Suchergebnisse - "Neoplasm Proteins"

Discovery of inhibitors of the cancer-promoting phosphatase PRL-3 and their evaluation in intestinal organoids.

Autoren: Hoffmann A Weyershaeuser J Chand Y et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 15; Vol. 131, pp. 118412. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatases*/antagonists & inhibitors , Protein Tyrosine Phosphatases*/metabolism , Organoids*/drug effects , Organoids*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Drug Discovery* , Neoplasm Proteins*/antagonists & inhibitors , Neoplasm Proteins*/metabolism , Intestines*/drug effects , Intestines*/cytology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis, Animals ; Humans ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology

PyaiVS unifies AI workflows to accelerate ligand discovery and yields ABCG2 inhibitors.

Autoren: Wang M Qu B Yang L et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118176. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: ATP Binding Cassette Transporter, Subfamily G, Member 2*/antagonists & inhibitors , ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism , Drug Discovery* , Neoplasm Proteins*/antagonists & inhibitors , Neoplasm Proteins*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Machine Learning*, Humans ; Ligands ; Structure-Activity Relationship ; Molecular Structure ; Molecular Docking Simulation ; Dose-Response Relationship, Drug ; Workflow

FBP1 promotes ABCG2-mediated uric acid excretion through activation of the PI3K/AKT/CREB signaling pathway.

Autoren: Bai Q Wang C Li J et al.

Quelle: Scientific reports [Sci Rep] 2025 Dec 05; Vol. 15 (1), pp. 43228. Date of Electronic Publication: 2025 Dec 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Uric Acid*/metabolism , ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism , ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics , Signal Transduction* , Proto-Oncogene Proteins c-akt*/metabolism , Fructose-Bisphosphatase*/metabolism , Fructose-Bisphosphatase*/genetics , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/genetics , Phosphatidylinositol 3-Kinases*/metabolism, Humans ; Hyperuricemia/metabolism ; Hyperuricemia/genetics ; Caco-2 Cells ; Hep G2 Cells

New players from the old chalcone scaffold: Synthesis, identification, and characterization of new potent ABCG2 inhibitors.

Autoren: Ruginsk BE Zattoni IF Gomes De Oliveira AH et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 05; Vol. 299, pp. 118077. Date of Electronic Publication: 2025 Aug 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: ATP Binding Cassette Transporter, Subfamily G, Member 2*/antagonists & inhibitors , ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism , Neoplasm Proteins*/antagonists & inhibitors , Neoplasm Proteins*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Chalcones*/pharmacology , Chalcones*/chemistry , Chalcones*/chemical synthesis , Chalcone*/pharmacology , Chalcone*/chemistry , Chalcone*/chemical synthesis, Humans ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Molecular Structure ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Molecular Docking Simulation ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor

Modelling the role of STIM1 and STIM2 in ... oscillations in T-lymphocytes.

Autoren: Castaneda Ruan P Benson JC Trebak M et al.

Quelle: Bulletin of mathematical biology [Bull Math Biol] 2025 Dec 03; Vol. 87 (12), pp. 184. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 0401404 Publication Model: Electronic Cited Medium: Internet ISSN: 1522-9602 (Electronic) Linking ISSN: 00928240 NLM ISO Abbreviation: Bull Math Biol Subsets: MEDLINE

MeSH-Schlagworte: Stromal Interaction Molecule 1*/metabolism , Stromal Interaction Molecule 1*/physiology , Stromal Interaction Molecule 1*/genetics , T-Lymphocytes*/metabolism , Calcium Signaling*/physiology , Calcium Signaling*/immunology , Stromal Interaction Molecule 2*/metabolism , Stromal Interaction Molecule 2*/physiology , Stromal Interaction Molecule 2*/genetics , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/physiology , Neoplasm Proteins*/genetics , Models, Biological*, Humans ; Jurkat Cells ; Mathematical Concepts ; Calcium/metabolism

Restoring chloride efflux in cystic fibrosis with TMEM16a antisense oligonucleotides.

Autoren: Mitri C Rousselet N Bardin P et al.

