Suchergebnisse - "Norepinephrine"

Myeloid sirtuin 6 deficiency causes obesity in mice by inducing norepinephrine degradation to limit thermogenic tissue function.

Autoren: Wang W Liang J Zhang Y et al.

Quelle: Science signaling [Sci Signal] 2025 Mar 11; Vol. 18 (877), pp. eadl6441. Date of Electronic Publication: 2025 Mar 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

MeSH-Schlagworte: Thermogenesis* , Obesity*/metabolism , Obesity*/genetics , Obesity*/pathology , Norepinephrine*/metabolism , Adipose Tissue, Brown*/metabolism , Sirtuins*/genetics , Sirtuins*/metabolism , Sirtuins*/deficiency , Myeloid Cells*/metabolism, Animals ; Mice ; Mice, Knockout ; Macrophages/metabolism ; Adipose Tissue, White/metabolism ; Mice, Inbred C57BL ; Male ; Energy Metabolism ; Insulin Resistance ; Norepinephrine Plasma Membrane Transport Proteins/metabolism ; Norepinephrine Plasma Membrane Transport Proteins/genetics

Structural Models of Human Norepinephrine Transporter Ensemble Reveal the Allosteric Sites and Ligand-Binding Mechanism.

Autoren: Luo D Zhang Y Li Y et al.

Quelle: The journal of physical chemistry. B [J Phys Chem B] 2024 Sep 12; Vol. 128 (36), pp. 8651-8661. Date of Electronic Publication: 2024 Aug 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5207 (Electronic) Linking ISSN: 15205207 NLM ISO Abbreviation: J Phys Chem B Subsets: MEDLINE

MeSH-Schlagworte: Norepinephrine Plasma Membrane Transport Proteins*/metabolism , Norepinephrine Plasma Membrane Transport Proteins*/chemistry , Allosteric Site* , Molecular Dynamics Simulation*, Humans ; Ligands ; Norepinephrine/metabolism ; Norepinephrine/chemistry ; Protein Binding ; Protein Conformation ; Thermodynamics

Norepinephrine Reuptake Inhibition, an Emergent Treatment for Neurogenic Orthostatic Hypotension.

Autoren: Mwesigwa N Shibao CA

Quelle: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Jul; Vol. 81 (7), pp. 1460-1466. Date of Electronic Publication: 2024 May 20.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE

MeSH-Schlagworte: Hypotension, Orthostatic*/drug therapy , Hypotension, Orthostatic*/physiopathology , Adrenergic Uptake Inhibitors*/therapeutic use , Adrenergic Uptake Inhibitors*/pharmacology , Norepinephrine* , Atomoxetine Hydrochloride*/therapeutic use , Atomoxetine Hydrochloride*/pharmacology, Humans ; Norepinephrine Plasma Membrane Transport Proteins/antagonists & inhibitors ; Norepinephrine Plasma Membrane Transport Proteins/metabolism ; Blood Pressure/drug effects ; Blood Pressure/physiology

Norepinephrine use at extubation in critically ill patients with obesity: a cohort study with multicenter validation.

Autoren: De Jong A Capdevila M Aarab Y et al.

Quelle: Intensive care medicine [Intensive Care Med] 2025 Dec; Vol. 51 (12), pp. 2341-2353. Date of Electronic Publication: 2025 Aug 06.

Publikationsart: Journal Article; Multicenter Study; Validation Study; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE

MeSH-Schlagworte: Norepinephrine*/therapeutic use , Norepinephrine*/administration & dosage , Critical Illness*/therapy , Obesity*/complications , Airway Extubation*/methods, Humans ; Male ; Female ; Middle Aged ; Aged ; Retrospective Studies ; Cohort Studies ; Intensive Care Units

Evaluating Rebound Hypotension Following Vasopressor Discontinuation Strategies in Patients With Septic Shock.

Autoren: Starkel S Schuler BR Kovacevic MP et al.

