Výsledky vyhľadávania - "Nitrogen Mustard Compounds"

Comprehensive reexamination of the acute toxicity of nitrogen mustards: HN-1, HN-2 and HN-3 as blister agents: application of multi in silico approach.

Autori: Noga M Jurowski K

Zdroj: Archives of toxicology [Arch Toxicol] 2025 Oct; Vol. 99 (10), pp. 4159-4180. Date of Electronic Publication: 2025 Jun 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Chemical Warfare Agents*/toxicity , Chemical Warfare Agents*/chemistry , Mechlorethamine*/toxicity , Mechlorethamine*/chemistry , Nitrogen Mustard Compounds*/toxicity , Nitrogen Mustard Compounds*/chemistry, Computer Simulation ; Quantitative Structure-Activity Relationship ; Humans ; Lethal Dose 50 ; Animals ; Toxicity Tests, Acute

Examination of a Chimeric Bis-Electrophile for Selective DNA-Protein Cross-Linking and Mechlorethamine Reveals an Unknown Source of Nitrogen Mustard Cytotoxicity.

Autori: Jiang X Vu S Yu H a ďalší

Zdroj: Journal of the American Chemical Society [J Am Chem Soc] 2025 Sep 03; Vol. 147 (35), pp. 31839-31848. Date of Electronic Publication: 2025 Aug 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mechlorethamine*/chemistry , Mechlorethamine*/toxicity , Mechlorethamine*/pharmacology , Cross-Linking Reagents*/chemistry , Cross-Linking Reagents*/pharmacology , DNA*/chemistry , DNA*/metabolism , Nitrogen Mustard Compounds*/chemistry , Nitrogen Mustard Compounds*/toxicity , Proteins*/chemistry, Cell Survival/drug effects ; Humans

Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents.

Autori: Owens M Thyagarajan A Travers JB a ďalší

Zdroj: Journal of applied toxicology : JAT [J Appl Toxicol] 2025 Aug; Vol. 45 (8), pp. 1417-1425. Date of Electronic Publication: 2025 Mar 04.

Spôsob vydávania: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Informácie o časopise: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1263 (Electronic) Linking ISSN: 0260437X NLM ISO Abbreviation: J Appl Toxicol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Chemical Warfare Agents*/toxicity , Nitrogen Mustard Compounds*/toxicity , Mustard Gas*/toxicity , Irritants*/toxicity, Humans ; Animals ; Mechlorethamine/toxicity ; Skin/drug effects ; Skin/pathology

Hypoxia-triggered singlet oxygen and nitrogen mustard release towards a synergistic therapeutic action.

Autori: Qiao Y Nie Y Si Y a ďalší

Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 May 30; Vol. 61 (45), pp. 8236-8239. Date of Electronic Publication: 2025 May 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Singlet Oxygen*/metabolism , Singlet Oxygen*/chemistry , Prodrugs*/chemistry , Prodrugs*/pharmacology , Prodrugs*/therapeutic use , Mechlorethamine*/chemistry , Mechlorethamine*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Nitrogen Mustard Compounds*/chemistry , Nitrogen Mustard Compounds*/pharmacology, Animals ; Humans ; Mice ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Cell Survival/drug effects ; Cell Hypoxia

Transfusion of Amustaline/Glutathione Pathogen-reduced Red Blood Cells in Cardiac Surgery: A Randomized Phase 3 Clinical Trial.

Autori: Sekela ME Snyder EL Welsby IJ a ďalší

Korporácia: Sekela ME Snyder EL Welsby IJ a ďalší

Zdroj: Anesthesiology [Anesthesiology] 2025 Nov 01; Vol. 143 (5), pp. 1196-1210. Date of Electronic Publication: 2025 Aug 12.

