Suchergebnisse - "Osteoclasts"

Bone-on-a-chip recapitulates dynamic bone remodeling.

Autoren: Zhang Y Zhao Y Sun Z et al.

Quelle: Acta biomaterialia [Acta Biomater] 2025 Dec; Vol. 208, pp. 280-292. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

MeSH-Schlagworte: Bone Remodeling*/drug effects , Osteoblasts*/metabolism , Osteoblasts*/pathology , Osteoblasts*/cytology , Lab-On-A-Chip Devices* , Osteoclasts*/metabolism , Osteoclasts*/pathology , Osteoclasts*/cytology, Animals ; Mice ; Coculture Techniques ; Osteoporosis/pathology ; Osteoporosis/metabolism ; Cell Differentiation ; Humans

Osteoclasts drive bone formation in ectopic and orthotopic environments.

Autoren: Zhang Y Yu T Xiang Q et al.

Quelle: Biomaterials [Biomaterials] 2025 Nov; Vol. 322, pp. 123377. Date of Electronic Publication: 2025 Apr 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

MeSH-Schlagworte: Osteoclasts*/cytology , Osteoclasts*/transplantation , Osteogenesis*/drug effects , Osteogenesis*/physiology, Animals ; Bone Morphogenetic Protein 2/pharmacology ; Mice ; Bone Regeneration ; Mice, Inbred C57BL ; Tissue Scaffolds/chemistry ; Mesenchymal Stem Cells/cytology ; Skull/pathology

Complement C3 deficiency inhibits osteoclast differentiation and prevents ovariectomy-induced osteoporosis.

Autoren: Guha A Prasad A Ashokkumar K et al.

Quelle: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2025 Nov 01; Vol. 214 (11), pp. 3069-3082.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

MeSH-Schlagworte: Osteoclasts*/physiology , Osteoclasts*/immunology , Cell Differentiation* , Complement C3*/deficiency , Complement C3*/genetics , Osteoporosis*/immunology , Osteoporosis*/prevention & control , Osteoporosis*/etiology, Animals ; Mice ; Mice, Knockout ; Female ; Ovariectomy/adverse effects ; Mice, Inbred C57BL

Loss of SMN Impairs Osteoblast-Osteoclast Coupling via IGF1-Akt-OPG Axis in Spinal Muscular Atrophy.

Autoren: Xiang T Zhou Z Li Y et al.

Quelle: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Oct 31; Vol. 39 (20), pp. e71095.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH-Schlagworte: Insulin-Like Growth Factor I*/metabolism , Insulin-Like Growth Factor I*/genetics , Osteoclasts*/metabolism , Osteoclasts*/pathology , Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/genetics , Osteoblasts*/metabolism , Osteoblasts*/pathology , Osteoprotegerin*/metabolism , Osteoprotegerin*/genetics , Muscular Atrophy, Spinal*/metabolism , Muscular Atrophy, Spinal*/pathology , Muscular Atrophy, Spinal*/genetics , Survival of Motor Neuron 1 Protein*/metabolism , Survival of Motor Neuron 1 Protein*/genetics, Animals ; Mice ; Mice, Knockout ; Signal Transduction ; Cell Differentiation ; Mesenchymal Stem Cells/metabolism ; Male ; Mice, Inbred C57BL

Macrophages and osteoclasts: similarity and divergence between bone phagocytes.

Autoren: Halper J Dolfi B Ivanov S et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Oct 08; Vol. 16, pp. 1683872. Date of Electronic Publication: 2025 Oct 08 (Print Publication: 2025).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Osteoclasts*/immunology , Osteoclasts*/metabolism , Osteoclasts*/cytology , Macrophages*/immunology , Macrophages*/metabolism , Bone and Bones*/immunology , Bone and Bones*/cytology , Phagocytes*/immunology, Humans ; Animals ; Phagocytosis ; Bone Resorption/immunology ; Bone Remodeling

Activation of ERK/MAPK signaling by MAZ through transcriptional repression of PPP3CA to promote osteoclastogenesis and osteoporosis progression: Functions and mechanisms.

