Suchergebnisse - "Osteoblasts drug effects"

Only bioactive forms of PTH (n-oxPTH and Met18(ox)-PTH) inhibit synthesis of sclerostin – evidence from in vitro and human studies

Autoren: Li, Mei Hasan, Ahmed A. Chu, Chang et al.

Quelle: Pflugers Arch

Schlagwörter: Genetic Markers, Male, 0301 basic medicine, Oxidized, Cell Line, 03 medical and health sciences, Methionine, Biowissenschaften, Biologie, Integrative Physiology, Humans, Animals, Adaptor Proteins, Signal Transducing/metabolism [MeSH], Genetic Markers [MeSH], Female [MeSH], KTRs, Humans [MeSH], Cell Line [MeSH], Osteoblasts/metabolism [MeSH], Rats [MeSH], Middle Aged [MeSH], Bone Morphogenetic Proteins/metabolism [MeSH], Oxidation-Reduction [MeSH], Animals [MeSH], Non-oxidized, Methionine/pharmacology [MeSH], Parathyroid Hormone/metabolism [MeSH], Male [MeSH], SOST, Methionine/metabolism [MeSH], PTH, Osteoblasts/drug effects [MeSH], Adaptor Proteins, Signal Transducing, 0303 health sciences, Osteoblasts, Middle Aged, Rats, Parathyroid Hormone, Bone Morphogenetic Proteins, Female, Oxidation-Reduction

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38393416
https://repository.publisso.de/resource/frl:6504677
https://refubium.fu-berlin.de/handle/fub188/46360
https://doi.org/10.1007/s00424-024-02928-x
https://doi.org/10.17169/refubium-46072

Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade

Autoren: Yu, Xin Jiang, Juan Li, Cheng et al.

Quelle: Mol Med
Molecular Medicine, Vol 30, Iss 1, Pp 1-26 (2024)

Schlagwörter: Male, 0301 basic medicine, Apoptosis, RM1-950, QD415-436, Osteolysis, Biochemistry, Mice, eIF-2 Kinase, 03 medical and health sciences, Coumarins, Osteogenesis, Animals, Humans, Aseptic loosening, 0303 health sciences, Osteoblasts, Osteoblast, Research, PERK signaling cascade, Osthole, Endoplasmic Reticulum Stress, Disease Models, Animal, Therapeutics. Pharmacology, Osteogenesis/drug effects [MeSH], eIF-2 Kinase/metabolism [MeSH], Endoplasmic Reticulum Stress/drug effects [MeSH], Osteoblasts/metabolism [MeSH], Coumarins/pharmacology [MeSH], Osteolysis/etiology [MeSH], Osteolysis/drug therapy [MeSH], Male [MeSH], Coumarins/chemistry [MeSH], Coumarins/therapeutic use [MeSH], Signal Transduction/drug effects [MeSH], Osteolysis/metabolism [MeSH], Disease Models, Animal [MeSH], Humans [MeSH], Apoptosis/drug effects [MeSH], Animals [MeSH], Evolutionary Aspects of Metabolic Diseases, ER stress, Mice [MeSH], Osteoblasts/drug effects [MeSH], Signal Transduction

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39707212
https://doaj.org/article/1db7541146d54e5b9afcf2a60182b294
https://repository.publisso.de/resource/frl:6517784

Lithium chloride inhibits the migration and invasion of osteosarcoma cells by blocking nuclear translocation of phospho-Erk

Autoren: Ju Yeong Kim Hun Hee Park Tai Soon Yong et al.

Weitere Verfasser: Ju Yeong Kim Hun Hee Park Tai Soon Yong et al.

Quelle: Biochemical and Biophysical Research Communications. 581:74-80

Schlagwörter: 0301 basic medicine, Osteoblasts / pathology, Culture, Proliferation, Osteoblasts / drug effects, Cell Nucleus / drug effects, MAP Kinase Signaling System / drug effects, Invasion, Cell Movement, beta Catenin / metabolism, Bone Marrow Cells / drug effects, Phosphorylation, Wnt Signaling Pathway, beta Catenin, Bone Marrow Cells / cytology, Mitogen-Activated Protein Kinase 1, Cell Movement / genetics, Diffusion Chambers, Osteosarcoma, 0303 health sciences, Tumor, Mitogen-Activated Protein Kinase 3, Protein Transport / drug effects, Cell Movement / drug effects, Osteoblasts / metabolism, Mitogen-Activated Protein Kinase 3 / genetics, 3. Good health, Gene Expression Regulation, Neoplastic, Protein Transport, Mitogen-Activated Protein Kinase 1 / genetics, Diffusion Chambers, Culture, Cell Proliferation / genetics, beta Catenin / genetics, Mitogen-Activated Protein Kinase 1 / antagonists & inhibitors, MAP Kinase Signaling System, Primary Cell Culture, Epidermal Growth Factor / pharmacology, Bone Marrow Cells, Cell Line, 03 medical and health sciences, Cell Line, Tumor, Glycogen Synthase Kinase 3 beta / genetics, Humans, Cell Proliferation, Cell Nucleus, Neoplastic, Phosphorylation / drug effects, Glycogen Synthase Kinase 3 beta, Osteoblasts, Mitogen-Activated Protein Kinase 3 / antagonists & inhibitors, Epidermal Growth Factor, Cell Nucleus / metabolism, Epidermal growth factor, Bone Marrow Cells / metabolism, Glycogen Synthase Kinase 3 beta / metabolism, Lithium Chloride / pharmacology, Lithium chloride, Gene Expression Regulation, Mitogen-Activated Protein Kinase 1 / metabolism, Wnt Signaling Pathway / drug effects, Cell Proliferation / drug effects, Lithium Chloride, Mitogen-Activated Protein Kinase 3 / metabolism

