Suchergebnisse - "OSTEOBLASTS"

Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest.

Autoren: Casey-Clyde T Liu SJ Pelonero A et al.

Quelle: ELife [Elife] 2025 Dec 02; Vol. 13. Date of Electronic Publication: 2025 Dec 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

MeSH-Schlagworte: Neural Crest*/cytology , Neural Crest*/embryology , Cell Differentiation* , Cell Proliferation* , Osteoblasts*/physiology , Osteoblasts*/cytology , Polycomb Repressive Complex 2*/metabolism , Polycomb Repressive Complex 2*/genetics , Mesoderm*, Animals ; Mice ; Mice, Knockout ; Osteogenesis ; Epigenesis, Genetic ; Gene Expression Regulation, Developmental ; Craniofacial Abnormalities/genetics ; Skull/embryology

Bone-on-a-chip recapitulates dynamic bone remodeling.

Autoren: Zhang Y Zhao Y Sun Z et al.

Quelle: Acta biomaterialia [Acta Biomater] 2025 Dec; Vol. 208, pp. 280-292. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

MeSH-Schlagworte: Bone Remodeling*/drug effects , Osteoblasts*/metabolism , Osteoblasts*/pathology , Osteoblasts*/cytology , Lab-On-A-Chip Devices* , Osteoclasts*/metabolism , Osteoclasts*/pathology , Osteoclasts*/cytology, Animals ; Mice ; Coculture Techniques ; Osteoporosis/pathology ; Osteoporosis/metabolism ; Cell Differentiation ; Humans

Mirt2 alleviates LPS-induced inflammation of osteoblasts in alveolar bone destruction.

Autoren: Wu Y Su Z Zhang B et al.

Quelle: Archives of oral biology [Arch Oral Biol] 2025 Dec; Vol. 180, pp. 106410. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0116711 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1506 (Electronic) Linking ISSN: 00039969 NLM ISO Abbreviation: Arch Oral Biol Subsets: MEDLINE

MeSH-Schlagworte: Alveolar Bone Loss*/metabolism , Alveolar Bone Loss*/genetics , Alveolar Bone Loss*/pathology , RNA, Long Noncoding*/metabolism , RNA, Long Noncoding*/genetics , Osteoblasts*/metabolism , Osteoblasts*/drug effects , Periodontitis*/metabolism , Inflammation* , Periapical Periodontitis*/metabolism, Animals ; Lipopolysaccharides/pharmacology ; Mice ; X-Ray Microtomography ; Osteogenesis ; Disease Models, Animal ; Cell Differentiation ; Enzyme-Linked Immunosorbent Assay ; Mice, Inbred C57BL ; Real-Time Polymerase Chain Reaction

METTL3 inhibits osteoporosis by promoting osteoblast differentiation through m6A-mediated activation of the FZD3/RUNX1 signaling axis.

Autoren: Wang Y Wang Z Zhang Q et al.

Quelle: European journal of medical research [Eur J Med Res] 2025 Nov 17; Vol. 30 (1), pp. 1131. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 9517857 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-783X (Electronic) Linking ISSN: 09492321 NLM ISO Abbreviation: Eur J Med Res Subsets: MEDLINE

MeSH-Schlagworte: Osteoblasts*/metabolism , Osteoblasts*/cytology , Frizzled Receptors*/metabolism , Frizzled Receptors*/genetics , Osteoporosis*/metabolism , Osteoporosis*/genetics , Osteoporosis*/pathology , Core Binding Factor Alpha 2 Subunit*/metabolism , Core Binding Factor Alpha 2 Subunit*/genetics , Methyltransferases*/metabolism , Methyltransferases*/genetics, Animals ; Cell Differentiation ; Mice ; Female ; Signal Transduction ; Osteogenesis/genetics ; Humans ; Disease Models, Animal ; Osteoclasts/metabolism

Osteoblast-Mesenchymal Stem Cell Coculture Drives In Vitro Osteogenesis in 3D Bioprinted Periosteum.

