Search Results - "NUCLEIC acids"

Evaluation of single-template ligand-based methods for the discovery of small-molecule nucleic acid binders.

Authors: Bajusz D Rácz A Bujnicki JM et al.

Source: Briefings in bioinformatics [Brief Bioinform] 2025 Nov 01; Vol. 26 (6).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100912837 Publication Model: Print Cited Medium: Internet ISSN: 1477-4054 (Electronic) Linking ISSN: 14675463 NLM ISO Abbreviation: Brief Bioinform Subsets: MEDLINE

MeSH Terms: Drug Discovery*/methods , Small Molecule Libraries*/chemistry , Small Molecule Libraries*/pharmacology , Nucleic Acids*/chemistry , Nucleic Acids*/metabolism , DNA*/chemistry , DNA*/metabolism , RNA*/chemistry, Ligands ; Molecular Docking Simulation ; Algorithms ; Nucleic Acid Conformation

Self-Assembled Tetrahedral Framework Nucleic Acids Alleviate Pulmonary Hypertension by Regulating Calcium Homeostasis.

Authors: Yang L Hou W Lan J et al.

Source: Advanced healthcare materials [Adv Healthc Mater] 2025 Nov; Vol. 14 (30), pp. e02810. Date of Electronic Publication: 2025 Aug 11.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE

MeSH Terms: Hypertension, Pulmonary*/metabolism , Hypertension, Pulmonary*/drug therapy , Hypertension, Pulmonary*/pathology , Calcium*/metabolism , Homeostasis*/drug effects , Nucleic Acids*/chemistry , Nucleic Acids*/pharmacology, Animals ; Pulmonary Artery/metabolism ; Pulmonary Artery/pathology ; Male ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/drug effects ; Mice ; Rats ; Cell Proliferation/drug effects ; Humans

Copy number variations in urine cell-free DNA from bladder neoplasm patients.

Authors: Haider CG Wang Q Wang G et al.

Source: Molecular and cellular probes [Mol Cell Probes] 2025 Oct; Vol. 83, pp. 102044. Date of Electronic Publication: 2025 Jul 18.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 8709751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1194 (Electronic) Linking ISSN: 08908508 NLM ISO Abbreviation: Mol Cell Probes Subsets: MEDLINE

MeSH Terms: Urinary Bladder Neoplasms*/genetics , Urinary Bladder Neoplasms*/urine , DNA Copy Number Variations*/genetics , Cell-Free Nucleic Acids*/urine , Cell-Free Nucleic Acids*/genetics, Humans ; Male ; Female ; Middle Aged ; Aged ; High-Throughput Nucleotide Sequencing

CRISPR-based non-nucleic acid detection.

Authors: Zhang S Xu D Li F et al.

Source: Trends in biotechnology [Trends Biotechnol] 2025 Oct; Vol. 43 (10), pp. 2494-2508. Date of Electronic Publication: 2025 May 14.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 8310903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3096 (Electronic) Linking ISSN: 01677799 NLM ISO Abbreviation: Trends Biotechnol Subsets: MEDLINE

MeSH Terms: CRISPR-Cas Systems*/genetics , Clustered Regularly Interspaced Short Palindromic Repeats*/genetics , Nucleic Acids*/genetics , Nucleic Acids*/analysis, Gene Editing/methods ; Humans

Two-step ultrasonic cavitation controlled delivery of brain exogenous nucleic acids for ischemic stroke using acoustic-cationic-polymeric-nanodroplets.

Authors: Dong W Wang G Chai Y et al.

Source: Drug delivery and translational research [Drug Deliv Transl Res] 2025 Oct; Vol. 15 (10), pp. 3695-3715. Date of Electronic Publication: 2025 Mar 06.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE

MeSH Terms: Nanoparticle Drug Delivery System* , Nucleic Acids*/administration & dosage , Nucleic Acids*/therapeutic use , Ischemic Stroke*/therapy, Ultrasonics ; Genetic Therapy ; Blood-Brain Barrier ; Male ; Animals ; Rats ; Rats, Sprague-Dawley ; Cations ; Polymers

Aptamer-mediated liver-targeted curcumin delivery system based on tetrahedral framework nucleic acids for NAFLD.

Authors: Chen S Liu Y Ma S et al.

