Suchergebnisse - "Neoplastic"

NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo.

Autoren: Gasnier M Chen TC Yada S et al.

Quelle: Nature cell biology [Nat Cell Biol] 2025 Oct; Vol. 27 (10), pp. 1632-1646. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE

MeSH-Schlagworte: NADPH Oxidase 1*/metabolism , NADPH Oxidase 1*/genetics , Colonic Neoplasms*/pathology , Colonic Neoplasms*/genetics , Colonic Neoplasms*/metabolism , Neoplastic Stem Cells*/pathology , Neoplastic Stem Cells*/metabolism , Colon*/pathology , Colon*/metabolism , Receptors, Neuropeptide Y*/metabolism , Receptors, Neuropeptide Y*/genetics, Animals ; Mice ; Wnt Signaling Pathway ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Receptors, G-Protein-Coupled/genetics ; Mice, Transgenic ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology

Homochlorcyclizine Dihydrochloride Inhibits Hepatocellular Carcinoma Progression and Cancer Stem Cell Properties.

Autoren: Wu J Fu X Chang S et al.

Quelle: Anticancer research [Anticancer Res] 2025 Dec; Vol. 45 (12), pp. 5465-5475.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Neoplastic Stem Cells*/drug effects , Neoplastic Stem Cells*/pathology , Neoplastic Stem Cells*/metabolism, Humans ; Animals ; Mice ; Cell Proliferation/drug effects ; Xenograft Model Antitumor Assays ; Cell Movement/drug effects ; Cell Line, Tumor ; Disease Progression ; Gene Expression Regulation, Neoplastic/drug effects

Acetylated KLF5 inhibits LACTB transcription, mediates mitochondrial dynamics, and regulates colorectal cancer cell stemness and differentiation.

Autoren: Ma L Lin C Xiao Z et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 333 (Pt 2), pp. 148905. Date of Electronic Publication: 2025 Nov 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Kruppel-Like Transcription Factors*/metabolism , Kruppel-Like Transcription Factors*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/metabolism , Cell Differentiation*/genetics , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Mitochondrial Dynamics*/genetics , Transcription, Genetic*, Humans ; Acetylation ; Animals ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Mice ; Male ; HT29 Cells

FENDRR represses Bladder Cancer Cell Proliferation, Stemness, Migration, Invasion, and EMT Process by Targeting miR-18a-5p/AFF4 Axis.

Autoren: Dai C Li Q Wang L et al.

Quelle: Biochemical genetics [Biochem Genet] 2025 Dec; Vol. 63 (6), pp. 5029-5047. Date of Electronic Publication: 2024 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4927 (Electronic) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE

MeSH-Schlagworte: MicroRNAs*/genetics , MicroRNAs*/metabolism , Urinary Bladder Neoplasms*/pathology , Urinary Bladder Neoplasms*/genetics , Urinary Bladder Neoplasms*/metabolism , Epithelial-Mesenchymal Transition* , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology, Humans ; Cell Proliferation ; Cell Movement ; Cell Line, Tumor ; Neoplasm Invasiveness ; Gene Expression Regulation, Neoplastic

Effect of extracellular vesicle ZNF280B derived from lung cancer stem cells on lung cancer progression.

Autoren: Guo Q Lu J Zhao H et al.

Quelle: Cancer biology & therapy [Cancer Biol Ther] 2025 Dec; Vol. 26 (1), pp. 2450849. Date of Electronic Publication: 2025 Jan 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137842 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-8576 (Electronic) Linking ISSN: 15384047 NLM ISO Abbreviation: Cancer Biol Ther Subsets: MEDLINE

MeSH-Schlagworte: Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Lung Neoplasms*/genetics , Extracellular Vesicles*/metabolism , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Repressor Proteins*/metabolism , Repressor Proteins*/genetics, Humans ; Animals ; Mice ; Disease Progression ; Cell Proliferation ; Mice, Nude ; Cell Movement ; Cell Line, Tumor ; Female ; Prognosis ; Gene Expression Regulation, Neoplastic ; Male

An altered proteome in ovarian cancer stem-like cells: profiling of the mDivi-1 induced proteome and its clinical significance.

Autoren: Raina M Lodhiya T Ashraf R et al.