Autoren: McLoughlin ST Wilcox P Caccamese JF et al.

Quelle: Tissue engineering. Part A [Tissue Eng Part A] 2025 Nov; Vol. 31 (21-22), pp. 1239-1252. Date of Electronic Publication: 2025 Apr 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101466659 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-335X (Electronic) Linking ISSN: 19373341 NLM ISO Abbreviation: Tissue Eng Part A Subsets: MEDLINE

MeSH-Schlagworte: Periosteum*/cytology , Periosteum*/metabolism , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism , Osteogenesis* , Osteoblasts*/cytology , Osteoblasts*/metabolism , Printing, Three-Dimensional* , Bioprinting*/methods, Coculture Techniques ; Humans ; Cell Differentiation ; Tissue Engineering/methods

Effects of PCL/PLA/HA nanocarrier on apoptosis, growth and functional metabolism of osteoblasts.

Autoren: He Z Wang S Xia X

Quelle: Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2025 Nov-Dec; Vol. 38 (6), pp. 2031-2038.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Faculty of Pharmacy, University of Karachi Country of Publication: Pakistan NLM ID: 9426356 Publication Model: Print Cited Medium: Internet ISSN: 1011-601X (Print) Linking ISSN: 1011601X NLM ISO Abbreviation: Pak J Pharm Sci Subsets: MEDLINE

MeSH-Schlagworte: Polyesters*/chemistry , Apoptosis*/drug effects , Osteoblasts*/drug effects , Osteoblasts*/metabolism , Cell Proliferation*/drug effects , Durapatite*/chemistry , Durapatite*/pharmacology, Nanofibers/chemistry ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry ; Animals ; Cell Survival/drug effects ; Alkaline Phosphatase/metabolism ; Mice

Synthesis, Characterization and Feasibility of a Gelatin Methacryloyl Hydrogel for Naringenin Release-Effect on Osteoblasts In Vitro.

Autoren: Chagas AC Cardoso LM Pansani TN et al.

Quelle: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2025 Nov; Vol. 113 (11), pp. e35690.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234238 Publication Model: Print Cited Medium: Internet ISSN: 1552-4981 (Electronic) Linking ISSN: 15524973 NLM ISO Abbreviation: J Biomed Mater Res B Appl Biomater Subsets: MEDLINE

MeSH-Schlagworte: Osteoblasts*/metabolism , Osteoblasts*/cytology , Flavanones*/pharmacology , Flavanones*/chemistry , Flavanones*/pharmacokinetics , Gelatin*/chemistry , Gelatin*/pharmacology , Gelatin*/pharmacokinetics , Hydrogels*/chemistry , Hydrogels*/pharmacology , Hydrogels*/pharmacokinetics , Hydrogels*/chemical synthesis , Coated Materials, Biocompatible*/chemistry , Coated Materials, Biocompatible*/pharmacology, Humans ; Titanium/chemistry ; Cell Line ; Matrix Metalloproteinase 9/metabolism ; Matrix Metalloproteinase 2/metabolism ; Methacrylates

Loss of SMN Impairs Osteoblast-Osteoclast Coupling via IGF1-Akt-OPG Axis in Spinal Muscular Atrophy.

Autoren: Xiang T Zhou Z Li Y et al.

Quelle: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Oct 31; Vol. 39 (20), pp. e71095.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH-Schlagworte: Insulin-Like Growth Factor I*/metabolism , Insulin-Like Growth Factor I*/genetics , Osteoclasts*/metabolism , Osteoclasts*/pathology , Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/genetics , Osteoblasts*/metabolism , Osteoblasts*/pathology , Osteoprotegerin*/metabolism , Osteoprotegerin*/genetics , Muscular Atrophy, Spinal*/metabolism , Muscular Atrophy, Spinal*/pathology , Muscular Atrophy, Spinal*/genetics , Survival of Motor Neuron 1 Protein*/metabolism , Survival of Motor Neuron 1 Protein*/genetics, Animals ; Mice ; Mice, Knockout ; Signal Transduction ; Cell Differentiation ; Mesenchymal Stem Cells/metabolism ; Male ; Mice, Inbred C57BL

Human platelet-derived extracellular vesicle fractions modulate bone cell metabolism and biologize volume-stable β-TCP matrix in vitro.

