Výsledky vyhľadávania - "NF-kappa B"

Discovery of an NF-κB1 p105 Degrader for Anti-Inflammatory Therapy via Structural Optimization of the Coumarin Natural Product Minutuminolate.

Autori: Choo MZY Lim ET Wong WSF a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Jun 12; Vol. 68 (11), pp. 11081-11099. Date of Electronic Publication: 2025 May 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Coumarins*/pharmacology , Coumarins*/chemistry , Coumarins*/chemical synthesis , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Biological Products*/pharmacology , Biological Products*/chemistry , NF-kappa B p50 Subunit*/metabolism , NF-kappa B p50 Subunit*/antagonists & inhibitors , Drug Discovery*, Structure-Activity Relationship ; Humans ; Animals ; Mice ; NF-kappa B/metabolism

The host restriction factor SERINC5 inhibits HIV-1 transcription by negatively regulating NF-κB signaling.

Autori: Li W Qu M Zhang T a ďalší

Zdroj: The Journal of biological chemistry [J Biol Chem] 2025 Jan; Vol. 301 (1), pp. 108058. Date of Electronic Publication: 2024 Dec 07.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: HIV-1*/genetics , HIV-1*/physiology , HIV-1*/metabolism , Signal Transduction* , Transcription, Genetic* , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , NF-kappa B*/metabolism , NF-kappa B*/genetics , Gene Expression Regulation, Viral*, Humans ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/genetics ; HEK293 Cells ; Receptors, Immunologic ; DEAD Box Protein 58 ; DEAD-box RNA Helicases/metabolism ; DEAD-box RNA Helicases/genetics ; Ubiquitination ; Transcription Factor RelA/metabolism ; Transcription Factor RelA/genetics ; Tripartite Motif Proteins ; Virus Replication ; HIV Infections/metabolism ; HIV Infections/genetics ; NF-kappa B p50 Subunit/metabolism ; NF-kappa B p50 Subunit/genetics ; HIV Long Terminal Repeat

Assessing the association between common functional Nuclear Factor Kappa-b gene polymorphisms (NFKB1, NFKBIZ, NFKBIA) and Alzheimer´s disease.

Autori: Vazquez-Coto D Perez-Oliveira S Menéndez-González M a ďalší

Zdroj: Behavioural brain research [Behav Brain Res] 2025 Jan 05; Vol. 476, pp. 115264. Date of Electronic Publication: 2024 Sep 23.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/genetics , NF-kappa B p50 Subunit*/genetics , NF-KappaB Inhibitor alpha*/genetics , Genetic Predisposition to Disease*/genetics , Polymorphism, Single Nucleotide*, Humans ; Female ; Male ; Aged ; Aged, 80 and over ; NF-kappa B/genetics ; Genotype ; Genetic Association Studies ; I-kappa B Proteins/genetics ; Spain ; Adaptor Proteins, Signal Transducing

Disseminated tuberculosis is associated with impaired T cell immunity mediated by non-canonical NF-κB pathway.

Autori: Jiang J Cao Z Li B a ďalší

Zdroj: The Journal of infection [J Infect] 2024 Sep; Vol. 89 (3), pp. 106231. Date of Electronic Publication: 2024 Jul 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: W.B. Saunders Country of Publication: England NLM ID: 7908424 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2742 (Electronic) Linking ISSN: 01634453 NLM ISO Abbreviation: J Infect Subsets: MEDLINE

Výrazy zo slovníka MeSH: Signal Transduction* , NF-kappa B*/metabolism , Interferon-gamma*/metabolism , Interferon-gamma*/genetics , Interferon-gamma*/immunology , Tumor Necrosis Factor-alpha*/metabolism , Tumor Necrosis Factor-alpha*/genetics, Humans ; Male ; Female ; Adult ; Middle Aged ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Tuberculosis/immunology ; Transcription Factor RelB/metabolism ; Transcription Factor RelB/genetics ; NF-kappa B p52 Subunit/metabolism ; NF-kappa B p52 Subunit/genetics ; Single-Cell Analysis ; CD8-Positive T-Lymphocytes/immunology ; Lymphotoxin-alpha/genetics ; Lymphotoxin-alpha/metabolism ; Young Adult ; Aged ; Gene Expression Profiling ; Mycobacterium tuberculosis/immunology

Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies.