Autoren: Shang X Hu W Zhang L et al.

Quelle: Tissue & cell [Tissue Cell] 2025 Oct; Vol. 96, pp. 103028. Date of Electronic Publication: 2025 Jun 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE

MeSH-Schlagworte: Osteoporosis*/pathology , Osteoporosis*/genetics , Osteoporosis*/metabolism , Osteoclasts*/metabolism , Osteoclasts*/pathology , Osteogenesis*/genetics , MAP Kinase Signaling System* , Transcription Factors*/metabolism , Transcription Factors*/genetics , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , Disease Progression* , Transcription, Genetic*, Animals ; Mice ; Female ; RAW 264.7 Cells ; Cell Differentiation/genetics ; NFATC Transcription Factors/metabolism

Substance P Augments Chemokine Production by Staphylococcus aureus Infected Murine Osteoclasts.

Autoren: Sipprell SE Krueger QA Mills EL et al.

Quelle: Inflammation [Inflammation] 2025 Oct; Vol. 48 (5), pp. 3506-3518. Date of Electronic Publication: 2025 Mar 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7600105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2576 (Electronic) Linking ISSN: 03603997 NLM ISO Abbreviation: Inflammation Subsets: MEDLINE

MeSH-Schlagworte: Osteoclasts*/microbiology , Osteoclasts*/metabolism , Osteoclasts*/immunology , Osteoclasts*/drug effects , Substance P*/pharmacology , Substance P*/metabolism , Staphylococcal Infections*/immunology , Staphylococcal Infections*/metabolism , Staphylococcal Infections*/drug therapy , Staphylococcus aureus*/immunology , Chemokines*/biosynthesis , Osteomyelitis*/microbiology , Osteomyelitis*/immunology , Osteomyelitis*/metabolism , Osteomyelitis*/drug therapy, Animals ; Mice ; Mice, Inbred C57BL ; Receptors, Neurokinin-1/metabolism ; Neurokinin-1 Receptor Antagonists/pharmacology

Kurarinone Mitigates LPS-Induced Inflammatory Osteolysis by Inhibiting Osteoclastogenesis Through the Reduction of ROS Levels and Suppression of the PI3K/AKT Signaling Pathway.

Autoren: Lv H Luo H Tan W et al.

Quelle: Inflammation [Inflammation] 2025 Oct; Vol. 48 (5), pp. 2986-3005. Date of Electronic Publication: 2025 Jan 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7600105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2576 (Electronic) Linking ISSN: 03603997 NLM ISO Abbreviation: Inflammation Subsets: MEDLINE

MeSH-Schlagworte: Osteogenesis*/drug effects , Reactive Oxygen Species*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/antagonists & inhibitors , Osteolysis*/chemically induced , Osteolysis*/drug therapy , Osteolysis*/metabolism , Osteolysis*/prevention & control , Osteoclasts*/drug effects , Osteoclasts*/metabolism , Flavonoids*/pharmacology , Flavonoids*/therapeutic use, Animals ; Lipopolysaccharides/toxicity ; Signal Transduction/drug effects ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; RAW 264.7 Cells ; Inflammation/drug therapy

Corosolic acid modulates RANKL-triggered signaling to suppress osteoclastogenesis and ovariectomy-induced bone loss.

Autoren: Zhao C Wu F Zhao L et al.