Autoren: Döding A Güllich A Koch S et al.

Quelle: BMC medicine [BMC Med] 2025 Oct 21; Vol. 23 (1), pp. 569. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Vesicles*/metabolism , Osteoblasts*/metabolism , Osteoblasts*/cytology , Osteoblasts*/drug effects , Calcium Phosphates*/metabolism , Calcium Phosphates*/chemistry , Blood Platelets*/metabolism , Bone and Bones*/metabolism, Humans ; Animals ; Mice ; Bone Regeneration/drug effects ; Cell Proliferation/drug effects ; Cell Differentiation ; Osteogenesis ; Cells, Cultured

BMSC-derived exosomal lncRNA-ZFAS1 regulates the proliferation and differentiation of osteoblasts via the miR-9/IGF-1 signaling axis.

Autoren: Sun H Liu Y Wang H et al.

Quelle: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2025 Oct 21; Vol. 20 (1), pp. 902. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101265112 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-799X (Electronic) Linking ISSN: 1749799X NLM ISO Abbreviation: J Orthop Surg Res Subsets: MEDLINE

MeSH-Schlagworte: Osteoblasts*/physiology , Osteoblasts*/metabolism , Osteoblasts*/cytology , MicroRNAs*/metabolism , MicroRNAs*/genetics , MicroRNAs*/physiology , RNA, Long Noncoding*/metabolism , RNA, Long Noncoding*/physiology , RNA, Long Noncoding*/genetics , Cell Differentiation*/genetics , Cell Differentiation*/physiology , Cell Proliferation*/genetics , Cell Proliferation*/physiology , Insulin-Like Growth Factor I*/metabolism , Insulin-Like Growth Factor I*/genetics , Exosomes*/metabolism , Exosomes*/genetics , Signal Transduction*/physiology , Signal Transduction*/genetics , Mesenchymal Stem Cells*/metabolism, Humans ; Cells, Cultured

Crosstalk between endothelial cells and osteoblasts stimulates ALP via Notch signaling and RANKL/OPG ratio independently of Notch signaling in vitro.

Autoren: Wirsig K Bürger N Bernhardt A

Quelle: Cellular & molecular biology letters [Cell Mol Biol Lett] 2025 Oct 02; Vol. 30 (1), pp. 108. Date of Electronic Publication: 2025 Oct 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 9607427 Publication Model: Electronic Cited Medium: Internet ISSN: 1689-1392 (Electronic) Linking ISSN: 14258153 NLM ISO Abbreviation: Cell Mol Biol Lett Subsets: MEDLINE

MeSH-Schlagworte: Osteoblasts*/metabolism , Osteoblasts*/cytology , Osteoblasts*/drug effects , RANK Ligand*/metabolism , Osteoprotegerin*/metabolism , Signal Transduction*/drug effects , Receptors, Notch*/metabolism , Alkaline Phosphatase*/metabolism, Humans ; Coculture Techniques ; Vascular Endothelial Growth Factor A/pharmacology ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/cytology ; Dexamethasone/pharmacology ; Cells, Cultured ; Cell Communication/drug effects

Cobalt-Doped Monetite-Induced Biomimetic Hypoxia Camouflages Osteogenic Healing Microenvironment.

Autoren: de Almeida GS Pinto TS Suter LC et al.

