Výsledky vyhledávání - "Neurotoxicity Syndromes/pathology"

Developmental Neurotoxicity of Fipronil and Rotenone on a Human Neuronal In Vitro Test System

Autoři: Anne Schmitz Silke Dempewolf Saime Tan a další

Zdroj: Neurotox Res

Témata: Neurons, 0301 basic medicine, Insecticides, 0303 health sciences, Dose-Response Relationship, Drug, Neuronal Outgrowth, Cell Differentiation, Cell Line, 3. Good health, 03 medical and health sciences, Dose-Response Relationship, Drug [MeSH], Cell Differentiation/physiology [MeSH], Cell Movement/physiology [MeSH], Humans [MeSH], Neurons/metabolism [MeSH], Cell Differentiation/drug effects [MeSH], Cell Line [MeSH], Neuronal Outgrowth/drug effects [MeSH], Cell Movement/drug effects [MeSH], NT2, Neurite outgrowth, Pyrazoles/toxicity [MeSH], Neurons/drug effects [MeSH], Rotenone/toxicity [MeSH], Neurotoxicity Syndromes/pathology [MeSH], Original Article, Insecticides/toxicity [MeSH], Migration, Neuronal Outgrowth/physiology [MeSH], NTera-2, Neurons/pathology [MeSH], Neurotoxicity Syndromes/metabolism [MeSH], DNT, Differentiation, Cell Movement, Rotenone, Humans, Pyrazoles, Neurotoxicity Syndromes

Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s12640-021-00364-8.pdf
https://pubmed.ncbi.nlm.nih.gov/33871813
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275550
https://link.springer.com/article/10.1007/s12640-021-00364-8
https://europepmc.org/article/MED/33871813
https://link.springer.com/content/pdf/10.1007/s12640-021-00364-8.pdf
https://www.ncbi.nlm.nih.gov/pubmed/33871813
https://pubmed.ncbi.nlm.nih.gov/33871813/
https://repository.publisso.de/resource/frl:6444214

Human neuronal signaling and communication assays to assess functional neurotoxicity

Autoři: Dominik Loser Jasmin Schaefer Timm Danker a další

Zdroj: Arch Toxicol
Archives of Toxicology

Témata: Neurons, 0301 basic medicine, Dopamine Plasma Membrane Transport Proteins, 0303 health sciences, Patch-Clamp Techniques, Time Factors, Receptors, Purinergic, Action Potentials, Voltage-Gated Sodium Channels, High-Throughput Screening Assays [MeSH], Neurotoxicity Syndromes/etiology [MeSH], Purinoceptor, Action Potentials/drug effects [MeSH], Receptors, Purinergic/metabolism [MeSH], Neurons/drug effects [MeSH], Toxicity Tests [MeSH], Neuronal network, Voltage-Gated Sodium Channels/metabolism [MeSH], Calcium Signaling/drug effects [MeSH], Calcium/metabolism [MeSH], Dopamine Plasma Membrane Transport Proteins/drug effects [MeSH], Dopamine transporter, Humans [MeSH], Neurons/metabolism [MeSH], Receptors, Purinergic/drug effects [MeSH], Organ Toxicity and Mechanisms, Nerve Net/drug effects [MeSH], Time Factors [MeSH], Neurotoxicity Syndromes/pathology [MeSH], Nerve Net/metabolism [MeSH], Receptors, Purinergic/genetics [MeSH], Nerve Net/pathology [MeSH], Network oscillations, Voltage-Gated Sodium Channels/drug effects [MeSH], Neurons/pathology [MeSH], Neurotoxicity Syndromes/metabolism [MeSH], Cells, Cultured [MeSH], Dopamine Plasma Membrane Transport Proteins/metabolism [MeSH], Channel toxins, Patch-Clamp Techniques [MeSH], Channel toxins, Neuronal network, Purinoceptor, Dopamine transporter, Network oscillations, High-Throughput Screening Assays, 3. Good health, 03 medical and health sciences, 13. Climate action, Toxicity Tests, Humans, Calcium, Neurotoxicity Syndromes, Calcium Signaling, Nerve Net, Cells, Cultured

Popis souboru: application/pdf

Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00204-020-02956-3.pdf
https://pubmed.ncbi.nlm.nih.gov/33269408
https://link.springer.com/content/pdf/10.1007/s00204-020-02956-3.pdf
https://kops.uni-konstanz.de/handle/123456789/52078
https://pubmed.ncbi.nlm.nih.gov/33269408/
https://link.springer.com/article/10.1007/s00204-020-02956-3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811517
https://repository.publisso.de/resource/frl:6466372
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-ijf7ewex24pc0

Involvement of glial cells in the neurotoxicity of parathion and chlorpyrifos.