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/34656851
https://pubmed.ncbi.nlm.nih.gov/34656851/
https://www.sciencedirect.com/science/article/pii/S0006291X21014327
https://www.ncbi.nlm.nih.gov/pubmed/34656851
https://yonsei.pure.elsevier.com/en/publications/lithium-chloride-inhibits-the-migration-and-invasion-of-osteosarc

Myostatin regulates the production of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast–like cells

Autoren: Franz Ewendt Martina Feger Michael Föller

Quelle: Pflugers Arch

Schlagwörter: 0301 basic medicine, Signaling and Cell Physiology, Pyridines, Activin Receptors, Dioxoles, p38 Mitogen-Activated Protein Kinases, Cell Line, Mice, 03 medical and health sciences, Cell Line, Tumor [MeSH], Activin Receptors/metabolism [MeSH], Cell Line [MeSH], Fibroblast Growth Factor-23/genetics [MeSH], Osteoblasts/metabolism [MeSH], Signaling and cell physiology, Withanolides/pharmacology [MeSH], TGF-β, Phosphate, p38 Mitogen-Activated Protein Kinases/antagonists, Vitamin D, Imidazoles/pharmacology [MeSH], Benzamides/pharmacology [MeSH], Pyridines/pharmacology [MeSH], Calcium/metabolism [MeSH], Protein Kinase Inhibitors/pharmacology [MeSH], NF-kappa B/antagonists, Fibroblast Growth Factor-23/metabolism [MeSH], Rats [MeSH], Animals [MeSH], Mice [MeSH], NF-kappa B/metabolism [MeSH], Ca, Myostatin/pharmacology [MeSH], p38 Mitogen-Activated Protein Kinases/metabolism [MeSH], p38MAPK, Dioxoles/pharmacology [MeSH], Osteoblasts/drug effects [MeSH], Cell Line, Tumor, Animals, Protein Kinase Inhibitors, Withanolides, 0303 health sciences, Osteoblasts, Imidazoles, NF-kappa B, Myostatin, Rats, Fibroblast Growth Factor-23, Benzamides, Calcium, ddc:570

Dateibeschreibung: 1 Online-Ressource; application/pdf

Zugangs-URL: https://link.springer.com/content/pdf/10.1007/s00424-021-02561-y.pdf
https://pubmed.ncbi.nlm.nih.gov/33895875
https://link.springer.com/content/pdf/10.1007/s00424-021-02561-y.pdf
https://www.ncbi.nlm.nih.gov/pubmed/33895875
https://link.springer.com/article/10.1007/s00424-021-02561-y
https://pubmed.ncbi.nlm.nih.gov/33895875/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164604
https://europepmc.org/article/MED/33895875
https://repository.publisso.de/resource/frl:6446960

Glucocorticoids dexamethasone and prednisolone suppress fibroblast growth factor 23 (FGF23)

Autoren: Martina Feger Franz Ewendt Jörg Strotmann et al.

Quelle: J Mol Med (Berl)

Schlagwörter: Male, 0301 basic medicine, Prednisolone, Bone and Bones, Dexamethasone, Phosphates, Mice, 03 medical and health sciences, Receptors, Glucocorticoid, Calcitriol, Cell Line, Tumor, Animals, Glucocorticoids, ddc:610, 0303 health sciences, Osteoblasts, Cell Line, Tumor [MeSH], Mice, Inbred C57BL [MeSH], Osteoblasts/metabolism [MeSH], αKlotho, Original Article, Phosphates/metabolism [MeSH], Male [MeSH], Phosphate, Dexamethasone/administration, Signal Transduction/drug effects [MeSH], Calcitriol/blood [MeSH], Glucocorticoids/administration, Bone and Bones/metabolism [MeSH], Female [MeSH], Fibroblast Growth Factors/metabolism [MeSH], Inflammation, Fibroblast Growth Factor-23/antagonists, Rats [MeSH], 1,25(OH), Animals [MeSH], Mice [MeSH], Renal Elimination/drug effects [MeSH], Fibroblast Growth Factor-23/blood [MeSH], Fibroblast Growth Factors/antagonists, Receptors, Glucocorticoid/antagonists, Mifepristone/pharmacology [MeSH], Osteoblasts/drug effects [MeSH], Prednisolone/administration, Rats, 3. Good health, Fibroblast Growth Factors, Mice, Inbred C57BL, Fibroblast Growth Factor-23, Mifepristone, Renal Elimination, Female, Signal Transduction

Dateibeschreibung: 1 Online-Ressource; application/pdf

Zugangs-URL: https://link.springer.com/content/pdf/10.1007/s00109-021-02036-8.pdf
https://pubmed.ncbi.nlm.nih.gov/33517471
https://www.ncbi.nlm.nih.gov/pubmed/33517471
https://pubmed.ncbi.nlm.nih.gov/33517471/
https://link.springer.com/content/pdf/10.1007/s00109-021-02036-8.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055636
https://link.springer.com/article/10.1007/s00109-021-02036-8
https://europepmc.org/article/MED/33517471
https://repository.publisso.de/resource/frl:6448295

Titanium particles inhibit osteoblast adhesion to fibronectin-coated substrates.