Quelle: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2025 Oct; Vol. 113 (10), pp. e37984.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234237 Publication Model: Print Cited Medium: Internet ISSN: 1552-4965 (Electronic) Linking ISSN: 15493296 NLM ISO Abbreviation: J Biomed Mater Res A Subsets: MEDLINE

MeSH-Schlagworte: Cobalt*/pharmacology , Cobalt*/chemistry , Osteogenesis*/drug effects , Biomimetic Materials*/pharmacology , Biomimetic Materials*/chemistry , Osteoblasts*/cytology , Osteoblasts*/metabolism , Osteoblasts*/drug effects , Calcium Phosphates*/pharmacology , Calcium Phosphates*/chemistry , Cellular Microenvironment*/drug effects , Wound Healing*/drug effects, Animals ; Mice ; Cell Differentiation/drug effects ; Extracellular Matrix/metabolism ; Extracellular Matrix/drug effects ; Cell Hypoxia/drug effects ; Cell Line ; Cell Adhesion/drug effects ; Core Binding Factor Alpha 1 Subunit/metabolism ; Cell Movement/drug effects

Osteoblasts in bone metastasis: Key players in the tumor microenvironment and therapeutic targets.

Autoren: Jin L Shao Z Ye Z et al.

Quelle: Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2025 Oct; Vol. 1880 (5), pp. 189435. Date of Electronic Publication: 2025 Aug 29.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9806362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2561 (Electronic) Linking ISSN: 0304419X NLM ISO Abbreviation: Biochim Biophys Acta Rev Cancer Subsets: MEDLINE

MeSH-Schlagworte: Tumor Microenvironment* , Bone Neoplasms*/secondary , Bone Neoplasms*/metabolism , Bone Neoplasms*/pathology , Bone Neoplasms*/drug therapy , Bone Neoplasms*/immunology , Osteoblasts*/pathology , Osteoblasts*/metabolism , Osteoblasts*/drug effects, Humans ; Animals ; Signal Transduction ; Chemokine CXCL12/metabolism

Impact of fluoride exposure at different concentrations on preosteoblastic cells: Molecular, biochemical, and morphological insights.

Autoren: Ferreira MKM Sabino VG Sousa JMM et al.

Quelle: Tissue & cell [Tissue Cell] 2025 Oct; Vol. 96, pp. 103000. Date of Electronic Publication: 2025 May 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE

MeSH-Schlagworte: Fluorides*/pharmacology , Osteoblasts*/drug effects , Osteoblasts*/metabolism , Osteoblasts*/cytology, Oxidative Stress/drug effects ; Apoptosis/drug effects ; Animals ; Cell Survival/drug effects ; Reactive Oxygen Species/metabolism ; Mice ; Cell Cycle/drug effects ; Cell Line ; Membrane Potential, Mitochondrial/drug effects ; Lipid Peroxidation/drug effects ; Cell Differentiation/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism

Use of a new micropattern tape method to detect chirality shifts in differentiating C2C12 cells.

Autoren: Weng Q Osaka T Onoe H et al.

Quelle: PloS one [PLoS One] 2025 Dec 04; Vol. 20 (12), pp. e0338032. Date of Electronic Publication: 2025 Dec 04 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Cell Differentiation* , Osteoblasts*/cytology , Osteoblasts*/metabolism , Myoblasts*/cytology, Animals ; Mice ; Cell Line ; Bone Morphogenetic Protein 2/metabolism ; Bone Morphogenetic Protein 2/pharmacology

Macro-scale, scaffold-assisted model of the human bone marrow endosteal niche using hiPSC-vascularized osteoblastic organoids.

Autoren: Li Q Nikolova MT Zhang G et al.