Autori: Deka A Kumar N Basu S a ďalší

Zdroj: The EMBO journal [EMBO J] 2024 Sep; Vol. 43 (18), pp. 3895-3915. Date of Electronic Publication: 2024 Jul 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Dendritic Cells*/immunology , Dendritic Cells*/metabolism , beta Catenin*/metabolism , beta Catenin*/genetics , Signal Transduction* , NF-kappa B*/metabolism , Colitis*/immunology , Colitis*/metabolism , Colitis*/chemically induced , Colitis*/pathology , Colitis*/genetics, Animals ; Mice ; Transcription Factor RelB/metabolism ; Transcription Factor RelB/genetics ; Retinal Dehydrogenase/metabolism ; Retinal Dehydrogenase/genetics ; Humans ; Mice, Inbred C57BL ; NF-kappa B p52 Subunit/metabolism ; NF-kappa B p52 Subunit/genetics ; Disease Models, Animal ; Mice, Knockout ; Immune Tolerance ; Tretinoin/metabolism ; Aldehyde Oxidoreductases

Exopolysaccharide from Lacticaseibacillus rhamnosus IR06 as a potential postbiotics attenuates photoaging through regulation of MAPK and NF-κB signaling.

Autori: Kim JH Lee WJ Choi KY a ďalší

Zdroj: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 843-856. Date of Electronic Publication: 2025 Sep 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Polysaccharides, Bacterial*/pharmacology , Polysaccharides, Bacterial*/chemistry , NF-kappa B*/metabolism , NF-kappa B*/genetics , Skin Aging*/drug effects , Skin Aging*/radiation effects , Lacticaseibacillus rhamnosus*/chemistry, Humans ; Ultraviolet Rays/adverse effects ; Reactive Oxygen Species/metabolism ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Keratinocytes/radiation effects ; Signal Transduction/drug effects ; MAP Kinase Signaling System/drug effects ; Probiotics ; Antioxidants/pharmacology ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism

TLR-2/4 inhibition accelerates bone repair via modulating MyD88/NF-κB signaling and inflammatory microenvironment.

Autori: Chen Q Tang X Cao X a ďalší

Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Dec 15; Vol. 792, pp. 152994. Date of Electronic Publication: 2025 Nov 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/immunology , Toll-Like Receptor 2*/antagonists & inhibitors , Toll-Like Receptor 2*/metabolism , Toll-Like Receptor 2*/immunology , NF-kappa B*/metabolism , NF-kappa B*/immunology , Fracture Healing*/drug effects , Toll-Like Receptor 4*/antagonists & inhibitors , Toll-Like Receptor 4*/metabolism, Animals ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Male ; Rats ; Inflammation/pathology ; Inflammation/metabolism ; Sulfonamides/pharmacology ; Cellular Microenvironment/drug effects

18β-glycyrrhetinic acid-amantadine hybrid: Synthesis and anti-EMCV activity via NF-κB modulation.

Autori: Xue W Zhang T Wen Y a ďalší

Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 15; Vol. 131, pp. 118431. Date of Electronic Publication: 2025 Oct 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glycyrrhetinic Acid*/chemistry , Glycyrrhetinic Acid*/pharmacology , Glycyrrhetinic Acid*/analogs & derivatives , Glycyrrhetinic Acid*/chemical synthesis , Antiviral Agents*/pharmacology , Antiviral Agents*/chemical synthesis , Antiviral Agents*/chemistry , NF-kappa B*/metabolism , NF-kappa B*/antagonists & inhibitors , Encephalomyocarditis virus*/drug effects , Amantadine*/chemistry , Amantadine*/pharmacology , Amantadine*/chemical synthesis, Humans ; Animals ; Mice ; HEK293 Cells ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests

Isoquercetin mitigates neuroinflammation and oxidative stress by targeting the NF-κB pathway.