Autoren: Kwon, S.Y. Takei, H. Pioletti, D.P. et al.

Schlagwörter: Actins/analysis, Animals, Cell Adhesion/drug effects, Cells, Cultured, Collagen/genetics, Cytochalasin D/pharmacology, Fibronectins/genetics, Fibronectins/physiology, Osteoblasts/drug effects, RNA, Messenger/analysis, Rats, Titanium/pharmacology

Relation: Journal of Orthopaedic Research; https://iris.unil.ch/handle/iris/76385; serval:BIB_17536; 000086949200006

Verfügbarkeit: https://iris.unil.ch/handle/iris/76385
https://doi.org/10.1002/jor.1100180207

Does Riluzole Influence Bone Formation?: An In Vitro Study of Human Mesenchymal Stromal Cells and Osteoblast

Autoren: Schroeder, Gregory D. Kepler, Christopher K. Grad, Sibylle et al.

Weitere Verfasser: Schroeder, Gregory D. Kepler, Christopher K. Grad, Sibylle et al.

Quelle: Spine. 44:1107-1117

Schlagwörter: Fracture Healing, 0301 basic medicine, Osteoblasts, Riluzole, Osteocalcin/metabolism, Osteocalcin, Cell Differentiation, Mesenchymal Stem Cells, Collagen Type I/metabolism, Alkaline Phosphatase, Collagen Type I, Osteogenesis/drug effects, Osteoblasts/drug effects, 03 medical and health sciences, Mesenchymal Stem Cells/drug effects, Alkaline Phosphatase/metabolism, Osteogenesis, Cell Differentiation/drug effects, Journal Article, Humans, Riluzole/pharmacology, Cells, Cultured

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/30896584
https://dspace.library.uu.nl/handle/1874/388536
https://digitalcommons.psjhealth.org/publications/1240/
https://pubmed.ncbi.nlm.nih.gov/30896584/
https://www.narcis.nl/publication/RecordID/oai%3Adspace.library.uu.nl%3A1874%2F388536
https://insights.ovid.com/spine/spne/2019/08/150/does-riluzole-influence-bone-formation-vitro-study/3/00007632
https://www.ncbi.nlm.nih.gov/pubmed/30896584
https://dspace.library.uu.nl/handle/1874/388536

The small-molecule protein ligand interface stabiliser E7820 induces differential cell line specific responses of integrin α2 expression

Autoren: Hülskamp, Michael David Kronenberg, Daniel Stange, Richard et al.

Weitere Verfasser: Hülskamp, Michael David Kronenberg, Daniel Stange, Richard et al.

Quelle: BMC Cancer
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)

Schlagwörter: 0301 basic medicine, Indoles, 610 Medicine and health, SPLINTS, Integrin alpha2, Ligands, Cell Line, Mice, 03 medical and health sciences, Human Umbilical Vein Endothelial Cells, Animals, Humans, Protein Isoforms, ddc:610, Promoter Regions, Genetic, CAPERα, RC254-282, Protein Isoforms/antagonists, Cell Line [MeSH], Osteoblasts/metabolism [MeSH], Trans-Activators/genetics [MeSH], Proteolysis/drug effects [MeSH], Ligands [MeSH], Indoles/pharmacology [MeSH], Integrin alpha2/genetics [MeSH], Up-Regulation/drug effects [MeSH], Protein Isoforms/metabolism [MeSH], RNA-Binding Proteins/metabolism [MeSH], Humans [MeSH], Human Umbilical Vein Endothelial Cells/metabolism [MeSH], Sulfonamides/pharmacology [MeSH], Animals [MeSH], Integrin α2, Protein Isoforms/genetics [MeSH], Promoter Regions, Genetic/genetics [MeSH], Mice [MeSH], Human Umbilical Vein Endothelial Cells/drug effects [MeSH], RNA-Binding Proteins/genetics [MeSH], Integrin alpha2/metabolism [MeSH], RNA-Binding Proteins/antagonists, Research, Trans-Activators/antagonists, E7820, Trans-Activators/metabolism [MeSH], Osteoblasts/drug effects [MeSH], Sulfonamides, 0303 health sciences, Osteoblasts, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RNA-Binding Proteins, Up-Regulation, 3. Good health, Medicine and health, Proteolysis, Trans-Activators

Dateibeschreibung: application/pdf

Zugangs-URL: https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-021-08301-w
https://pubmed.ncbi.nlm.nih.gov/34006252
https://doaj.org/article/b07632ce4aa24c3e908f7c29ea4bdb3b
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-021-08301-w
https://link.springer.com/article/10.1186/s12885-021-08301-w
https://link.springer.com/content/pdf/10.1186/s12885-021-08301-w.pdf
https://europepmc.org/article/MED/34006252
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132423
https://www.ncbi.nlm.nih.gov/pubmed/34006252
https://repository.publisso.de/resource/frl:6462829
https://repositorium.uni-muenster.de/transfer/miami/c6ff0dff-7a18-478e-9edf-e56ff41c6864

Antibody-based inhibition of circulating DLK1 protects from estrogen deficiency-induced bone loss in mice

Autoren: Ditte Caroline Andersen Moustapha Kassem Casper A. Nipper Nielsen et al.