Source: Drug delivery [Drug Deliv] 2025 Dec 31; Vol. 32 (1), pp. 2576222. Date of Electronic Publication: 2025 Nov 09.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9417471 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0464 (Electronic) Linking ISSN: 10717544 NLM ISO Abbreviation: Drug Deliv Subsets: MEDLINE

MeSH Terms: Curcumin*/administration & dosage , Curcumin*/chemistry , Non-alcoholic Fatty Liver Disease*/drug therapy , Non-alcoholic Fatty Liver Disease*/metabolism , Drug Delivery Systems*/methods , Aptamers, Nucleotide*/chemistry , Liver*/metabolism , Liver*/drug effects , Nucleic Acids*/chemistry, Humans ; Animals ; Solubility ; Drug Carriers/chemistry ; SELEX Aptamer Technique/methods ; Biological Availability

Cell-free DNA in sepsis: from molecular insights to clinical management.

Authors: Li L Huang HC He Y et al.

Source: Military Medical Research [Mil Med Res] 2025 Dec 02; Vol. 12 (1), pp. 85. Date of Electronic Publication: 2025 Dec 02.

Publication Type: Journal Article; Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101643181 Publication Model: Electronic Cited Medium: Internet ISSN: 2054-9369 (Electronic) Linking ISSN: 20549369 NLM ISO Abbreviation: Mil Med Res Subsets: MEDLINE

MeSH Terms: Sepsis*/physiopathology , Sepsis*/blood , Sepsis*/therapy , Sepsis*/diagnosis , Cell-Free Nucleic Acids*/analysis , Cell-Free Nucleic Acids*/blood, Humans ; Biomarkers/analysis ; Biomarkers/blood ; Extracellular Traps

Functions and applications of enzymes in nucleic acid nanotechnology.

Authors: Rong Q Chu Z Xu Y et al.

Source: Journal of nanobiotechnology [J Nanobiotechnology] 2025 Dec 02; Vol. 23 (1), pp. 750. Date of Electronic Publication: 2025 Dec 02.

Publication Type: Journal Article; Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE

MeSH Terms: Nanotechnology*/methods , Nucleic Acids*/chemistry , Nucleic Acids*/metabolism , Enzymes*/metabolism , Enzymes*/chemistry, Nanostructures/chemistry ; Humans ; Animals ; DNA, Catalytic/metabolism ; DNA, Catalytic/chemistry ; DNA/chemistry

Ultrasensitive Nucleic Acid Testing: From Foundational Research to Clinical Translation.

Authors: Li B Gu X Zeng W et al.

Source: ACS nano [ACS Nano] 2025 Dec 02; Vol. 19 (47), pp. 40304-40344. Date of Electronic Publication: 2025 Nov 19.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE

MeSH Terms: Nucleic Acids*/analysis , Nucleic Acids*/genetics , Translational Research, Biomedical*, Humans ; Biosensing Techniques/methods ; Nanotechnology/methods ; Polymerase Chain Reaction ; Limit of Detection

Valence-programmable nucleic acid constructs targeting FGFR1 for promotion of tissue regeneration.

Authors: Wang J Wang X He F et al.

Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 Dec 02; Vol. 61 (97), pp. 19297-19300. Date of Electronic Publication: 2025 Dec 02.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

MeSH Terms: Receptor, Fibroblast Growth Factor, Type 1*/metabolism , Receptor, Fibroblast Growth Factor, Type 1*/agonists , Regeneration*/drug effects , DNA*/chemistry , DNA*/pharmacology , Nucleic Acids*/chemistry , Nucleic Acids*/pharmacology, Animals ; Cell Proliferation/drug effects ; Humans ; Mice ; Cell Movement/drug effects

[Correlation analysis of cell-free DNA in gingival crevicular fluid with periodontal clinical indicators and cyclic guanosine phosphate-adenosine phosphate synthase-stimulator of interferon genes signaling pathway].

Authors: Chen L Zhu X Zhou J et al.

Source: Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology [Hua Xi Kou Qiang Yi Xue Za Zhi] 2025 Dec 01; Vol. 43 (6), pp. 808-818.

Publication Type: English Abstract; Journal Article

Journal Info: Publisher: Sichuan yi xue yuan Country of Publication: China NLM ID: 9422648 Publication Model: Print Cited Medium: Internet ISSN: 2618-0456 (Electronic) Linking ISSN: 10001182 NLM ISO Abbreviation: Hua Xi Kou Qiang Yi Xue Za Zhi Subsets: MEDLINE

MeSH Terms: Gingival Crevicular Fluid*/chemistry , Gingival Crevicular Fluid*/metabolism , Signal Transduction* , Nucleotidyltransferases*/metabolism , Nucleotidyltransferases*/genetics , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Cell-Free Nucleic Acids*/metabolism , Cell-Free Nucleic Acids*/analysis , Periodontitis*/metabolism, Humans ; Gingiva/metabolism ; Gingiva/cytology ; Fibroblasts/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Adult ; RNA, Messenger/metabolism ; Male ; Female

Identification of maternal ^G γ( ^A γδβ) ⁰ thalassemia through retrospective reanalysis of prenatal cfDNA sequencing data.