Quelle: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Dec 03; Vol. 33 (12), pp. 6463-6478. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH-Schlagworte: Cystic Fibrosis*/metabolism , Cystic Fibrosis*/genetics , Cystic Fibrosis*/therapy , Anoctamin-1*/genetics , Anoctamin-1*/metabolism , Oligonucleotides, Antisense*/genetics , Oligonucleotides, Antisense*/pharmacology , Oligonucleotides, Antisense*/administration & dosage , Chlorides*/metabolism , Neoplasm Proteins*/genetics , Neoplasm Proteins*/metabolism, Animals ; Mice ; Humans ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Disease Models, Animal

The role of chimeric FAM72B transcripts generated by intergenic mRNA trans-splicing in breast cancer.

Autoren: Patra G Kim PS Kutzner A et al.

Quelle: Functional & integrative genomics [Funct Integr Genomics] 2025 Dec 02; Vol. 25 (1), pp. 260. Date of Electronic Publication: 2025 Dec 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Germany NLM ID: 100939343 Publication Model: Electronic Cited Medium: Internet ISSN: 1438-7948 (Electronic) Linking ISSN: 1438793X NLM ISO Abbreviation: Funct Integr Genomics Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Trans-Splicing* , RNA, Messenger*/genetics , RNA, Messenger*/metabolism , Neoplasm Proteins*/genetics , Neoplasm Proteins*/metabolism, Humans ; Female ; Cell Proliferation ; Cell Line, Tumor

Human coronavirus 3CL protease manipulates host protein STIM1 to facilitate immune evasion.

Autoren: Lee YY Lee AR Seo S et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 02; Vol. 122 (48), pp. e2503436122. Date of Electronic Publication: 2025 Nov 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Stromal Interaction Molecule 1*/metabolism , Stromal Interaction Molecule 1*/immunology , Stromal Interaction Molecule 1*/genetics , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/genetics , Neoplasm Proteins*/immunology , Immune Evasion* , Coronavirus 3C Proteases*/metabolism , SARS-CoV-2*/enzymology, Humans ; HEK293 Cells ; Host-Pathogen Interactions/immunology ; Phosphorylation ; Signal Transduction

UTP3: A Prognostic Marker in Hepatocellular Carcinoma and Its Role in Immunity and Epigenetics.

Autoren: Xu Y Zhang S Wei G et al.

Quelle: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2025 Dec; Vol. 39 (12), pp. e70632.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/diagnosis , Liver Neoplasms*/immunology , Liver Neoplasms*/genetics , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Liver Neoplasms*/diagnosis , Epigenesis, Genetic* , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/immunology , Biomarkers, Tumor*/metabolism , Neoplasm Proteins*/genetics , Neoplasm Proteins*/immunology, Humans ; Prognosis ; Male ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic

MT1H Inhibited Colon Cancer Development via Interacting With DUSP1 and MAPK Signaling Pathway Inactivation.

Autoren: Jiang L An X Li Y et al.

Quelle: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2025 Dec; Vol. 39 (12), pp. e70625.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Colonic Neoplasms*/metabolism , Colonic Neoplasms*/pathology , Colonic Neoplasms*/genetics , Dual Specificity Phosphatase 1*/metabolism , Dual Specificity Phosphatase 1*/genetics , MAP Kinase Signaling System* , Metallothionein*/metabolism , Metallothionein*/genetics , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/genetics, Humans ; Animals ; Mice ; Cell Movement ; Cell Proliferation ; Mice, Nude ; HCT116 Cells ; Male ; Cell Line, Tumor ; Neoplasm Invasiveness ; Female

LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity.

Autoren: Li JY Li YQ Dai JH et al.

Quelle: The Journal of clinical investigation [J Clin Invest] 2025 Dec 01; Vol. 135 (23). Date of Electronic Publication: 2025 Dec 01 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

MeSH-Schlagworte: STAT1 Transcription Factor*/immunology , STAT1 Transcription Factor*/metabolism , STAT1 Transcription Factor*/genetics , Macrophages*/immunology , Macrophages*/pathology , Macrophages*/metabolism , Chemokine CXCL9*/immunology , Chemokine CXCL9*/genetics , Chemokine CXCL9*/metabolism , STAT2 Transcription Factor*/immunology , STAT2 Transcription Factor*/metabolism , STAT2 Transcription Factor*/genetics , Neoplasm Proteins*/immunology , Neoplasm Proteins*/genetics , Neoplasm Proteins*/metabolism, Animals ; Mice ; CD8-Positive T-Lymphocytes/immunology ; Humans ; Phosphorylation ; Cell Line, Tumor ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction

Elucidating the binding specificity of interactive compounds targeting ATP-binding cassette subfamily G member 2 (ABCG2).

