Search Results - "Optogenetics"

Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans.

Authors: Lüscher C Emiliani V Farahany N et al.

Source: Nature neuroscience [Nat Neurosci] 2025 Dec; Vol. 28 (12), pp. 2415-2431. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Optogenetics*/trends , Translational Research, Biomedical*/methods , Brain*/physiology, Humans ; Animals

Cholinergic suppression of heart rate acceleration during intrinsic optogenetic activation of sympathetic cardiac neurons in perfused hearts.

Authors: Russo R Moreno A Dwyer MK et al.

Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2025 Dec 01; Vol. 329 (6), pp. H1499-H1507. Date of Electronic Publication: 2025 Oct 24.

Publication Type: Journal Article

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE

MeSH Terms: Optogenetics* , Heart Rate*/drug effects , Heart*/innervation , Sympathetic Nervous System*/drug effects , Sympathetic Nervous System*/physiology , Acetylcholine*/pharmacology , Neurons*/drug effects, Animals ; Mice, Transgenic ; Norepinephrine/pharmacology ; Channelrhodopsins/genetics ; Channelrhodopsins/metabolism ; Mice ; Tyrosine 3-Monooxygenase/metabolism ; Tyrosine 3-Monooxygenase/genetics ; Male ; Mice, Inbred C57BL ; Isolated Heart Preparation ; Perfusion

Optogenetic control of peripheral nerves: A novel approach to modulation of detrusor contractility in vivo.

Authors: Maeda A Yoshida F Kawasaki M et al.

Source: Journal of neuroscience methods [J Neurosci Methods] 2025 Dec; Vol. 424, pp. 110591. Date of Electronic Publication: 2025 Sep 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7905558 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-678X (Electronic) Linking ISSN: 01650270 NLM ISO Abbreviation: J Neurosci Methods Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Urinary Bladder*/innervation , Urinary Bladder*/physiology , Muscle Contraction*/physiology , Peripheral Nerves*/physiology, Animals ; Rats, Sprague-Dawley ; Female ; Rats ; Dependovirus/genetics

Emerging bioelectronics and optogenetics for neurogastroenterology.

Authors: Liu H Luo W Xu M et al.

Source: Biosensors & bioelectronics [Biosens Bioelectron] 2025 Nov 15; Vol. 288, pp. 117795. Date of Electronic Publication: 2025 Jul 16.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Optogenetics*/instrumentation , Biosensing Techniques*/instrumentation , Biosensing Techniques*/methods , Enteric Nervous System*/physiopathology , Enteric Nervous System*/physiology , Hirschsprung Disease*/diagnosis , Hirschsprung Disease*/physiopathology , Gastrointestinal Tract*/innervation, Humans ; Animals ; Neurons

An essential experimental control for functional connectivity mapping with optogenetics.

Authors: Tadres D Shiozaki HM Tastekin I et al.

Source: Genetics [Genetics] 2025 Nov 12; Vol. 231 (3).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods, Animals ; Neurons/metabolism ; Neurons/physiology ; Drosophila/genetics ; Drosophila melanogaster/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism

Optogenetic vision restoration in the face of secondary and tertiary remodeling in the rd1 mouse retina.

Authors: Hughes S Rodgers J Lindner M et al.

Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Nov 05; Vol. 33 (11), pp. 5840-5859. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Retinal Degeneration*/pathology , Retinal Degeneration*/physiopathology , Retinal Degeneration*/genetics , Retinal Degeneration*/metabolism , Retinal Degeneration*/therapy , Retina*/metabolism , Retina*/pathology , Vision, Ocular*, Animals ; Mice ; Disease Models, Animal ; Retinal Ganglion Cells/metabolism

Red-shifted excitation enhances the sensitivity of red genetically encoded Ca ²⁺ indicator and enables crosstalk-free two-photon holographic optophysiology.

Authors: Gore PS Nishi M Kumar M et al.

Source: Journal of biomedical optics [J Biomed Opt] 2025 Nov; Vol. 30 (11), pp. 116003. Date of Electronic Publication: 2025 Nov 22.

Publication Type: Journal Article

Journal Info: Publisher: Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society Country of Publication: United States NLM ID: 9605853 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1560-2281 (Electronic) Linking ISSN: 10833668 NLM ISO Abbreviation: J Biomed Opt Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Holography*/methods , Calcium*/metabolism , Calcium*/analysis , Microscopy, Fluorescence, Multiphoton*/methods, Animals ; Rats ; PC12 Cells ; Photons ; Luminescent Proteins/genetics

Optogenetic engineering of lipid droplet spatial organization for tumor suppression.

Authors: Bai Q Shao X Xia Q et al.

Source: Trends in biotechnology [Trends Biotechnol] 2025 Nov; Vol. 43 (11), pp. 2838-2855. Date of Electronic Publication: 2025 Jul 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 8310903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3096 (Electronic) Linking ISSN: 01677799 NLM ISO Abbreviation: Trends Biotechnol Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Lipid Droplets*/metabolism , Lipid Droplets*/radiation effects , Neoplasms*/metabolism , Neoplasms*/therapy, Animals ; Humans ; Mice ; Mitochondria/metabolism ; Cell Line, Tumor ; Fatty Acids/metabolism ; Tumor Microenvironment

Functional probing of neuronal subtypes via intersectional expression of optogenetic actuators reveals non-linear components in a linear circuit.

