Výsledky vyhledávání - "Non-coding RNA Networks"
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Zdroj: Brief Bioinform
Témata: FOS: Computer and information sciences, 0301 basic medicine, Cancer Research, RNA, Untranslated, Non-coding RNA Networks, MicroRNA Regulation in Cancer and Development, Bioinformatics, Role of Long Noncoding RNAs in Cancer and Development, Review, Gene, Computational biology, 03 medical and health sciences, Malabsorption Syndromes, Pregnancy, Biochemistry, Genetics and Molecular Biology, Genetics, Humans, Regulation of gene expression, Disease, Non-coding RNA, Molecular Biology, Biology, Internal medicine, Gestational diabetes, ENCODE, 0303 health sciences, mRNA modification, microRNA, Genome, Human, RNA Regulation, Life Sciences, 16. Peace & justice, 3. Good health, Diabetes, Gestational, Gene Expression Regulation, RNA Methylation and Modification in Gene Expression, FOS: Biological sciences, RNA, Medicine, Female, Gestation, Biomarkers, Carbohydrate Metabolism, Inborn Errors
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38189542
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Zdroj: The Egyptian Journal of Internal Medicine, Vol 35, Iss 1, Pp 1-9 (2023)
Témata: 0301 basic medicine, Cancer Research, Non-coding RNA Networks, Immunology, Role of Long Noncoding RNAs in Cancer and Development, Cancer research, Gene, 03 medical and health sciences, Long Noncoding RNAs, Biochemistry, Genetics and Molecular Biology, Genetics, Biogenesis and Functions of Circular RNAs, Molecular Biology, Biology, Internal medicine, 0303 health sciences, Acute myeloid leukemia, Leukemia, FOS: Clinical medicine, Life Sciences, Cancer Biomarkers, RC31-1245, Downregulation and upregulation, 3. Good health, Myeloid leukemia, Oncology, FOS: Biological sciences, Regulation of RNA Processing and Function, Long non-coding RNA, Medicine, Gene expression, DANCR, Adult leukemia, Long noncoding RNA
Přístupová URL adresa: https://doaj.org/article/781b22ca44884e75b3d82e619591139c
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Zdroj: Egyptian Liver Journal, Vol 12, Iss 1, Pp 1-8 (2022)
Témata: 0301 basic medicine, Cancer Research, Non-coding RNA Networks, RD1-811, Hepatocellular carcinoma, Lipid Metabolism and Cardiovascular Disease, Role of Long Noncoding RNAs in Cancer and Development, RC799-869, Cancer research, Gene, Long Noncoding RNAs, 03 medical and health sciences, lncRNA gene, Biochemistry, Genetics and Molecular Biology, Health Sciences, Genetics, Molecular Biology, Internal medicine, Biology, Glypican3 (GPC3), 0303 health sciences, Life Sciences, Biomarker, Diseases of the digestive system. Gastroenterology, Prognosis, 3. Good health, Gene Expression Regulation, Oncology, RNA Methylation and Modification in Gene Expression, FOS: Biological sciences, Long non-coding RNA, Medicine, RNA, Surgery, Gene expression, Cardiology and Cardiovascular Medicine, Alpha fetoprtotein (AFP)
Přístupová URL adresa: https://doaj.org/article/0d9d4176554441909fb710c9a23c03f0
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Zdroj: Cancer Cell Int
Cancer Cell International, Vol 22, Iss 1, Pp 1-14 (2022)Témata: 0301 basic medicine, Cancer Research, Non-coding RNA Networks, Role of Long Noncoding RNAs in Cancer and Development, Apoptosis, Review, Cancer research, Cell cycle, Gene, Metastasis, Long Noncoding RNAs, 03 medical and health sciences, Biochemistry, Genetics and Molecular Biology, Genetics, MEG3, Molecular Biology, Biology, RC254-282, Oncogene, miRNA, Cancer, 0303 health sciences, mRNA modification, QH573-671, RNA Regulation, Epigenetic, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Life Sciences, Gene silencing, Long Non-coding RNA, Competing endogenous RNA, Colorectal cancer, Downregulation and upregulation, 3. Good health, Gene Expression Regulation, RNA Methylation and Modification in Gene Expression, FOS: Biological sciences, Regulation of RNA Processing and Function, Long non-coding RNA, Cytology