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 882-898. Date of Electronic Publication: 2025 Oct 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: RANK Ligand*/metabolism , RANK Ligand*/genetics , Osteogenesis*/drug effects , Osteoclasts*/drug effects , Osteoclasts*/metabolism , Osteoclasts*/pathology , Triterpenes*/pharmacology , Bone Resorption*/drug therapy , Bone Resorption*/pathology , Bone Resorption*/metabolism , Osteoporosis*/drug therapy , Osteoporosis*/pathology , Osteoporosis*/metabolism , Osteoporosis*/etiology, Animals ; Ovariectomy/adverse effects ; Mice ; Female ; Cell Differentiation/drug effects ; Signal Transduction/drug effects ; Reactive Oxygen Species/metabolism ; NF-kappa B/metabolism ; NF-kappa B/genetics ; NFATC Transcription Factors/genetics ; NFATC Transcription Factors/metabolism ; Humans ; Macrophages/drug effects ; Macrophages/metabolism ; Oxidative Stress/drug effects ; Mice, Inbred C57BL

Human peripheral osteoclast-precursor-development patterns reveal the significance of RPS17-dependent ribosome synthesis to Ankylosing Spondylitis lesions.

Autoren: Ke D Dai H Han J et al.

Quelle: Bone research [Bone Res] 2025 Dec 04; Vol. 13 (1), pp. 100. Date of Electronic Publication: 2025 Dec 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE

MeSH-Schlagworte: Spondylitis, Ankylosing*/pathology , Spondylitis, Ankylosing*/metabolism , Spondylitis, Ankylosing*/genetics , Osteoclasts*/metabolism , Osteoclasts*/pathology , Ribosomes*/metabolism , Ribosomal Proteins*/metabolism , Ribosomal Proteins*/genetics, Humans ; Animals ; Mice ; Female ; Monocytes/metabolism ; Leukocytes, Mononuclear/metabolism ; Mice, Inbred C57BL ; Osteogenesis ; Male

Microstructure-tailored β-tricalcium phosphate scaffolds utilize degradation-guided osteoclast suppression to accelerate bone regeneration.

Autoren: Lu Q Zeng F Diao J et al.

Quelle: Journal of materials chemistry. B [J Mater Chem B] 2025 Dec 03; Vol. 13 (47), pp. 15282-15296. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-7518 (Electronic) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B Subsets: MEDLINE

MeSH-Schlagworte: Calcium Phosphates*/chemistry , Calcium Phosphates*/pharmacology , Bone Regeneration*/drug effects , Tissue Scaffolds*/chemistry , Osteoclasts*/drug effects , Osteoclasts*/cytology , Osteoclasts*/metabolism , Biocompatible Materials*/chemistry , Biocompatible Materials*/pharmacology, Animals ; Osteogenesis/drug effects ; Mice ; Cell Proliferation/drug effects ; Cell Differentiation/drug effects ; Cells, Cultured ; Particle Size

Validation of the therapeutic potential of soluble CD93 lectin-like domain in arthritis and its inhibitory role in inflammatory osteolysis.

Autoren: Huang SE Kuo CH Wu HL et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115533. Date of Electronic Publication: 2025 Sep 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Osteolysis*/drug therapy , Osteolysis*/immunology , Osteoclasts*/drug effects , Osteoclasts*/physiology , Arthritis, Experimental*/drug therapy , Arthritis, Experimental*/immunology , Membrane Glycoproteins*/therapeutic use , Arthritis, Rheumatoid*/drug therapy , Arthritis, Rheumatoid*/immunology, Animals ; Mice ; RANK Ligand/metabolism ; Male ; Tumor Necrosis Factor-alpha/metabolism ; Humans ; Mice, Inbred C57BL ; Macrophages/drug effects ; NFATC Transcription Factors/metabolism ; Signal Transduction ; Osteogenesis/drug effects ; NF-kappa B/metabolism ; RAW 264.7 Cells ; TNF Receptor-Associated Factor 6/metabolism ; Cell Differentiation/drug effects

Liquiritin targets NF-κB/MAPK signaling to attenuate osteoclastogenesis and triggers apoptosis through PPARγ activation.

Autoren: Wu J Zhang Y Wang Y et al.