Autoři: Zurich, M.G. Honegger, P. Schilter, B. a další

Témata: Acetylcholinesterase/metabolism, Animals, Astrocytes/pathology, Brain/cytology, Cells, Cultured, Chlorpyrifos/analogs &, derivatives, Chlorpyrifos/metabolism, Choline O-Acetyltransferase/metabolism, Cholinesterase Inhibitors/toxicity, Glutamate Decarboxylase/metabolism, Glutamate-Ammonia Ligase/metabolism, Immunohistochemistry, Insecticides/toxicity, L-Lactate Dehydrogenase/metabolism, Neuroglia/pathology, Neurotoxicity Syndromes/pathology, Paraoxon/metabolism, Paraoxon/toxicity, Parathion/toxicity, Protein Binding, Rats

Relation: Toxicology and Applied Pharmacology; 0041-008X[print], 0041-008X[linking]; https://iris.unil.ch/handle/iris/212496; serval:BIB_759E42496F83; 000225338000002

Dostupnost: https://iris.unil.ch/handle/iris/212496
https://doi.org/10.1016/j.taap.2004.05.003

Neurotoxicant-induced inflammatory response in three-dimensional brain cell cultures.

Autoři: Monnet-Tschudi, F. Zurich, M.G. Honegger, P.

Témata: Brain/growth & development, Brain/pathology, Cells, Cultured, Cytological Techniques, Glial Fibrillary Acidic Protein/metabolism, Humans, Inflammation/chemically induced, Inflammation/pathology, Neuroglia/pathology, Neurons/pathology, Neurotoxicity Syndromes/pathology

Relation: Human and Experimental Toxicology; https://iris.unil.ch/handle/iris/174928; serval:BIB_6CBE69625C7B; 000246413500009

Dostupnost: https://iris.unil.ch/handle/iris/174928
https://doi.org/10.1177/0960327107074589

RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease

Autoři: Pérez-Sisqués, Leticia Sancho-Balsells, Anna Giralt, Albert a další

Zdroj: Cell death & disease 12(6), 616 (2021). doi:10.1038/s41419-021-03899-y

Témata: info:eu-repo/classification/ddc/570, Alzheimer Disease: complications, Alzheimer Disease: genetics, Alzheimer Disease: pathology, Animals, Case-Control Studies, Disease Models, Animal, Encephalitis: etiology, Encephalitis: genetics, Encephalitis: pathology, Female, Humans, Male, Memory Disorders: etiology, Memory Disorders: genetics, Memory Disorders: pathology, Mice, Transgenic, Neuroimmunomodulation: genetics, Neurotoxicity Syndromes: etiology, Neurotoxicity Syndromes: genetics, Neurotoxicity Syndromes: pathology, Severity of Illness Index, Transcription Factors: physiology

Geografické téma: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/2041-4889; info:eu-repo/semantics/altIdentifier/pmid/34131105; info:eu-repo/semantics/altIdentifier/pmid/pmid:34131105; https://pub.dzne.de/record/154788

Dostupnost: https://pub.dzne.de/record/154788
https://pub.dzne.de/search?p=id:%22DZNE-2021-00368%22

Anesthesia‐related neurotoxicity and the developing animal brain is not a significant problem in children

Autoři: Hansen, Tom G

Zdroj: Hansen, T G 2015, ' Anesthesia-related neurotoxicity and the developing animal brain is not a significant problem in children ', Paediatric Anaesthesia, vol. 25, no. 1, pp. 65-72 . https://doi.org/10.1111/pan.12548

Témata: neurodevelopment, Neurotoxicity Syndromes/pathology, age: infants, Brain, general anesthesia, neonates, 3. Good health, infants [age], 03 medical and health sciences, 0302 clinical medicine, Species Specificity, Anesthetics/adverse effects, outcome, Humans, Anesthesia, Neurotoxicity Syndromes, Brain/growth & development, Child, Anesthesia/adverse effects, Anesthetics