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Zdroj: J Ovarian Res
Journal of Ovarian Research, Vol 15, Iss 1, Pp 1-11 (2022)Témata: FOS: Computer and information sciences, 0301 basic medicine, Cancer Research, Non-coding RNA Networks, tRNA-derived small RNAs, MicroRNA Regulation in Cancer and Development, Carcinogenesis, Bioinformatics, Role of Long Noncoding RNAs in Cancer and Development, Review, Cancer research, Carcinoma, Ovarian Epithelial, Gene, 03 medical and health sciences, Ovarian cancer, Biochemistry, Genetics and Molecular Biology, Biomarkers, Tumor, Genetics, Humans, Disease, Biogenesis and Functions of Circular RNAs, Non-coding RNA, Small non-coding-RNA, Molecular Biology, Biology, Internal medicine, Cancer, Ovarian Neoplasms, 0303 health sciences, microRNAs (miRNAs), microRNA, RNA Regulation, Gynecological malignancies, Life Sciences, Gynecology and obstetrics, Cancer Biomarkers, Long coding RNA, 3. Good health, Gene Expression Regulation, Neoplastic, FOS: Biological sciences, Long non-coding RNA, RG1-991, Medicine, RNA, Female, RNA, Long Noncoding
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Zdroj: Front Genet
Frontiers in Genetics, Vol 13 (2022)Témata: explainable artificial intelligence (XAI), Cancer Research, Artificial intelligence, Non-coding RNA Networks, one-dimensional convolutional neural network (1D CNN), Role of Long Noncoding RNAs in Cancer and Development, Convolutional neural network, QH426-470, long non-coding RNA (lncRNA), Gene, Computational biology, SHAP (SHapley additive exPlanations), Long Noncoding RNAs, Identification (biology), Biochemistry, Genetics and Molecular Biology, Genetics, FOS: Mathematics, RNA Sequencing Data Analysis, Molecular Biology, tRNA, Biology, Coding (social sciences), Statistics, Botany, deep learning, Life Sciences, Computer science, RNA Methylation and Modification in Gene Expression, FOS: Biological sciences, Long non-coding RNA, RNA, Mathematics
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Zdroj: FEBS Open Bio
Témata: FOS: Computer and information sciences, 0301 basic medicine, Cancer Research, Non-coding RNA Networks, MicroRNA Regulation in Cancer and Development, Bioinformatics, Role of Long Noncoding RNAs in Cancer and Development, Real-Time Polymerase Chain Reaction, Competing Endogenous RNA, Gene, Computational biology, Long Noncoding RNAs, 03 medical and health sciences, Biochemistry, Genetics and Molecular Biology, Genetics, Non-coding RNA, Molecular Biology, Biology, Research Articles, Cancer, 2. Zero hunger, 0303 health sciences, microRNA, Small nuclear RNA, RNA Regulation, DNA microarray, Life Sciences, 3. Good health, Small nucleolar RNA, FOS: Biological sciences, Long non-coding RNA, Cervical cancer, RNA, Real-Time PCR, Gene expression, Reference genes
Přístupová URL adresa: https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.12523
https://pubmed.ncbi.nlm.nih.gov/30410863
https://europepmc.org/article/MED/30410863
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12523
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212646
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/2211-5463.12523 -
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Zdroj: Front Genet
