Suchergebnisse - "Nitric Oxide Synthase Type II"

SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function.

Autoren: Duan S Zhang Q Zhu J et al.

Quelle: Organogenesis [Organogenesis] 2025 Dec; Vol. 21 (1), pp. 2519649. Date of Electronic Publication: 2025 Jun 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101253266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-8592 (Electronic) Linking ISSN: 15476278 NLM ISO Abbreviation: Organogenesis Subsets: MEDLINE

MeSH-Schlagworte: Mesenchymal Stem Cells*/drug effects , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism , Osteogenesis*/drug effects , Mitochondria*/drug effects , Mitochondria*/metabolism , Cell Differentiation*/drug effects , Nitric Oxide Synthase Type II*/metabolism , Nitric Oxide Synthase Type II*/genetics , Nitric Oxide Synthase Type II*/antagonists & inhibitors , Aging*/drug effects, Humans ; Aged ; Reactive Oxygen Species/metabolism ; Cells, Cultured ; Cellular Senescence/drug effects

Neutrophilic granule protein promotes lipopolysaccharide-induced iNOS/NO expression via JAK2/STAT1 signaling pathway and augments bacteria clearance of macrophages.

Autoren: Tian L Yin S Wang J et al.

Quelle: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2025 Nov 06; Vol. 82 (1), pp. 385. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

MeSH-Schlagworte: Lipopolysaccharides*/pharmacology , Nitric Oxide Synthase Type II*/metabolism , Nitric Oxide Synthase Type II*/genetics , Nitric Oxide*/metabolism , Signal Transduction*/drug effects , STAT1 Transcription Factor*/metabolism , Macrophages*/metabolism , Macrophages*/immunology , Macrophages*/microbiology , Macrophages*/drug effects , Janus Kinase 2*/metabolism, Animals ; Mice ; RAW 264.7 Cells ; Mice, Inbred C57BL ; Escherichia coli ; Male ; Mice, Knockout

New Bis-sesquiterpenoids From the Lindera glauca With Anti-inflammatory Activity by Inhibiting the Lipopolysaccharide-induced Expression of Inducible Nitric Oxide Synthase.

Autoren: Chang B Chen Z Li J et al.

Quelle: Chemistry & biodiversity [Chem Biodivers] 2025 Nov; Vol. 22 (11), pp. e01246. Date of Electronic Publication: 2025 Jun 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

MeSH-Schlagworte: Nitric Oxide Synthase Type II*/antagonists & inhibitors , Nitric Oxide Synthase Type II*/metabolism , Lindera*/chemistry , Sesquiterpenes*/chemistry , Sesquiterpenes*/pharmacology , Sesquiterpenes*/isolation & purification , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/isolation & purification , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemistry , Anti-Inflammatory Agents, Non-Steroidal*/isolation & purification, Lipopolysaccharides/pharmacology ; Lipopolysaccharides/antagonists & inhibitors ; Mice ; Animals ; Nitric Oxide/biosynthesis ; Nitric Oxide/antagonists & inhibitors ; RAW 264.7 Cells ; Molecular Structure ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Cyclooxygenase 2/metabolism

Circular RNA hsa_circ_0099188 regulates inducible nitric oxide synthase and chemokine transcription in macrophages by targeting the hsa-miR-381-3p/PPP3CA and hsa-miR-381-3p/KLF4 pathways in response to 4,4'-methylene diphenyl diisocyanate-glutathione conjugate exposure.

Autoren: Lin CC Law BF Hettick JM

Quelle: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2025 Nov 01; Vol. 208 (1), pp. 122-135.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

MeSH-Schlagworte: MicroRNAs*/genetics , MicroRNAs*/metabolism , Nitric Oxide Synthase Type II*/genetics , Nitric Oxide Synthase Type II*/metabolism , RNA, Circular*/genetics , RNA, Circular*/metabolism , Macrophages*/drug effects , Macrophages*/metabolism , Isocyanates*/toxicity , Chemokines*/genetics , Chemokines*/metabolism , Glutathione*/toxicity, Humans ; Kruppel-Like Factor 4 ; Animals ; Mice ; Transcription, Genetic/drug effects ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Benzhydryl Compounds

Deciphering mutational effects on inducible NO synthase conformational dynamics via quantitative cross-linking mass spectrometry and AlphaFold2 subsampling.

