Search Results - "PEPTIDASE"

Dipeptidyl Peptidase 4 Mediated Caspase-8 Affects Cognitive Impairment in Mice With Alzheimer's Disease.

Authors: Wang X Chen L Qiu J et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Dec 15; Vol. 39 (23), pp. e71264.

Publication Type: Journal Article

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/metabolism , Dipeptidyl Peptidase 4*/metabolism , Dipeptidyl Peptidase 4*/genetics , Caspase 8*/metabolism , Caspase 8*/genetics , Cognitive Dysfunction*/metabolism, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Amyloid beta-Peptides/toxicity ; Disease Models, Animal ; Pyroptosis ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Maze Learning ; Hippocampus/metabolism ; Neurons/metabolism

Screening of key dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from casein hydrolysates based on peptidomics, chemometrics, recombination, and omission experiments.

Authors: Wang S Zhou M Qian J et al.

Source: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 3), pp. 146639. Date of Electronic Publication: 2025 Oct 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/administration & dosage , Caseins*/chemistry , Peptides*/chemistry , Peptides*/administration & dosage , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/administration & dosage, Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism ; Animals ; Male ; Humans ; Amino Acid Sequence ; Rats ; Mice

Pyrrolidine-2-carbonitrile Derivatives as Multifunctional Antidiabetic Agents: Inhibition of α-Amylase, α-Glucosidase, and DPP-IV With Structure-Activity Relationships, HSA Binding, and Molecular Docking Studies.

Authors: Bhat AA Singh I

Source: Drug development research [Drug Dev Res] 2025 Nov; Vol. 86 (7), pp. e70170.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print Cited Medium: Internet ISSN: 1098-2299 (Electronic) Linking ISSN: 02724391 NLM ISO Abbreviation: Drug Dev Res Subsets: MEDLINE

MeSH Terms: Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/chemical synthesis , alpha-Amylases*/antagonists & inhibitors , alpha-Amylases*/metabolism , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/pharmacology , Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/chemical synthesis , Pyrrolidines*/chemistry , Pyrrolidines*/pharmacology , Pyrrolidines*/chemical synthesis , Nitriles*/chemistry , Nitriles*/pharmacology, Molecular Docking Simulation ; Structure-Activity Relationship ; alpha-Glucosidases/metabolism ; alpha-Glucosidases/chemistry ; Humans ; Dipeptidyl Peptidase 4/metabolism ; Dipeptidyl Peptidase 4/chemistry ; Protein Binding

Potential antidiabetic activity and permeability assessment of the modified yeast-derived peptide, VLSTSFPPW (VW9).

Authors: Alahyaribeik S Mirdamadi S Shim H et al.

Source: Food chemistry [Food Chem] 2025 Oct 30; Vol. 490, pp. 144968. Date of Electronic Publication: 2025 Jun 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/metabolism , Peptides*/chemistry , Peptides*/pharmacology , Peptides*/metabolism , Saccharomyces cerevisiae*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/pharmacology, Humans ; Caco-2 Cells ; Permeability ; Molecular Docking Simulation ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism ; Tandem Mass Spectrometry ; Kinetics ; Amino Acid Sequence ; Digestion

DPP-IV inhibitory peptides from highland barley via machine learning and multi-scale validation.

Authors: Bao X Zhang Y Wang L et al.

Source: Food chemistry [Food Chem] 2025 Oct 15; Vol. 489, pp. 144979. Date of Electronic Publication: 2025 May 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Hordeum*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/administration & dosage , Peptides*/chemistry , Peptides*/administration & dosage , Plant Proteins*/chemistry , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/administration & dosage, Machine Learning ; Molecular Docking Simulation ; Humans ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism ; Animals ; Molecular Dynamics Simulation ; Male

Dual-source DPP4 drives intestinal fibrosis in Crohn's disease: synergistic therapeutic targeting of host and microbiota pathways.

Authors: Li J Xu Y Wang M et al.