Spôsob vydávania: Clinical Trial, Phase III; Equivalence Trial; Journal Article; Multicenter Study

Informácie o časopise: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1300217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1175 (Electronic) Linking ISSN: 00033022 NLM ISO Abbreviation: Anesthesiology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cardiac Surgical Procedures*/methods , Cardiac Surgical Procedures*/adverse effects , Erythrocyte Transfusion*/methods , Erythrocyte Transfusion*/adverse effects , Erythrocytes*/drug effects , Glutathione*/administration & dosage, Aged ; Female ; Humans ; Male ; Middle Aged ; Acute Kidney Injury/epidemiology ; Blood Loss, Surgical/prevention & control ; Double-Blind Method ; Acridines ; Nitrogen Mustard Compounds

Somatic hypermutation mechanisms during lymphomagenesis and transformation.

Autori: Lauring MC Basu U

Zdroj: Current opinion in genetics & development [Curr Opin Genet Dev] 2024 Apr; Vol. 85, pp. 102165. Date of Electronic Publication: 2024 Feb 29.

Spôsob vydávania: Journal Article; Review; Research Support, N.I.H., Extramural

Informácie o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 9111375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0380 (Electronic) Linking ISSN: 0959437X NLM ISO Abbreviation: Curr Opin Genet Dev Subsets: MEDLINE

Výrazy zo slovníka MeSH: Genomics* , Hydantoins* , Nitrogen Mustard Compounds*, Mutation

Analytical methods based on liquid chromatography for the analysis of albumin adducts involved in retrospective biomonitoring of exposure to mustard agents.

Autori: Avigo L Hallez F Combès A a ďalší

Zdroj: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2024 Apr; Vol. 416 (9), pp. 2173-2188. Date of Electronic Publication: 2023 Sep 13.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mustard Gas*/analysis , Nitrogen Mustard Compounds*/analysis , Chemical Warfare Agents*/analysis, Humans ; Biological Monitoring ; Retrospective Studies ; Tandem Mass Spectrometry/methods ; Albumins/chemistry ; Chromatography, Liquid ; Peptides ; Biomarkers ; Nitrogen/analysis

Characterization of AST-001 non-clinical pharmacokinetics: A novel selective AKR1C3-activated prodrug in mice, rats, and cynomolgus monkeys.

Autori: Meng T Jung D Cai XH a ďalší

Zdroj: Biopharmaceutics & drug disposition [Biopharm Drug Dispos] 2024 Apr; Vol. 45 (2), pp. 83-92. Date of Electronic Publication: 2024 Mar 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: England NLM ID: 7911226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-081X (Electronic) Linking ISSN: 01422782 NLM ISO Abbreviation: Biopharm Drug Dispos Subsets: MEDLINE

Výrazy zo slovníka MeSH: Prodrugs* , Nitrogen Mustard Compounds*/pharmacokinetics, Animals ; Female ; Mice ; Rats ; Aldo-Keto Reductase Family 1 Member C3/drug effects ; Macaca fascicularis ; Mice, Nude ; Rats, Sprague-Dawley ; Aziridines/pharmacokinetics ; Dose-Response Relationship, Drug

Ethanolysis of nitrogen mustards: A novel strategy for nitrogen mustard identification in environmental matrices by liquid chromatography-electrospray ionization-tandem mass spectrometry.

Autori: Belay C Shifrovitch A Prihed H a ďalší

Zdroj: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2024 Mar 15; Vol. 38 (5), pp. e9701.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: John Wiley And Sons Ltd Country of Publication: England NLM ID: 8802365 Publication Model: Print Cited Medium: Internet ISSN: 1097-0231 (Electronic) Linking ISSN: 09514198 NLM ISO Abbreviation: Rapid Commun Mass Spectrom Subsets: MEDLINE

Výrazy zo slovníka MeSH: Chemical Warfare Agents*/chemistry , Nitrogen Mustard Compounds*/analysis, Mechlorethamine/analysis ; Tandem Mass Spectrometry/methods ; Spectrometry, Mass, Electrospray Ionization/methods ; Chromatography, Liquid/methods ; Ethanol ; Chromatography, High Pressure Liquid/methods

Diagnosis and treatment of diabetic foot ulcer complicated with lower extremity vasculopathy: Consensus recommendation from the Chinese Medical Association (CMA), Chinese Medical Doctor Association (CMDA).