Autori: Kaur D Singh S

Zdroj: Brain research [Brain Res] 2025 Dec 15; Vol. 1869, pp. 150004. Date of Electronic Publication: 2025 Oct 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: NF-kappa B*/metabolism , NF-kappa B*/drug effects , Oxidative Stress*/drug effects , Neuroprotective Agents*/pharmacology , Neuroinflammatory Diseases*/metabolism , Neuroinflammatory Diseases*/drug therapy , Quercetin*/pharmacology , Quercetin*/analogs & derivatives, Animals ; Zebrafish ; Signal Transduction/drug effects ; Male ; Disease Models, Animal

TLR2/NF-κB signaling could oversee the function of CD56bright NK cells in patients afflicted with severe fever and thrombocytopenia syndrome (SFTS).

Autori: Li MM Yue HR Wang J a ďalší

Zdroj: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115627. Date of Electronic Publication: 2025 Sep 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Killer Cells, Natural*/immunology , Toll-Like Receptor 2*/metabolism , Toll-Like Receptor 2*/immunology , NF-kappa B*/metabolism , NF-kappa B*/immunology , Severe Fever with Thrombocytopenia Syndrome*/immunology , Phlebovirus*/immunology, Humans ; Signal Transduction ; CD56 Antigen/metabolism ; Middle Aged ; Male ; Female ; Aged ; Adult ; Cells, Cultured

Sphingomyelin Synthase 2 Deletion Mitigates Oxidative Stress-Induced NF-κB Activation via Lipid Metabolic Reprogramming in Dry Eye Disease.

Autori: Lu Y Wan X Ye H a ďalší

Zdroj: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2025 Dec 01; Vol. 66 (15), pp. 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Oxidative Stress*/physiology , Dry Eye Syndromes*/metabolism , Dry Eye Syndromes*/genetics , Dry Eye Syndromes*/pathology , NF-kappa B*/metabolism , NF-kappa B*/genetics , Transferases (Other Substituted Phosphate Groups)*/genetics , Transferases (Other Substituted Phosphate Groups)*/biosynthesis , Lipid Metabolism*/physiology , Gene Expression Regulation*, Animals ; Mice ; Mice, Knockout ; Epithelium, Corneal/metabolism ; Epithelium, Corneal/pathology ; Humans ; Disease Models, Animal ; Real-Time Polymerase Chain Reaction ; Blotting, Western ; Enzyme-Linked Immunosorbent Assay ; Mice, Inbred C57BL ; Cells, Cultured ; Tears/metabolism ; Metabolic Reprogramming

YTHDC2 promotes sepsis-induced cardiomyopathy by activating apoptosis and NF-κB pathway.

Autori: Wang W Zhang TN Wang ZM a ďalší

Zdroj: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2597565. Date of Electronic Publication: 2025 Dec 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

Výrazy zo slovníka MeSH: Apoptosis* , Cardiomyopathies*/etiology , Cardiomyopathies*/metabolism , Cardiomyopathies*/genetics , Sepsis*/complications , Signal Transduction* , NF-kappa B*/metabolism , NF-kappa B*/genetics , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics, Animals ; Rats ; Myocytes, Cardiac/metabolism ; Lipopolysaccharides ; Rats, Sprague-Dawley ; Male ; Cell Line ; Adenosine/analogs & derivatives

Inhibition of mycobacteria proliferation in macrophages by diaryl ether derivatives of Dehydrozingerone compound and repurposed drugs (Rebamipide, Sofalcone) via NF-κB pathway inhibition.

Autori: Mehraj S Ali S Kumar C a ďalší

Zdroj: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2025 Dec; Vol. 155, pp. 102706. Date of Electronic Publication: 2025 Nov 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100971555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-281X (Electronic) Linking ISSN: 14729792 NLM ISO Abbreviation: Tuberculosis (Edinb) Subsets: MEDLINE

Výrazy zo slovníka MeSH: NF-kappa B*/metabolism , NF-kappa B*/antagonists & inhibitors , Macrophages*/drug effects , Macrophages*/microbiology , Macrophages*/metabolism , Macrophages*/immunology , Mycobacterium smegmatis*/drug effects , Mycobacterium smegmatis*/growth & development , Mycobacterium smegmatis*/pathogenicity , Quinolones*/pharmacology , Chalcones*/pharmacology , Antitubercular Agents*/pharmacology, Humans ; Signal Transduction/drug effects ; Reactive Oxygen Species/metabolism ; THP-1 Cells ; Drug Repositioning ; I-kappa B Kinase/metabolism ; Matrix Metalloproteinase 9/metabolism ; Matrix Metalloproteinase 2/metabolism ; Microbial Viability/drug effects ; Host-Pathogen Interactions ; Alanine/analogs & derivatives

Pyxinol derivative suppresses LPS-induced inflammation by targeting the p65-p50 heterodimer.