Quelle: The Annals of pharmacotherapy [Ann Pharmacother] 2025 Dec; Vol. 59 (12), pp. 1069-1076. Date of Electronic Publication: 2025 Apr 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Sage Country of Publication: United States NLM ID: 9203131 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-6270 (Electronic) Linking ISSN: 10600280 NLM ISO Abbreviation: Ann Pharmacother Subsets: MEDLINE

MeSH-Schlagworte: Vasoconstrictor Agents*/administration & dosage , Vasoconstrictor Agents*/adverse effects , Shock, Septic*/drug therapy , Shock, Septic*/mortality , Hypotension*/epidemiology , Hypotension*/chemically induced , Hypotension*/etiology , Norepinephrine*/administration & dosage , Norepinephrine*/adverse effects , Vasopressins*/administration & dosage , Vasopressins*/adverse effects, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Aged ; Intensive Care Units ; Length of Stay/statistics & numerical data ; Incidence ; Time Factors ; Withholding Treatment

Phenylephrine Vs. Norepinephrine on the Renin-Angiotensin-Aldosterone System and Postoperative Complications in Acute Abdomen Emergency Surgery: A Randomized Controlled Trial.

Autoren: Chen J Wang X Yin T et al.

Quelle: Critical care medicine [Crit Care Med] 2025 Dec 01; Vol. 53 (12), pp. e2629-e2641. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0355501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0293 (Electronic) Linking ISSN: 00903493 NLM ISO Abbreviation: Crit Care Med Subsets: MEDLINE

MeSH-Schlagworte: Norepinephrine*/therapeutic use , Norepinephrine*/pharmacology , Renin-Angiotensin System*/drug effects , Postoperative Complications*/epidemiology , Phenylephrine*/therapeutic use , Phenylephrine*/pharmacology , Vasoconstrictor Agents*/therapeutic use , Vasoconstrictor Agents*/pharmacology, Humans ; Male ; Female ; Middle Aged ; Aged ; Renin/blood ; Aldosterone/blood

Inhibition of mPFC norepinephrine improved chronic post-thoracotomy pain in adult rats.

Autoren: Zhang F Qiu W Qing W et al.

Quelle: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2451759. Date of Electronic Publication: 2025 Jan 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH-Schlagworte: Norepinephrine*/metabolism , Norepinephrine*/antagonists & inhibitors , Thoracotomy*/adverse effects , Pain, Postoperative*/drug therapy , Pain, Postoperative*/metabolism , Pain, Postoperative*/etiology , Prefrontal Cortex*/metabolism , Prefrontal Cortex*/drug effects , Chronic Pain*/etiology , Chronic Pain*/drug therapy , Chronic Pain*/metabolism, Animals ; Rats, Sprague-Dawley ; Male ; Rats ; Disease Models, Animal ; Pain Threshold/drug effects

Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation.

Autoren: Wang YM Dong HK Dai M et al.

Quelle: Redox report : communications in free radical research [Redox Rep] 2025 Dec; Vol. 30 (1), pp. 2494314. Date of Electronic Publication: 2025 Apr 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9511366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-2928 (Electronic) Linking ISSN: 13510002 NLM ISO Abbreviation: Redox Rep Subsets: MEDLINE

MeSH-Schlagworte: Oxidative Stress*/drug effects , Protein Kinase C*/metabolism , NADPH Oxidase 2*/metabolism , NADPH Oxidase 2*/genetics , Fibroblasts*/metabolism , Fibroblasts*/drug effects , Norepinephrine*/pharmacology , Norepinephrine*/metabolism , NF-kappa B*/metabolism, Animals ; Rats ; Rats, Inbred WKY ; Up-Regulation/drug effects ; Male ; Adventitia/metabolism ; Adventitia/cytology ; Rats, Inbred SHR ; Cell Proliferation/drug effects ; Cells, Cultured

Unveiling conformation-selective regulation of the norepinephrine transporter.

Autoren: Zhang H Zhang T Wang D et al.