Quelle: Figeac, F, Andersen, D C, Nipper Nielsen, C A, Ditzel, N, Sheikh, S P, Skjødt, K, Kassem, M, Jensen, C H & Abdallah, B M 2018, ' Antibody-based inhibition of circulating DLK1 protects from estrogen deficiency-induced bone loss in mice ', Bone, vol. 110, pp. 312-320 . https://doi.org/10.1016/j.bone.2018.02.030

Schlagwörter: Monoclonal antibody, 0301 basic medicine, Ovariectomy, Osteoclasts, Intercellular Signaling Peptides and Proteins/immunology, Antibodies, Cell Line, Osteoblasts/drug effects, Mice, 03 medical and health sciences, Antibodies, Neutralizing/therapeutic use, Bone Density, Osteogenesis, Osteoporosis/prevention & control, Animals, Humans, Bone Resorption, Pref-1, 0303 health sciences, Bone Resorption/prevention & control, Osteoblasts, Estrogens/deficiency, Dlk1, Osteoblast, Calcium-Binding Proteins, Bone Density/drug effects, Estrogens, X-Ray Microtomography, Flow Cytometry, Antibodies, Neutralizing, Osteogenesis/drug effects, 3. Good health, Neutralizing/therapeutic use, NIH 3T3 Cells, Osteoclast, Intercellular Signaling Peptides and Proteins, Osteoporosis, Osteoclasts/drug effects, Female, Antibodies/therapeutic use

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/29499415
https://pubmed.ncbi.nlm.nih.gov/29499415/
https://www.sciencedirect.com/science/article/abs/pii/S8756328218300899
https://portal.findresearcher.sdu.dk/da/publications/antibody-based-inhibition-of-circulating-dlk1-protects-from-estro
https://findresearcher.sdu.dk:8443/ws/files/137909280/Antibody_based_inhibition_of_circulating_DLK1_protects_from_estrogen_deficiency_induced_bone_loss_in_mice.pdf
https://www.ncbi.nlm.nih.gov/pubmed/29499415
https://findresearcher.sdu.dk:8443/ws/files/137909280/Antibody_based_inhibition_of_circulating_DLK1_protects_from_estrogen_deficiency_induced_bone_loss_in_mice.pdf

Simvastatin induces adverse effects on proliferation and mineralization of human primary osteoblasts

Autoren: Sabandal, Martin M. I. Schäfer, Edgar Aed, Jonathan et al.

Weitere Verfasser: Sabandal, Martin M. I. Schäfer, Edgar Aed, Jonathan et al.

Quelle: Head Face Med
Head & Face Medicine, Vol 16, Iss 1, Pp 1-9 (2020)

Schlagwörter: Adult, Male, 0301 basic medicine, Simvastatin, Mineralization, 610 Medicine and health, Specialties of internal medicine, 03 medical and health sciences, Osteogenesis, Humans, ddc:610, Cell Proliferation, 0303 health sciences, Osteoblasts, Adverse effects, Research, Anticholesteremic Agents, Osteogenesis/drug effects [MeSH], Female [MeSH], Cell Proliferation [MeSH], Adult [MeSH], Humans [MeSH], Cell Differentiation [MeSH], Anticholesteremic Agents/adverse effects [MeSH], Simvastatin/adverse effects [MeSH], Male [MeSH], Osteoblasts/drug effects [MeSH], Cell Differentiation, 3. Good health, RC581-951, Medicine and health, Female

Dateibeschreibung: application/pdf

Zugangs-URL: https://head-face-med.biomedcentral.com/track/pdf/10.1186/s13005-020-00232-4
https://pubmed.ncbi.nlm.nih.gov/32819403
https://doaj.org/article/c5e0da6a123e4d58a0f14394b6ee80ce
https://link.springer.com/article/10.1186/s13005-020-00232-4
https://www.scilit.net/article/98c15e6d5ca85172daf282887fb5172c
https://head-face-med.biomedcentral.com/articles/10.1186/s13005-020-00232-4
https://www.ncbi.nlm.nih.gov/pubmed/32819403
https://pubmed.ncbi.nlm.nih.gov/32819403/
https://link.springer.com/content/pdf/10.1186/s13005-020-00232-4.pdf
https://repository.publisso.de/resource/frl:6466172
https://repositorium.uni-muenster.de/transfer/miami/24b52f47-539e-4505-a082-7247dd93f1f1

Correlation study between osteoporosis and hematopoiesis in the context of adjuvant chemotherapy for breast cancer

Autoren: Jérôme Pasquier Olaia Naveiras Olivier Lamy et al.