Source: Gut microbes [Gut Microbes] 2025 Dec 31; Vol. 17 (1), pp. 2593119. Date of Electronic Publication: 2025 Dec 03.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH Terms: Dipeptidyl Peptidase 4*/metabolism , Dipeptidyl Peptidase 4*/genetics , Crohn Disease*/pathology , Crohn Disease*/drug therapy , Crohn Disease*/microbiology , Crohn Disease*/metabolism , Gastrointestinal Microbiome*/drug effects , Intestines*/pathology, Animals ; Humans ; Mice ; Fibrosis ; Disease Models, Animal ; Male ; Myofibroblasts/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Sitagliptin Phosphate/pharmacology ; Mice, Inbred C57BL ; Female ; Dextran Sulfate

Gastrointestinal stability and DPP-IV inhibitory activity of tilapia (Oreochromis niloticus) viscera hydrolysate-derived novel peptides LPCL and TPFLPDE, with LPCL-modulated GLP-1 and PepT1 expression in STC-1 cells.

Authors: Ortizo RGG Lai CS Anwar C et al.

Source: Food research international (Ottawa, Ont.) [Food Res Int] 2025 Nov; Vol. 219, pp. 116986. Date of Electronic Publication: 2025 Jul 08.

Publication Type: Journal Article

Journal Info: Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE

MeSH Terms: Glucagon-Like Peptide 1*/metabolism , Dipeptidyl-Peptidase IV Inhibitors*/pharmacology , Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Peptide Transporter 1*/metabolism , Peptide Transporter 1*/genetics , Protein Hydrolysates*/pharmacology , Protein Hydrolysates*/chemistry , Peptides*/pharmacology , Peptides*/chemistry , Cichlids*/metabolism , Tilapia* , Gastrointestinal Tract*/metabolism, Animals ; Cell Line ; Dipeptidyl Peptidase 4/metabolism ; Digestion

Curcuma Aeruginosa Roxb. [C. zedoaria non Rosc.] Inhibits Human Papillomavirus-related Cervical Cancer via Dipeptidyl Peptidase IV.

Authors: Zhu Y Cheng H Xu M et al.

Source: The Tohoku journal of experimental medicine [Tohoku J Exp Med] 2025 Oct 22; Vol. 267 (2), pp. 177-183. Date of Electronic Publication: 2025 Feb 13.

Publication Type: Journal Article

Journal Info: Publisher: Tohoku University Medical Library Country of Publication: Japan NLM ID: 0417355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-3329 (Electronic) Linking ISSN: 00408727 NLM ISO Abbreviation: Tohoku J Exp Med Subsets: MEDLINE

MeSH Terms: Uterine Cervical Neoplasms*/virology , Uterine Cervical Neoplasms*/drug therapy , Uterine Cervical Neoplasms*/pathology , Uterine Cervical Neoplasms*/enzymology , Dipeptidyl Peptidase 4*/metabolism , Dipeptidyl Peptidase 4*/chemistry , Curcuma*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/therapeutic use , Papillomaviridae*/physiology , Papillomaviridae*/drug effects, Humans ; Female ; Molecular Docking Simulation ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Movement/drug effects ; Animals ; Rats ; Rats, Sprague-Dawley ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Apoptosis/drug effects ; Human Papillomavirus Viruses

Investigating the impact of dipeptidyl peptidase-1 inhibition in humans using multi-omics.

Authors: Long MB Gilmour A Hull RC et al.

Source: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2025 Nov; Vol. 156 (5), pp. 1356-1367. Date of Electronic Publication: 2025 Aug 06.

Publication Type: Journal Article; Randomized Controlled Trial

Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE

MeSH Terms: COVID-19*/immunology , COVID-19 Drug Treatment* , SARS-CoV-2* , Tripeptidyl-Peptidase 1*/antagonists & inhibitors, Humans ; Male ; Female ; Middle Aged ; Aged ; Neutrophils/immunology ; Neutrophils/drug effects ; Neutrophils/metabolism ; Proteomics ; Cathepsin C ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Multiomics

Release pattern of potent dipeptidyl peptidase IV(DPP-IV) inhibitory peptides from tilapia (Oreochromis niloticus) skin collagen.

Authors: Li J Yang D Xu Q et al.

Source: Food chemistry [Food Chem] 2025 Oct 15; Vol. 489, pp. 144970. Date of Electronic Publication: 2025 May 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Collagen*/chemistry , Fish Proteins*/chemistry , Skin*/chemistry , Peptides*/chemistry , Cichlids*, Animals ; Dipeptidyl Peptidase 4/chemistry ; Amino Acid Sequence

Design and experimental verification of novel angiotensin-converting enzyme and dipeptidyl peptidase IV inhibitory peptides from Ziziphus jujuba peptide KALVAP.

Authors: Wen H Lan J Dang K et al.