Quelle: Cell [Cell] 2025 Nov 26; Vol. 188 (24), pp. 6861-6872.e14. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

MeSH-Schlagworte: Norepinephrine Plasma Membrane Transport Proteins*/metabolism , Norepinephrine Plasma Membrane Transport Proteins*/chemistry , Norepinephrine Plasma Membrane Transport Proteins*/antagonists & inhibitors, Cryoelectron Microscopy ; Humans ; Allosteric Regulation ; Allosteric Site ; Antidepressive Agents/pharmacology ; Antidepressive Agents/chemistry ; Protein Conformation ; Animals ; Piperidines/chemistry ; Piperidines/pharmacology ; Models, Molecular

Sex differences in noradrenergic regulation of the medial prefrontal cortex in mice.

Autoren: Scroger MV Athanason AC Paperny NM et al.

Quelle: Biology of sex differences [Biol Sex Differ] 2025 Nov 12; Vol. 16 (1), pp. 97. Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101548963 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-6410 (Electronic) Linking ISSN: 20426410 NLM ISO Abbreviation: Biol Sex Differ Subsets: MEDLINE

MeSH-Schlagworte: Prefrontal Cortex*/physiology , Prefrontal Cortex*/metabolism , Prefrontal Cortex*/drug effects , Norepinephrine*/metabolism , Norepinephrine*/physiology , Sex Characteristics*, Animals ; Male ; Female ; Mice, Inbred C57BL ; Mice ; Locus Coeruleus/physiology ; Locus Coeruleus/metabolism

Mutational effects of the asparagine198 and glutamate223 residues on the human norepinephrine transporter on basal and HIV-1 Tat protein-induced inhibition of dopamine transport.

Autoren: Porter KD Adeniran C Jimenez-Torres AC et al.

Quelle: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 05; Vol. 1006, pp. 178131. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: tat Gene Products, Human Immunodeficiency Virus*/metabolism , tat Gene Products, Human Immunodeficiency Virus*/pharmacology , Norepinephrine Plasma Membrane Transport Proteins*/genetics , Norepinephrine Plasma Membrane Transport Proteins*/metabolism , Norepinephrine Plasma Membrane Transport Proteins*/chemistry , Dopamine*/metabolism , Mutation* , Glutamic Acid*/genetics , Glutamic Acid*/metabolism , Asparagine*/genetics , Asparagine*/metabolism , HIV-1*, Humans ; Animals ; CHO Cells ; Cricetulus ; Biological Transport/drug effects ; Cocaine/pharmacology ; Cocaine/metabolism ; Fluoxetine/analogs & derivatives

Release and Reuptake Sites for Norepinephrine Are Differently Distributed Across Layers of the Primary Visual Cortex in Macaque Monkeys.

Autoren: Roach C Rios R Pearson J et al.

Quelle: The Journal of comparative neurology [J Comp Neurol] 2025 Nov; Vol. 533 (11), pp. e70110.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0406041 Publication Model: Print Cited Medium: Internet ISSN: 1096-9861 (Electronic) Linking ISSN: 00219967 NLM ISO Abbreviation: J Comp Neurol Subsets: MEDLINE

MeSH-Schlagworte: Norepinephrine*/metabolism , Norepinephrine Plasma Membrane Transport Proteins*/metabolism , Primary Visual Cortex*/metabolism , Primary Visual Cortex*/cytology , Visual Cortex*/metabolism, Animals ; Macaca mulatta ; Male ; Dopamine beta-Hydroxylase/metabolism ; Locus Coeruleus/metabolism ; Axons/metabolism ; Female

Determination of ED90s of Phenylephrine and Norepinephrine Infusion for Strict Blood Pressure Management Targets in Preeclamptic Patients Undergoing Cesarean Section: A Randomized Sequential Allocation Study.

Autoren: Ma Y Ma R Shi Y et al.