Autoren: Jiang T Zhang H Da Silva GM et al.

Quelle: The Journal of biological chemistry [J Biol Chem] 2025 Nov; Vol. 301 (11), pp. 110673. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH-Schlagworte: Nitric Oxide Synthase Type II*/genetics , Nitric Oxide Synthase Type II*/chemistry , Nitric Oxide Synthase Type II*/metabolism , Mutation, Missense*, Humans ; Calmodulin/metabolism ; Calmodulin/chemistry ; Calmodulin/genetics ; Mass Spectrometry/methods ; Mutation ; Flavin Mononucleotide/metabolism ; Flavin Mononucleotide/chemistry ; Protein Conformation ; Heme/metabolism ; Heme/chemistry ; Animals ; Cross-Linking Reagents/chemistry

Proinflammatory Cytokines Mediate Pancreatic β-Cell-Specific Alterations to Golgi Integrity via iNOS-Dependent Mitochondrial Inhibition.

Autoren: Blom SE Narsian PR Behan-Bush RM et al.

Quelle: Diabetes [Diabetes] 2025 Nov 01; Vol. 74 (11), pp. 1992-2007.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

MeSH-Schlagworte: Insulin-Secreting Cells*/metabolism , Insulin-Secreting Cells*/drug effects , Nitric Oxide Synthase Type II*/metabolism , Nitric Oxide Synthase Type II*/genetics , Golgi Apparatus*/metabolism , Golgi Apparatus*/drug effects , Mitochondria*/metabolism , Mitochondria*/drug effects , Cytokines*/metabolism , Diabetes Mellitus, Type 1*/metabolism , Diabetes Mellitus, Type 1*/immunology , Diabetes Mellitus, Type 1*/pathology, Humans ; Animals ; Mice ; Nitric Oxide/metabolism ; Rats ; Male

Deficiency of HMGN2 enhances antibacterial activity of macrophages by promoting H3 histone modification-mediated CD14/iNOS expression.

Autoren: Yang Z Zhang X Liu C et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Oct 30; Vol. 16, pp. 1621440. Date of Electronic Publication: 2025 Oct 30 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Macrophages*/immunology , Macrophages*/metabolism , Histones*/metabolism , HMGN2 Protein*/genetics , HMGN2 Protein*/deficiency , HMGN2 Protein*/immunology , Lipopolysaccharide Receptors*/genetics , Lipopolysaccharide Receptors*/metabolism , Lipopolysaccharide Receptors*/immunology , Nitric Oxide Synthase Type II*/metabolism , Nitric Oxide Synthase Type II*/genetics , Histone Code*, Animals ; Mice ; RAW 264.7 Cells ; Mice, Knockout ; Phagocytosis ; Epigenesis, Genetic

Inhibition of inducible nitric oxide synthase (iNOS) alleviates thoracic aortic aneurysm by regulating mitochondrial dynamics.

Autoren: Zheng ZF Zhang JJ Wu LF et al.

Quelle: European journal of pharmacology [Eur J Pharmacol] 2025 Oct 15; Vol. 1005, pp. 178071. Date of Electronic Publication: 2025 Aug 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Mitochondrial Dynamics*/drug effects , Nitric Oxide Synthase Type II*/antagonists & inhibitors , Nitric Oxide Synthase Type II*/metabolism , Aortic Aneurysm, Thoracic*/pathology , Aortic Aneurysm, Thoracic*/drug therapy , Aortic Aneurysm, Thoracic*/metabolism , Aortic Aneurysm, Thoracic*/chemically induced , Aortic Aneurysm, Thoracic*/enzymology , Amidines*/pharmacology , Amidines*/therapeutic use , Benzylamines*/pharmacology , Benzylamines*/therapeutic use , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/therapeutic use, Animals ; Humans ; Mice ; Male ; Reactive Oxygen Species/metabolism ; Mice, Inbred C57BL ; Disease Models, Animal ; Aminopropionitrile ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism

Neudesin attenuates ischemic brain injury by regulating Nos2 expression in microglia.