Frontiers in Genetics, Vol 12 (2021)Témata: 0301 basic medicine, Cancer Research, Non-coding RNA Networks, MicroRNA Regulation in Cancer and Development, Genotype, lncRNAs, SNP, Role of Long Noncoding RNAs in Cancer and Development, Cancer research, QH426-470, Competing Endogenous RNA, Gene, BC, Long Noncoding RNAs, 03 medical and health sciences, Breast cancer, Biochemistry, Genetics and Molecular Biology, Genetics, MEG3, 10. No inequality, Molecular Biology, Biology, Cancer, Single-nucleotide polymorphism, Allele, mRNA modification, microRNA, Life Sciences, Biomarker, 3. Good health, Gene Expression Regulation, Oncology, RNA Methylation and Modification in Gene Expression, FOS: Biological sciences, miRNAs, Long non-coding RNA, RNA, Medicine
Přístupová URL adresa: https://www.frontiersin.org/articles/10.3389/fgene.2021.683809/pdf
https://pubmed.ncbi.nlm.nih.gov/34421993
https://doaj.org/article/b7826d8aedd241f3857a69cb6db66e0f
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371747
https://www.frontiersin.org/articles/10.3389/fgene.2021.683809/full
https://pubmed.ncbi.nlm.nih.gov/34421993/
http://repository.msa.edu.eg/xmlui/handle/123456789/4652 -
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Zdroj: Front Oncol
Frontiers in Oncology, Vol 11 (2021)
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y TécnicasTémata: 0301 basic medicine, Cancer Research, MICRORNAS, Carcinogenesis, Role of Long Noncoding RNAs in Cancer and Development, Gene, Computational biology, long non-coding RNAs, Long Noncoding RNAs, Druggability, Druggable targets, RC254-282, mRNA modification, microRNA, RNA Regulation, Network pathways, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Life Sciences, Competing endogenous RNA, microRNAs, 3. Good health, Oncology, RNA Methylation and Modification in Gene Expression, miRNAs, Long non-coding RNA, RNA methylation, Medicine, network pathways, Non-coding RNA Networks, NETWORK PATHWAYS, lncRNAs, KSHV, Long non-coding, 03 medical and health sciences, Biochemistry, Genetics and Molecular Biology, DRUGGABLE TARGETS, Health Sciences, Genetics, Non-coding RNA, druggable targets, Molecular Biology, Biology, RNAs, LONG NON-CODING RNAS, FOS: Biological sciences, Ciencias Médicas, RNA, Gene expression, Viral-Related Cancers in Immunocompromised Patients, Transcriptome
Popis souboru: application/pdf
Přístupová URL adresa: https://www.frontiersin.org/articles/10.3389/fonc.2021.687629/pdf
http://sedici.unlp.edu.ar/bitstream/handle/10915/125572/Documento_completo.pdf?sequence=1
https://pubmed.ncbi.nlm.nih.gov/34222014
https://doaj.org/article/dc4bc52eeeac495798c79437d7886da7
http://www.biorxiv.org/content/10.1101/2021.03.05.434134v1
https://biorxiv.org/content/10.1101/2021.03.05.434134v1.full.pdf
https://www.biorxiv.org/content/10.1101/2021.03.05.434134v1
https://europepmc.org/article/PMC/PMC8242244
https://www.frontiersin.org/articles/10.3389/fonc.2021.687629/full
https://ri.conicet.gov.ar/handle/11336/137090
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242244
https://pubmed.ncbi.nlm.nih.gov/34222014/
https://miami.pure.elsevier.com/en/publications/a-non -coding -rna -network-involved-in-kshv-tumorigenesis
http://sedici.unlp.edu.ar/handle/10915/125575
http://sedici.unlp.edu.ar/handle/10915/125572
http://hdl.handle.net/11336/137090 -
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Témata: 0301 basic medicine, Cancer Research, Artificial intelligence, Non-coding RNA Networks, MicroRNA Regulation in Cancer and Development, genome annotation, Role of Long Noncoding RNAs in Cancer and Development, Convolutional neural network, Gene prediction, Gene, Computational biology, 03 medical and health sciences, Computer security, Biochemistry, Genetics and Molecular Biology, Machine learning, Genetics, FOS: Mathematics, RNA Sequencing Data Analysis, Key (lock), Molecular Biology, Data mining, Biology, Coding (social sciences), Precision and recall, 0303 health sciences, Genome, microRNA, RNA Regulation, Statistics, Life Sciences, Deep learning, Computer science, Algorithm, MicroRNAs, Residual, FOS: Biological sciences, sequence alignment, Mathematics
