Suchergebnisse - "NECROSIS"

TNFR1 and TNFR2 levels in patients with severe alcohol use disorder undergoing withdrawal and their relationship with delirium tremens.

Autoren: Hsu SH Huang MC Liu TH et al.

Quelle: Brain, behavior, and immunity [Brain Behav Immun] 2025 Oct; Vol. 129, pp. 409-415. Date of Electronic Publication: 2025 Jun 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Tumor Necrosis Factor, Type II*/blood , Receptors, Tumor Necrosis Factor, Type I*/blood , Alcoholism*/blood , Alcoholism*/complications , Alcohol Withdrawal Delirium*/blood , Alcohol Withdrawal Delirium*/metabolism , Substance Withdrawal Syndrome*/blood, Humans ; Male ; Female ; Middle Aged ; Adult ; Tumor Necrosis Factor-alpha/blood

Association between serum cytokine levels with pulp necrosis and apical periodontitis in sickle cell disease.

Autoren: Yilmaz M Aksu S Karahan F et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 20; Vol. 15 (1), pp. 41149. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Anemia, Sickle Cell*/complications , Anemia, Sickle Cell*/blood , Periapical Periodontitis*/blood , Periapical Periodontitis*/etiology , Periapical Periodontitis*/complications , Cytokines*/blood , Dental Pulp Necrosis*/blood , Dental Pulp Necrosis*/etiology , Dental Pulp Necrosis*/complications, Humans ; Male ; Female ; Adolescent ; Tumor Necrosis Factor-alpha/blood ; Child

TNFR1 Suppression by XPro1595 Reduces Peripheral Neuropathies Associated with Perineural Invasion in Female Mice.

Autoren: Zhang M Liu N Asam K et al.

Quelle: Cells [Cells] 2025 Nov 07; Vol. 14 (22). Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Tumor Necrosis Factor, Type I*/metabolism , Receptors, Tumor Necrosis Factor, Type I*/antagonists & inhibitors , Receptors, Tumor Necrosis Factor, Type I*/genetics , Peripheral Nervous System Diseases*/drug therapy , Peripheral Nervous System Diseases*/pathology , Peripheral Nervous System Diseases*/metabolism, Animals ; Female ; Mice ; Mice, Inbred C57BL ; Sciatic Nerve/pathology ; Sciatic Nerve/drug effects ; Mice, Knockout ; Neoplasm Invasiveness ; Signal Transduction/drug effects ; Hyperalgesia ; Tumor Necrosis Factor-alpha

Tumor Necrosis Factor-Like Ligand 1A/Death Receptor 3 Signaling Regulates the Generation of Pathogenic T Helper 9 Cells in Experimental Crohn's Disease.

Autoren: Menghini P Buttó LF Gomez-Nguyen A et al.

Quelle: Gastroenterology [Gastroenterology] 2025 Oct; Vol. 169 (5), pp. 892-908. Date of Electronic Publication: 2025 May 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE

MeSH-Schlagworte: Crohn Disease*/immunology , Crohn Disease*/pathology , Crohn Disease*/metabolism , Crohn Disease*/genetics , Tumor Necrosis Factor Ligand Superfamily Member 15*/metabolism , Tumor Necrosis Factor Ligand Superfamily Member 15*/genetics , Tumor Necrosis Factor Ligand Superfamily Member 15*/immunology , Receptors, Tumor Necrosis Factor, Member 25*/genetics , Receptors, Tumor Necrosis Factor, Member 25*/metabolism , Receptors, Tumor Necrosis Factor, Member 25*/deficiency , Receptors, Tumor Necrosis Factor, Member 25*/immunology , T-Lymphocytes, Helper-Inducer*/immunology , T-Lymphocytes, Helper-Inducer*/metabolism , Ileitis*/immunology , Ileitis*/pathology , Ileitis*/metabolism , Ileitis*/genetics, Animals ; Signal Transduction ; Disease Models, Animal ; Mice, Knockout ; Humans ; Mice ; Adoptive Transfer ; Cell Differentiation ; Interleukin-9/metabolism ; Male ; Female ; DNA-Binding Proteins/genetics ; Mice, Inbred C57BL ; Interleukin-10/metabolism ; Receptors, Tumor Necrosis Factor, Type II

Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues, ameliorating GVHD post-HSCT.

Autoren: McManus D Copsel SN Pfeiffer BJ et al.

Quelle: Blood [Blood] 2025 Nov 27; Vol. 146 (22), pp. 2710-2727.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

MeSH-Schlagworte: T-Lymphocytes, Regulatory*/immunology , T-Lymphocytes, Regulatory*/drug effects , Graft vs Host Disease*/prevention & control , Graft vs Host Disease*/immunology , Graft vs Host Disease*/etiology , Interleukin-2 Receptor alpha Subunit*/immunology , Interleukin-2 Receptor alpha Subunit*/antagonists & inhibitors , Hematopoietic Stem Cell Transplantation*/adverse effects , Receptors, Tumor Necrosis Factor, Member 25*/immunology , Receptors, Tumor Necrosis Factor, Member 25*/antagonists & inhibitors, Animals ; Mice ; Tumor Necrosis Factor Ligand Superfamily Member 15/immunology ; Mice, Inbred C57BL ; Mice, Inbred BALB C ; Interleukin-2/pharmacology ; Female ; Recombinant Fusion Proteins/pharmacology ; Transplantation, Homologous

Immunogenicity and Safety of Recombinant Herpes Zoster Vaccine in Patients With Inflammatory Bowel Disease on Vedolizumab or Anti-Tumor Necrosis Factor Therapy.