Autoren: Shimizu R Shikaura R Hasegawa H et al.

Quelle: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Oct 10; Vol. 784, pp. 152647. Date of Electronic Publication: 2025 Sep 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH-Schlagworte: Microglia*/metabolism , Microglia*/pathology , Microglia*/drug effects , Nitric Oxide Synthase Type II*/metabolism , Nitric Oxide Synthase Type II*/genetics , Nitric Oxide Synthase Type II*/antagonists & inhibitors , Brain Ischemia*/pathology , Brain Ischemia*/metabolism , Brain Ischemia*/genetics, Animals ; Mice, Knockout ; Mice ; Mice, Inbred C57BL ; Male

Augmenter of liver regeneration (ALR) can regulate iron homeostasis through the INOS/NO/SLC39A14 pathway to reduce ferroptosis in acute kidney injury.

Autoren: Tan F Cao D Huang L et al.

Quelle: The FEBS journal [FEBS J] 2025 Oct; Vol. 292 (19), pp. 5130-5150. Date of Electronic Publication: 2025 Apr 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/genetics , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/pathology , Acute Kidney Injury*/genetics , Iron*/metabolism , Nitric Oxide Synthase Type II*/metabolism , Nitric Oxide Synthase Type II*/genetics , Nitric Oxide*/metabolism , Nitric Oxide*/genetics , Cation Transport Proteins*/metabolism , Cation Transport Proteins*/genetics , Coenzyme A Ligases*/genetics , Coenzyme A Ligases*/metabolism, Animals ; Mice ; Humans ; Homeostasis ; Mice, Knockout ; Male ; Disease Models, Animal ; Mice, Inbred C57BL ; Reperfusion Injury/pathology ; Reperfusion Injury/genetics ; Reperfusion Injury/metabolism ; Signal Transduction

Targeting inducible nitric oxide synthase with 1400W mitigates septic acute lung injury through inhibiting SLC7A11/GPX4 mediated ferroptosis.

Autoren: Wang ZY Zeng T Wang X et al.

Quelle: Nitric oxide : biology and chemistry [Nitric Oxide] 2025 Oct; Vol. 158, pp. 4-10. Date of Electronic Publication: 2025 May 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 9709307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8611 (Electronic) Linking ISSN: 10898603 NLM ISO Abbreviation: Nitric Oxide Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/drug effects , Acute Lung Injury*/drug therapy , Acute Lung Injury*/metabolism , Acute Lung Injury*/chemically induced , Acute Lung Injury*/pathology , Nitric Oxide Synthase Type II*/antagonists & inhibitors , Nitric Oxide Synthase Type II*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/antagonists & inhibitors , Amino Acid Transport System y+*/metabolism , Amino Acid Transport System y+*/antagonists & inhibitors , Sepsis*/drug therapy , Sepsis*/metabolism , Amidines*/pharmacology , Amidines*/therapeutic use , Enzyme Inhibitors*/pharmacology, Animals ; Mice ; Lipopolysaccharides/pharmacology ; Male ; Molecular Docking Simulation ; Mice, Inbred C57BL ; Molecular Dynamics Simulation ; Imines

Inhibition of iNOS reduced cerebral vasoconstriction from chronic cocaine and enhanced angiogenesis in the prefrontal cortex.

Autoren: Liu Y Jetalpuria Y Ren J et al.

Quelle: Brain research bulletin [Brain Res Bull] 2025 Oct 01; Vol. 230, pp. 111490. Date of Electronic Publication: 2025 Jul 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE

MeSH-Schlagworte: Prefrontal Cortex*/drug effects , Prefrontal Cortex*/blood supply , Prefrontal Cortex*/metabolism , Nitric Oxide Synthase Type II*/antagonists & inhibitors , Nitric Oxide Synthase Type II*/metabolism , Nitric Oxide Synthase Type II*/genetics , Cocaine*/pharmacology , Vasoconstriction*/drug effects , Vasoconstriction*/physiology, Animals ; Mice ; Cerebrovascular Circulation/drug effects ; Mice, Knockout ; Male ; Mice, Inbred C57BL ; Angiogenesis

Protective Role of Coenzyme Q10 Against Isoniazid and Rifampicin-Induced Hepatotoxicity in Rats via Modulation of PPAR-γ, iNOS, and NF-κB.

