Search Results - "Nicotinamide Phosphoribosyltransferase/metabolism"

NAD+ metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma

Authors: Soncini, Debora Becherini, Pamela Ladisa, Francesco et al.

Source: Blood Adv
Blood Advances, Vol 9, Iss 5, Pp 1024-1039 (2025)
Blood advances, vol. 9, no. 5, pp. 1024-1039

Subject Terms: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, RC581-951, Multiple Myeloma/drug therapy, Multiple Myeloma/metabolism, Multiple Myeloma/pathology, Humans, NAD/metabolism, Nicotinamide Phosphoribosyltransferase/metabolism, Nicotinamide Phosphoribosyltransferase/genetics, Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors, Melphalan/pharmacology, Melphalan/therapeutic use, Melphalan/administration & dosage, Cell Line, Tumor, Pentosyltransferases/metabolism, Pentosyltransferases/genetics, Cytokines/metabolism, Specialties of internal medicine, Plasma Cell Disorders

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39661983
https://doaj.org/article/597a206371e14f2eafa28f986e80aa00
https://serval.unil.ch/notice/serval:BIB_6A1D49B7E1D9
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6A1D49B7E1D95
https://serval.unil.ch/resource/serval:BIB_6A1D49B7E1D9.P001/REF.pdf
https://hdl.handle.net/11567/1226642
https://doi.org/10.1182/bloodadvances.2024013425

Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer.

Authors: Fratta, S. Biniecka, P. Moreno-Vargas, A.J. et al.

Source: European journal of medicinal chemistry, vol. 250, pp. 115170

Subject Terms: Humans, Nicotinamide Phosphoribosyltransferase/metabolism, NAD/metabolism, Cell Line, Tumor, Cytokines/metabolism, Antineoplastic Agents/pharmacology, Leukemia/metabolism, Structure-Activity Relationship, Hematologic Neoplasms/drug therapy, Enzyme Inhibitors/pharmacology, Cancer, Cyanoguanidines, Cytotoxic agents, Furan, NAD(+), NAMPT inhibitors

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Relation: info:eu-repo/semantics/altIdentifier/pmid/36787658; info:eu-repo/semantics/altIdentifier/eissn/1768-3254; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_FD14B5315A4E9; https://serval.unil.ch/notice/serval:BIB_FD14B5315A4E; https://serval.unil.ch/resource/serval:BIB_FD14B5315A4E.P001/REF.pdf

Availability: https://serval.unil.ch/notice/serval:BIB_FD14B5315A4E
https://doi.org/10.1016/j.ejmech.2023.115170
https://serval.unil.ch/resource/serval:BIB_FD14B5315A4E.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_FD14B5315A4E9

Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia.

Authors: ElMokh, O. Matsumoto, S. Biniecka, P. et al.

Subject Terms: Cell Line, Tumor, Cytokines/metabolism, Gastrointestinal Microbiome, Humans, Leukemia, NAD/metabolism, Neoplasms, Niacinamide/pharmacology, Niacinamide/therapeutic use, Nicotinamide Phosphoribosyltransferase/metabolism

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Relation: Cell Death & Disease; https://iris.unil.ch/handle/iris/218628; serval:BIB_D8A172BF5015; 000781395700002

Availability: https://iris.unil.ch/handle/iris/218628
https://doi.org/10.1038/s41419-022-04763-3

Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD.

Authors: Busso, Nathalie Karababa, Mahir Nobile, Massimo et al.

Subject Terms: Animals, Arthritis, Experimental/enzymology, Collagen/administration & dosage, Enzyme Inhibitors/pharmacology, Female, Humans, Inflammation/enzymology, Male, Mice, Inbred C57BL, Inbred DBA, NAD/metabolism, Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors, Nicotinamide Phosphoribosyltransferase/metabolism, Tumor Necrosis Factor-alpha/blood, Up-Regulation

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Relation: PloS One; 1932-6203[electronic]; https://iris.unil.ch/handle/iris/190752; serval:BIB_B50CB9BAECBD; 000262258700061

Availability: https://iris.unil.ch/handle/iris/190752
https://doi.org/10.1371/journal.pone.0002267

Exploratory Analysis in the Differences in Blood Serum and Seminal Plasma of Adipose-Tissue Related Peptides in Obese and Non-Obese Men and Their Correlations With Semen Parameters

Authors: Antinozzi, Cristina Lista, Marco Caponecchia, Luisa et al.