Quelle: Drug design, development and therapy [Drug Des Devel Ther] 2025 Nov 01; Vol. 19, pp. 9751-9757. Date of Electronic Publication: 2025 Nov 01 (Print Publication: 2025).

Publikationsart: Journal Article; Randomized Controlled Trial; Case Reports; Clinical Trial

Info zur Zeitschrift: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE

MeSH-Schlagworte: Phenylephrine*/administration & dosage , Phenylephrine*/pharmacology , Cesarean Section* , Norepinephrine*/administration & dosage , Norepinephrine*/pharmacology , Pre-Eclampsia*/drug therapy , Pre-Eclampsia*/physiopathology , Pre-Eclampsia*/surgery , Blood Pressure*/drug effects , Vasoconstrictor Agents*/administration & dosage , Vasoconstrictor Agents*/pharmacology , Hypotension*/drug therapy, Humans ; Female ; Pregnancy ; Adult ; Infusions, Intravenous ; Young Adult

Relative potency of norepinephrine and mephentermine bolus for the treatment of spinal hypotension during elective caesarean delivery: a randomized, blinded up-down sequential allocation study.

Autoren: Mohta M Kumar R Salhotra R et al.

Quelle: International journal of obstetric anesthesia [Int J Obstet Anesth] 2025 Nov; Vol. 64, pp. 104729. Date of Electronic Publication: 2025 Jul 13.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9200430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3374 (Electronic) Linking ISSN: 0959289X NLM ISO Abbreviation: Int J Obstet Anesth Subsets: MEDLINE

MeSH-Schlagworte: Cesarean Section* , Hypotension*/drug therapy , Norepinephrine*/therapeutic use , Norepinephrine*/administration & dosage , Vasoconstrictor Agents*/therapeutic use , Vasoconstrictor Agents*/administration & dosage , Anesthesia, Spinal*/adverse effects , Mephentermine*/therapeutic use , Mephentermine*/administration & dosage , Anesthesia, Obstetrical*/adverse effects, Humans ; Female ; Pregnancy ; Adult ; Elective Surgical Procedures ; Young Adult

Dopamine versus norepinephrine in fluid-refractory septic shock among preterm neonates: a double-blind randomized controlled trial.

Autoren: Singh R Bandyopadhyay T Maria A

Quelle: Journal of tropical pediatrics [J Trop Pediatr] 2025 Oct 23; Vol. 71 (6).

Publikationsart: Journal Article; Randomized Controlled Trial; Comparative Study

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 8010948 Publication Model: Print Cited Medium: Internet ISSN: 1465-3664 (Electronic) Linking ISSN: 01426338 NLM ISO Abbreviation: J Trop Pediatr Subsets: MEDLINE

MeSH-Schlagworte: Shock, Septic*/drug therapy , Shock, Septic*/mortality , Dopamine*/administration & dosage , Dopamine*/therapeutic use , Norepinephrine*/administration & dosage , Norepinephrine*/therapeutic use , Vasoconstrictor Agents*/administration & dosage , Vasoconstrictor Agents*/therapeutic use, Humans ; Double-Blind Method ; Infant, Newborn ; Female ; Male ; Infant, Premature ; Treatment Outcome ; India ; Gestational Age ; Fluid Therapy/methods ; Infusions, Intravenous

The effects of norepinephrine in shockable cardiac arrest, a scoping review.

Autoren: Bouman SJM Baldussu E Franssen GHLM et al.

Quelle: Scandinavian journal of trauma, resuscitation and emergency medicine [Scand J Trauma Resusc Emerg Med] 2025 Oct 02; Vol. 33 (1), pp. 155. Date of Electronic Publication: 2025 Oct 02.

Publikationsart: Journal Article; Scoping Review; Review

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101477511 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-7241 (Electronic) Linking ISSN: 17577241 NLM ISO Abbreviation: Scand J Trauma Resusc Emerg Med Subsets: MEDLINE

MeSH-Schlagworte: Norepinephrine*/therapeutic use , Norepinephrine*/pharmacology , Out-of-Hospital Cardiac Arrest*/therapy , Out-of-Hospital Cardiac Arrest*/drug therapy , Cardiopulmonary Resuscitation*/methods , Vasoconstrictor Agents*/therapeutic use , Electric Countershock*/methods, Humans

Reduction of norepinephrine versus vasopressin in the stabilization phase of septic shock: RENOVA clinical trial.