Quelle: Molecular omics [Mol Omics] 2025 Dec 01; Vol. 21 (6), pp. 621-632. Date of Electronic Publication: 2025 Dec 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101713384 Publication Model: Electronic Cited Medium: Internet ISSN: 2515-4184 (Electronic) Linking ISSN: 25154184 NLM ISO Abbreviation: Mol Omics Subsets: MEDLINE

MeSH-Schlagworte: Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/drug therapy , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/drug effects , Neoplastic Stem Cells*/pathology , Proteome*/metabolism, Humans ; Female ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/drug effects ; Cell Line, Tumor ; Proteomics/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Clinical Relevance

Circ_0000972 Inhibits Hepatocellular Carcinoma Cell Stemness by Targeting miR-96-5p/PFN1.

Autoren: Tang J Tang R Xue F et al.

Quelle: Biochemical genetics [Biochem Genet] 2025 Dec; Vol. 63 (6), pp. 5175-5192. Date of Electronic Publication: 2024 Dec 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4927 (Electronic) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE

MeSH-Schlagworte: MicroRNAs*/genetics , MicroRNAs*/metabolism , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/genetics , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , RNA, Circular*/genetics , RNA, Circular*/metabolism , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Profilins*/genetics , Profilins*/metabolism, Humans ; Animals ; Mice ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Mice, Nude ; Male ; Female ; Mice, Inbred BALB C

CENPU promotes tumorigenesis and stem cell properties in triple‑negative breast cancer by suppressing lysosomal furin degradation.

Autoren: Sun S Hou Z Qiang L et al.

Quelle: International journal of molecular medicine [Int J Mol Med] 2025 Dec; Vol. 56 (6). Date of Electronic Publication: 2025 Oct 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE

MeSH-Schlagworte: Furin*/metabolism , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/genetics , Carcinogenesis*/metabolism , Carcinogenesis*/pathology , Carcinogenesis*/genetics , Lysosomes*/metabolism , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology, Humans ; Female ; Animals ; Mice ; Cell Line, Tumor ; Proteolysis ; Cell Movement ; Mice, Nude ; Gene Expression Regulation, Neoplastic ; Nerve Growth Factor/metabolism

ATF5 inhibits autophagy and the Wnt/β-catenin pathway by upregulating mTOR to suppress the stemness of liver cancer stem cells.

Autoren: Jiang J Li X Zhang H et al.

Quelle: Tissue & cell [Tissue Cell] 2025 Dec; Vol. 97, pp. 103094. Date of Electronic Publication: 2025 Aug 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE

MeSH-Schlagworte: Neoplastic Stem Cells*/pathology , Neoplastic Stem Cells*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Liver Neoplasms*/genetics , Activating Transcription Factors*/metabolism , Activating Transcription Factors*/genetics , Autophagy*/genetics , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/genetics , Wnt Signaling Pathway*/genetics , TOR Serine-Threonine Kinases*/metabolism , TOR Serine-Threonine Kinases*/genetics , Up-Regulation*, Humans ; Cell Line, Tumor ; Animals ; Gene Expression Regulation, Neoplastic ; Male ; Mice ; Female ; Cell Proliferation

SUV39H2 is a vulnerability in glioblastoma stem cells enhanced by co-targeting SUV39H1.

Autoren: Cao B Xie Q Li C et al.

Quelle: Epigenomics [Epigenomics] 2025 Dec; Vol. 17 (17), pp. 1225-1232. Date of Electronic Publication: 2025 Oct 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101519720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-192X (Electronic) Linking ISSN: 1750192X NLM ISO Abbreviation: Epigenomics Subsets: MEDLINE

MeSH-Schlagworte: Glioblastoma*/genetics , Glioblastoma*/pathology , Glioblastoma*/metabolism , Glioblastoma*/mortality , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Brain Neoplasms*/genetics , Brain Neoplasms*/pathology , Brain Neoplasms*/metabolism , Repressor Proteins*/genetics , Repressor Proteins*/metabolism , Histone-Lysine N-Methyltransferase*/genetics , Histone-Lysine N-Methyltransferase*/metabolism, Humans ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Prognosis ; Methyltransferases

High serum LDL promotes EMT and stemness through LDLR/FOXQ1/NF-κB1 pathway in epithelial ovarian cancer.

Autoren: Tang S Chen K Zheng F et al.

