Výsledky vyhľadávania - "Nootropic Agents"

Antioxidant, anti-inflammatory, and nootropic activities in flavonoid-rich fractions derived from Clerodendrum infortunatum leaf and root extracts: A comparative analysis.

Autori: Verma N Singh S Gupta A a ďalší

Zdroj: Fitoterapia [Fitoterapia] 2025 Oct; Vol. 186, pp. 106842. Date of Electronic Publication: 2025 Aug 22.

Spôsob vydávania: Journal Article; Comparative Study

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

Výrazy zo slovníka MeSH: Flavonoids*/pharmacology , Flavonoids*/isolation & purification , Antioxidants*/pharmacology , Antioxidants*/isolation & purification , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Clerodendrum*/chemistry , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/isolation & purification , Nootropic Agents*/pharmacology , Nootropic Agents*/isolation & purification, Animals ; Plant Leaves/chemistry ; Rats ; Plant Roots/chemistry ; Male ; Rats, Wistar ; Phytochemicals/pharmacology ; Phytochemicals/isolation & purification ; Oxidative Stress/drug effects ; Phenols/pharmacology

Synergistic stress-relieving and cognitive-enhancing effects of walnut peptide and theanine in human brain organoid and mouse stress models.

Autori: Zhong Q Li Q Jia X a ďalší

Zdroj: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov; Vol. 147, pp. 157187. Date of Electronic Publication: 2025 Aug 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

Výrazy zo slovníka MeSH: Stress, Psychological*/drug therapy , Stress, Psychological*/metabolism , Juglans*/chemistry , Brain*/drug effects , Brain*/metabolism , Cognition*/drug effects , Peptides*/pharmacology , Nootropic Agents*/pharmacology , Plant Proteins*/pharmacology, Animals ; Humans ; Mice, Inbred C57BL ; Brain-Derived Neurotrophic Factor/metabolism ; Male ; Mice ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Organoids/drug effects ; Disease Models, Animal ; Serotonin/metabolism ; Drug Synergism ; Neurotransmitter Agents/metabolism ; gamma-Aminobutyric Acid/metabolism ; Dopamine/metabolism ; Glutamates

Differential cognitive enhancer effects of acetylcholinesterase inhibitors and memantine on age-related deficits in vigilance and sustained attention: a preclinical validation study.

Autori: Bali ZK Bruszt N Göntér K a ďalší

Zdroj: Behavioral and brain functions : BBF [Behav Brain Funct] 2025 Oct 28; Vol. 21 (1), pp. 35. Date of Electronic Publication: 2025 Oct 28.

Spôsob vydávania: Journal Article; Validation Study

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101245751 Publication Model: Electronic Cited Medium: Internet ISSN: 1744-9081 (Electronic) Linking ISSN: 17449081 NLM ISO Abbreviation: Behav Brain Funct Subsets: MEDLINE

Výrazy zo slovníka MeSH: Memantine*/pharmacology , Cholinesterase Inhibitors*/pharmacology , Attention*/drug effects , Nootropic Agents*/pharmacology , Aging*/drug effects , Aging*/psychology , Arousal*/drug effects, Animals ; Donepezil/pharmacology ; Galantamine/pharmacology ; Rats ; Male ; Psychomotor Performance/drug effects ; Reaction Time/drug effects ; Cognition/drug effects ; Indans/pharmacology ; Cognitive Dysfunction/drug therapy

Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024.

Autori: Saleh AY Saputra DAY Valentina R a ďalší

Zdroj: F1000Research [F1000Res] 2025 Oct 15; Vol. 14, pp. 275. Date of Electronic Publication: 2025 Oct 15 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: F1000 Research Ltd Country of Publication: England NLM ID: 101594320 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-1402 (Electronic) Linking ISSN: 20461402 NLM ISO Abbreviation: F1000Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ginkgo biloba*/chemistry , Bibliometrics* , Nootropic Agents*/pharmacology , Cognition*/drug effects , Plant Extracts*/pharmacology, Humans

Investigating cognitive-enhancing supplement use among students at a Dutch life science university.