Source: Frontiers in endocrinology, 12

Subject Terms: Hormones/metabolism [MeSH], Adult [MeSH], Biomarkers/blood [MeSH], Humans [MeSH], Hormones/blood [MeSH], Middle Aged [MeSH], obesity, Peptides/blood [MeSH], incretins, male reproduction, Semen/metabolism [MeSH], Obesity/metabolism [MeSH], Male [MeSH], sex hormones, Biomarkers/metabolism [MeSH], Adipose Tissue/metabolism [MeSH], Obesity/blood [MeSH], Peptides/metabolism [MeSH], Endocrinology, Nicotinamide Phosphoribosyltransferase/metabolism [MeSH], adipokines

Relation: https://repository.publisso.de/resource/frl:6475082; https://doi.org/10.3389/fendo.2021.681939; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355985/

Availability: https://repository.publisso.de/resource/frl:6475082
https://doi.org/10.3389/fendo.2021.681939
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355985/

The Nicotinamide Phosphoribosyltransferase: A Molecular Link between Metabolism, Inflammation, and Cancer

Authors: Gallí, Mara Van Gool, Frédéric Rongvaux, Anthony et al.

Source: Cancer Research. 70:8-11

Subject Terms: Inflammation, 0301 basic medicine, Neoplasms -- metabolism, 0303 health sciences, Sciences bio-médicales et agricoles, Nicotinamide Phosphoribosyltransferase -- metabolism, NAD, Inflammation -- metabolism, 3. Good health, 03 medical and health sciences, Neoplasms, NAD -- metabolism, Animals, Humans, Nicotinamide Phosphoribosyltransferase

File Description: 1 full-text file(s): application/pdf

Access URL: http://cancerres.aacrjournals.org/content/70/1/8.full.pdf
https://pubmed.ncbi.nlm.nih.gov/20028851
https://pubmed.ncbi.nlm.nih.gov/20028851/
http://cancerres.aacrjournals.org/content/70/1/8.full
https://europepmc.org/article/MED/20028851
http://cancerres.aacrjournals.org/content/70/1/8
https://cancerres.aacrjournals.org/content/70/1/8
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50764/Details

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

Authors: Pierre Paul Prevot Frederick W. Alt Oberdan Leo et al.

Source: Nature Medicine. 15:206-210

Subject Terms: 0301 basic medicine, 0303 health sciences, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha, Tumor Necrosis Factor-alpha -- biosynthesis, Enzyme-Linked Immunosorbent Assay, Nicotinamide Phosphoribosyltransferase -- metabolism, NAD, Sciences biomédicales, 3. Good health, Mice, 03 medical and health sciences, NAD -- metabolism, Animals, Nicotinamide Phosphoribosyltransferase

File Description: 1 full-text file(s): application/pdf; text

Access URL: https://europepmc.org/articles/pmc2845476?pdf=render
https://pubmed.ncbi.nlm.nih.gov/19151729
https://pubmed.ncbi.nlm.nih.gov/19151729/
https://www.nature.com/articles/nm.1906
https://www.nature.com/articles/nm.1906.pdf
https://europepmc.org/articles/PMC2845476
http://authors.fhcrc.org/397/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845476/

Visfatin, a New Adipocytokine, Is Predominantly Related to Inflammation/Endothelial Damage in Kidney Allograft Recipients

Authors: E Koc-Zorawska Michal Mysliwiec Jacek S. Malyszko

Source: Transplantation Proceedings. 41:150-153

Subject Terms: Adult, Male, 0301 basic medicine, Kidney transplantation - pathology, Biomarkers - blood, Reference values, 03 medical and health sciences, 0302 clinical medicine, Reference Values, vascular - pathology, Diabetic nephropathies - enzymology, Humans, Transplantation, Homologous, Cytokines - metabolism, Diabetic Nephropathies, Endothelium, Inflammation - enzymology, Inflammation - pathology, Middle aged, Nicotinamide phosphoribosyltransferase - metabolism, Nicotinamide Phosphoribosyltransferase, Blood Coagulation, Aged, Inflammation, Transplantation, vascular - enzymology, Fibrinolysis, Kidney transplantation - immunology, Blood coagulation, Middle Aged, Kidney Transplantation, Diabetic nephropathies - surgery, 3. Good health, homologous, Cytokines, Female, Endothelium, Vascular, Biomarkers, Immunosuppressive Agents, Immunosuppressive agents - therapeutic use

Access URL: https://pubmed.ncbi.nlm.nih.gov/19249500
https://www.ncbi.nlm.nih.gov/pubmed/19249500
https://europepmc.org/article/MED/19249500
https://www.sciencedirect.com/science/article/pii/S004113450801614X
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00007890-200807271-01061

Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD.