Quelle: Oncogene [Oncogene] 2025 Dec; Vol. 44 (47), pp. 4587-4600. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

MeSH-Schlagworte: Epithelial-Mesenchymal Transition*/genetics , Forkhead Transcription Factors*/metabolism , Forkhead Transcription Factors*/genetics , Receptors, LDL*/metabolism , Receptors, LDL*/genetics , Carcinoma, Ovarian Epithelial*/pathology , Carcinoma, Ovarian Epithelial*/blood , Carcinoma, Ovarian Epithelial*/genetics , Carcinoma, Ovarian Epithelial*/metabolism , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/blood , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/metabolism , Neoplastic Stem Cells*/pathology , Neoplastic Stem Cells*/metabolism , NF-kappa B p50 Subunit*/metabolism , NF-kappa B p50 Subunit*/genetics , Lipoproteins, LDL*/blood, Humans ; Female ; Animals ; Mice ; Cell Line, Tumor ; Signal Transduction ; Gene Expression Regulation, Neoplastic ; beta Catenin/metabolism

N2 neutrophils induce cell stemness reprogramming to promote gastric cancer progression via exosomal miRNAs.

Autoren: Tang H Zhong Y Wang J et al.

Quelle: Cellular signalling [Cell Signal] 2025 Dec; Vol. 136, pp. 112085. Date of Electronic Publication: 2025 Aug 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH-Schlagworte: Stomach Neoplasms*/pathology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism , MicroRNAs*/metabolism , MicroRNAs*/genetics , Exosomes*/metabolism , Exosomes*/genetics , Neutrophils*/metabolism , Neutrophils*/pathology , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Cellular Reprogramming*, Humans ; Animals ; Disease Progression ; Cell Line, Tumor ; Mice ; Cell Proliferation ; PTEN Phosphohydrolase/metabolism ; PTEN Phosphohydrolase/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Forkhead Box Protein O3/metabolism ; Forkhead Box Protein O3/genetics ; Signal Transduction ; Phosphatidylinositol 3-Kinases/metabolism ; Oxaliplatin/pharmacology ; Gene Expression Regulation, Neoplastic ; Male ; Mice, Nude

Epigenetic regulation of circulating tumor cells in precision oncology.

Autoren: Farah H Abosaoda MK Mousa HM et al.

Quelle: Pathology, research and practice [Pathol Res Pract] 2025 Dec; Vol. 276, pp. 156282. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE

MeSH-Schlagworte: Neoplastic Cells, Circulating*/pathology , Neoplastic Cells, Circulating*/metabolism , Epigenesis, Genetic*/genetics , Precision Medicine*/methods , Neoplasms*/genetics , Neoplasms*/pathology, Humans ; Epithelial-Mesenchymal Transition/genetics ; Biomarkers, Tumor/genetics ; Gene Expression Regulation, Neoplastic

Sparking malignancy: nicotine as a driver of stemness and metastasis in triple-negative breast cancer ^† .

Autoren: Simpkins C Toska E

Quelle: The Journal of pathology [J Pathol] 2025 Dec; Vol. 267 (4), pp. 367-370. Date of Electronic Publication: 2025 Sep 09.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 0204634 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9896 (Electronic) Linking ISSN: 00223417 NLM ISO Abbreviation: J Pathol Subsets: MEDLINE

MeSH-Schlagworte: Neoplastic Stem Cells*/pathology , Neoplastic Stem Cells*/drug effects , Neoplastic Stem Cells*/metabolism , Nicotine*/adverse effects , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/genetics, Animals ; Female ; Humans ; Gene Expression Regulation, Neoplastic ; Neoplasm Metastasis ; Receptor, IGF Type 1/metabolism ; Receptor, IGF Type 1/genetics ; Receptors, Nicotinic/metabolism ; Receptors, Nicotinic/genetics ; Xenograft Model Antitumor Assays

Par6/SOX2 interact to modulate stemness maintenance in glioma by regulating the EGFR/PI3K/AKT signaling cascade.

Autoren: Yang T Zeng Y Li Y et al.