Authors: Zhu X Hu L Pei Y et al.

Source: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2596498. Date of Electronic Publication: 2025 Dec 02.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH Terms: Cell-Free Nucleic Acids*/genetics , Cell-Free Nucleic Acids*/analysis , Prenatal Diagnosis*/methods , Thalassemia*/diagnosis , Thalassemia*/genetics , Noninvasive Prenatal Testing*/methods, Humans ; Female ; Pregnancy ; Retrospective Studies ; DNA Copy Number Variations/genetics ; Adult ; China/epidemiology

Associations between donor-derived cell-free DNA dynamics and clinical outcomes after kidney allograft rejection: A prospective, multicenter study.

Authors: Bunnapradist S Leca N Zaky ZS et al.

Corporate Authors: Bunnapradist S Leca N Zaky ZS et al.

Source: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2025 Dec; Vol. 25 (12), pp. 2543-2553. Date of Electronic Publication: 2025 Jul 23.

Publication Type: Journal Article; Multicenter Study

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE

MeSH Terms: Kidney Transplantation*/adverse effects , Graft Rejection*/etiology , Graft Rejection*/blood , Graft Rejection*/diagnosis , Graft Rejection*/pathology , Tissue Donors* , Cell-Free Nucleic Acids*/blood , Cell-Free Nucleic Acids*/genetics , Kidney Failure, Chronic*/surgery , Biomarkers*/blood , Postoperative Complications*, Humans ; Prospective Studies ; Female ; Male ; Middle Aged ; Prognosis ; Graft Survival ; Follow-Up Studies ; Adult ; Risk Factors ; Glomerular Filtration Rate ; Kidney Function Tests

Effects of acute psychological stress on blood cell-free mitochondrial DNA (cf-mtDNA): A crossover experimental study.

Authors: Trumpff C Shire D Lee S et al.

Source: Psychoneuroendocrinology [Psychoneuroendocrinology] 2025 Dec; Vol. 182, pp. 107644. Date of Electronic Publication: 2025 Oct 12.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE

MeSH Terms: Stress, Psychological*/metabolism , Stress, Psychological*/blood , Stress, Psychological*/physiopathology , Cell-Free Nucleic Acids*/blood , Cell-Free Nucleic Acids*/analysis , DNA, Mitochondrial*/blood , DNA, Mitochondrial*/analysis, Humans ; Female ; Cross-Over Studies ; Male ; Adult ; Hydrocortisone/analysis ; Hydrocortisone/blood ; Cytokines/blood ; Cytokines/analysis ; Middle Aged ; Young Adult ; Anxiety/metabolism ; Anxiety/blood ; Heart Rate/physiology ; Interleukin-6/blood ; Interleukin-6/analysis ; Catecholamines/blood ; Catecholamines/analysis ; Norepinephrine/blood ; Norepinephrine/analysis ; Blood Pressure/physiology ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/analysis ; Interleukin-10/blood ; Interleukin-10/analysis

Comparative Performance of a Targeted Next-Generation Sequencing Assay Against Multiplexed Digital PCR Assays in Detecting ERBB2, ESR1, and PIK3CA Mutations in Plasma Circulating Cell-Free DNA from Liquid Biopsies.

Authors: Corné J Godey F Legros A et al.

Source: The Journal of molecular diagnostics : JMD [J Mol Diagn] 2025 Dec; Vol. 27 (12), pp. 1202-1212. Date of Electronic Publication: 2025 Oct 08.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100893612 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-7811 (Electronic) Linking ISSN: 15251578 NLM ISO Abbreviation: J Mol Diagn Subsets: MEDLINE

MeSH Terms: Class I Phosphatidylinositol 3-Kinases*/genetics , Estrogen Receptor alpha*/genetics , High-Throughput Nucleotide Sequencing*/methods , Mutation* , Receptor, ErbB-2*/genetics , Breast Neoplasms*/genetics , Breast Neoplasms*/blood , Breast Neoplasms*/diagnosis , Breast Neoplasms*/pathology , Multiplex Polymerase Chain Reaction*/methods , Circulating Tumor DNA*/genetics , Circulating Tumor DNA*/blood , Cell-Free Nucleic Acids*/blood , Cell-Free Nucleic Acids*/genetics, Humans ; Liquid Biopsy/methods ; Female ; DNA Mutational Analysis/methods

Cell-free DNA screening results by stage of maternal malignancy.

Authors: Zhao E Miller KA Webster J et al.