Quelle: Ann Hematol
Annals of hematology, vol. 97, no. 2, pp. 309-317

Schlagwörter: Adult, Blood Platelets, 0301 basic medicine, Neutropenia, Neutrophils, Absorptiometry, Photon, Adipocytes/drug effects, Adipocytes/immunology, Adipocytes/pathology, Aged, Antineoplastic Agents/administration & dosage, Antineoplastic Agents/adverse effects, Blood Platelets/drug effects, Blood Platelets/immunology, Blood Platelets/pathology, Body Mass Index, Bone Density/drug effects, Bone Density/immunology, Bone Diseases, Metabolic/complications, Bone Diseases, Metabolic/diagnostic imaging, Bone Diseases, Metabolic/drug therapy, Bone Diseases, Metabolic/immunology, Bone Marrow Cells/drug effects, Bone Marrow Cells/immunology, Bone Marrow Cells/pathology, Breast Neoplasms/complications, Breast Neoplasms/diagnostic imaging, Breast Neoplasms/drug therapy, Breast Neoplasms/immunology, Cell Count, Chemotherapy, Adjuvant, Female, Hematopoiesis/drug effects, Hematopoiesis/immunology, Humans, Lumbar Vertebrae/diagnostic imaging, Lumbar Vertebrae/drug effects, Lumbar Vertebrae/immunology, Lumbar Vertebrae/pathology, Middle Aged, Neutropenia/chemically induced, Neutropenia/diagnostic imaging, Neutropenia/immunology, Neutropenia/pathology, Neutrophils/drug effects, Neutrophils/immunology, Neutrophils/pathology, Osteoblasts/drug effects, Osteoblasts/immunology, Osteoblasts/pathology, Osteoporosis/complications, Osteoporosis/diagnostic imaging, Osteoporosis/drug therapy, Osteoporosis/immunology, Retrospective Studies, Anemia, Bone marrow adipocytes, Bone marrow microenvironment, Breast cancer, Chemotherapy, Febrile neutropenia, Graded toxicity of chemotherapy, Hematopoiesis, Neutrophil, Osteoblast, Osteoporosis, Platelet, Stress hematopoiesis, T-score, TBS, Trabecular bone score, Antineoplastic Agents, Bone Marrow Cells, Breast Neoplasms, 03 medical and health sciences, Bone Density, Adipocytes, 2. Zero hunger, 0303 health sciences, Lumbar Vertebrae, 3. Good health, Bone Diseases, Metabolic, Original Article

Dateibeschreibung: application/pdf

Zugangs-URL: https://link.springer.com/content/pdf/10.1007/s00277-017-3184-6.pdf
https://pubmed.ncbi.nlm.nih.gov/29170810
https://infoscience.epfl.ch/record/258592
http://europepmc.org/articles/PMC5754401
https://link.springer.com/content/pdf/10.1007%2Fs00277-017-3184-6.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754401
https://link.springer.com/article/10.1007/s00277-017-3184-6
https://www.ncbi.nlm.nih.gov/pubmed/29170810
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_FBB20C5D91BD7
https://serval.unil.ch/notice/serval:BIB_FBB20C5D91BD
https://serval.unil.ch/resource/serval:BIB_FBB20C5D91BD.P001/REF.pdf

Investigation of the effect of astaxanthin on alveolar bone loss in experimental periodontitis

Autoren: Balci Yuce, H. Lektemur Alpan, Aysan Gevrek, F. et al.

Weitere Verfasser: Balci Yuce, H. Lektemur Alpan, Aysan Gevrek, F. et al.

Quelle: Journal of Periodontal Research. 53:131-138

Schlagwörter: alveolar bone loss, antioxidant, Osteocalcin, Wistar, Alveolar Bone Loss, osteocalcin, Bone Morphogenetic Protein 2, Cell Count, bone morphogenetic protein 2, Alveolar Bone Loss/*prevention & control, Animals, Antioxidants/*pharmacology, Bone Morphogenetic Protein 2/metabolism, Disease Models, Animal, Nitric Oxide Synthase/metabolism, Osteoblasts/drug effects, Osteocalcin/metabolism, Periodontitis/*drug therapy, Rats, Wistar, Xanthophylls/pharmacology, bcl-2-Associated X Protein/metabolism, Wistar rat, Xanthophylls, Antioxidants, 03 medical and health sciences, Bax protein, rat, 0302 clinical medicine, rat, xanthophyll, animal, Periodontitis, periodontitis, cell count, experimental periodontitis, bcl-2-Associated X Protein, Osteoblasts, Animal, nitric oxide synthase, disease model, drug effect, inducible nitric oxide synthase, 16. Peace & justice, Rats, 3. Good health, astaxanthin, antioxidants, Disease Models, osteoblast, tartrate-resistant acid phosphatase, Nitric Oxide Synthase, Bax protein, metabolism, protein Bax

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/29044575
https://www.ncbi.nlm.nih.gov/pubmed/29044575
https://onlinelibrary.wiley.com/doi/10.1111/jre.12497/full?scrollTo=references
https://onlinelibrary.wiley.com/doi/10.1111/jre.12497
https://europepmc.org/article/MED/29044575
https://hdl.handle.net/20.500.12418/6388
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/10857

Promising bio-composites of polypyrrole and chitosan: Surface protective and in vitro biocompatibility performance on 316L SS implants

Autoren: Ime B. Obot Suresh Ramakrishna Akeem Yusuf Adesina et al.

Weitere Verfasser: Ime B. Obot Suresh Ramakrishna Akeem Yusuf Adesina et al.