Source: Journal of the science of food and agriculture [J Sci Food Agric] 2026 Jan 15; Vol. 106 (1), pp. 249-259. Date of Electronic Publication: 2025 Aug 29.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE

MeSH Terms: Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/administration & dosage , Ziziphus*/chemistry , Angiotensin-Converting Enzyme Inhibitors*/chemistry , Angiotensin-Converting Enzyme Inhibitors*/administration & dosage , Peptides*/chemistry , Peptides*/administration & dosage , Plant Extracts*/chemistry , Plant Extracts*/administration & dosage, Animals ; Humans ; Mice ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism ; Molecular Docking Simulation ; Male ; Caco-2 Cells

Preparation, identification, and molecular mechanism of novel DPP-IV inhibitory peptides from pumpkin seed: In silico screening and experimental validation.

Authors: Chen X Zhang W Pan Y et al.

Source: Food chemistry [Food Chem] 2025 Sep 15; Vol. 486, pp. 144530. Date of Electronic Publication: 2025 May 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/administration & dosage , Dipeptidyl-Peptidase IV Inhibitors*/isolation & purification , Cucurbita*/chemistry , Peptides*/chemistry , Peptides*/administration & dosage , Peptides*/isolation & purification , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/enzymology , Plant Proteins*/chemistry , Plant Proteins*/administration & dosage , Plant Proteins*/isolation & purification , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/isolation & purification , Plant Extracts*/chemistry , Plant Extracts*/administration & dosage, Seeds/chemistry ; Animals ; Molecular Docking Simulation ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism ; Mice ; Mice, Inbred C57BL ; Humans ; Male

Identification of DPP-IV Inhibitory Peptides from Eggshell Membranes: Structure-Activity Relationships, Digestive Stability, and Molecular Mechanisms.

Authors: Wang S Li Z Abou-Elsoud M et al.

Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Aug 20; Vol. 73 (33), pp. 20916-20928. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH Terms: Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/pharmacology , Dipeptidyl-Peptidase IV Inhibitors*/metabolism , Peptides*/chemistry , Peptides*/pharmacology , Peptides*/metabolism , Egg Shell*/chemistry, Humans ; Caco-2 Cells ; Structure-Activity Relationship ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism ; Animals ; Digestion ; Amino Acid Sequence ; Molecular Docking Simulation ; Chickens ; Tandem Mass Spectrometry

Teneligliptin, a DPP4 inhibitor protects dopaminergic neurons in PD models via inhibiting of oxidative stress and ferroptosis.

Authors: Huang L Pi J Gu L et al.

Source: European journal of pharmacology [Eur J Pharmacol] 2025 Sep 05; Vol. 1002, pp. 177782. Date of Electronic Publication: 2025 May 27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH Terms: Oxidative Stress*/drug effects , Dopaminergic Neurons*/drug effects , Dopaminergic Neurons*/metabolism , Dopaminergic Neurons*/pathology , Ferroptosis*/drug effects , Dipeptidyl-Peptidase IV Inhibitors*/pharmacology , Dipeptidyl-Peptidase IV Inhibitors*/therapeutic use , Thiazolidines*/pharmacology , Thiazolidines*/therapeutic use , Pyrazoles*/pharmacology , Pyrazoles*/therapeutic use , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Parkinson Disease*/drug therapy , Parkinson Disease*/pathology , Parkinson Disease*/metabolism, Animals ; Mice ; Humans ; Male ; Reactive Oxygen Species/metabolism ; Cell Line, Tumor ; Disease Models, Animal ; Mice, Inbred C57BL ; Cell Survival/drug effects ; Dipeptidyl Peptidase 4/metabolism

Efficient Production of a Novel Subtilisin-like Serine Protease in Aspergillus niger for the Preparation of DPP-IV Inhibitory Activity Peptides from Protein Byproducts.

Authors: Xue Y Zeng L Yan Q et al.

Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Sep 03; Vol. 73 (35), pp. 22014-22026. Date of Electronic Publication: 2025 Aug 22.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH Terms: Aspergillus niger*/genetics , Aspergillus niger*/enzymology , Aspergillus niger*/metabolism , Aspergillus niger*/chemistry , Fungal Proteins*/genetics , Fungal Proteins*/chemistry , Fungal Proteins*/metabolism , Peptides*/chemistry , Peptides*/metabolism , Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/metabolism , Subtilisin*/genetics , Subtilisin*/chemistry , Subtilisin*/metabolism, Substrate Specificity ; Kinetics ; Fermentation ; Waste Products/analysis ; Dipeptidyl Peptidase 4/chemistry

DPP4 inhibition curbs systemic inflammation.