Autori: Luan X Zou Z Chen J a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109269. Date of Electronic Publication: 2025 Nov 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Inflammation*/drug therapy , Inflammation*/chemically induced , Inflammation*/metabolism , Transcription Factor RelA*/metabolism , Transcription Factor RelA*/antagonists & inhibitors , NF-kappa B p50 Subunit*/metabolism , NF-kappa B p50 Subunit*/antagonists & inhibitors , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/chemical synthesis , Ginsenosides*/pharmacology , Ginsenosides*/chemistry , Ginsenosides*/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemistry , Anti-Inflammatory Agents, Non-Steroidal*/chemical synthesis, Animals ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Mice ; RAW 264.7 Cells ; Molecular Structure ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/biosynthesis ; Male

S100A8 and S100A9-mediated keratinocyte affecting T lymphocyte immune imbalance through TLR4/NF-κ B in psoriasis.

Autori: He Y Xing J Li J a ďalší

Zdroj: Acta histochemica [Acta Histochem] 2025 Dec; Vol. 127 (4), pp. 152297. Date of Electronic Publication: 2025 Nov 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 0370320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0372 (Electronic) Linking ISSN: 00651281 NLM ISO Abbreviation: Acta Histochem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Psoriasis*/immunology , Psoriasis*/metabolism , Psoriasis*/pathology , Psoriasis*/chemically induced , Calgranulin B*/metabolism , Calgranulin B*/genetics , Calgranulin B*/immunology , Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/immunology , Toll-Like Receptor 4*/genetics , Keratinocytes*/metabolism , Keratinocytes*/immunology , Keratinocytes*/pathology , Calgranulin A*/metabolism , Calgranulin A*/genetics , Calgranulin A*/immunology , NF-kappa B*/metabolism , NF-kappa B*/immunology , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism, Humans ; Animals ; Mice ; Signal Transduction ; Imiquimod ; Male ; Cytokines/metabolism ; Disease Models, Animal

Dehydroepiandrosterone opposes cardiac aging via NFκB/IL-10/Sirt1/Nrf2 mediated pathway in aged rats.

Autori: Naguib YM Rizk MS Abo-Elsoud RAA

Zdroj: Experimental gerontology [Exp Gerontol] 2025 Dec; Vol. 212, pp. 112968. Date of Electronic Publication: 2025 Nov 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0047061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6815 (Electronic) Linking ISSN: 05315565 NLM ISO Abbreviation: Exp Gerontol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Dehydroepiandrosterone*/pharmacology , Sirtuin 1*/metabolism , Sirtuin 1*/genetics , NF-kappa B*/metabolism , NF-kappa B*/genetics , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , Aging*/drug effects , Aging*/physiology , Aging*/metabolism , Heart*/drug effects , Heart*/physiology, Animals ; Male ; Rats, Wistar ; Oxidative Stress/drug effects ; Interleukin-10/metabolism ; Interleukin-10/genetics ; Rats ; Signal Transduction/drug effects ; Myocardium/metabolism

Leonurine improves manifestation of chronic obstructive pulmonary disease in rats by inhibiting NF-κB and JAK2/STAT3 signaling pathways.