Autori: Escano E Sezer N Pustjens AM

Zdroj: PloS one [PLoS One] 2025 Oct 09; Vol. 20 (10), pp. e0332433. Date of Electronic Publication: 2025 Oct 09 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Výrazy zo slovníka MeSH: Students*/psychology , Students*/statistics & numerical data , Dietary Supplements*/statistics & numerical data , Nootropic Agents*/administration & dosage , Cognition*/drug effects, Humans ; Male ; Female ; Universities ; Netherlands ; Young Adult ; Adult ; Surveys and Questionnaires ; Adolescent ; Motivation

Triterpene and Caffeoylquinic Acid Constituents Contribute to the Cognitive-Enhancing, but Not Anxiolytic, Effects of a Water Extract of Centella asiatica in Aged Mice.

Autori: Hack W Kuhnau L Martinez J a ďalší

Zdroj: Nutrients [Nutrients] 2025 Oct 08; Vol. 17 (19). Date of Electronic Publication: 2025 Oct 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Výrazy zo slovníka MeSH: Triterpenes*/pharmacology , Quinic Acid*/analogs & derivatives , Quinic Acid*/pharmacology , Plant Extracts*/pharmacology , Centella*/chemistry , Cognition*/drug effects , Anti-Anxiety Agents*/pharmacology , Aging* , Nootropic Agents*/pharmacology, Animals ; Male ; Female ; Mice ; Anxiety/drug therapy ; Mice, Inbred C57BL ; Memory/drug effects ; Behavior, Animal/drug effects ; Learning/drug effects ; Water/chemistry

Investigation of cognitive enhancements and mechanisms of kinsenoside in APP/PS1 mice through network pharmacology, in vivo experiments, and machine learning.

Autori: Chen Y Deng Q Wang C a ďalší

Zdroj: Life sciences [Life Sci] 2025 Oct 01; Vol. 378, pp. 123810. Date of Electronic Publication: 2025 Jun 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Network Pharmacology*/methods , Machine Learning* , Cognition*/drug effects , Nootropic Agents*/pharmacology, Animals ; Mice ; Mice, Transgenic ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Presenilin-1/genetics ; Presenilin-1/metabolism ; Molecular Docking Simulation ; Male ; Disease Models, Animal ; Maze Learning/drug effects ; Brain/drug effects ; Brain/metabolism ; Amyloid beta-Peptides/metabolism

Optimized Ginkgo biloba extract EGb 761 ^® : boosted therapeutic benefits with minimized CYP enzyme interference.

Autori: Kwon S Jeong S Lee S

Zdroj: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques [J Pharm Pharm Sci] 2025 Aug 26; Vol. 28, pp. 14614. Date of Electronic Publication: 2025 Aug 26 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 9807281 Publication Model: eCollection Cited Medium: Internet ISSN: 1482-1826 (Electronic) Linking ISSN: 14821826 NLM ISO Abbreviation: J Pharm Pharm Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ginkgo biloba*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Cytochrome P-450 Enzyme Inhibitors*/pharmacology , Cytochrome P-450 Enzyme Inhibitors*/chemistry , Cytochrome P-450 Enzyme System*/metabolism , Nootropic Agents*/pharmacology , Nootropic Agents*/chemistry, Humans ; Molecular Docking Simulation ; Tandem Mass Spectrometry ; Chromatography, High Pressure Liquid ; Ginkgo Extract

Causal effect of conventional anti-dementia drugs on economic burden: an orthogonal double/debiased machine learning approach.