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Zdroj: Front Pharmacol
Frontiers in Pharmacology, Vol 11 (2020)Témata: FOS: Computer and information sciences, 0301 basic medicine, Cancer Research, Non-coding RNA Networks, MicroRNA Regulation in Cancer and Development, Bioinformatics, kidney disease, Role of Long Noncoding RNAs in Cancer and Development, RM1-950, Diabetic nephropathy, Kidney, Gene, Computational biology, Long Noncoding RNAs, 03 medical and health sciences, lncRNA, Biochemistry, Genetics and Molecular Biology, Genetics, circRNA, Disease, Biogenesis and Functions of Circular RNAs, Non-coding RNA, Molecular Biology, Biology, Circular RNA, Internal medicine, miRNA, Pharmacology, microRNA, RNA Regulation, diabetic nephropathy, biomarkers, Life Sciences, 3. Good health, MicroRNAs, FOS: Biological sciences, Long non-coding RNA, RNA, Medicine, Therapeutics. Pharmacology, Circular RNAs
Přístupová URL adresa: https://www.frontiersin.org/articles/10.3389/fphar.2020.00191/pdf
https://pubmed.ncbi.nlm.nih.gov/32194418
https://doaj.org/article/42ae30b5c9054ef18d5003dc4aadbfec
https://www.frontiersin.org/articles/10.3389/fphar.2020.00191/full
http://www.ncbi.nlm.nih.gov/pubmed/32194418
https://www.frontiersin.org/article/10.3389/fphar.2020.00191/full
https://europepmc.org/article/MED/32194418
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062796
https://pubmed.ncbi.nlm.nih.gov/32194418/ -
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Zdroj: Front Physiol
Frontiers in Physiology, Vol 10 (2019)Témata: FOS: Computer and information sciences, 0301 basic medicine, Cancer Research, Non-coding RNA Networks, Steatosis, Physiology, Epidemiology, Bioinformatics, Immunology, lncRNAs, Role of Long Noncoding RNAs in Cancer and Development, Pathogenesis, Gene, Epidemiology and Management of NAFLD, Computational biology, 03 medical and health sciences, Endocrinology, Biochemistry, Genetics and Molecular Biology, NAFLD, Fatty liver, Health Sciences, Genetics, Pathology, QP1-981, Disease, Biogenesis and Functions of Circular RNAs, Non-coding RNA, Molecular Biology, Biology, Internal medicine, Steatohepatitis, microRNA, RNA Regulation, FOS: Clinical medicine, NASH, Life Sciences, Alcoholic liver disease, microRNAs, 3. Good health, Cirrhosis, FOS: Biological sciences, biomarker, Medicine, circRNAs
Přístupová URL adresa: https://www.frontiersin.org/articles/10.3389/fphys.2019.00279/pdf
https://pubmed.ncbi.nlm.nih.gov/30941061
https://doaj.org/article/3203cf9630b74436a6bd25d303cdd054
https://www.frontiersin.org/articles/10.3389/fphys.2019.00279/full
https://khepri-node.dev.meta-infra.org/papers/regulatory-non -coding -rnas-network-in-non -alcoholi/30941061
https://www.frontiersin.org/article/10.3389/fphys.2019.00279/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433939
https://europepmc.org/article/MED/30941061
https://pubmed.ncbi.nlm.nih.gov/30941061/ -
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Zdroj: BMC Genomics