Quelle: Carbohydrate Polymers. 173:121-130

Schlagwörter: Polymers, Surface Properties, Chitosan / chemistry, Osteoblasts / drug effects, 02 engineering and technology, 01 natural sciences, Cell Line, Biomaterials, Pyrroles / chemistry, Coated Materials, Biocompatible, Coatings, Humans, Pyrroles, 10. No inequality, Polymers / chemistry, Chitosan, Osteoblasts, Coated Materials, Prostheses and Implants, Biocompatible, 0104 chemical sciences, Corrosion, Biocompatibility, 0210 nano-technology

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/28732850
http://www.sciencedirect.com/science/article/pii/S0144861717306082
https://www.ncbi.nlm.nih.gov/pubmed/28732850
https://pubmed.ncbi.nlm.nih.gov/28732850/
https://www.sciencedirect.com/science/article/pii/S0144861717306082
https://europepmc.org/article/MED/28732850

Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity

Autoren: Katarzyna Niemirowicz Jan Ryszard Dąbrowski Mateusz Cieśluk et al.

Quelle: Int J Nanomedicine
International Journal of Nanomedicine, Vol Volume 12, Pp 7833-7846 (2017)

Schlagwörter: 0301 basic medicine, magnetic nanoparticles, Medicine (General), antimicrobial properties, Plankton - microbiology, Microbial Sensitivity Tests, Microbial sensitivity tests, Gram-Positive Bacteria, Gram-negative bacteria - drug effects, Cell Line, 03 medical and health sciences, R5-920, Drug Delivery Systems, Anti-Infective Agents, International Journal of Nanomedicine, Gram-Negative Bacteria, Interleukin-8 - metabolism, Gram-positive bacteria - drug effects, Humans, anti-biofilm, Magnetite Nanoparticles, Chlorhexidine - administration & dosage, Original Research, Osteoblasts - drug effects, 0303 health sciences, Osteoblasts, Chlorhexidine - pharmacology, chlorhexidine, Chlorhexidine, Interleukin-8, Plankton, 16. Peace & justice, Drug delivery systems - methods, Osteoblasts - metabolism, 3. Good health, Oxidative stress - drug effects, Biofilms - drug effects, Oxidative Stress, Anti-infective agents - administration & dosage, Biofilms, Magnetite nanoparticles - administration & dosage, Anti-infective agents - pharmacology, Magnetite nanoparticles - chemistry, Cell line

Dateibeschreibung: text/html; application/pdf

Zugangs-URL: https://www.dovepress.com/getfile.php?fileID=39028
https://pubmed.ncbi.nlm.nih.gov/29123396
https://doaj.org/article/70139e271e2f4264b4c77848d4274809
https://www.dovepress.com/use-of-magnetic-nanoparticles-as-a-drug-delivery-system-to-improve-chl-peer-reviewed-article-IJN
https://europepmc.org/articles/PMC5661836
https://www.ncbi.nlm.nih.gov/pubmed/29123396
https://www.dovepress.com/getfile.php?fileID=39028
https://pubmed.ncbi.nlm.nih.gov/29123396/
https://www.dovepress.com/use-of-magnetic-nanoparticles-as-a-drug-delivery-system-to-improve-chl-peer-reviewed-fulltext-article-IJN

Effects of gastric inhibitory polypeptide, glucagon‐like peptide‐1 and glucagon‐like peptide‐1 receptor agonists on Bone Cell Metabolism

Autoren: Michaela Tencerova Moustapha Kassem Jacob Stampe Frølich et al.

Quelle: Hansen, M S S, Tencerova, M, Frølich, J, Kassem, M & Frost, M 2018, ' Effects of gastric inhibitory polypeptide, glucagon-like peptide-1 and glucagon-like peptide-1 receptor agonists on Bone Cell Metabolism ', Basic & Clinical Pharmacology & Toxicology, vol. 122, no. 1, pp. 25–37 . https://doi.org/10.1111/bcpt.12850

Schlagwörter: 0301 basic medicine, Diabetes Mellitus, Type 2/drug therapy, Bone/chemically induced, Insulin/metabolism, Osteocalcin/metabolism, Fractures, Bone/chemically induced, Obesity/drug therapy, Osteocalcin, Osteoclasts, Incretins/pharmacology, Gastric Inhibitory Polypeptide, Incretins, Bone and Bones, Glucagon-Like Peptide-1 Receptor, Osteoblasts/drug effects, Fractures, Bone, 03 medical and health sciences, Glucagon-Like Peptide 1/metabolism, Bone Density, Glucagon-Like Peptide 1, Diabetes Mellitus, Glucagon-Like Peptide-1 Receptor/agonists, Animals, Humans, Insulin, Obesity, Bone Resorption/chemically induced, Bone and Bones/cytology, Bone Resorption, Gastric Inhibitory Polypeptide/metabolism, Osteoblasts, Animal, Bone Density/drug effects, Disease Models, Animal, Type 2/drug therapy, Diabetes Mellitus, Type 2, Glucagon-Like Peptide-1 Receptor Agonists, Disease Models, Osteoclasts/drug effects, Fractures

Dateibeschreibung: application/pdf

Zugangs-URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcpt.12850
https://pubmed.ncbi.nlm.nih.gov/28722834
https://findresearcher.sdu.dk:8443/ws/files/156523501/11.07.17_MSH.pdf
https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcpt.12850
https://pubmed.ncbi.nlm.nih.gov/28722834/
https://onlinelibrary.wiley.com/doi/10.1111/bcpt.12850
https://www.ncbi.nlm.nih.gov/pubmed/28722834
https://portal.findresearcher.sdu.dk/da/publications/effects-of-gastric-inhibitory-polypeptide-glucagon-like-peptide-1
https://findresearcher.sdu.dk:8443/ws/files/156523501/11.07.17_MSH.pdf

An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice

Autoren: Panwar, Preety Xue, Liming Søe, Kent et al.