Autoren: Caldera F Mogallapalli H Abusalim AR et al.

Quelle: Clinical and translational gastroenterology [Clin Transl Gastroenterol] 2025 Nov 01; Vol. 16 (11), pp. e00924. Date of Electronic Publication: 2025 Nov 01.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 101532142 Publication Model: Electronic Cited Medium: Internet ISSN: 2155-384X (Electronic) Linking ISSN: 2155384X NLM ISO Abbreviation: Clin Transl Gastroenterol Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Monoclonal, Humanized*/therapeutic use , Antibodies, Monoclonal, Humanized*/adverse effects , Antibodies, Monoclonal, Humanized*/administration & dosage , Herpes Zoster Vaccine*/immunology , Herpes Zoster Vaccine*/administration & dosage , Herpes Zoster Vaccine*/adverse effects , Inflammatory Bowel Diseases*/drug therapy , Inflammatory Bowel Diseases*/immunology , Herpes Zoster*/prevention & control , Herpes Zoster*/immunology , Immunogenicity, Vaccine* , Tumor Necrosis Factor Inhibitors*/therapeutic use , Tumor Necrosis Factor Inhibitors*/adverse effects , Gastrointestinal Agents*/therapeutic use , Gastrointestinal Agents*/adverse effects, Humans ; Female ; Male ; Prospective Studies ; Adult ; Middle Aged ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Vaccines, Synthetic/immunology ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/adverse effects ; Immunity, Cellular/drug effects ; Immunity, Humoral ; Herpesvirus 3, Human/immunology ; Treatment Outcome

Patterns of Use and Discontinuation for Tumor Necrosis Factor Inhibitors in Pregnant Women: Insights From a Real-World Sample.

Autoren: Flatman LK Bernatsky S Bérard A et al.

Quelle: The Journal of rheumatology [J Rheumatol] 2025 Nov 01; Vol. 52 (11), pp. 1159-1165. Date of Electronic Publication: 2025 Nov 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Journal Of Rheumatology Publishing Co Country of Publication: Canada NLM ID: 7501984 Publication Model: Electronic Cited Medium: Internet ISSN: 1499-2752 (Electronic) Linking ISSN: 0315162X NLM ISO Abbreviation: J Rheumatol Subsets: MEDLINE

MeSH-Schlagworte: Tumor Necrosis Factor Inhibitors*/therapeutic use , Pregnancy Complications*/drug therapy , Antirheumatic Agents*/therapeutic use, Humans ; Female ; Pregnancy ; Adult ; Adolescent ; Young Adult ; Inflammatory Bowel Diseases/drug therapy ; Middle Aged ; Arthritis, Rheumatoid/drug therapy ; Adrenal Cortex Hormones/therapeutic use ; Arthritis, Psoriatic/drug therapy ; Psoriasis/drug therapy ; Retrospective Studies ; Tumor Necrosis Factor-alpha/antagonists & inhibitors

Risks of 75 Major Congenital Malformations After In Utero Exposure to Thiopurines and Anti-TNF for Maternal Inflammatory Bowel Disease.

Autoren: Meyer A Marty L Drouin J et al.

Quelle: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2025 Nov; Vol. 23 (12), pp. 2292-2305.e12. Date of Electronic Publication: 2025 Feb 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE

MeSH-Schlagworte: Inflammatory Bowel Diseases*/drug therapy , Pregnancy Complications*/drug therapy , Abnormalities, Drug-Induced*/epidemiology , Congenital Abnormalities*/epidemiology , Tumor Necrosis Factor Inhibitors*/adverse effects , Tumor Necrosis Factor Inhibitors*/therapeutic use , Prenatal Exposure Delayed Effects*/epidemiology , Immunosuppressive Agents*/adverse effects , Immunosuppressive Agents*/therapeutic use, Humans ; Female ; Pregnancy ; Adult ; France/epidemiology ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Prevalence ; Registries ; Infant, Newborn ; Young Adult

Harnessing the TNF-TNFR pathway for graft tolerance: Selective immunomodulation in islet transplantation.

Autoren: Wu Q Yuan Y Yang H et al.