Quelle: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Dec; Vol. 149, pp. 157604. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH-Schlagworte: Glucosides*/pharmacology , PPAR gamma*/metabolism , Flavanones*/pharmacology , Apoptosis*/drug effects , Osteoclasts*/drug effects , Osteogenesis*/drug effects , Osteoporosis, Postmenopausal*/drug therapy, Animals ; Mice ; NF-kappa B/metabolism ; Female ; Molecular Docking Simulation ; MAP Kinase Signaling System/drug effects ; Mice, Inbred C57BL ; Bone Resorption/drug therapy ; Signal Transduction/drug effects ; Macrophages/drug effects ; Glycyrrhiza uralensis/chemistry

Inhibition of Gremlin1 reduces osteoclast activation and alleviates inflammation-induced bone loss by disrupting the NF-κB signaling pathway.

Autoren: Wang Y Li W Tang Y et al.

Quelle: Journal of oral biosciences [J Oral Biosci] 2025 Dec; Vol. 67 (4), pp. 100686. Date of Electronic Publication: 2025 Aug 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101226721 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-3865 (Electronic) Linking ISSN: 13490079 NLM ISO Abbreviation: J Oral Biosci Subsets: MEDLINE

MeSH-Schlagworte: Osteoclasts*/metabolism , NF-kappa B*/metabolism , Intercellular Signaling Peptides and Proteins*/metabolism , Intercellular Signaling Peptides and Proteins*/genetics , Alveolar Bone Loss*/metabolism , Alveolar Bone Loss*/etiology , Periodontitis*, Animals ; Signal Transduction ; Humans ; X-Ray Microtomography ; Mice ; Disease Models, Animal ; Male ; Cell Differentiation ; Inflammation ; Gene Knockdown Techniques

Fe₃O₄-MXene as a dual-function root canal agent for disinfection and osteoclast inhibition in persistent apical periodontitis.

Autoren: Lai S Shui S Li Y et al.

Quelle: Acta biomaterialia [Acta Biomater] 2025 Dec; Vol. 208, pp. 510-524. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

MeSH-Schlagworte: Periapical Periodontitis*/pathology , Periapical Periodontitis*/drug therapy , Periapical Periodontitis*/metabolism , Periapical Periodontitis*/microbiology , Osteoclasts*/pathology , Osteoclasts*/metabolism , Osteoclasts*/drug effects , Disinfection*/methods, Animals ; Enterococcus faecalis/drug effects ; Enterococcus faecalis/physiology ; Mice ; Biofilms/drug effects ; RAW 264.7 Cells ; Root Canal Therapy ; Humans ; Reactive Oxygen Species/metabolism ; Nitrites ; Transition Elements

P. Gingivalis LPS Drives Osteoclastogenesis and Impairs Osteoblast Differentiation by Suppressing Sema3A/Nrp1 Via TLR-4.

Autoren: Feng J Fu D Phan S et al.

Quelle: International dental journal [Int Dent J] 2025 Dec; Vol. 75 (6), pp. 103941. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 0374714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-595X (Electronic) Linking ISSN: 00206539 NLM ISO Abbreviation: Int Dent J Subsets: MEDLINE

MeSH-Schlagworte: Semaphorin-3A*/metabolism , Cell Differentiation*/drug effects , Osteoblasts*/drug effects , Osteoblasts*/cytology , Osteoblasts*/metabolism , Osteogenesis*/drug effects , Lipopolysaccharides*/pharmacology , Porphyromonas gingivalis* , Neuropilin-1*/metabolism , Toll-Like Receptor 4*/metabolism , Osteoclasts*/drug effects , Osteoclasts*/metabolism, Animals ; Mice ; Cell Proliferation ; Osteolysis ; Real-Time Polymerase Chain Reaction ; Enzyme-Linked Immunosorbent Assay ; Blotting, Western ; Down-Regulation ; Mesenchymal Stem Cells

Epimedin B attenuates ovariectomy-induced bone loss by suppressing osteoclastogenesis through decreasing ROS production and targeting ESR1.