Autoren: Kumar P Kumari I Prasad R et al.

Quelle: Molecular diversity [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 5635-5648. Date of Electronic Publication: 2025 Jan 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

MeSH-Schlagworte: ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism , ATP Binding Cassette Transporter, Subfamily G, Member 2*/chemistry , ATP Binding Cassette Transporter, Subfamily G, Member 2*/antagonists & inhibitors , Neoplasm Proteins*/chemistry , Neoplasm Proteins*/antagonists & inhibitors , Neoplasm Proteins*/metabolism, Molecular Docking Simulation ; Molecular Dynamics Simulation ; Humans ; Protein Binding ; Binding Sites

The fourth-generation EGFR tyrosine kinase inhibitor BLU-945 resensitizes ABCG2-overexpressing multidrug-resistant non-small cell lung cancer cells to cytotoxic anticancer drugs.

Autoren: Li YC Lin BH Murakami M et al.

Quelle: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Dec 01; Vol. 215, pp. 107337. Date of Electronic Publication: 2025 Oct 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

MeSH-Schlagworte: ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism , ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/metabolism , Drug Resistance, Neoplasm*/drug effects , Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Protein Kinase Inhibitors*/pharmacology , Antineoplastic Agents*/pharmacology , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/genetics , Drug Resistance, Multiple*/drug effects, Humans ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Cell Line, Tumor ; Acrylamides/pharmacology ; Tyrosine Kinase Inhibitors

FERMT1 suppresses the ferroptosis of glioma cells by interacting with MBOAT2.

Autoren: Pan Z Ke C Zhang B et al.

Quelle: Experimental cell research [Exp Cell Res] 2025 Dec 01; Vol. 453 (2), pp. 114794. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0373226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2422 (Electronic) Linking ISSN: 00144827 NLM ISO Abbreviation: Exp Cell Res Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/genetics , Ferroptosis*/drug effects , Glioma*/pathology , Glioma*/metabolism , Glioma*/genetics , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/genetics , Brain Neoplasms*/pathology , Brain Neoplasms*/metabolism , Brain Neoplasms*/genetics, Humans ; Cell Line, Tumor ; Animals ; Mice ; Gene Expression Regulation, Neoplastic ; Cyclohexylamines ; Phenylenediamines ; Piperazines

Identification and validation of the m6A-binding protein LRPPRC to promote tumorigenesis in multiple myeloma.

Autoren: Tang J Li J Qin S et al.

Quelle: Hematology (Amsterdam, Netherlands) [Hematology] 2025 Dec; Vol. 30 (1), pp. 2523082. Date of Electronic Publication: 2025 Jul 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8454 (Electronic) Linking ISSN: 10245332 NLM ISO Abbreviation: Hematology Subsets: MEDLINE

MeSH-Schlagworte: Multiple Myeloma*/metabolism , Multiple Myeloma*/pathology , Multiple Myeloma*/genetics , Neoplasm Proteins*/genetics , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/biosynthesis , Gene Expression Regulation, Neoplastic* , Carcinogenesis*/genetics , Carcinogenesis*/metabolism, Humans ; Cell Line, Tumor ; Apoptosis ; Male ; Female ; Prognosis ; Cell Proliferation ; Adenosine/analogs & derivatives ; Adenosine/metabolism

[Expression of Concern] Inhibition of tumorigenesis and invasion of hepatocellular carcinoma by siRNA‑mediated silencing of the livin gene.

Autoren: Liu H Wang S Sun H et al.

Quelle: Molecular medicine reports [Mol Med Rep] 2025 Dec; Vol. 32 (6). Date of Electronic Publication: 2025 Sep 19.

