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2025 Dec; Vol. 774, pp. 110620. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0384 (Electronic) Linking ISSN: 00039861 NLM ISO Abbreviation: Arch Biochem Biophys Subsets: MEDLINE

MeSH-Schlagworte: Serum Albumin, Bovine*/chemistry , Polyethylene Glycols*/chemistry, Animals ; Cattle ; Temperature ; Solutions ; Phase Transition ; Spectroscopy, Fourier Transform Infrared ; Hydrogen-Ion Concentration ; Kinetics ; Phase Separation

Liquid-liquid phase separation-related genes in the immune microenvironment and diagnosis of focal segmental glomerulosclerosis and minimal change disease.

Autoren: Lu H Sun J

Quelle: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2573857. Date of Electronic Publication: 2025 Oct 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

MeSH-Schlagworte: Glomerulosclerosis, Focal Segmental*/genetics , Glomerulosclerosis, Focal Segmental*/diagnosis , Glomerulosclerosis, Focal Segmental*/immunology , Nephrosis, Lipoid*/genetics , Nephrosis, Lipoid*/diagnosis , Nephrosis, Lipoid*/immunology, Humans ; ROC Curve ; Gene Expression Profiling ; Nomograms ; Proto-Oncogene Mas ; Phase Separation

Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity.

Autoren: Zhang DW Xu XS Xie L et al.

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2501743. Date of Electronic Publication: 2025 May 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: SARS-CoV-2*/drug effects , Coronavirus Nucleocapsid Proteins*/metabolism , Coronavirus Nucleocapsid Proteins*/antagonists & inhibitors , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Nucleocapsid Proteins*/metabolism , Nucleocapsid Proteins*/antagonists & inhibitors , Biological Products*/pharmacology , Biological Products*/chemistry, Humans ; Protein Binding/drug effects ; Binding Sites/drug effects ; RNA, Viral/metabolism ; Dose-Response Relationship, Drug ; Phase Separation ; Phosphoproteins

RNA-seq analyses reveal the relevance of RNAs involved in ribosomal complex to induce mammalian prion protein aggregation and phase separation in vitro .

Autoren: Tahira AC Gomes MPB Freire MH et al.

Quelle: RNA biology [RNA Biol] 2025 Dec; Vol. 22 (1), pp. 1-16. Date of Electronic Publication: 2025 May 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101235328 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-8584 (Electronic) Linking ISSN: 15476286 NLM ISO Abbreviation: RNA Biol Subsets: MEDLINE

MeSH-Schlagworte: Prion Proteins*/metabolism , Prion Proteins*/chemistry , Prion Proteins*/genetics , Ribosomes*/metabolism , Ribosomes*/genetics , RNA, Ribosomal*/metabolism , RNA, Ribosomal*/genetics , RNA*/metabolism , RNA*/genetics, Animals ; Mice ; RNA-Seq ; Protein Aggregates ; Cell Line, Tumor ; Phase Separation

CaMKII Drives Synaptic Maturation by Coordinating Spine Remodeling and Receptor Segregation via Liquid-Liquid Phase Separation.

Autoren: Kuo LMS Liu PW Arizono M et al.

Quelle: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2025 Nov 26; Vol. 45 (48). Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Calcium-Calmodulin-Dependent Protein Kinase Type 2*/metabolism , Calcium-Calmodulin-Dependent Protein Kinase Type 2*/genetics , Dendritic Spines*/physiology , Dendritic Spines*/metabolism , Synapses*/physiology , Synapses*/metabolism , Receptors, AMPA*/metabolism , Receptors, N-Methyl-D-Aspartate*/metabolism, Animals ; Rats ; Hippocampus/cytology ; Hippocampus/metabolism ; Cells, Cultured ; Female ; Rats, Sprague-Dawley ; Male ; Phase Separation

Energy status orchestrates YTHDF1 phase separation and tumorigenesis.

Autoren: Yu H Shi J He R et al.

Quelle: Cell reports [Cell Rep] 2025 Nov 25; Vol. 44 (11), pp. 116466. Date of Electronic Publication: 2025 Oct 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH-Schlagworte: RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , Carcinogenesis*/metabolism , Carcinogenesis*/pathology , Energy Metabolism*, Humans ; Animals ; Phosphorylation ; AMP-Activated Protein Kinases/metabolism ; Mice ; Cell Line, Tumor ; HEK293 Cells ; Mice, Nude ; Phase Separation

IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation.

Autoren: Xiong X Wang X Wang Z et al.

Quelle: Cell reports [Cell Rep] 2025 Nov 25; Vol. 44 (11), pp. 116511. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH-Schlagworte: Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/genetics , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , Disease Progression* , Protein Biosynthesis*, Humans ; Female ; Cell Line, Tumor ; Adenosine/analogs & derivatives ; Adenosine/metabolism ; Acetylation ; Animals ; Phase Separation

Spatiotemporal Control of Liquid-Liquid Phase Separation for Advanced Biomanufacturing.

Autoren: Li Y Zeng C Lyu X et al.

Quelle: ACS synthetic biology [ACS Synth Biol] 2025 Nov 21; Vol. 14 (11), pp. 4255-4265. Date of Electronic Publication: 2025 Oct 29.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101575075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2161-5063 (Electronic) Linking ISSN: 21615063 NLM ISO Abbreviation: ACS Synth Biol Subsets: MEDLINE

MeSH-Schlagworte: Metabolic Engineering*/methods , Liquid-Liquid Extraction*/methods, Biosensing Techniques/methods ; Humans ; Phase Separation