Quelle: Panwar, P, Xue, L, Søe, K, Srivastava, K, Law, S, Delaisse, J-M & Brömme, D 2017, ' An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice ', Journal of Bone and Mineral Research, vol. 32, no. 12, pp. 2415-2430 . https://doi.org/10.1002/jbmr.3227

Schlagwörter: 0301 basic medicine, Ovariectomy, Cathepsin K, Osteoclasts, Cell Count, Inbred C57BL, Transforming Growth Factor beta1, Mice, Osteoblasts/drug effects, 03 medical and health sciences, Cathepsin K/antagonists & inhibitors, Osteogenesis, Animals, Humans, Protease Inhibitors, Femur, Bone Resorption, Fibroblasts/metabolism, 0303 health sciences, Osteoblasts, Protease Inhibitors/chemistry, Femur/pathology, Fibroblasts, Bone Resorption/drug therapy, Osteogenesis/drug effects, 3. Good health, Mice, Inbred C57BL, Transforming Growth Factor beta1/metabolism, Osteoclasts/drug effects, Cattle, Female

Zugangs-URL: https://asbmr.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.3227
https://asbmr.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.3687
https://pubmed.ncbi.nlm.nih.gov/28745432
https://europepmc.org/article/MED/28745432
https://pubmed.ncbi.nlm.nih.gov/28745432/
https://asbmr.onlinelibrary.wiley.com/doi/10.1002/jbmr.3227
https://core.ac.uk/display/145226839
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/jbmr.3227
https://www.ncbi.nlm.nih.gov/pubmed/28745432
https://portal.findresearcher.sdu.dk/da/publications/e9798d3b-a927-43a3-91e2-b4ca24479986

Molecular mechanisms, current management and next generation therapy in myeloma bone disease

Autoren: Heusschen, Roy Muller, Joséphine Duray, Elodie et al.

Weitere Verfasser: Heusschen, Roy Muller, Joséphine Duray, Elodie et al.

Quelle: Leukemia & Lymphoma. 59:14-28

Schlagwörter: 0301 basic medicine, Multiple Myeloma/complications, Drug Evaluation, Preclinical, Osteoclasts, Signal transduction, Sciences de la santé humaine, Osteoblasts/drug effects, 03 medical and health sciences, Multiple myeloma, Bone Marrow, Osteogenesis, Bone Diseases/diagnosis, Diphosphonates/pharmacology, novel therapies, Tumor Microenvironment, Animals, Humans, Bone Density Conservation Agents/pharmacology, Human health sciences, Bone Resorption, bisphosphonates, clinical trials, Clinical Trials as Topic, 0303 health sciences, Osteoblasts, Bone Density Conservation Agents, Diphosphonates, Disease Management, Bone Marrow/drug effects, Bisphosphonates, Hematology, Bone Resorption/drug therapy, Osteogenesis/drug effects, 3. Good health, multiple myeloma, Treatment Outcome, bone disease, Osteoclasts/drug effects, Bone Remodeling, Bone Diseases, Multiple Myeloma, TUMOR MICROENVIRONMENT, Hématologie, Signal Transduction

Zugangs-URL: https://biblio.vub.ac.be/vubirfiles/72379168/Heusschen_et_al_MMBD_Leukemia_Lymphoma.pdf
https://pubmed.ncbi.nlm.nih.gov/28573897
https://orbi.uliege.be/handle/2268/212206
https://researchportal.vub.be/en/publications/molecular-mechanisms-current-management-and-next-generation-thera
https://core.ac.uk/display/84066518
https://www.tandfonline.com/doi/full/10.1080/10428194.2017.1323272
https://www.ncbi.nlm.nih.gov/pubmed/28573897
https://europepmc.org/abstract/MED/28573897
https://biblio.vub.ac.be/vubir/molecular-mechanisms-current-management-and-next-generation-therapy-in-myeloma-bone-disease(e71377f5-4088-4dab-984c-d124c726bf20).html

The antibacterial and angiogenic effect of magnesium oxide in a hydroxyapatite bone substitute

Autoren: Coelho, CC Padrão, T Costa, L et al.

Weitere Verfasser: Coelho, CC Padrão, T Costa, L et al.

Schlagwörter: Animals, Anti-Bacterial Agents / pharmacology, Bone Substitutes / pharmacology, Bone Transplantation / methods, Cell Line, Durapatite / pharmacology, Magnesium Oxide / pharmacology, Mice, Osteoblasts / drug effects

Dateibeschreibung: application/pdf

Relation: info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBDE%2F108971%2F2015/PT; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04378%2F2019/PT; Scientific Reports, vol.10(1):19098; https://www.nature.com/articles/s41598-020-76063-9; https://hdl.handle.net/10216/145279

Verfügbarkeit: https://hdl.handle.net/10216/145279
https://doi.org/10.1038/s41598-020-76063-9

Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells

Autoren: Rimi Hamam Abdullah Aldahmash Musaed Alfayez et al.