Authors: Hellenthal KEM Kintrup S Wirth T et al.

Source: Critical care (London, England) [Crit Care] 2025 Aug 15; Vol. 29 (1), pp. 359. Date of Electronic Publication: 2025 Aug 15.

Publication Type: Journal Article; Observational Study

Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE

MeSH Terms: Dipeptidyl-Peptidase IV Inhibitors*/therapeutic use , Dipeptidyl-Peptidase IV Inhibitors*/pharmacology , Inflammation*/drug therapy, Aged ; Animals ; Female ; Humans ; Male ; Mice ; Middle Aged ; Dipeptidyl Peptidase 4 ; Sitagliptin Phosphate/therapeutic use ; Sitagliptin Phosphate/pharmacology

Virtual Hydrolysis-Based Screening of Wheat-Derived DPP-IV Inhibitory Peptides: A Mechanistic Analysis Integrating Cell Experiments and Molecular Dynamics Simulations.

Authors: Liu Y Zhang Y Liu M et al.

Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Aug 06; Vol. 73 (31), pp. 19410-19426. Date of Electronic Publication: 2025 Jul 07.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH Terms: Triticum*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Peptides*/chemistry , Plant Proteins*/chemistry, Molecular Dynamics Simulation ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism ; Humans ; Hydrolysis ; Amino Acid Sequence

EGFR-TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer.

Authors: Zhang Y Zhang X Yang X et al.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Aug; Vol. 12 (31), pp. e06950. Date of Electronic Publication: 2025 Jun 06.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/therapeutic use , Dipeptidyl Peptidase 4*/metabolism , Dipeptidyl Peptidase 4*/genetics, Humans ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; ErbB Receptors/antagonists & inhibitors ; Animals ; Mice ; Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects ; Acrylamides/pharmacology ; Aniline Compounds/pharmacology ; Sitagliptin Phosphate/pharmacology ; Xenograft Model Antitumor Assays ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Metabolic Reprogramming ; Indoles ; Pyrimidines

Design, Synthesis and Antidiabetic Activity of Novel Pyrrole-3-Carboximidamide Derivatives as Dipeptidyl Peptidase-4 Inhibitors.

Authors: Dastjerdi HF Naderi N Garmabdari A et al.

Source: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2025 Aug; Vol. 358 (8), pp. e70077.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

MeSH Terms: Dipeptidyl-Peptidase IV Inhibitors*/pharmacology , Dipeptidyl-Peptidase IV Inhibitors*/chemical synthesis , Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemical synthesis , Hypoglycemic Agents*/chemistry , Drug Design* , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Type 2*/drug therapy , Pyrroles*/pharmacology , Pyrroles*/chemical synthesis , Pyrroles*/chemistry, Animals ; Rats, Wistar ; Structure-Activity Relationship ; Mice ; Rats ; Male ; Blood Glucose/drug effects ; Dipeptidyl Peptidase 4/metabolism ; Molecular Structure ; Glucose Tolerance Test ; Humans ; Dose-Response Relationship, Drug

Serum Proteome Profiling of Diabetic Patients Treated With DPP4 and SGLT2 Inhibitors Shows Improved Cognitive and Cardiovascular Functions.

Authors: Hakim MA Sanni A Osman ST et al.

Source: Proteomics [Proteomics] 2025 Jul; Vol. 25 (14), pp. e70000. Date of Electronic Publication: 2025 Jul 17.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101092707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-9861 (Electronic) Linking ISSN: 16159853 NLM ISO Abbreviation: Proteomics Subsets: MEDLINE

MeSH Terms: Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/blood , Sodium-Glucose Transporter 2 Inhibitors*/therapeutic use , Sodium-Glucose Transporter 2 Inhibitors*/pharmacology , Dipeptidyl-Peptidase IV Inhibitors*/therapeutic use , Dipeptidyl-Peptidase IV Inhibitors*/pharmacology , Proteome*/analysis , Proteome*/metabolism , Cognition*/drug effects, Humans ; Male ; Female ; Middle Aged ; Metformin/therapeutic use ; Aged ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/pharmacology ; Proteomics/methods ; Cardiovascular Diseases/drug therapy ; Dipeptidyl Peptidase 4