Autoren: Mallmann C Galiotto TMB de Oliveira MS et al.

Quelle: Medicina intensiva [Med Intensiva (Engl Ed)] 2025 Oct; Vol. 49 (10), pp. 502147. Date of Electronic Publication: 2025 Jan 30.

Publikationsart: Clinical Trial, Phase IV; Comparative Study; Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Elsevier España Country of Publication: Spain NLM ID: 101717568 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2173-5727 (Electronic) Linking ISSN: 21735727 NLM ISO Abbreviation: Med Intensiva (Engl Ed) Subsets: MEDLINE

MeSH-Schlagworte: Hypotension*/epidemiology , Hypotension*/chemically induced , Norepinephrine*/administration & dosage , Norepinephrine*/adverse effects , Shock, Septic*/drug therapy , Shock, Septic*/mortality , Vasoconstrictor Agents*/administration & dosage , Vasoconstrictor Agents*/adverse effects , Vasopressins*/administration & dosage , Vasopressins*/adverse effects, Aged ; Female ; Humans ; Male ; Middle Aged ; Incidence ; Length of Stay/statistics & numerical data ; Renal Dialysis/statistics & numerical data

Oligopeptides and Polypeptides Impact Norepinephrine Detection in Lymphoid Tissue.

Autoren: Ojha S Brooke AK Ostertag BJ et al.

Quelle: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Oct 01; Vol. 16 (19), pp. 3851-3860. Date of Electronic Publication: 2025 Sep 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Norepinephrine*/analysis , Norepinephrine*/metabolism , Lymphoid Tissue*/metabolism , Lymphoid Tissue*/chemistry , Peptides*/metabolism, Animals ; Electrochemical Techniques/methods ; Neuropeptide Y/metabolism ; Substance P/metabolism ; Calcitonin Gene-Related Peptide/metabolism ; Microelectrodes

Substrate binding and inhibition mechanism of norepinephrine transporter.

Autoren: Ji W Miao A Liang K et al.

Quelle: Nature [Nature] 2024 Sep; Vol. 633 (8029), pp. 473-479. Date of Electronic Publication: 2024 Aug 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

MeSH-Schlagworte: Norepinephrine Plasma Membrane Transport Proteins*/antagonists & inhibitors , Norepinephrine Plasma Membrane Transport Proteins*/chemistry , Norepinephrine Plasma Membrane Transport Proteins*/metabolism , Norepinephrine Plasma Membrane Transport Proteins*/ultrastructure, Humans ; Binding Sites ; Cryoelectron Microscopy ; Models, Molecular ; Norepinephrine/metabolism ; Protein Binding ; Substrate Specificity ; 3-Iodobenzylguanidine/metabolism ; Apoproteins

Eye movement evidence for locus coeruleus-noradrenaline system contributions to age differences in attention.

Autoren: Kim AJ Nguyen K Tian Y et al.

Quelle: Psychology and aging [Psychol Aging] 2025 Dec; Vol. 40 (8), pp. 929-944. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Psychological Association Country of Publication: United States NLM ID: 8904079 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-1498 (Electronic) Linking ISSN: 08827974 NLM ISO Abbreviation: Psychol Aging Subsets: MEDLINE

MeSH-Schlagworte: Attention*/physiology , Locus Coeruleus*/physiology , Eye Movements*/physiology , Aging*/physiology , Norepinephrine*/physiology , Norepinephrine*/metabolism, Humans ; Male ; Female ; Adult ; Aged ; Young Adult ; Arousal/physiology ; Middle Aged ; Pupil/physiology ; Eye Movement Measurements ; Age Factors