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/25266176
http://onlinelibrary.wiley.com/doi/10.1111/pan.12548/abstract
https://pubmed.ncbi.nlm.nih.gov/25266176/
https://portal.findresearcher.sdu.dk/da/publications/3aefcb3e-fa4f-4b6a-b4eb-5cc0be38cd5c

Gallic acid, a histone acetyltransferase inhibitor, suppresses β‐amyloid neurotoxicity by inhibiting microglial‐mediated neuroinflammation

Autoři: Yoo-Hyun Lee Woo Jin Jun Mi Jeong Kim a další

Přispěvatelé: Yoo-Hyun Lee Woo Jin Jun Mi Jeong Kim a další

Zdroj: Molecular Nutrition & Food Research. 55:1798-1808

Témata: Inflammation/pathology, Male, 0301 basic medicine, Gallic acid, Cell Survival, Enzyme Inhibitors/pharmacology, Blotting, Western, Microglia/drug effects, Down-Regulation, Real-Time Polymerase Chain Reaction, Microglia/cytology, Cytokines/biosynthesis, Neurons/cytology, Mice, 03 medical and health sciences, Neuroinflammation, Inflammation/drug therapy, Gallic Acid, Animals, Amyloid beta-Peptides/toxicity, Histone Acetyltransferases/metabolism, Cytokines/drug effects, Enzyme Inhibitors, Histone Acetyltransferases, Inflammation, Neurons, Mice, Inbred ICR, Amyloid beta-Peptides, Cytokines/genetics, Blotting, Gallic Acid/pharmacology, NF-kappa B/genetics, Neurotoxicity Syndromes/pathology, NF-kappa B, Histone Acetyltransferases/antagonists & inhibitors, NF-kappa B/antagonists & inhibitors, Inbred ICR, Neurons/drug effects, Coculture Techniques, 3. Good health, NF-kappa B/metabolism, Histone acetyltransferase inhibitor, Cytokines, Neurotoxicity Syndromes, Microglia, Alzheimer disease, Western, Cell Survival/drug effects

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/22038937
https://www.ncbi.nlm.nih.gov/pubmed/22038937
http://europepmc.org/abstract/MED/22038937
http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201100262/full
https://pubmed.ncbi.nlm.nih.gov/22038937/
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94647
https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201100262

Hippocampal neuron number loss in rats exposed to ingested sulfite

Autoři: Yonguç, Nilüfer G. Akdoğan, Ilgaz Murk, W. a další

Zdroj: Toxicology and Industrial Health. 27:771-778

Témata: Male, 0301 basic medicine, hippocampus, Administration, Oral, Animals, CA1 Region, Hippocampal/drug effects/pathology, CA2 Region, Hippocampal/drug effects/pathology, CA3 Region, Hippocampal/drug effects/pathology, Cell Count, Cell Death/drug effects, Food Preservatives/administration & dosage/*toxicity, Hippocampus/*drug effects/pathology, Microscopy, Video, Neurons/*drug effects/pathology, Neurotoxicity Syndromes/*pathology, Preservatives, Pharmaceutical/administration & dosage/*toxicity, Pyramidal Cells/drug effects/pathology, Wistar, animal cell, Hippocampus, sulfite, Hippocampal, rat, cell count, Neurons, Microscopy, Sulfite, sulfite oxidase, the optical fractionator, 0303 health sciences, Cell Death, Pyramidal Cells, apoptosis, article, CA1 Region, pyramidal nerve cell, Video, CA3 Region, CA3 Region, Hippocampal, 3. Good health, Administration, Neurotoxicity Syndromes, Oral, animal experiment, CA2 Region, Hippocampal, hippocampal CA1 region, animal tissue, 03 medical and health sciences, hippocampal CA3 region, male, RIVATIVES, MECHANISM, TOXICITY, TISSUES, VOLUME, hippocampal CA2 region, Animalia, Sulfites, controlled study, cell loss, Rats, Wistar, CA1 Region, Hippocampal, nonhuman, Rattus, Preservatives, Pharmaceutical, CA2 Region, Rats, Pharmaceutical, stereology, Food Preservatives, Preservatives

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/21511899
https://www.ncbi.nlm.nih.gov/pubmed/21511899
https://journals.sagepub.com/doi/abs/10.1177/0748233710397418
https://pubmed.ncbi.nlm.nih.gov/21511899/
http://journals.sagepub.com/doi/pdf/10.1177/0748233710397418
https://avesis.deu.edu.tr/publication/details/c2379704-59ba-4e7b-b516-edf034be808f/oai
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/6142
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/20353
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/13264