BMC Genomics, Vol 19, Iss S1, Pp 57-66 (2018)Témata: 0301 basic medicine, Cancer Research, Alternative medicine, Non-coding RNA Networks, MicroRNA Regulation in Cancer and Development, PHAS, Bioinformatics, Panax notoginseng, Role of Long Noncoding RNAs in Cancer and Development, Plant Science, QH426-470, Gene, Molecular Mechanisms of Plant Development and Regulation, Agricultural and Biological Sciences, Computational biology, 03 medical and health sciences, Gene Expression Regulation, Plant, Biochemistry, Genetics and Molecular Biology, Genetics, Pathology, DNA sequencing, RNA, Small Interfering, Biology, Plant Proteins, 0303 health sciences, High-throughput sequencing, microRNA, Phased small interfering RNA (phasiRNA), Sequence Analysis, RNA, RNA Regulation, Research, High-Throughput Nucleotide Sequencing, Life Sciences, 15. Life on land, Small RNA, FOS: Biological sciences, Medicine, TP248.13-248.65, Genome, Plant, Biotechnology
Přístupová URL adresa: https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-017-4331-0
https://pubmed.ncbi.nlm.nih.gov/29363419
https://doaj.org/article/53b00aa441c146e69756e9de3d5f4d3b
https://www.ncbi.nlm.nih.gov/pubmed/29363419
https://pubmed.ncbi.nlm.nih.gov/29363419/
https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-4331-0
https://link.springer.com/content/pdf/10.1186/s12864-017-4331-0.pdf
https://link.springer.com/article/10.1186/s12864-017-4331-0
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780745 -
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Zdroj: PLoS One
PLoS ONE, Vol 16, Iss 3, p e0242530 (2021)Témata: Epigenomics, 0301 basic medicine, Cancer Research, Non-coding RNA Networks, Science, Role of Long Noncoding RNAs in Cancer and Development, Gene, Epigenesis, Genetic, Histones, Long Noncoding RNAs, RNA-Directed DNA Methylation, 03 medical and health sciences, Endocrinology, Biochemistry, Genetics and Molecular Biology, Genetics, RNA, Small Interfering, RNA Sequencing Data Analysis, Molecular Biology, Mycoviruses in Fungal Symbiosis and Pathogenesis, Biology, Plant Proteins, DNA methylation, Genome, Reverse Transcriptase Polymerase Chain Reaction, RNA Regulation, Inverted Repeat Sequences, Brassica rapa, Life Sciences, DNA Methylation, Diploidy, Plant Leaves, Gene Ontology, Small nucleolar RNA, RNA, Plant, FOS: Biological sciences, Long non-coding RNA, Medicine, RNA, RNA, Long Noncoding, Epigenetics, Gene expression, Genome, Plant, Research Article
Přístupová URL adresa: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0242530&type=printable
https://pubmed.ncbi.nlm.nih.gov/33788851
https://doaj.org/article/2225d8dc8c584b2f9976afebe1a15bc5
https://dx.plos.org/10.1371/journal.pone.0242530
https://www.ncbi.nlm.nih.gov/pubmed/33788851
https://ui.adsabs.harvard.edu/abs/2021PLoSO..1642530M/abstract
https://pubmed.ncbi.nlm.nih.gov/33788851/
https://europepmc.org/article/PMC/PMC8011741 -
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Zdroj: Curr Biol
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
Current BiologyTémata: GENETIC VARIATION, 0301 basic medicine, Cancer Research, RNA, Untranslated, Gene Expression, Role of Long Noncoding RNAs in Cancer and Development, Gene, BYSTANDER EXPRESSION, Computational biology, Long Noncoding RNAs, RNA interference, Sociology, Regulation of gene expression, TRANSCRIPTION, In Situ Hybridization, Fluorescence, LNCRNA, 0303 health sciences, RNA Regulation, Gene Expression Regulation, Developmental, Life Sciences, FOS: Sociology, NON-CODING RNA, Drosophila melanogaster, Phenotype, Organ Specificity, RNA Methylation and Modification in Gene Expression, Function (biology), Long non-coding RNA, Embryogenesis, RNA, Long Noncoding, Cell biology, Non-coding RNA Networks, RNA Phase Transitions, Population, Embryonic Development, Article, 03 medical and health sciences, Biochemistry, Genetics and Molecular Biology, Genetics, Animals, Molecular Biology, Biology, Demography, EMBRYONIC DEVELOPMENT, NON-ESSENTIAL GENES, Gene Expression Regulation, FOS: Biological sciences, Regulation of RNA Processing and Function, RNA, Gene expression