Autoren: Lai Y Li H Zhou T et al.

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 01; Vol. 240, pp. 347-363. Date of Electronic Publication: 2025 Aug 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: Reactive Oxygen Species*/metabolism , Osteoclasts*/drug effects , Osteoclasts*/metabolism , Osteoclasts*/pathology , Osteogenesis*/drug effects , Bone Resorption*/drug therapy , Bone Resorption*/metabolism , Bone Resorption*/pathology , Estrogen Receptor alpha*/genetics , Estrogen Receptor alpha*/metabolism , Osteoporosis*/drug therapy , Osteoporosis*/pathology , Osteoporosis*/metabolism , Osteoporosis*/etiology , Flavonoids*/pharmacology, Animals ; Ovariectomy/adverse effects ; Mice ; Female ; Cell Differentiation/drug effects ; Signal Transduction/drug effects ; RANK Ligand/genetics ; RANK Ligand/metabolism ; Humans ; Mice, Inbred C57BL ; Disease Models, Animal

FSTL1 promotes osteoclast differentiation and Accelerates periprosthetic osteolysis via PP2A Cα-Mediated activation of the JNK signaling pathway.

Autoren: Li M Wang L Lu F et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 4), pp. 117450. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Osteolysis*/metabolism , Osteolysis*/pathology , Osteolysis*/chemically induced , Osteoclasts*/metabolism , Osteoclasts*/drug effects , Osteoclasts*/pathology , Cell Differentiation*/physiology , Cell Differentiation*/drug effects , Follistatin-Related Proteins*/genetics , Follistatin-Related Proteins*/metabolism , Protein Phosphatase 2*/metabolism , Protein Phosphatase 2*/genetics , MAP Kinase Signaling System*/physiology , MAP Kinase Signaling System*/drug effects, Animals ; Humans ; Mice ; Proto-Oncogene Mas ; Male ; Mice, Inbred C57BL ; Female ; Osteogenesis

Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection.

Autoren: Chao R Wang Y Liu Z et al.

Quelle: International journal of molecular medicine [Int J Mol Med] 2025 Dec; Vol. 56 (6). Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE

MeSH-Schlagworte: NF-E2-Related Factor 2*/metabolism , Osteoclasts*/drug effects , Osteoclasts*/metabolism , Kelch-Like ECH-Associated Protein 1*/metabolism , Osteolysis*/drug therapy , Osteolysis*/metabolism , Osteolysis*/pathology , MAP Kinase Signaling System*/drug effects, Animals ; Mice ; Bone Resorption/drug therapy ; Bone Resorption/metabolism ; Bone Resorption/pathology ; Male ; Signal Transduction/drug effects ; Cell Differentiation/drug effects ; Osteogenesis/drug effects ; RAW 264.7 Cells ; Mitogen-Activated Protein Kinases/metabolism

The osteoclast blind spot and other unresolved mechanisms in the exosomal theory of tuberculosis-induced osteoporosis.

Autoren: Qi L Gu Q Chen B et al.

Quelle: Immunologic research [Immunol Res] 2025 Nov 26; Vol. 73 (1), pp. 170. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article; Letter

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8611087 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0755 (Electronic) Linking ISSN: 0257277X NLM ISO Abbreviation: Immunol Res Subsets: MEDLINE

MeSH-Schlagworte: Exosomes*/metabolism , Osteoclasts*/immunology , Osteoclasts*/metabolism , Osteoporosis*/etiology , Osteoporosis*/immunology , Osteoporosis*/metabolism , Mycobacterium tuberculosis*/physiology , Mycobacterium tuberculosis*/immunology , Tuberculosis*/complications , Tuberculosis*/immunology, Humans ; Animals ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Macrophages/immunology ; Macrophages/microbiology