Výsledky vyhledávání - "PEPTIDE synthesis"

Finding new drugs for CNS diseases by targeting proteases: the case of matrix metalloproteinase-9 and prolyl oligopeptidase

Autoři: Trallero Canela, Nuria

Přispěvatelé: University/Department: Universitat de Barcelona. Facultat de Farmàcia i Ciències de l'Alimentació

Thesis Advisors: Tarragó Clua, Maria Teresa, Prades Cosano, Roger, Badía Palacín, Josefa

Zdroj: TDX (Tesis Doctorals en Xarxa)

Témata: Síntesi de pèptids, Síntesis de péptidos, Peptide synthesis, Malalties del sistema nerviós central, Enfermedades del sistema nervioso central, Central nervous system diseases, Enzims proteolítics, Enzimas proteolíticas, Proteolytic enzymes, Ciències de la Salut

Popis souboru: application/pdf

Přístupová URL adresa: http://hdl.handle.net/10803/694364

Advancing sustainable peptide synthesis: methanesulfonic acid–formic acid as a greener substitute for TFA in final global deprotection.

Autoři: Fidha, Fathima Kumar, Ashish Leko, Maria a další

Zdroj: Green Chemistry. 12/14/2025, Vol. 27 Issue 46, p14911-14918. 8p.

Témata: *PEPTIDE synthesis, *TRIFLUOROACETIC acid, *ENVIRONMENTAL responsibility, *SUSTAINABLE chemistry, *METHANESULFONATES, *FORMIC acid, *PEPTIDES

Addressing Sustainability Challenges in Peptide Synthesis with Flow Chemistry and Machine Learning.

Autoři: Ferentzi, Kristóf Farkas, Viktor Perczel, András

Zdroj: Chemistry - A European Journal. Nov2025, p1. 10p. 9 Illustrations.

Témata: *PEPTIDE synthesis, *FLOW chemistry, *MACHINE learning, *HAZARDOUS wastes, *PROCESS optimization, *SOLVENT analysis, *SUSTAINABILITY

A General Synthesis Approach to Double‐Guanidinium Stapled Peptides and Foldamers.

Autoři: Neuville, Maxime Bornez, Marta Martin Bourgeais, Mathieu a další

Zdroj: Chemistry - A European Journal. 11/6/2025, Vol. 31 Issue 62, p1-8. 8p.

Témata: *PEPTIDE synthesis, *PROTEIN-protein interactions, *CROSSLINKING (Polymerization), *MACROMOLECULES, *RING formation (Chemistry), *PEPTIDES, *LIGANDS (Biochemistry)

Determination of Diketopiperazine Formation During the Solid‐Phase Synthesis of C‐Terminal Acid Peptides.

Autoři: Kaushal, Mani Kumar, Ashish Gamal, Hassan a další

Zdroj: Chemistry - Methods. Nov2025, Vol. 5 Issue 11, p1-7. 7p.

Témata: *DIKETOPIPERAZINES, *PEPTIDE synthesis, *PRODUCTION losses, *PEPTIDES, *SOLID-phase synthesis, *CHEMICAL synthesis, *CHEMICAL reactions

β-Acyloxyl alkenyl amide synthesis via multiple defluorination: α-Trifluoromethyl ketone-amine as synergystic peptide coupling reagent.

Autoři: Sufang Cao Haijin Guo Zukang Zhong a další

Zdroj: Science Advances. 10/24/2025, Vol. 11 Issue 43, p1-10. 10p.

Témata: *PEPTIDE synthesis, *ACYLATION, *TRIFLUOROMETHYL compounds, *AMIDES, *INORGANIC compounds, *CHEMICAL reactions, *CHEMICAL synthesis, *DEHALOGENATION

Síntesi d’un pèptid terapèutic: Un estudi metodològic vers la producció a escala de planta pilot

Autoři: Teruel Sánchez, Carolina

Přispěvatelé: University/Department: Universitat de Barcelona. Departament de Química Inorgànica i Orgànica

Thesis Advisors: Nicolás Galindo, Ernesto, Racamonde Villanueva, Marta

Zdroj: TDX (Tesis Doctorals en Xarxa)

Témata: Química orgànica, Química orgánica, Organic chemistry, Síntesi de pèptids, Síntesis de péptidos, Peptide synthesis, Ciències Experimentals i Matemàtiques

Popis souboru: application/pdf

Přístupová URL adresa: http://hdl.handle.net/10803/692182

Divergent Synthesis of ΔAA‐Peptides Using a Bioorthogonal pro‐Amino Acid and Aqueous Flavin Photocatalyst: Green Light Enhances Catalyst Performance and Product Selectivity.

Autoři: Chen, Pei‐Hsuan Bloom, Steven

Zdroj: Angewandte Chemie International Edition. 9/22/2025, Vol. 64 Issue 39, p1-9. 9p.

Témata: *CATALYSTS, *PEPTIDE synthesis, *MODEL validation, *CHEMICAL reagents, *CHEMICAL synthesis, *PHOTOCATALYSTS

Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases.

Autoři: Diecker, Julia Hermanns, Benedikt Rüschenbaum, Jennifer a další

Zdroj: Angewandte Chemie. Sep2025, Vol. 137 Issue 36, p1-10. 10p.

Témata: *NONRIBOSOMAL peptide synthetases, *PEPTIDE synthesis, *PEPTIDES, *HYPOTHESIS, *CRYSTAL structure, *PROTEIN-protein interactions

Discovery of a Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening.