Autori: Jiang X Lv G Franklin J a ďalší

Zdroj: BMC geriatrics [BMC Geriatr] 2025 Aug 25; Vol. 25 (1), pp. 659. Date of Electronic Publication: 2025 Aug 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 100968548 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2318 (Electronic) Linking ISSN: 14712318 NLM ISO Abbreviation: BMC Geriatr Subsets: MEDLINE

Výrazy zo slovníka MeSH: Machine Learning* , Dementia*/economics , Dementia*/drug therapy , Health Care Costs*/statistics & numerical data , Cost of Illness* , Alzheimer Disease*/economics , Alzheimer Disease*/drug therapy , Nootropic Agents*/economics , Nootropic Agents*/therapeutic use , Health Expenditures*/statistics & numerical data, Humans ; United States/epidemiology ; Aged ; Male ; Female ; Medicare/economics ; Cholinesterase Inhibitors/economics ; Cholinesterase Inhibitors/therapeutic use ; Aged, 80 and over

Novel role of serum albumin imidase activity in the formation of BI 761036 (M232), a major metabolite of iclepertin.

Autori: Raymond KG Taub ME Wölke S a ďalší

Zdroj: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2025 Jul; Vol. 53 (7), pp. 100093. Date of Electronic Publication: 2025 May 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amidohydrolases*/blood , Cognitive Dysfunction*/drug therapy , Nootropic Agents*/blood , Nootropic Agents*/metabolism , Nootropic Agents*/pharmacology, Humans ; Serum Albumin/metabolism ; Cytochrome P-450 CYP3A/metabolism ; Hepatocytes/physiology ; Butyrylcholinesterase/metabolism ; Aryldialkylphosphatase/metabolism ; Male ; Female

Safety, tolerability, pharmacokinetic and pharmacodynamic effects of the muscarinic M 1 positive allosteric modulator VU0467319 for Alzheimer's disease: a single ascending-dose study in healthy participants.

Autori: Conley AC Key AP Blackford JU a ďalší

Zdroj: Alzheimer's research & therapy [Alzheimers Res Ther] 2025 Jul 01; Vol. 17 (1), pp. 144. Date of Electronic Publication: 2025 Jul 01.

Spôsob vydávania: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial

Informácie o časopise: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/drug therapy , Nootropic Agents*/administration & dosage , Nootropic Agents*/adverse effects , Nootropic Agents*/pharmacokinetics , Receptor, Muscarinic M1*/agonists , Receptor, Muscarinic M1*/metabolism, Adolescent ; Adult ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Allosteric Regulation/drug effects ; Brain/drug effects ; Cognition/drug effects ; Dose-Response Relationship, Drug ; Double-Blind Method ; Electroencephalography ; Evoked Potentials/drug effects ; Healthy Volunteers ; Neuropsychological Tests

Design, Synthesis, In Vitro, and In Silico Studies of 5-(Diethylamino)-2-Formylphenyl Naphthalene-2-Sulfonate Based Thiosemicarbazones as Potent Anti-Alzheimer Agents.

Autori: Farooq U Islam M Batool Z a ďalší

Zdroj: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2025 Jul; Vol. 358 (7), pp. e70050.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/drug therapy , Alzheimer Disease*/enzymology , Cholinesterase Inhibitors*/chemical synthesis , Cholinesterase Inhibitors*/pharmacokinetics , Thiosemicarbazones*/chemical synthesis , Thiosemicarbazones*/pharmacokinetics , Nootropic Agents*/chemical synthesis , Nootropic Agents*/pharmacokinetics , Drug Design*, Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/pharmacokinetics ; Molecular Docking Simulation ; Humans

Apigenin exhibits memory enhancing activity through the restoration of oxido-endocrine balance and upregulation of BDNF/ERK/CREB signalling pathways in stressed mice.

Autori: Olayinka JN Eduviere AT Okosun MO a ďalší

Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Jul; Vol. 398 (7), pp. 8845-8859. Date of Electronic Publication: 2025 Jan 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Brain-Derived Neurotrophic Factor*/metabolism , Apigenin*/pharmacology , Apigenin*/therapeutic use , Stress, Psychological*/drug therapy , Stress, Psychological*/metabolism , Stress, Psychological*/psychology , Memory*/drug effects , Nootropic Agents*/pharmacology , Nootropic Agents*/therapeutic use, Animals ; Male ; Mice ; Cyclic AMP Response Element-Binding Protein/metabolism ; Oxidative Stress/drug effects ; Corticosterone/blood ; Up-Regulation/drug effects ; Signal Transduction/drug effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Malondialdehyde/metabolism ; Cognitive Dysfunction/drug therapy ; MAP Kinase Signaling System/drug effects ; Hippocampus/drug effects ; Hippocampus/metabolism ; Behavior, Animal/drug effects ; Superoxide Dismutase/metabolism ; Maze Learning/drug effects ; Glutathione/metabolism

Neuroprotective and cognitive-enhancing potentials of herbal remedies: Focus on St. John's wort, green tea, and Ashwagandha.