Safety and pharmacokinetics of intrathecal administration of pemetrexed in rats

Autoři: Soo-Youn Lee Keunchil Park Youn Lim Suh a další

Přispěvatelé: Soo-Youn Lee Keunchil Park Youn Lim Suh a další

Zdroj: Cancer Chemotherapy and Pharmacology. 68:531-538

Témata: Male, Antimetabolites, Glutamates/analysis, Drug Evaluation, Preclinical, Rats, Sprague-Dawley, Antineoplastic/analysis, Catheters, Indwelling, 0302 clinical medicine, Glutamates, Tandem Mass Spectrometry, Guanine/analogs & derivatives, Neurotoxicity Syndromes*/blood, Tissue Distribution, Leptomeningeal carcinomatosis, Antineoplastic/administration & dosage, Chromatography, High Pressure Liquid, Injections, Spinal, Neurons, Chromatography, Guanine/administration & dosage, Neurons/drug effects, Glutamates/administration & dosage, Guanine/analysis, Preclinical, Guanine/adverse effects, 3. Good health, Indwelling, High Pressure Liquid, Neurotoxicity Syndromes*/pathology, Neurotoxicity Syndromes, Drug, Half-Life, Antimetabolites, Antineoplastic, Catheters, Guanine, Spinal, Metabolic Clearance Rate, Pemetrexed, Neurotoxicity Syndromes*/cerebrospinal fluid, Subarachnoid Space, Injections, Dose-Response Relationship, 03 medical and health sciences, Toxicity Tests, Animals, Pharmacokinetics, Glutamates/pharmacokinetics, No-Observed-Adverse-Effect Level, Toxicity, Dose-Response Relationship, Drug, Antineoplastic/pharmacokinetics, Glutamates/adverse effects, Guanine/pharmacokinetics, Neurons/pathology, Rats, Antineoplastic/adverse effects, Drug Evaluation, Sprague-Dawley

Popis souboru: 531~538

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/21107572
https://link.springer.com/article/10.1007/s00280-010-1522-7
https://rd.springer.com/article/10.1007/s00280-010-1522-7
https://snucm.elsevierpure.com/en/publications/safety-and-pharmacokinetics-of-intrathecal-administration-of-peme
https://www.ncbi.nlm.nih.gov/pubmed/21107572
https://pubmed.ncbi.nlm.nih.gov/21107572/

Ultrastructural study of cerebellar dentate nucleus astrocytes in chronic experimental model with valproate

Zdroj: Folia Neuropathologica. 43(3):166-171

Témata: Zwierzęta, Choroby mózgu - patomorfologia, Szczury, Zespoły neurotoksyczne - patomorfologia, Astrocyty - wpływ środków chemicznych, Brain diseases - pathology, Astrocyty - ultrastruktura, Cerebellar nuclei - drug effects, Rats, Choroby mózgu - etiologia chemiczna, Kwas walproinowy - toksykologia, Jądra móżdżku - wpływ środków chemicznych, Valproic acid - toxicity, Brain diseases - chemically induced, Astrocytes - drug effects, Środki przeciwdrgawkowe - toksykologia, Anticonvulsants - toxicity, Animals, Astrocytes - ultrastructure, Neurotoxicity syndromes - pathology, Cerebellar nuclei - ultrastructure, Jądra móżdżku - ultrastruktura

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.

Autoři: Fritsche, E. Grandjean, P. Crofton, K.M. a další

Témata: Age Factors, Animal Testing Alternatives/standards, Animals, Brain/drug effects, Brain/growth & development, Brain/pathology, Consensus, Diffusion of Innovation, Humans, Neurons/drug effects, Neurons/pathology, Neurotoxicity Syndromes/etiology, Neurotoxicity Syndromes/pathology, Neurotoxicity Syndromes/physiopathology, Policy Making, Reproducibility of Results, Risk Assessment, Stakeholder Participation, Toxicity Tests/methods, Toxicity Tests/standards, Toxicology/methods, Toxicology/standards, Developmental neurotoxicity, In vitro testing, Regulatory purposes