Autoren: B UL Mukherjee AG Sabina EP et al.

Quelle: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2025 Nov; Vol. 39 (11), pp. e70585.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Ubiquinone*/analogs & derivatives , Ubiquinone*/pharmacology , Isoniazid*/toxicity , Isoniazid*/adverse effects , PPAR gamma*/metabolism , Rifampin*/toxicity , Rifampin*/adverse effects , NF-kappa B*/metabolism , Nitric Oxide Synthase Type II*/metabolism , Chemical and Drug Induced Liver Injury*/prevention & control , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/pathology , Liver*/metabolism , Liver*/drug effects , Liver*/pathology, Animals ; Rats ; Male ; Rats, Wistar

By modulating pAMPK/iNOS2 and MMP signalling, Immunogrit drives cellular resilience against D-galactose-induced senescence-associated stress markers in human keratinocytes.

Autoren: Balkrishna A Lochab S Guin S et al.

Quelle: Archives of gerontology and geriatrics [Arch Gerontol Geriatr] 2025 Nov; Vol. 138, pp. 105974. Date of Electronic Publication: 2025 Jul 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Biomedical Press Country of Publication: Netherlands NLM ID: 8214379 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6976 (Electronic) Linking ISSN: 01674943 NLM ISO Abbreviation: Arch Gerontol Geriatr Subsets: MEDLINE

MeSH-Schlagworte: Keratinocytes*/drug effects , Keratinocytes*/metabolism , Cellular Senescence*/drug effects , Galactose*/pharmacology , Nitric Oxide Synthase Type II*/metabolism , AMP-Activated Protein Kinases*/metabolism , Matrix Metalloproteinases*/metabolism, Humans ; Signal Transduction/drug effects ; Oxidative Stress/drug effects ; Biomarkers/metabolism ; HaCaT Cells

Complex Chalcone Scaffolds from Mallotus philippinensis Fruits as Potential iNOS Inhibitors.

Autoren: Thi Hoang Kieu Y Hattori H Toda M et al.

Quelle: Journal of natural products [J Nat Prod] 2025 Oct 24; Vol. 88 (10), pp. 2383-2393. Date of Electronic Publication: 2025 Sep 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

MeSH-Schlagworte: Nitric Oxide Synthase Type II*/antagonists & inhibitors , Fruit*/chemistry , Chalcones*/pharmacology , Chalcones*/chemistry , Chalcones*/isolation & purification , Mallotus Plant*/chemistry , Chalcone*/pharmacology , Chalcone*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry, Animals ; Mice ; RAW 264.7 Cells ; Molecular Structure ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Nitric Oxide/biosynthesis ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry

Association of NOS Gene Polymorphisms with Sepsis-Related Complications in Secondary Peritonitis.

Autoren: Rasic M Maksimovic N Grk M et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 23; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Peritonitis*/genetics , Peritonitis*/complications , Sepsis*/genetics , Sepsis*/complications , Polymorphism, Single Nucleotide* , Genetic Predisposition to Disease* , Nitric Oxide Synthase Type III*/genetics , Nitric Oxide Synthase Type II*/genetics, Humans ; Male ; Female ; Middle Aged ; Aged ; Haplotypes ; Multiple Organ Failure/genetics ; Multiple Organ Failure/etiology ; Adult ; Respiratory Distress Syndrome/genetics ; Respiratory Distress Syndrome/etiology ; Genotype

N-acyl hydrazone derivatives reduce pro-inflammatory cytokines, iNOS and COX-2 in acute lung inflammation model.

Autoren: de Lima Porto Ramos KR Silva JAG de Sousa RS et al.

