Suchergebnisse - "OPIOID receptors"

Presence and Location of CatSper 1–4, Opioid (μ, δ and κ) and CD44 Receptors in Spermatozoa from Aoudad, Iberian Ibex and Mouflon.

Autoren: Vicente‐Carrillo, Alejandro Álvarez‐Rodríguez, Manuel Castaño, Cristina et al.

Quelle: Veterinary Medicine & Science. Jul2025, Vol. 11 Issue 4, p1-12. 12p.

Schlagworte: Reproductive technology, Opioid receptors, Endangered species, Domestic animals, Mouflon

Involvement of central opioid and melanocortin receptors in spexin-induced hypophagia following intracerebroventricular injection in neonatal broiler chicks.

Autoren: Badri, Mohanna Alimohammadi, Samad Zendehdel, Morteza et al.

Quelle: BMC Veterinary Research. 2/26/2025, Vol. 21 Issue 1, p1-11. 11p.

Schlagworte: Opioid receptors, Saline injections, Food consumption, Chicks, Control groups, Melanocortin receptors

A novel peptide‐fentanyl conjugate with μ‐opioid and neuropeptide FF receptor agonism produces antinociception with limited side effects in male mice.

Autoren: Li, Ning Zhang, Mengna Xu, Biao et al.

Quelle: British Journal of Pharmacology. Dec2025, Vol. 182 Issue 24, p6136-6157. 22p.

Schlagwörter: *FENTANYL, *OPIOID receptors, *PAIN measurement, *NEUROPEPTIDES, *ANALGESICS, *ANALGESIA, *OPIOID peptides, *DRUG side effects

κ-Opioid receptor activation suppresses triple-negative breast cancer progression by inducing urea cycle dysfunction and mitochondrial damage in vitro and in mice.

Autoren: Shi, Yumiao Tao, Yiying Pan, Zhiying et al.

Quelle: BJA: The British Journal of Anaesthesia. Dec2025, Vol. 135 Issue 6, p1803-1815. 13p.

Schlagwörter: *TRIPLE-negative breast cancer, *OPIOID receptors, *MITOCHONDRIAL pathology, *CANCER invasiveness, *APOPTOSIS, *METABOLOMICS

Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.

Autoren: Liu, Rongjie Chen, Yituo Huang, Haosheng et al.

Quelle: British Journal of Pharmacology. Nov2025, Vol. 182 Issue 22, p5489-5516. 28p.

Schlagwörter: *OPIOID receptors, *UBIQUITINATION, *LABORATORY mice, *REHABILITATION, *SPINAL cord injuries, *NEUROPROTECTIVE agents

O‐Silyl Codeine Analogues as Ligands for Opioid Receptors.

Autoren: Barmaki, Samira Butt, Arsala Ali, Arlene et al.

Quelle: ChemistrySelect. 11/10/2025, Vol. 10 Issue 42, p1-6. 6p.

Schlagwörter: *OPIOID receptors, *OPIOIDS, *CHEMICAL inhibitors, *LIGANDS (Chemistry), *SILYL ethers

μOR-ligand: target-aware view-based hybrid feature selection for μ-opioid receptor ligand functional classification.

Autoren: Ugurlu, Sadettin Y.^1,2 (AUTHOR) s.yavuz.ugurlu@gmail.com

Quelle: Journal of Computer-Aided Molecular Design. 10/24/2025, Vol. 39 Issue 2, p1-29. 29p.

Schlagwörter: *OPIOID receptors, *DRUG discovery, *MACHINE learning, *FEATURE selection, *LIGANDS (Biochemistry), *CHEMICAL agonists, *RECEIVER operating characteristic curves

Elucidating zerumbone's low-efficacy agonism at the μ-opioid receptor via molecular dynamics simulation and Markov state modeling.

Autoren: Ayub, Wan Mardhiyana Wan Marjohan, Nurul Amirah Khalid, Mohamed Haneif et al.

Quelle: Journal of Computer-Aided Molecular Design. 10/24/2025, Vol. 39 Issue 2, p1-11. 11p.

Schlagwörter: *OPIOID receptors, *ANALGESICS, *RECEPTOR-ligand complexes, *HYDROPHOBIC interactions, *MOLECULAR dynamics, *SESQUITERPENES, *MARKOV processes

Interconversion of the (+)-O-desmethyltramadol to the lowest-energy conformer when coupled to µ-opioid receptor: comprehensive analysis using in silico molecular modeling.

Autoren: Velázquez-Ponce, Manuel Marin-Aranda, Cesar Alonso Tovar-Domínguez, Aldo Hiram et al.

Quelle: Journal of Computer-Aided Molecular Design. 10/24/2025, Vol. 39 Issue 2, p1-18. 18p.

Schlagwörter: *OPIOID receptors, *OPIOIDS, *MOLECULAR docking, *PAIN management, *CONFORMATIONAL analysis, *MOLECULAR models, *MOLECULAR dynamics

Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking.

Autoren: Damonte, Valentina Martinez Bailey, Lydia G. Thakar, Amit et al.

Quelle: Journal of Neuroscience. 10/22/2025, Vol. 45 Issue 43, p1-15. 15p.