Authors: Busso, Nathalie Karababa, Mahir Nobile, Massimo et al.

Source: PloS one, 3 (5

Subject Terms: Sciences bio-médicales et agricoles, Animals, Arthritis, Experimental -- enzymology, Collagen -- administration & dosage, Enzyme Inhibitors -- pharmacology, Female, Humans, Inflammation -- enzymology, Male, Mice, Inbred C57BL, Inbred DBA, NAD -- metabolism, Nicotinamide Phosphoribosyltransferase -- antagonists & inhibitors, Nicotinamide Phosphoribosyltransferase -- metabolism, Tumor Necrosis Factor-alpha -- blood, Up-Regulation

File Description: 1 full-text file(s): application/pdf

Relation: uri/info:doi/10.1371/journal.pone.0002267; uri/info:pmid/18493620; uri/info:scp/48249105497; uri/info:pmcid/PMC2377336; https://dipot.ulb.ac.be/dspace/bitstream/2013/50819/4/doi_25864.pdf

Availability: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50819
https://dipot.ulb.ac.be/dspace/bitstream/2013/50819/4/doi_25864.pdf

Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle

Authors: De Guia, Roland Agerholm, Marianne Nielsen, Thomas et al.

Source: Physiological Reports. 7(12):Article ID 14139

Subject Terms: Adult, Intracellular signaling peptides and proteins - metabolism, Male, skeletal - metabolism, Adolescent, Nicotinamide-nucleotide adenylyltransferase - metabolism, Aging - physiology, Insulin - blood, Resistance training, Adipose tissue - enzymology, skeletal - physiology, Young adult, Phosphotransferases (alcohol group acceptor) - metabolism, Exercise therapy - methods, 80 and over, Blood glucose - metabolism, Humans, Muscle, NAD - metabolism, Cytokines - metabolism, Female, Middle aged, Nicotinamide phosphoribosyltransferase - metabolism, Anthropometry - methods, Aged

Access URL: https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.14139

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

Authors: Diguet, Nicolas Trammell, Samuel A.J. Tannous, Cynthia et al.

Contributors: Diguet, Nicolas Trammell, Samuel A.J. Tannous, Cynthia et al.

Source: ISSN: 0009-7322.

Subject Terms: NAD, acetyl coenzyme A, cardiomyopathy, dilated, energy metabolism, nicotinamide-beta-riboside, serum response factor, heart failure, glycolysis, MESH: AMP-Activated Protein Kinases/metabolism, MESH: Acrylamides/therapeutic use, MESH: Heart Failure/prevention & control, MESH: Metabolome/drug effects, MESH: Mice, Transgenic, MESH: Myocytes, Cardiac/cytology, Cardiac/drug effects, Cardiac/metabolism, MESH: NAD/metabolism, MESH: Niacinamide/analogs & derivatives, MESH: Niacinamide/therapeutic use, MESH: Animals, MESH: Nicotinamide Phosphoribosyltransferase/genetics, MESH: Nicotinamide Phosphoribosyltransferase/metabolism, MESH: PPAR alpha/metabolism, MESH: Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors, MESH: Phosphotransferases (Alcohol Group Acceptor)/genetics, MESH: Phosphotransferases (Alcohol Group Acceptor)/metabolism, MESH: Piperidines/therapeutic use

Relation: info:eu-repo/semantics/altIdentifier/pmid/29217642; PUBMED: 29217642

Availability: https://hal.science/hal-02397524
https://doi.org/10.1161/CIRCULATIONAHA.116.026099

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.

Authors: Van Gool, Frédéric Galli, Mara Gueydan, Cyril et al.

Source: Nature medicine, 15 (2

Subject Terms: Sciences biomédicales, Animals, Enzyme-Linked Immunosorbent Assay, Mice, NAD -- metabolism, Nicotinamide Phosphoribosyltransferase -- metabolism, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha -- biosynthesis

File Description: 1 full-text file(s): application/pdf

Relation: uri/info:doi/10.1038/nm.1906; uri/info:pii/nm.1906; uri/info:pmid/19151729; uri/info:pmcid/PMC2845476; https://dipot.ulb.ac.be/dspace/bitstream/2013/157176/4/PMC2845476.pdf

Availability: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/157176
https://dipot.ulb.ac.be/dspace/bitstream/2013/157176/4/PMC2845476.pdf