Autoři: Chang, Huailong Tao, Kan Huang, Hu a další

Zdroj: Skin Research & Technology. Sep2025, Vol. 31 Issue 9, p1-8. 8p.

Témata: *PEPTIDE synthesis, *PHENOL oxidase, *CYTOTOXINS, *MOLECULAR docking, *CHEMICAL synthesis, *MELANOGENESIS

Structural Design and Synthesis of Cyclosenegalin A Analogue.

Autoři: Aloanis, Anderson Arnold Herlina, Tati Hardianto, Ari a další

Zdroj: Journal of Heterocyclic Chemistry. Sep2025, Vol. 62 Issue 9, p781-790. 10p.

Témata: *PEPTIDE synthesis, *ANTIMICROBIAL peptides, *DESIGN, *PEPTIDES, *CHEMICAL synthesis, *ANTI-infective agents, *CHEMICAL derivatives, *SIMULATION methods & models

Life's homochirality: Across a prebiotic network.

Autoři: Ozturk, S. Furkan Sasselov, Dimitar D.

Zdroj: Proceedings of the National Academy of Sciences of the United States of America. 8/26/2025, Vol. 122 Issue 34, p1-4. 4p.

Témata: *BIOLOGICAL systems, *PEPTIDE synthesis, *ORIGIN of life, *NUCLEIC acids, *HANDEDNESS

Amide Chemistry Enables Redox Locking of Cyclic Disulfides for Polypeptide Assembly.

Autoři: Diemer, Vincent Roy, Eliott Snella, Benoît a další

Zdroj: Angewandte Chemie. 8/18/2025, Vol. 137 Issue 34, p1-9. 9p.

Témata: *DISULFIDES, *PEPTIDE synthesis, *OXIDATION-reduction reaction, *ORGANIC synthesis, *AMIDES, *CHEMICAL reagents

Tetrahydropyranyl Backbone Protection for Enhanced Fmoc Solid‐Phase Peptide Synthesis.

Autoři: Paravizzini, Samuel J. Hutton, Craig A. Karas, John A.

Zdroj: Chemistry - A European Journal. 8/13/2025, Vol. 31 Issue 45, p1-7. 7p.

Témata: *PEPTIDE synthesis, *SOLID-phase synthesis, *TETRAHYDROPYRANYL compounds, *AMYLOID beta-protein, *PEPTIDES

Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis.

Autoři: Paravizzini, Samuel J. Haugaard‐Kedström, Linda M. Hutton, Craig A. a další

Zdroj: Angewandte Chemie. 8/11/2025, Vol. 137 Issue 33, p1-26. 26p.

Témata: *PEPTIDE synthesis, *PROTEIN synthesis, *BIOLOGICAL research methodology, *CHEMICAL reactions, *CYCLIC peptides, *CHEMICAL synthesis

Comparison of Alternative Piperidine Deblocking Agents in the Solid-Phase Synthesis of Ingramon and Methylin.

Autoři: Klimova, M. V. Molokoedov, A. S. Ovchinnikov, M. V. a další

Zdroj: Russian Journal of Bioorganic Chemistry. Aug2025, Vol. 51 Issue 4, p1725-1733. 9p.

Témata: *SOLID-phase synthesis, *PEPTIDE synthesis, *CARDIOVASCULAR diseases, *HIGH performance liquid chromatography, *PEPTIDES, *PIPERIDINE

Upscaled Synthesis of α‐ and β‐Peptides in a Continuous‐Flow Reactor Using Propylene Carbonate as an Eco‐Friendly Solvent.

Autoři: Varró, Nikolett Mándityné Huszka, Beáta Erdei, Eszter a další

Zdroj: Chemistry - Methods. Aug2025, Vol. 5 Issue 8, p1-7. 7p.

Témata: *PROPYLENE carbonate, *PEPTIDE synthesis, *CONTINUOUS flow reactors, *SUSTAINABILITY, *NONAQUEOUS solvents, *SUSTAINABLE chemistry

Towards a Consensus for the Analysis and Exchange of TFA as a Counterion in Synthetic Peptides and Its Influence on Membrane Permeation.

Autoři: Erckes, Vanessa Streuli, Alessandro Chamera Rendueles, Laura a další

Zdroj: Pharmaceuticals (14248247). Aug2025, Vol. 18 Issue 8, p1163. 17p.

Témata: *PEPTIDE synthesis, *TRIFLUOROACETIC acid, *PEPTIDOMIMETICS, *ION exchange (Chemistry), *MEMBRANE permeability (Biology), *BIOLOGICAL assay

Design and evaluation of the biosafety and bioactivity of highly stable nano collagen.

Autoři: Zhang, Jingting Ling, Biyang Yang, Yi a další

Zdroj: New Journal of Chemistry. 7/28/2025, Vol. 49 Issue 28, p12231-12242. 12p.

Témata: *EXTRACELLULAR matrix proteins, *PEPTIDE synthesis, *SOLID-phase synthesis, *REGENERATIVE medicine, *ORGANIC solvents

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects.

Autoři: Fukuoka, Ryo Yano, Yusuke Hara, Nozomi a další

Zdroj: Angewandte Chemie International Edition. Jul2025, Vol. 64 Issue 27, p1-11. 11p.

Témata: *MOLECULAR dynamics, *PEPTIDE synthesis, *PEPTIDES, *MOLECULAR docking, *NEUROTOXIC agents, *OPIOID peptides, *CALCIUM channels