Quelle: Cell stem cell [Cell Stem Cell] 2025 Dec 04; Vol. 32 (12), pp. 1941-1958.e8. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

MeSH-Schlagworte: Induced Pluripotent Stem Cells*/cytology , Induced Pluripotent Stem Cells*/metabolism , Osteoblasts*/cytology , Osteoblasts*/metabolism , Organoids*/cytology , Organoids*/metabolism , Stem Cell Niche* , Tissue Scaffolds*/chemistry , Bone Marrow*/metabolism , Neovascularization, Physiologic* , Models, Biological*, Humans ; Vascular Endothelial Growth Factor A/metabolism ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Chemokine CXCL12/metabolism ; Animals ; Cell Differentiation

Fine-Tuned Functionalizable Terpolymer Brush Nanocoating Resists Protein Adsorption and Bacterial Adhesion while Promoting Macrophage Activity and Osteoblast Proliferation.

Autoren: Pilipenco A Subbiahdoss G Forinová M et al.

Quelle: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2025 Dec 03; Vol. 17 (48), pp. 65399-65410. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE

MeSH-Schlagworte: Bacterial Adhesion*/drug effects , Osteoblasts*/cytology , Osteoblasts*/drug effects , Macrophages*/drug effects , Macrophages*/cytology , Polymers*/chemistry , Polymers*/pharmacology , Coated Materials, Biocompatible*/chemistry , Coated Materials, Biocompatible*/pharmacology, Adsorption/drug effects ; Staphylococcus epidermidis/drug effects ; Staphylococcus epidermidis/physiology ; Animals ; Mice ; Cell Proliferation/drug effects ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/physiology ; Humans ; Betaine/chemistry ; Betaine/analogs & derivatives ; Surface Properties ; Biofouling/prevention & control ; Biofilms/drug effects ; RAW 264.7 Cells ; Wettability

Chromobox protein homolog 7 (CBX7) deficiency inhibits osteoblast ferroptosis by activating the Nrf2 function in type 2 diabetic osteoporosis.

Autoren: Du Y Xu F Miao S et al.

Quelle: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2025 Dec; Vol. 189, pp. 106866. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9508482 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5875 (Electronic) Linking ISSN: 13572725 NLM ISO Abbreviation: Int J Biochem Cell Biol Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis* , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , Osteoblasts*/metabolism , Osteoblasts*/pathology , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/pathology , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/genetics , Osteoporosis*/metabolism , Osteoporosis*/pathology , Osteoporosis*/genetics, Animals ; Mice ; Humans ; Male ; Female ; Middle Aged

Identification of Transforming Growth Factor-β3 Signaling by Compressive Force in MC3T3-E1 Cells Reactions.

Autoren: Togawa M Nakajima A Fukumashi N et al.

Quelle: Cell biochemistry and biophysics [Cell Biochem Biophys] 2025 Dec; Vol. 83 (4), pp. 4517-4530. Date of Electronic Publication: 2025 Jun 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE

MeSH-Schlagworte: Signal Transduction* , Osteoblasts*/metabolism , Osteoblasts*/cytology , Transforming Growth Factor beta3*/metabolism , Transforming Growth Factor beta3*/genetics , Stress, Mechanical*, Animals ; Mice ; Cell Line ; Phosphorylation ; Core Binding Factor Alpha 1 Subunit/metabolism ; Core Binding Factor Alpha 1 Subunit/genetics ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2/genetics ; Interleukin-6/metabolism ; Interleukin-6/genetics ; Smad3 Protein/metabolism ; RNA, Small Interfering/metabolism ; Smad2 Protein/metabolism ; Smad Proteins/metabolism

Plectin promotes bone formation via phase separation and sequestering annexin A2.

Autoren: Zheng K He X Yu Y et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 4), pp. 117403. Date of Electronic Publication: 2025 Oct 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Plectin*/metabolism , Plectin*/pharmacology , Plectin*/genetics , Osteogenesis*/physiology , Osteogenesis*/drug effects , Osteoblasts*/metabolism , Osteoblasts*/drug effects , Annexin A2*/metabolism, Animals ; Mice ; Humans ; Cell Differentiation/physiology ; Cell Differentiation/drug effects ; Mice, Inbred C57BL ; Osteoporosis/metabolism ; Osteoporosis/drug therapy ; Male ; Phase Separation