Schlagwörter: *OPIOID receptors, *PSYCHOLOGICAL stress, *SUBSTANCE abuse relapse, *NEUROBIOLOGY, *ADDICTIONS, *GABA agents, *DOPAMINERGIC neurons

MBD1-dependent recruitment of SUV39h1 induces H3K9me3-mediated transcriptional silencing of Oprm1 in dorsal root ganglia after peripheral nerve injury.

Autoren: Sheng, Hengwei Gong, Hualei Liu, Xiaolin et al.

Quelle: Molecular Pain. 10/15/2025, Vol. 21, p1-12. 12p.

Schlagwörter: *DORSAL root ganglia, *OPIOID receptors, *HISTONE methyltransferases, *PROTEINS, *NEURALGIA, *HISTONES, *GENE silencing, *PERIPHERAL nerve injuries

Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed With Positron Emission Tomography Imaging and Neuronally Derived Exosomes.

Autoren: Johnson, Bernard N. Allen, Mia I. Nader, Susan H. et al.

Quelle: Biological Psychiatry. Oct2025, Vol. 98 Issue 8, p624-633. 10p.

Schlagwörter: *COCAINE, *OPIOID receptors, *THERAPEUTICS, *POSITRON emission tomography, *KRA, *EXOSOMES

Electroacupuncture alleviates pain-like behaviors through modulating DNMT3a/MOR signaling pathway in CCI rats.

Autoren: Wang, Feng Zhou, Chengcheng Xie, Chuangbo et al.

Quelle: PLoS ONE. 10/16/2025, Vol. 20 Issue 10, p1-17. 17p.

Schlagwörter: *ELECTROACUPUNCTURE, *OPIOID receptors, *ANIMAL disease models, *ANALGESIA, *NERVOUS system injuries, *NEURALGIA, *METHYLTRANSFERASES

Novel dual kappa/mu opioid ligands based on a tetrahydroisoquinoline-valine hybrid nucleus.

Autoren: Abdelwaly, Ahmad Safwan, Hesham Chatterjee, Shamba et al.

Quelle: Scientific Reports. 10/16/2025, Vol. 15 Issue 1, p1-16. 16p.

Schlagwörter: *OPIOID receptors, *TETRAHYDROISOQUINOLINES, *OPIOID abuse, *RECEPTOR-ligand complexes, *LIGANDS (Biochemistry), *COMPUTER-assisted molecular design, ANALGESIC effectiveness

κ-Opioid Receptor Agonists as Robust Pain-Modulating Agents: Mechanisms and Therapeutic Potential in Pain Modulation.

Autoren: García-Domínguez, Mario^1,2,3 (AUTHOR)

Quelle: Journal of Clinical Medicine. Oct2025, Vol. 14 Issue 20, p7263. 28p.

Schlagwörter: *OPIOID receptors, *PAIN management, *PHARMACOLOGY, *MEDICAL sciences, *ANALGESICS, *CLINICAL trials

Semi-synthesis in the exploration of opioid-targeting natural products.

Autoren: Riley, Andrew P.¹ (AUTHOR) apriley@uic.edu

Quelle: Natural Product Reports. Oct2025, Vol. 42 Issue 10, p1664-1675. 12p.

Schlagwörter: *OPIOID receptors, *OPIOIDS, *COMBINATORIAL chemistry, *NATURAL products, *SALVINORIN A, *KRATOM

Herkinorin Promotes µ-Opioid Receptor Internalization and Protects iPSC-Derived Neurons from Hypoxic/Ischemic Injury.

Autoren: Ju, Zhihai Wang, Guyan Yan, Yanhong et al.

Quelle: Journal of Integrative Neuroscience. Oct2025, Vol. 24 Issue 10, p1-11. 11p.

Schlagwörter: *OPIOID receptors, *NEUROPROTECTIVE agents, *REPERFUSION injury, *DOWNREGULATION, *APOPTOSIS, *INDUCED pluripotent stem cells, *CEREBRAL ischemia, *APOPTOSIS inhibition

Chronic administration of methocinnamox, a mu-opioid receptor antagonist, reduces hedonic response without impacting motivation in mice.

Autoren: Sheikh, Misbah Cambre, Emily Langreck, Cory et al.

Quelle: Psychopharmacology. Oct2025, Vol. 242 Issue 10, p2327-2339. 13p.

Schlagwörter: *OPIOID receptors, *MOTIVATION (Psychology), *NARCOTIC antagonists, *MICE, *REWARD (Psychology), *MENTAL depression

Ketamine Evokes Acute Behavioral Effects Via μ Opioid Receptor–Expressing Neurons of the Central Amygdala.

Autoren: Pomrenze, Matthew B. Vaillancourt, Sam Llorach, Pierre et al.

Quelle: Biological Psychiatry. Oct2025, Vol. 98 Issue 7, p538-548. 11p.

Schlagwörter: *OPIOID receptors, *KETAMINE, *NALTREXONE, *ANIMAL models in research, *NEURONS

Advances in the Molecular Mechanism of Kappa Opioid Receptors Signaling and the Important Sampling Methods to Probe the Activation Landscape of GPCRs.

Autoren: Tong, Mingqiong Sun, Wan Dong, Pingxuan et al.

Quelle: Chemical Biology & Drug Design. Oct2025, Vol. 106 Issue 4, p1-11. 11p.

Schlagwörter: *OPIOID receptors, *G protein coupled receptors, *MOLECULAR dynamics, *SAMPLING methods, *PAIN perception, *COMPUTATIONAL mechanics, *PROTEINS