Autori: Ahmed M; Department of pharmacology, Faculty of veterinary medicine, Cairo university, Giza, Egypt. Electronic address: vet100539@stud.vet.cu.edu.eg.

Zdroj: Neurotoxicology and teratology [Neurotoxicol Teratol] 2025 Sep-Oct; Vol. 111, pp. 107549. Date of Electronic Publication: 2025 Aug 25.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Pergamon Press Country of Publication: United States NLM ID: 8709538 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9738 (Electronic) Linking ISSN: 08920362 NLM ISO Abbreviation: Neurotoxicol Teratol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hypericum*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Tea*/chemistry , Withania*/chemistry , Camellia sinensis*/chemistry , Cognition*/drug effects , Plant Extracts*/pharmacology , Nootropic Agents*/pharmacology, Humans ; Animals

Procognitive effects of methyl 2-amino-3-methoxybenzoate (or daopine) may involve the dorsal striatal anthranilic acid pathway and mutimetabolite-multitarget pharmacology.

Autori: Bright Y Amatdjais-Groenen HIV Verheij MMM a ďalší

Zdroj: Behavioural pharmacology [Behav Pharmacol] 2025 Sep 01; Vol. 36 (6), pp. 397-414. Date of Electronic Publication: 2025 Jul 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Lippincott Williams and Wilkins Country of Publication: England NLM ID: 9013016 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5849 (Electronic) Linking ISSN: 09558810 NLM ISO Abbreviation: Behav Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: ortho-Aminobenzoates*/pharmacology , ortho-Aminobenzoates*/metabolism , Nootropic Agents*/pharmacology, Animals ; Rats ; Male ; Kynurenine/pharmacology ; Rats, Sprague-Dawley ; Corpus Striatum/metabolism ; Corpus Striatum/drug effects ; Disease Models, Animal ; Schizophrenia/drug therapy ; Cognition/drug effects ; Kynurenic Acid/metabolism ; Brain/metabolism ; Brain/drug effects

Assessing the Efficacy of Cognitive Enhancers in Electroconvulsive Therapy: A Randomized Controlled Trial of Rivastigmine and Memantine.

Autori: Molaee P Jahangiri Zarkani N Tavakoli-Ardakani M a ďalší

Zdroj: Clinical neuropharmacology [Clin Neuropharmacol] 2025 Sep-Oct 01; Vol. 48 (5), pp. 171-178. Date of Electronic Publication: 2025 Aug 08.

Spôsob vydávania: Journal Article; Randomized Controlled Trial; Multicenter Study

Informácie o časopise: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7607910 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-162X (Electronic) Linking ISSN: 03625664 NLM ISO Abbreviation: Clin Neuropharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Rivastigmine*/therapeutic use , Rivastigmine*/pharmacology , Memantine*/therapeutic use , Electroconvulsive Therapy*/methods , Electroconvulsive Therapy*/adverse effects , Nootropic Agents*/therapeutic use, Humans ; Male ; Female ; Double-Blind Method ; Middle Aged ; Aged ; Treatment Outcome ; Adult ; Cognition/drug effects

Exploring the neuropharmacological potential of empagliflozin on nootropic and scopolamine-induced amnesic model of Alzheimer's like conditions in rats.