Publikationsart: Journal Article; Expression of Concern

Info zur Zeitschrift: Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , RNA, Small Interfering*/genetics , RNA, Small Interfering*/metabolism , Neoplasm Proteins*/genetics , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/antagonists & inhibitors , Adaptor Proteins, Signal Transducing*/genetics , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/antagonists & inhibitors , Inhibitor of Apoptosis Proteins*/genetics , Inhibitor of Apoptosis Proteins*/metabolism , Inhibitor of Apoptosis Proteins*/antagonists & inhibitors , RNA Interference* , Gene Silencing* , Carcinogenesis*/genetics, Humans ; Cell Line, Tumor ; Neoplasm Invasiveness ; Gene Expression Regulation, Neoplastic ; Cell Movement

Mapping the ABC transporter landscape in the human lung: A comprehensive characterisation of P-gp, MRP1 and BCRP expression and functional activity in human lung epithelial cells.

Autoren: Simon S Shanmugalingam T Neu T et al.

Quelle: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Dec 01; Vol. 215, pp. 107333. Date of Electronic Publication: 2025 Oct 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

MeSH-Schlagworte: ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism , ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics , Multidrug Resistance-Associated Proteins*/metabolism , Multidrug Resistance-Associated Proteins*/genetics , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/genetics , Lung*/metabolism , Lung*/cytology , Epithelial Cells*/metabolism , ATP Binding Cassette Transporter, Subfamily B, Member 1*/metabolism , ATP Binding Cassette Transporter, Subfamily B, Member 1*/genetics, Humans ; Cell Line ; Biological Transport

CDC5L binds to ELAVL1 to inhibit pyroptosis in hepatocellular carcinoma through the Caspase 3/GSDME signaling pathway.

Autoren: Liang S Zhu Z Tang Y et al.

Quelle: International journal of molecular medicine [Int J Mol Med] 2025 Dec; Vol. 56 (6). Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Pyroptosis*/genetics , ELAV-Like Protein 1*/metabolism , ELAV-Like Protein 1*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Signal Transduction* , Caspase 3*/metabolism , Caspase 3*/genetics , Cell Cycle Proteins*/metabolism , Cell Cycle Proteins*/genetics , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/genetics, Humans ; Animals ; Cell Line, Tumor ; Mice ; Male ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Female ; Middle Aged ; Gasdermins ; RNA-Binding Proteins

KMT2D deficiency potentiates antitumor immunity and sensitizes immune checkpoint blockade in urologic cancers.

Autoren: Ye Y Liao Y Zhang Y et al.

Quelle: The Journal of pathology [J Pathol] 2025 Dec; Vol. 267 (4), pp. 450-463. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 0204634 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9896 (Electronic) Linking ISSN: 00223417 NLM ISO Abbreviation: J Pathol Subsets: MEDLINE

MeSH-Schlagworte: Immune Checkpoint Inhibitors*/pharmacology , DNA-Binding Proteins*/deficiency , DNA-Binding Proteins*/genetics , Urologic Neoplasms*/immunology , Urologic Neoplasms*/drug therapy , Urologic Neoplasms*/genetics , Urologic Neoplasms*/pathology , Neoplasm Proteins*/deficiency , Neoplasm Proteins*/genetics, Humans ; Animals ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/drug effects ; Mice ; Cell Line, Tumor ; Male ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/drug effects ; Female ; Tumor Microenvironment ; Lymphocyte Activation/drug effects ; Cell Movement ; Programmed Cell Death 1 Receptor/antagonists & inhibitors

An SNP-dependent cancer-testis antigenic epitope serves as a promising immunotherapeutic target for cancer.

Autoren: Murata K Minowa T Tsukahara T et al.

Quelle: Oncoimmunology [Oncoimmunology] 2025 Dec; Vol. 14 (1), pp. 2528110. Date of Electronic Publication: 2025 Jul 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE

MeSH-Schlagworte: Antigens, Neoplasm*/immunology , Antigens, Neoplasm*/genetics , Polymorphism, Single Nucleotide* , Melanoma*/immunology , Melanoma*/genetics , Melanoma*/therapy , Epitopes*/immunology , Epitopes*/genetics , Epitopes, T-Lymphocyte*/immunology , Epitopes, T-Lymphocyte*/genetics , Neoplasm Proteins*/immunology , Neoplasm Proteins*/genetics, Humans ; Male ; Immunotherapy/methods ; Lymphocytes, Tumor-Infiltrating/immunology ; Testis/immunology ; Receptors, Antigen, T-Cell/immunology