Quelle: Oncogene [Oncogene] 2025 Dec; Vol. 44 (46), pp. 4441-4461. Date of Electronic Publication: 2025 Oct 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

MeSH-Schlagworte: SOXB1 Transcription Factors*/metabolism , SOXB1 Transcription Factors*/genetics , Glioma*/pathology , Glioma*/metabolism , Glioma*/genetics , Glioma*/drug therapy , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/genetics , Phosphatidylinositol 3-Kinases*/metabolism , Phosphatidylinositol 3-Kinases*/genetics , Brain Neoplasms*/pathology , Brain Neoplasms*/metabolism , Brain Neoplasms*/genetics, Humans ; Signal Transduction ; ErbB Receptors/metabolism ; ErbB Receptors/genetics ; Animals ; Mice ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Prognosis ; Female ; Mice, Nude ; Male

Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas.

Autoren: Li X Wei F Jiang T et al.

Quelle: Cell reports [Cell Rep] 2025 Nov 25; Vol. 44 (11), pp. 116487. Date of Electronic Publication: 2025 Oct 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH-Schlagworte: Plakophilins*/metabolism , Plakophilins*/genetics , Acinar Cells*/metabolism , Acinar Cells*/pathology , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/genetics , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/metabolism , Carcinoma, Pancreatic Ductal*/genetics , Cell Transformation, Neoplastic*/metabolism , Cell Transformation, Neoplastic*/pathology, Humans ; Forkhead Box Protein M1/metabolism ; Forkhead Box Protein M1/genetics ; Animals ; Mice ; Disease Progression ; Cell Line, Tumor ; Pancreas/pathology ; Pancreas/metabolism ; Carcinogenesis/pathology ; Gene Expression Regulation, Neoplastic ; Male ; Signal Transduction

MiRNome alterations drive the malignant transformation of endometriosis into endometriosis-correlated ovarian cancer.

Autoren: Coada CA Perrone AM Gorini F et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 21; Vol. 15 (1), pp. 41434. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: MicroRNAs*/genetics , Endometriosis*/genetics , Endometriosis*/pathology , Endometriosis*/complications , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Cell Transformation, Neoplastic*/genetics , Cell Transformation, Neoplastic*/pathology, Humans ; Female ; Adult ; Gene Expression Regulation, Neoplastic ; Gene Expression Profiling ; Middle Aged ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/pathology

METTL3-mediated m6A modification of LINC00857 enhances stemness and metastasis of ovarian cancer cells by activating the YAP-TEAD pathway.

Autoren: Lin X Hong Y You S et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 20; Vol. 15 (1), pp. 41132. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Methyltransferases*/metabolism , Methyltransferases*/genetics , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/metabolism , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Transcription Factors*/metabolism , Transcription Factors*/genetics , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/genetics , Adenosine*/analogs & derivatives , Adenosine*/metabolism, Humans ; Female ; Cell Line, Tumor ; YAP-Signaling Proteins ; Cell Movement/genetics ; Gene Expression Regulation, Neoplastic ; Signal Transduction ; Cell Proliferation ; Neoplasm Metastasis

ZIC5, a survival biomarker, facilitates tumor progression and stemness in colon cancer via the activation of the Wnt signaling pathway.

Autoren: Li X Zhao C Mu M et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 20; Vol. 15 (1), pp. 40943. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Colonic Neoplasms*/pathology , Colonic Neoplasms*/metabolism , Colonic Neoplasms*/genetics , Colonic Neoplasms*/mortality , Transcription Factors*/genetics , Transcription Factors*/metabolism , Wnt Signaling Pathway* , Biomarkers, Tumor*/metabolism , Biomarkers, Tumor*/genetics , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism, Humans ; Female ; Gene Expression Regulation, Neoplastic ; Male ; Disease Progression ; Cell Proliferation/genetics ; Cell Movement/genetics ; Cell Line, Tumor ; Middle Aged ; Prognosis

N-glycosylation of NANOG regulates stemness and apoptosis in colon cancer cells.

Autoren: Tian Y Zeng Y Liu Y et al.

Quelle: PloS one [PLoS One] 2025 Nov 20; Vol. 20 (11), pp. e0336779. Date of Electronic Publication: 2025 Nov 20 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Apoptosis* , Nanog Homeobox Protein*/metabolism , Nanog Homeobox Protein*/genetics , Colonic Neoplasms*/metabolism , Colonic Neoplasms*/pathology , Colonic Neoplasms*/genetics , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology, Humans ; Glycosylation ; Cell Proliferation ; Cell Movement ; HCT116 Cells ; Cell Line, Tumor ; AC133 Antigen/metabolism ; Gene Expression Regulation, Neoplastic