Autori: Borikar SP Sonawane DS Tapre DN a ďalší

Zdroj: The International journal of neuroscience [Int J Neurosci] 2025 Sep; Vol. 135 (9), pp. 1010-1022. Date of Electronic Publication: 2024 May 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 0270707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1563-5279 (Electronic) Linking ISSN: 00207454 NLM ISO Abbreviation: Int J Neurosci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Benzhydryl Compounds*/pharmacology , Benzhydryl Compounds*/administration & dosage , Glucosides*/pharmacology , Glucosides*/administration & dosage , Alzheimer Disease*/drug therapy , Alzheimer Disease*/chemically induced , Amnesia*/drug therapy , Amnesia*/chemically induced , Sodium-Glucose Transporter 2 Inhibitors*/pharmacology , Nootropic Agents*/pharmacology, Animals ; Scopolamine/toxicity ; Rats ; Male ; Disease Models, Animal ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/metabolism ; Receptors, N-Methyl-D-Aspartate/drug effects ; Donepezil/pharmacology

Food for thought: dietary nootropics for the optimisation of military operators' cognitive performance.

Autori: Vine CAJ Spurr TJ Blacker SD

Zdroj: BMJ military health [BMJ Mil Health] 2025 Jul 23; Vol. 171 (4), pp. 297-300. Date of Electronic Publication: 2025 Jul 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101761581 Publication Model: Electronic Cited Medium: Internet ISSN: 2633-3775 (Electronic) Linking ISSN: 26333767 NLM ISO Abbreviation: BMJ Mil Health Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cognition*/drug effects , Cognition*/physiology , Dietary Supplements*/standards , Military Personnel*/psychology , Military Personnel*/statistics & numerical data , Nootropic Agents*/administration & dosage, Humans ; Caffeine/administration & dosage ; Tyrosine/administration & dosage

Memory-Enhancing Effects of Dauricine in Swiss Mice: Possible Molecular Interventions Through In Vivo and In Silico Studies.

Autori: Akbor MS Al Hasan MS Haque MF a ďalší

Zdroj: Neuromolecular medicine [Neuromolecular Med] 2025 Jun 05; Vol. 27 (1), pp. 45. Date of Electronic Publication: 2025 Jun 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 101135365 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1174 (Electronic) Linking ISSN: 15351084 NLM ISO Abbreviation: Neuromolecular Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Dopamine D2*/metabolism , Receptors, Dopamine D2*/chemistry , Receptors, Dopamine D2*/agonists , Memory*/drug effects , Benzylisoquinolines*/pharmacology , Benzylisoquinolines*/pharmacokinetics , Benzylisoquinolines*/toxicity , Benzylisoquinolines*/therapeutic use , Benzylisoquinolines*/chemistry , Tetrahydroisoquinolines*/pharmacology , Tetrahydroisoquinolines*/pharmacokinetics , Tetrahydroisoquinolines*/toxicity , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/pharmacokinetics , Neuroprotective Agents*/toxicity , Nootropic Agents*/pharmacology , Nootropic Agents*/pharmacokinetics , Nootropic Agents*/toxicity, Animals ; Mice ; Molecular Docking Simulation ; Male ; Behavior, Animal/drug effects ; Anxiety ; Dose-Response Relationship, Drug ; Cognition/drug effects ; Dopamine Agonists/pharmacology ; Swimming ; Maze Learning/drug effects ; Protein Binding ; Motor Activity/drug effects

Novel GC MS/MS method for bioanalysis of pyrroloquinoline quinone, a potential cognitive enhancer in mice brains.

Autori: Mostafa M Abdel-Kader R Hanafi R

Zdroj: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2025 Apr 15; Vol. 1256, pp. 124559. Date of Electronic Publication: 2025 Mar 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: PQQ Cofactor*/analysis , PQQ Cofactor*/pharmacokinetics , Gas Chromatography-Mass Spectrometry*/methods , Tandem Mass Spectrometry*/methods , Brain*/metabolism , Nootropic Agents*/analysis , Nootropic Agents*/pharmacokinetics , Brain Chemistry*, Animals ; Mice ; Male ; Blood-Brain Barrier/metabolism ; Reproducibility of Results ; Linear Models ; Limit of Detection