Autori: Wang K Wang Y Shi W a ďalší

Zdroj: Diabetes/metabolism research and reviews [Diabetes Metab Res Rev] 2024 Mar; Vol. 40 (3), pp. e3776.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883450 Publication Model: Print Cited Medium: Internet ISSN: 1520-7560 (Electronic) Linking ISSN: 15207552 NLM ISO Abbreviation: Diabetes Metab Res Rev Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetic Foot*/complications , Diabetic Foot*/diagnosis , Diabetic Foot*/therapy , Foot Ulcer* , Diabetes Mellitus* , Glutamates* , Nitrogen Mustard Compounds*, Humans ; Consensus ; Quality of Life ; Lower Extremity

"Our desire is to make this village intestinal worm free": Identifying determinants of high coverage of community-wide mass drug administration for soil transmitted helminths in Benin, India, and Malawi.

Autori: Saxena M Roll A Walson JL a ďalší

Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Feb 06; Vol. 18 (2), pp. e0011819. Date of Electronic Publication: 2024 Feb 06 (Print Publication: 2024).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anthelmintics* , Carcinoma, Hepatocellular*/drug therapy , Liver Neoplasms*/drug therapy , Helminthiasis*/prevention & control , Helminths* , Trematode Infections*/drug therapy , Glutamates* , Intestinal Diseases, Parasitic* , Nitrogen Mustard Compounds*, Child ; Adult ; Animals ; Humans ; Female ; Adolescent ; Young Adult ; Middle Aged ; Mass Drug Administration/methods ; Soil/parasitology ; Benin ; Malawi ; Prevalence

SCR Disease Name: Intestinal helminthiasis

Identifying opportunities to optimize mass drug administration for soil-transmitted helminths: A visualization and descriptive analysis using process mapping.

Autori: Kazura E Johnson J Morozoff C a ďalší

Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Jan 04; Vol. 18 (1), pp. e0011772. Date of Electronic Publication: 2024 Jan 04 (Print Publication: 2024).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE

Výrazy zo slovníka MeSH: Helminthiasis*/drug therapy , Helminthiasis*/prevention & control , Helminthiasis*/parasitology , Anthelmintics*/therapeutic use , Helminths* , Glutamates* , Nitrogen Mustard Compounds*, Child ; Animals ; Humans ; Mass Drug Administration/methods ; Soil/parasitology

H 2 O 2 -Inducible DNA Cross-linking Agents Capable of Releasing Multiple DNA Alkylators as Anticancer Prodrugs.

Autori: Cao S Wang Y Li D a ďalší

Zdroj: ChemMedChem [ChemMedChem] 2023 Oct 04; Vol. 18 (19), pp. e202300273. Date of Electronic Publication: 2023 Jul 31.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Prodrugs*/pharmacology , Nitrogen Mustard Compounds*/pharmacology, Alkylating Agents ; DNA/genetics ; Amines/pharmacology ; Cross-Linking Reagents/pharmacology

Design, synthesis and anticancer evaluation of novel oncolytic peptide-chlorambucil conjugates.

Autori: Yin H Fu XY Gao HY a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2023 Sep; Vol. 138, pp. 106674. Date of Electronic Publication: 2023 Jun 09.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Neoplasms* , Nitrogen Mustard Compounds*/pharmacology, Animals ; Mice ; Chlorambucil/pharmacology ; DNA/metabolism ; Nitrogen ; Peptides/pharmacology

Glutathione conjugation of nitrogen mustards: In vitro study.

Autori: Hamzah N Kjellberg M Vanninen P

Zdroj: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2023 May 15; Vol. 37 (9), pp. e9495.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: John Wiley And Sons Ltd Country of Publication: England NLM ID: 8802365 Publication Model: Print Cited Medium: Internet ISSN: 1097-0231 (Electronic) Linking ISSN: 09514198 NLM ISO Abbreviation: Rapid Commun Mass Spectrom Subsets: MEDLINE

Výrazy zo slovníka MeSH: Nitrogen Mustard Compounds*, Chromatography, Liquid/methods ; Mass Spectrometry ; Glutathione/metabolism ; Nitrogen

The dinitrobenzamide mustard prodrugs, PR-104A and SN27686, for use in a novel MNDEPT cancer prodrug therapy approach.