Popis souboru: application/pdf

Relation: Toxicology and applied pharmacology; https://iris.unil.ch/handle/iris/88782; serval:BIB_0F4E2D75CCBF; 000442335500002

Dostupnost: https://iris.unil.ch/handle/iris/88782
https://doi.org/10.1016/j.taap.2018.02.004

Increased white matter hyperintensities in male methamphetamine abusers

Autoři: Bae, Soojeong C Lyoo, In Kyoon Sung, Young Hoon a další

Přispěvatelé: Bae, Soojeong C Lyoo, In Kyoon Sung, Young Hoon a další

Témata: Adult, Amphetamine-Related Disorders/*pathology, Brain/pathology, Cerebral Ventricles/pathology, Dementia, Vascular/*chemically induced/pathology, Demyelinating Diseases/*chemically induced/pathology, Dose-Response Relationship, Drug, Humans, Korea, Male, Methamphetamine/*toxicity, Midline Thalamic Nuclei/pathology, Neurotoxicity Syndromes/*pathology, Reference Values, Risk Factors, Statistics as Topic, Magnetic Resonance Imaging

Relation: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16005161; https://hdl.handle.net/10371/29544

Dostupnost: https://hdl.handle.net/10371/29544
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T63-4GJVB5D-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=b3351ec22a3b9a2f477a7d23d83dc4ae
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16005161
https://doi.org/10.1016/j.drugalcdep.2005.05.016

TRPV4 inhibition prevents paclitaxel-induced neurotoxicity in preclinical models.

Autoři: Boehmerle, Wolfgang Huehnchen, Petra Lee, Sabrina Lin Lin a další

Zdroj: Experimental neurology 306, 64-75 (2018). doi:10.1016/j.expneurol.2018.04.014

Témata: info:eu-repo/classification/ddc/610, Animals, Antineoplastic Agents, Phytogenic: toxicity, Calcium Channels: drug effects, Calcium Channels: metabolism, Calcium Signaling: drug effects, Cell Death: drug effects, Cell Membrane: drug effects, Cell Membrane: metabolism, Endoplasmic Reticulum: drug effects, Endoplasmic Reticulum: metabolism, Ganglia, Spinal: pathology, Immunohistochemistry, Inositol 1,4,5-Trisphosphate Receptors: genetics, Mice, Inbred C57BL, Neurotoxicity Syndromes: pathology, Neurotoxicity Syndromes: prevention & control, Paclitaxel: toxicity, Rats, Wistar, TRPV Cation Channels: antagonists & inhibitors, Transfection, Phytogenic, Calcium Channels, Inositol 1,4,5-Trisphosphate Receptors, TRPV Cation Channels, Trpv4 protein

Geografické téma: DE

Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:29715474; info:eu-repo/semantics/altIdentifier/issn/0014-4886; info:eu-repo/semantics/altIdentifier/issn/1090-2430; https://pub.dzne.de/record/140030

Dostupnost: https://pub.dzne.de/record/140030
https://pub.dzne.de/search?p=id:%22DZNE-2020-06352%22

Neurotoxicity of Dietary Supplements from Annonaceae Species.

Autoři: Höllerhage, Matthias Rösler, Thomas W Höglinger, Günter U a další

Zdroj: International journal of toxicology 34(6), 543-550 (2015). doi:10.1177/1091581815602252

Témata: info:eu-repo/classification/ddc/610, Annonaceae: toxicity, Cell Survival: drug effects, Cells, Cultured, Dietary Supplements: toxicity, Fruit: chemistry, Fruit: toxicity, Humans, L-Lactate Dehydrogenase: analysis, L-Lactate Dehydrogenase: metabolism, Mesencephalon: cytology, Mesencephalon: drug effects, Neurons: drug effects, Neurotoxicity Syndromes: pathology, Plant Extracts: toxicity, Seeds: chemistry, Seeds: toxicity, Tetrazolium Salts, Thiazoles, Plant Extracts, L-Lactate Dehydrogenase, thiazolyl blue

Geografické téma: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/1091-5818; info:eu-repo/semantics/altIdentifier/issn/0730-0913; info:eu-repo/semantics/altIdentifier/pmid/pmid:26405269; info:eu-repo/semantics/altIdentifier/issn/1092-874X; https://pub.dzne.de/record/138284

Dostupnost: https://pub.dzne.de/record/138284
https://pub.dzne.de/search?p=id:%22DZNE-2020-04606%22