Quelle: Stem Cells Translational Medicine, Vol 5, Iss 8, Pp 1036-1047 (2016)
Ali, D, Hamam, R, Alfayez, M, Kassem, M, Aldahmash, A & Alajez, N M 2016, ' Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells ', Stem Cells Translational Medicine, vol. 5, no. 8, pp. 1036-1047 . https://doi.org/10.5966/sctm.2015-0331

Schlagwörter: 0301 basic medicine, Medicine (General), Hydroxamic Acids, Epigenesis, Genetic, Myoblasts, Myoblasts, Skeletal/drug effects, Adipogenesis/drug effects, Signal Transduction/drug effects, Histone deacetylase inhibitors, Adipocytes, Developmental, Oligonucleotide Array Sequence Analysis, Adipocyte, Adipogenesis, Osteoblast, Epigenetic, Gene Expression Regulation, Developmental, Cell Differentiation, Benzofurans/pharmacology, Osteogenesis/drug effects, Mesenchymal Stem Cells/drug effects, Phenotype, Chromatin Immunoprecipitation, Genotype, Myoblasts, Skeletal, Transcription Factors/genetics, Epigenesis, Genetic/drug effects, Cell Line, Osteoblasts/drug effects, 03 medical and health sciences, R5-920, Humans, Cell Lineage, Skeletal/drug effects, Benzofurans, Gene Library, Genetic/drug effects, Osteoblasts, QH573-671, Gene Expression Profiling, Computational Biology, Mesenchymal Stem Cells, Histone Deacetylase Inhibitors, Gene Expression Regulation, Cell Differentiation/drug effects, Mesenchymal stem cells, Gene Expression Profiling/methods, Cytology, Histone Deacetylase Inhibitors/pharmacology, Epigenesis, Adipocytes/drug effects, Hydroxamic Acids/pharmacology

Dateibeschreibung: application/pdf

Zugangs-URL: https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.5966/sctm.2015-0331
https://pubmed.ncbi.nlm.nih.gov/27194745
https://doaj.org/article/eebe0aeffba64f40b9efaa48b710bc81
https://www.ncbi.nlm.nih.gov/pubmed/27194745
https://core.ac.uk/display/50718679
http://findresearcher.sdu.dk/portal/da/publications/epigenetic-library-screen-identifies-abexinostat-as-novel-regulator-of-adipocytic-and-osteoblastic-differentiation-of-human-skeletal-mesenchymal-stem-cells(56d038ea-347b-40c2-bfb6-2cd3116da8c5).html
https://onlinelibrary.wiley.com/doi/10.5966/sctm.2015-0331/full
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.5966/sctm.2015-0331
https://pubmed.ncbi.nlm.nih.gov/27194745/
https://findresearcher.sdu.dk:8443/ws/files/134252860/Epigenetic_Library_Screen_Identifies_Abexinostat_as_Novel_Regulator_of_Adipocytic_and_Osteoblastic_Differentiation_of_Human_Skeletal_Mesenchymal_Stem_Cells.pdf
https://portal.findresearcher.sdu.dk/da/publications/56d038ea-347b-40c2-bfb6-2cd3116da8c5
https://doi.org/10.5966/sctm.2015-0331

Role of bacterial γ-glutamyltranspeptidase as a novel virulence factor in bone-resorbing pathogenesis

Autoren: Niluka Gunawardhana Aeryun Kim Hanfu Su et al.

Weitere Verfasser: Niluka Gunawardhana Aeryun Kim Hanfu Su et al.

Quelle: Journal of Microbiology. 54:396-402

Schlagwörter: gamma-Glutamyltransferase/genetics, 0301 basic medicine, Virulence Factors/genetics, Bone Resorption/pathology, Virulence Factors, Bacillus subtilis/enzymology, Virulence Factors/physiology, Osteoclasts, Bone Marrow Cells, Osteoblasts/drug effects, Mice, 03 medical and health sciences, gamma-Glutamyltransferase/physiology, Osteogenesis, Osteogenesis/drug effects, Recombinant Proteins/genetics, Animals, Bone Resorption/chemically induced, Recombinant Proteins/pharmacology, Bone Resorption, osteoclastogenesis, Recombinant Proteins/metabolism, 0303 health sciences, Osteoblasts, Bone Resorption/microbiology, Cytokines/metabolism, gamma-Glutamyltransferase, γ-glutamyltranspeptidase, gamma-Glutamyltransferase/pharmacology, Coculture Techniques, Recombinant Proteins, Virulence Factors/pharmacology, Bone Marrow Cells/drug effects, Cytokines, Osteoclasts/drug effects, bone resorption, Bacillus subtilis

Dateibeschreibung: 396~402

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/27095459
https://www.ncbi.nlm.nih.gov/pubmed/27095459
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147195
https://yonsei.pure.elsevier.com/en/publications/role-of-bacterial-%CE%B3-glutamyltranspeptidase-as-a-novel-virulence-f
https://link.springer.com/article/10.1007/s12275-016-6137-1
https://pubmed.ncbi.nlm.nih.gov/27095459/