Autori: Ball P Thompson E Anderson S a ďalší

Zdroj: Bioscience reports [Biosci Rep] 2023 Apr 26; Vol. 43 (4).

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Print Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Prodrugs*/metabolism , Prodrugs*/pharmacology , Nitrogen Mustard Compounds*/metabolism , Neoplasms* , Antineoplastic Agents*/metabolism, Humans ; Antineoplastic Agents, Alkylating

Human leukocyte antigen alloimmunization in a randomized trial of amustaline/glutathione pathogen-reduced red cells in complex cardiac surgery patients.

Autori: Norris PJ Stone M Di Germanio C a ďalší

Zdroj: Transfusion [Transfusion] 2025 Mar; Vol. 65 (3), pp. 459-465. Date of Electronic Publication: 2025 Jan 13.

Spôsob vydávania: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III

Informácie o časopise: Publisher: American Association Of Blood Banks Country of Publication: United States NLM ID: 0417360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-2995 (Electronic) Linking ISSN: 00411132 NLM ISO Abbreviation: Transfusion Subsets: MEDLINE

Výrazy zo slovníka MeSH: Erythrocyte Transfusion*/adverse effects , Erythrocyte Transfusion*/methods , Isoantibodies*/blood , Isoantibodies*/immunology , Glutathione*/administration & dosage , HLA Antigens*/immunology , Cardiac Surgical Procedures* , Erythrocytes*/immunology , Erythrocytes*/drug effects , Erythrocytes*/microbiology, Humans ; Female ; Male ; Middle Aged ; Aged ; Acridines ; Nitrogen Mustard Compounds

Activation of the human TRPA1 channel by different alkylating sulfur and nitrogen mustards and structurally related chemotherapeutic drugs.

Autori: Müller-Dott K Raßmuß SC Blum MM a ďalší

Zdroj: Toxicology letters [Toxicol Lett] 2023 Mar 01; Vol. 376, pp. 51-59. Date of Electronic Publication: 2023 Jan 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ifosfamide* , Nitrogen Mustard Compounds*, Humans ; TRPA1 Cation Channel ; HEK293 Cells ; Alkylating Agents/toxicity ; Nitrogen

Serum immunoglobulin G as a discriminator of infection in follicular lymphoma patients undergoing chemotherapy with bendamustine in combination with rituximab.

Autori: Hirata A Miyashita K Tanaka T a ďalší

Zdroj: Hematology (Amsterdam, Netherlands) [Hematology] 2022 Dec; Vol. 27 (1), pp. 384-395.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708388 Publication Model: Print Cited Medium: Internet ISSN: 1607-8454 (Electronic) Linking ISSN: 10245332 NLM ISO Abbreviation: Hematology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Lymphoma, Follicular*/complications , Lymphoma, Follicular*/drug therapy , Nitrogen Mustard Compounds*/adverse effects, Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bendamustine Hydrochloride/adverse effects ; Humans ; Immunoglobulin G ; Retrospective Studies ; Rituximab/therapeutic use

Bendamustine: A review of pharmacology, clinical use and immunological effects (Review).

Autori: Lalic H Aurer I Batinic D a ďalší

Zdroj: Oncology reports [Oncol Rep] 2022 Jun; Vol. 47 (6). Date of Electronic Publication: 2022 May 04.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antineoplastic Agents*/pharmacology , Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy , Lymphoma, B-Cell*/drug therapy , Nitrogen Mustard Compounds*/chemistry , Nitrogen Mustard Compounds*/pharmacology , Nitrogen Mustard Compounds*/therapeutic use, Bendamustine Hydrochloride/pharmacology ; Bendamustine Hydrochloride/therapeutic use ; Humans