Autori: Peng S Sun YY Chu Q a ďalší

Zdroj: Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2025 Dec; Vol. 47 (6), pp. 847-858. Date of Electronic Publication: 2025 Nov 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8800150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2513 (Electronic) Linking ISSN: 08923973 NLM ISO Abbreviation: Immunopharmacol Immunotoxicol Subsets: MEDLINE

Výrazy zo slovníka MeSH: STAT3 Transcription Factor*/metabolism , STAT3 Transcription Factor*/antagonists & inhibitors , STAT3 Transcription Factor*/immunology , Janus Kinase 2*/metabolism , Janus Kinase 2*/antagonists & inhibitors , Janus Kinase 2*/immunology , Pulmonary Disease, Chronic Obstructive*/drug therapy , Pulmonary Disease, Chronic Obstructive*/metabolism , Pulmonary Disease, Chronic Obstructive*/chemically induced , Pulmonary Disease, Chronic Obstructive*/pathology , Pulmonary Disease, Chronic Obstructive*/immunology , NF-kappa B*/metabolism , NF-kappa B*/antagonists & inhibitors , NF-kappa B*/immunology , Signal Transduction*/drug effects , Gallic Acid*/analogs & derivatives , Gallic Acid*/pharmacology , Gallic Acid*/therapeutic use, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Oxidative Stress/drug effects ; Lipopolysaccharides/toxicity

RSAD2 inhibits Senecavirus A replication by promoting type I interferons induction downstream of cGAS-STING and NF-κB signaling pathway.

Autori: Li H Mo J Li S a ďalší

Zdroj: Veterinary microbiology [Vet Microbiol] 2025 Dec; Vol. 311, pp. 110777. Date of Electronic Publication: 2025 Oct 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Scientific Pub. Co Country of Publication: Netherlands NLM ID: 7705469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2542 (Electronic) Linking ISSN: 03781135 NLM ISO Abbreviation: Vet Microbiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Signal Transduction* , NF-kappa B*/metabolism , NF-kappa B*/genetics , Virus Replication* , Interferon Type I*/genetics , Interferon Type I*/metabolism , Interferon Type I*/immunology , Nucleotidyltransferases*/metabolism , Nucleotidyltransferases*/genetics , Picornaviridae*/physiology, Animals ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Swine ; Immunity, Innate ; Humans

SCR Organism: Senecavirus A

Tussilagone suppresses triple-negative breast cancer progression by inhibiting the TLR4/NF-κB pathway and enhancing anti-tumor immunity.

Autori: Huang R Yu H Tang Z

Zdroj: Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2025 Dec; Vol. 47 (6), pp. 740-750. Date of Electronic Publication: 2025 Sep 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8800150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2513 (Electronic) Linking ISSN: 08923973 NLM ISO Abbreviation: Immunopharmacol Immunotoxicol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/immunology , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/metabolism , Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/antagonists & inhibitors , Toll-Like Receptor 4*/immunology , NF-kappa B*/metabolism , NF-kappa B*/antagonists & inhibitors , NF-kappa B*/immunology , Sesquiterpenes*/pharmacology, Humans ; Female ; Animals ; Mice ; Cell Line, Tumor ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Xenograft Model Antitumor Assays ; Epithelial-Mesenchymal Transition/drug effects ; Mice, Nude ; Cell Proliferation/drug effects ; Mice, Inbred BALB C ; Disease Progression

Asterosaponin CN-3 performs an anti-glioma effect by inhibiting the migration and invasion of glioma cells through the regulation of miR-4465/HMGA1/NF-κB signaling pathway.

Autori: Du Y Qiu PC Li TY a ďalší

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 3), pp. 117355. Date of Electronic Publication: 2025 Sep 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Saponins*/pharmacology , Saponins*/therapeutic use , Glioma*/drug therapy , Glioma*/metabolism , Glioma*/pathology , MicroRNAs*/metabolism , MicroRNAs*/genetics , Cell Movement*/drug effects , Cell Movement*/physiology , NF-kappa B*/metabolism , NF-kappa B*/genetics , HMGA1a Protein*/metabolism , HMGA1a Protein*/genetics , Steroids*/pharmacology , Steroids*/therapeutic use , Brain Neoplasms*/metabolism , Brain Neoplasms*/drug therapy , Brain Neoplasms*/pathology, Humans ; Cell Line, Tumor ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Neoplasm Invasiveness ; Animals ; Mice, Nude ; Mice ; Mice, Inbred BALB C ; Gene Expression Regulation, Neoplastic/drug effects