Popis souboru: application/pdf
Přístupová URL adresa: http://www.cell.com/article/S0960982218312211/pdf
https://pubmed.ncbi.nlm.nih.gov/30393032
https://www.sciencedirect.com/science/article/abs/pii/S0960982218312211
https://www.sciencedirect.com/science/article/pii/S0960982218312211
http://europepmc.org/abstract/MED/30393032
https://www.cell.com/current-biology/fulltext/S0960-9822(18)31221-1
https://www.ncbi.nlm.nih.gov/pubmed/30393032
http://hdl.handle.net/11336/88518 -
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Zdroj: PLoS One
PLoS ONE, Vol 13, Iss 10, p e0198231 (2018)Témata: Male, FOS: Computer and information sciences, 0301 basic medicine, Cancer Research, Hepatocellular carcinoma, Role of Long Noncoding RNAs in Cancer and Development, Gene, Long Noncoding RNAs, Neoplasms, GAS5, Internal medicine, Cancer, 0303 health sciences, microRNA, Liver Neoplasms, Life Sciences, Cancer Biomarkers, Middle Aged, Kidney Neoplasms, 3. Good health, Gene Expression Regulation, Neoplastic, Oncology, Long non-coding RNA, Medicine, Egypt, Female, RNA, Long Noncoding, Research Article, Carcinoma, Hepatocellular, Non-coding RNA Networks, MicroRNA Regulation in Cancer and Development, Bioinformatics, Science, Cancer research, 03 medical and health sciences, Biochemistry, Genetics and Molecular Biology, Biomarkers, Tumor, Genetics, Humans, Biogenesis and Functions of Circular RNAs, Carcinoma, Renal Cell, Molecular Biology, Biology, MicroRNAs, FOS: Biological sciences, RNA, Glioblastoma, Biomarkers
Přístupová URL adresa: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198231&type=printable
https://pubmed.ncbi.nlm.nih.gov/30289954
https://doaj.org/article/759e99a51a454618a1439f93e9edeb67
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198231
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173395/
http://ui.adsabs.harvard.edu/abs/2018PLoSO..1398231T/abstract
https://dx.plos.org/10.1371/journal.pone.0198231
https://pubmed.ncbi.nlm.nih.gov/30289954/
https://www.ncbi.nlm.nih.gov/pubmed/30289954 -
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Zdroj: PLoS One
PLoS ONE, Vol 9, Iss 11, p e111877 (2014)Témata: Adult, 0301 basic medicine, Cancer Research, Tunisia, Non-coding RNA Networks, MicroRNA Regulation in Cancer and Development, Science, Gene Expression, Triple Negative Breast Neoplasms, Role of Long Noncoding RNAs in Cancer and Development, Cancer research, Gene, 03 medical and health sciences, Breast cancer, 0302 clinical medicine, Triple-negative breast cancer, Biochemistry, Genetics and Molecular Biology, Biomarkers, Tumor, MicroRNA Sponges, Genetics, Humans, Biogenesis and Functions of Circular RNAs, Molecular Biology, Internal medicine, Biology, Cancer, microRNA, RNA Regulation, Carcinoma, Ductal, Breast, Life Sciences, Prognosis, 3. Good health, MicroRNAs, Treatment Outcome, ROC Curve, Oncology, FOS: Biological sciences, Medicine, Female, Triple negative, Research Article
Přístupová URL adresa: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0111877&type=printable
https://pubmed.ncbi.nlm.nih.gov/25369070
https://doaj.org/article/fb2d5d4b899e40729ad4a5a2c7ee3635
https://dx.plos.org/10.1371/journal.pone.0111877
https://core.ac.uk/display/150462020
https://pubmed.ncbi.nlm.nih.gov/25369070/
https://paperity.org/p/60539306/micrornas-expression-in-triple-negative-vs-non -triple-negative-breast-cancer-in-tunisia
http://ui.adsabs.harvard.edu/abs/2014PLoSO...9k1877M/abstract
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219794
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