Quelle: Chemico-biological interactions [Chem Biol Interact] 2025 Oct 22; Vol. 420, pp. 111677. Date of Electronic Publication: 2025 Jul 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

MeSH-Schlagworte: Nitric Oxide Synthase Type II*/metabolism , Hydrazones*/chemistry , Hydrazones*/pharmacology , Hydrazones*/therapeutic use , Cyclooxygenase 2*/metabolism , Cytokines*/metabolism , Acute Lung Injury*/drug therapy , Acute Lung Injury*/pathology , Acute Lung Injury*/chemically induced , Acute Lung Injury*/metabolism , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/therapeutic use, Animals ; Mice ; Lipopolysaccharides/toxicity ; Disease Models, Animal ; Male ; Nitric Oxide/metabolism ; RAW 264.7 Cells ; Pneumonia/drug therapy ; Macrophages/drug effects ; Macrophages/metabolism ; Cell Movement/drug effects ; Lung/pathology ; Lung/drug effects ; Lung/metabolism

From liver to kidney: Telmisartan attenuates NLRP3 inflammasome-driven systemic inflammation and the iNOS/Hsp70 axis partially via the Mas receptor in a hepatic ischemia-reperfusion model.

Autoren: Shehata H El-Abhar HS Abdallah DM et al.

Quelle: European journal of pharmacology [Eur J Pharmacol] 2025 Oct 15; Vol. 1005, pp. 178098. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Telmisartan*/pharmacology , Telmisartan*/therapeutic use , Inflammasomes*/metabolism , Inflammasomes*/drug effects , Reperfusion Injury*/drug therapy , Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Liver*/drug effects , Liver*/pathology , Liver*/metabolism , Liver*/blood supply , Kidney*/drug effects , Kidney*/metabolism , Kidney*/pathology , Nitric Oxide Synthase Type II*/metabolism , HSP70 Heat-Shock Proteins*/metabolism , Receptors, G-Protein-Coupled*/metabolism , Proto-Oncogene Proteins*/metabolism, Animals ; Male ; Proto-Oncogene Mas ; Rats, Wistar ; Rats ; Disease Models, Animal ; Inflammation/drug therapy ; Inflammation/metabolism ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Signal Transduction/drug effects

AT 1 receptors play a role in sepsis-induced vasoplegia by increasing iNOS expression in the perivascular adipose tissue.

Autoren: Awata WMC Pimenta GF Dourado TMH et al.

Quelle: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2025 Oct; Vol. 477 (10), pp. 1259-1271. Date of Electronic Publication: 2025 Aug 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Germany NLM ID: 0154720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2013 (Electronic) Linking ISSN: 00316768 NLM ISO Abbreviation: Pflugers Arch Subsets: MEDLINE

MeSH-Schlagworte: Sepsis*/metabolism , Sepsis*/complications , Nitric Oxide Synthase Type II*/metabolism , Adipose Tissue*/metabolism , Adipose Tissue*/drug effects , Receptor, Angiotensin, Type 1*/metabolism , Vasoplegia*/metabolism , Vasoplegia*/etiology, Animals ; Male ; Rats ; Rats, Wistar ; Losartan/pharmacology ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Nitric Oxide/metabolism ; Angiotensin II/blood ; Angiotensin II/metabolism

Anti-Inflammatory, Anti-Colitis, and Antioxidant Effects of Salidroside against Dextran Sodium Sulfate Induced Ulcerative Colitis in Rats via Inhibition of NF-κB-INOS-No and TLR4-NF-κB Signaling Pathways.

Autoren: Li S Wang B

Quelle: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2025 Oct; Vol. 39 (10), pp. e70520.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Glucosides*/pharmacology , Phenols*/pharmacology , Dextran Sulfate*/toxicity , NF-kappa B*/metabolism , Signal Transduction*/drug effects , Antioxidants*/pharmacology , Colitis, Ulcerative*/chemically induced , Colitis, Ulcerative*/metabolism , Colitis, Ulcerative*/drug therapy , Colitis, Ulcerative*/pathology , Toll-Like Receptor 4*/metabolism , Anti-Inflammatory Agents*/pharmacology , Nitric Oxide Synthase Type II*/metabolism , Nitric Oxide*/metabolism, Animals ; Rats ; Male