Source: American journal of obstetrics & gynecology MFM [Am J Obstet Gynecol MFM] 2025 Dec; Vol. 7 (12), pp. 101804. Date of Electronic Publication: 2025 Sep 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101746609 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-9333 (Electronic) Linking ISSN: 25899333 NLM ISO Abbreviation: Am J Obstet Gynecol MFM Subsets: MEDLINE

MeSH Terms: Cell-Free Nucleic Acids*/blood , Cell-Free Nucleic Acids*/analysis , Pregnancy Complications, Neoplastic*/diagnosis , Pregnancy Complications, Neoplastic*/blood , Pregnancy Complications, Neoplastic*/genetics , Pregnancy Complications, Neoplastic*/pathology , Neoplasms*/diagnosis , Prenatal Diagnosis*/methods, Humans ; Female ; Retrospective Studies ; Pregnancy ; Adult ; Neoplasm Staging ; Aneuploidy ; Pregnancy Trimester, First

Impact of large-scale magnetic particle synthesis on nucleic acid extraction consistency and efficiency.

Authors: Stejskalová P Ženka M Šplíchal Z et al.

Source: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2025 Dec; Vol. 256 (Pt 1), pp. 114975. Date of Electronic Publication: 2025 Jul 23.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE

MeSH Terms: Nucleic Acids*/isolation & purification , Nucleic Acids*/chemistry , DNA, Viral*/isolation & purification , RNA, Viral*/isolation & purification, Particle Size ; Hepacivirus/genetics ; Hepacivirus/chemistry

A Prospective Pilot Study to Investigate Whether Donor-Derived Cell-Free DNA Can Be Used as a Biomarker of Recurrent IgA Nephropathy Post-Kidney Transplantation.

Authors: Asiedu-Basoah JO Weston S Barratt J et al.

Source: International journal of immunogenetics [Int J Immunogenet] 2025 Dec; Vol. 52 (6), pp. 342-351. Date of Electronic Publication: 2025 Aug 28.

Publication Type: Journal Article

Journal Info: Publisher: Blackwell Pub Country of Publication: England NLM ID: 101232337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-313X (Electronic) Linking ISSN: 17443121 NLM ISO Abbreviation: Int J Immunogenet Subsets: MEDLINE

MeSH Terms: Glomerulonephritis, IGA*/blood , Glomerulonephritis, IGA*/diagnosis , Glomerulonephritis, IGA*/genetics , Glomerulonephritis, IGA*/pathology , Kidney Transplantation*/adverse effects , Biomarkers*/blood , Cell-Free Nucleic Acids*/blood , Cell-Free Nucleic Acids*/genetics, Humans ; Male ; Female ; Pilot Projects ; Adult ; Prospective Studies ; Middle Aged ; Recurrence ; Tissue Donors ; Glomerular Filtration Rate

Nucleic acid-encoded antibody gene transfer-next generation of antibody therapies.

Authors: Yu K Xiao G Chen B et al.

Source: Drug delivery [Drug Deliv] 2025 Dec; Vol. 32 (1), pp. 2566782. Date of Electronic Publication: 2025 Oct 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9417471 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0464 (Electronic) Linking ISSN: 10717544 NLM ISO Abbreviation: Drug Deliv Subsets: MEDLINE

MeSH Terms: Antibodies, Monoclonal*/genetics , Antibodies, Monoclonal*/administration & dosage , Nucleic Acids*/genetics , Nucleic Acids*/administration & dosage , Gene Transfer Techniques*, Humans ; Animals ; Immunotherapy/methods

Diagnosing tuberculous meningitis from cell-free DNA by multi-targeted real-time PCR: An experience from 170 cases.

Authors: Sharma K Sharma M Shree R et al.

Source: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2025 Dec; Vol. 155, pp. 102705. Date of Electronic Publication: 2025 Oct 29.

Publication Type: Journal Article; Evaluation Study

Journal Info: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100971555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-281X (Electronic) Linking ISSN: 14729792 NLM ISO Abbreviation: Tuberculosis (Edinb) Subsets: MEDLINE

MeSH Terms: Tuberculosis, Meningeal*/diagnosis , Tuberculosis, Meningeal*/microbiology , Tuberculosis, Meningeal*/cerebrospinal fluid , Tuberculosis, Meningeal*/drug therapy , Cell-Free Nucleic Acids*/cerebrospinal fluid , Cell-Free Nucleic Acids*/genetics , Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/isolation & purification , Mycobacterium tuberculosis*/drug effects , DNA, Bacterial*/genetics , DNA, Bacterial*/cerebrospinal fluid , Real-Time Polymerase Chain Reaction*/methods, Humans ; Male ; Female ; Predictive Value of Tests ; Adult ; Middle Aged ; Young Adult ; Adolescent ; Child ; Reproducibility of Results ; Aged ; Case-Control Studies