Authors: Li T Kumar S Poon H et al.

Source: Cell reports [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116327. Date of Electronic Publication: 2025 Sep 20.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Caenorhabditis elegans*/physiology , Caenorhabditis elegans*/metabolism , Caenorhabditis elegans*/genetics , Neurons*/metabolism, Animals ; Animals, Genetically Modified ; Touch/physiology ; Caenorhabditis elegans Proteins/metabolism ; Caenorhabditis elegans Proteins/genetics

zHORSE as an optogenetic zebrafish strain for precise spatiotemporal control over gene expression during development.

Authors: Varady A Grissenberger S Fischer K et al.

Source: Developmental cell [Dev Cell] 2025 Oct 20; Vol. 60 (20), pp. 2825-2839.e4. Date of Electronic Publication: 2025 Jun 26.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE

MeSH Terms: Zebrafish*/genetics , Zebrafish*/embryology , Optogenetics*/methods , Gene Expression Regulation, Developmental*/genetics, Animals ; Animals, Genetically Modified ; Integrases/genetics ; Integrases/metabolism ; Cell Lineage ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism ; Animal Fins/metabolism

A real-time all-optical interface for dynamic perturbation of neural activity during behavior.

Authors: Zhang Z Dzialecka P Russell LE et al.

Source: Cell reports methods [Cell Rep Methods] 2025 Oct 20; Vol. 5 (10), pp. 101180. Date of Electronic Publication: 2025 Sep 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918227360606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2375 (Electronic) Linking ISSN: 26672375 NLM ISO Abbreviation: Cell Rep Methods Subsets: MEDLINE

MeSH Terms: Neurons*/physiology , Neurons*/metabolism , Optogenetics*/methods , Behavior, Animal*/physiology, Animals ; Mice ; Calcium/metabolism ; Software

Computational Simulations Show Proof-of-Concept for Optogenetic Suppression of Ectopic Activity in Cardiac Stem Cell Therapy.

Authors: Yang JS Ochs AR Gibbs CE et al.

Source: Cardiovascular engineering and technology [Cardiovasc Eng Technol] 2025 Oct; Vol. 16 (5), pp. 563-576. Date of Electronic Publication: 2025 Jul 16.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101531846 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-4098 (Electronic) Linking ISSN: 1869408X NLM ISO Abbreviation: Cardiovasc Eng Technol Subsets: MEDLINE

MeSH Terms: Optogenetics* , Myocytes, Cardiac*/transplantation , Myocytes, Cardiac*/metabolism , Models, Cardiovascular* , Computer Simulation* , Stem Cell Transplantation*/adverse effects , Stem Cell Transplantation*/methods , Tachycardia, Ventricular*/physiopathology , Tachycardia, Ventricular*/prevention & control , Tachycardia, Ventricular*/metabolism , Tachycardia, Ventricular*/etiology , Tachycardia, Ventricular*/pathology , Heart Rate* , Pluripotent Stem Cells*/transplantation , Pluripotent Stem Cells*/metabolism, Humans ; Action Potentials ; Proof of Concept Study ; Feasibility Studies ; Opsins/genetics ; Opsins/metabolism

Advances in optogenetically engineered bacteria in disease diagnosis and therapy.

Authors: Wang H Feng Z Liu P et al.

Source: Biotechnology advances [Biotechnol Adv] 2025 Oct; Vol. 83, pp. 108645. Date of Electronic Publication: 2025 Jul 15.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8403708 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1899 (Electronic) Linking ISSN: 07349750 NLM ISO Abbreviation: Biotechnol Adv Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Bacteria*/genetics, Humans

Using DeepLabCut-Live to probe state dependent neural circuits of behavior with closed-loop optogenetic stimulation.

Authors: Gonzalez M Gradwell MA Thackray JK et al.

Source: Journal of neuroscience methods [J Neurosci Methods] 2025 Oct; Vol. 422, pp. 110495. Date of Electronic Publication: 2025 May 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7905558 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-678X (Electronic) Linking ISSN: 01650270 NLM ISO Abbreviation: J Neurosci Methods Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Locomotion*/physiology , Behavior, Animal*/physiology, Animals ; Mice ; Male ; Hindlimb/physiology ; Mice, Inbred C57BL ; TRPV Cation Channels/metabolism ; TRPV Cation Channels/genetics ; Channelrhodopsins ; Biomechanical Phenomena ; Mice, Transgenic ; Sensory Receptor Cells/physiology ; Spinal Cord/physiology

Fetal rat neural progenitor cell transplantation after spinal cord injury improves motor recovery following optogenetic stimulation.

Authors: Sánchez-Martín MDM Giraldo E Alastrue-Agudo A et al.

Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Oct 01; Vol. 33 (10), pp. 5073-5098. Date of Electronic Publication: 2025 Jul 28.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH Terms: Spinal Cord Injuries*/therapy , Spinal Cord Injuries*/physiopathology , Spinal Cord Injuries*/metabolism , Neural Stem Cells*/metabolism , Neural Stem Cells*/transplantation , Neural Stem Cells*/cytology , Optogenetics*/methods , Recovery of Function* , Stem Cell Transplantation*, Animals ; Rats ; Disease Models, Animal ; Female ; Motor Neurons/metabolism ; Dependovirus/genetics ; Rats, Sprague-Dawley ; Channelrhodopsins/genetics ; Genetic Vectors/genetics ; Locomotion

Optogenetic methods to stimulate gamma motor neuron axons ex vivo.

Authors: Karekal A Mandawe R Chun C et al.

Source: Experimental physiology [Exp Physiol] 2025 Oct; Vol. 110 (10), pp. 1531-1541. Date of Electronic Publication: 2025 Feb 03.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9002940 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-445X (Electronic) Linking ISSN: 09580670 NLM ISO Abbreviation: Exp Physiol Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Axons*/physiology , Motor Neurons, Gamma*/physiology , Motor Neurons, Gamma*/metabolism , Motor Neurons*/physiology, Animals ; Mice ; Mice, Transgenic ; Muscle Spindles/physiology ; Muscle Contraction/physiology ; Sciatic Nerve/physiology ; Muscle, Skeletal/physiology ; Male ; Mice, Inbred C57BL

Optogenetic engineered macrophages for light-induced M1 polarization and enhanced chemo-immunotherapy in melanoma models.

Authors: He K Jiang H Zhang W et al.

Source: Experimental cell research [Exp Cell Res] 2025 Oct 01; Vol. 452 (2), pp. 114770. Date of Electronic Publication: 2025 Sep 22.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0373226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2422 (Electronic) Linking ISSN: 00144827 NLM ISO Abbreviation: Exp Cell Res Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Macrophages*/immunology , Macrophages*/metabolism , Macrophages*/drug effects , Melanoma*/therapy , Melanoma*/pathology , Melanoma*/immunology , Immunotherapy*/methods, Animals ; Mice ; Tumor Microenvironment/immunology ; Humans ; Light ; Cell Line, Tumor ; Mice, Inbred C57BL ; Cell Proliferation ; Temozolomide/pharmacology ; Cell Polarity ; Macrophage Activation ; Cell Movement

Optogenetic engineering for precision cancer immunotherapy.

Authors: Ke Y Liu S Huang Y et al.

Source: Trends in pharmacological sciences [Trends Pharmacol Sci] 2025 Oct; Vol. 46 (10), pp. 1018-1037. Date of Electronic Publication: 2025 Jun 10.

Publication Type: Journal Article; Review

Journal Info: Publisher: Published By Elsevier In Association With The International Union Of Pharmacology Country of Publication: England NLM ID: 7906158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3735 (Electronic) Linking ISSN: 01656147 NLM ISO Abbreviation: Trends Pharmacol Sci Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Neoplasms*/therapy , Neoplasms*/immunology , Immunotherapy*/methods , Precision Medicine*/methods, Humans ; Animals

Design and Modeling of a Bio-Inspired Aequorin-Based Light-Emitting Unit: Applications in Optogenetics and Beyond.

Authors: Azarnoush A Dambri OA Karatop EU et al.

Source: IEEE transactions on bio-medical engineering [IEEE Trans Biomed Eng] 2025 Oct; Vol. 72 (10), pp. 2925-2936.

Publication Type: Journal Article

Journal Info: Publisher: Institute Of Electrical And Electronics Engineers Country of Publication: United States NLM ID: 0012737 Publication Model: Print Cited Medium: Internet ISSN: 1558-2531 (Electronic) Linking ISSN: 00189294 NLM ISO Abbreviation: IEEE Trans Biomed Eng Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Optogenetics*/instrumentation , Aequorin*/chemistry , Luminescent Measurements*/methods , Luminescent Measurements*/instrumentation , Models, Biological*, Equipment Design ; Humans ; Animals ; Wireless Technology

Optogenetic Cancer Therapy Using the Light-Driven Outward Proton Pump Rhodopsin Archaerhodopsin-3 (AR3).

Authors: Nakao S Kojima K Sato K et al.

Source: Journal of the American Chemical Society [J Am Chem Soc] 2025 Dec 03; Vol. 147 (48), pp. 44131-44140. Date of Electronic Publication: 2025 Nov 04.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH Terms: Optogenetics* , Light* , Archaeal Proteins*/genetics , Archaeal Proteins*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Proton Pumps*/metabolism , Neoplasms*/therapy , Neoplasms*/pathology, Animals ; Mice ; Apoptosis/radiation effects ; Apoptosis/drug effects ; Mice, Inbred C57BL ; Cell Line, Tumor ; Humans ; Cell Proliferation/drug effects