Quelle: Transplantation reviews (Orlando, Fla.) [Transplant Rev (Orlando)] 2025 Dec; Vol. 39 (4), pp. 100962. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8804364 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9816 (Electronic) Linking ISSN: 0955470X NLM ISO Abbreviation: Transplant Rev (Orlando) Subsets: MEDLINE

MeSH-Schlagworte: Islets of Langerhans Transplantation*/immunology , Islets of Langerhans Transplantation*/methods , Transplantation Tolerance*/immunology , Tumor Necrosis Factor-alpha*/immunology , Immunomodulation*, Humans ; Signal Transduction/immunology ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Survival/immunology ; Receptors, Tumor Necrosis Factor, Type II/immunology ; Animals ; T-Lymphocytes, Regulatory/immunology

Validation of prediction models for anti-tumor necrosis factor treatment response in pediatric Crohn's disease: a systematic review and prospective cohort study.

Autoren: Rotem-Tryfus O Kang B Orlanski-Meyer E et al.

Quelle: Journal of Crohn's & colitis [J Crohns Colitis] 2025 Nov 08; Vol. 19 (10).

Publikationsart: Journal Article; Systematic Review; Validation Study

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 101318676 Publication Model: Print Cited Medium: Internet ISSN: 1876-4479 (Electronic) Linking ISSN: 18739946 NLM ISO Abbreviation: J Crohns Colitis Subsets: MEDLINE

MeSH-Schlagworte: Crohn Disease*/drug therapy , Tumor Necrosis Factor-alpha*/antagonists & inhibitors, Humans ; Child ; Prospective Studies ; Treatment Outcome ; C-Reactive Protein/analysis ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Adrenal Cortex Hormones/therapeutic use

SCR Disease Name: Pediatric Crohn's disease

Ustekinumab enhances intestinal stenosis resolution by modulating fibrotic pathways in crohn's disease: a retrospective single-center study with translational analysis.

Autoren: Nakata R Hosomi S Kobayashi Y et al.

Quelle: BMC gastroenterology [BMC Gastroenterol] 2025 Nov 05; Vol. 25 (1), pp. 785. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE

MeSH-Schlagworte: Crohn Disease*/drug therapy , Crohn Disease*/pathology , Crohn Disease*/complications , Ustekinumab*/therapeutic use , Intestinal Obstruction*/etiology , Intestinal Obstruction*/drug therapy , Intestinal Obstruction*/pathology , Tumor Necrosis Factor Inhibitors*/therapeutic use, Humans ; Retrospective Studies ; Male ; Female ; Adult ; Fibrosis ; Middle Aged ; Constriction, Pathologic/drug therapy ; Constriction, Pathologic/etiology ; Constriction, Pathologic/pathology ; Ileum/pathology ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Young Adult ; Collagen Type III/metabolism ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta1/genetics

TNFR2 contributes to synaptic potentiation failure in hippocampal synapses and memory loss in a familial Alzheimer's disease mouse model.

Autoren: Almazán JL Cortes-Flores E Ramírez-Olvera A et al.

Quelle: Brain, behavior, and immunity [Brain Behav Immun] 2025 Oct; Vol. 129, pp. 521-536. Date of Electronic Publication: 2025 Jun 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/metabolism , Alzheimer Disease*/physiopathology , Hippocampus*/metabolism , Receptors, Tumor Necrosis Factor, Type II*/metabolism , Long-Term Potentiation*/physiology , Long-Term Potentiation*/drug effects , Memory Disorders*/metabolism, Animals ; Mice ; Synapses/metabolism ; Disease Models, Animal ; Mice, Transgenic ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Male ; Mice, Inbred C57BL ; Amyloid beta-Peptides/metabolism ; Caspase 1/metabolism ; Synaptosomes/metabolism ; Neuronal Plasticity/physiology

Paracrine Smooth Muscle-to-Endothelial Signaling via TNF Elevates Blood Pressure in Obesity.

Autoren: Kuppusamy M Ottolini M Chen YL et al.

Quelle: Circulation research [Circ Res] 2025 Aug 29; Vol. 137 (6), pp. 812-828. Date of Electronic Publication: 2025 Aug 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE

MeSH-Schlagworte: Obesity*/metabolism , Obesity*/physiopathology , Tumor Necrosis Factor-alpha*/metabolism , Tumor Necrosis Factor-alpha*/genetics , Blood Pressure* , Paracrine Communication* , Myocytes, Smooth Muscle*/metabolism , Muscle, Smooth, Vascular*/metabolism , Muscle, Smooth, Vascular*/physiopathology , Hypertension*/metabolism , Hypertension*/physiopathology , Hypertension*/etiology , Endothelial Cells*/metabolism , Endothelium, Vascular*/metabolism, Animals ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Receptors, Tumor Necrosis Factor, Type I/genetics ; Cells, Cultured ; TRPV Cation Channels/metabolism ; Female ; Signal Transduction ; Diet, High-Fat ; Mice, Knockout

Molecular mechanisms and complications of TNF blockade in heart failure: targeting signalling and genetic determinants of therapeutic response.

Autoren: Javed Q; Department of Health and Social Science, London School of Science and Technology, 4 Dunstable Road, Luton, LU1 1DX, UK. qjaved6@gmail.com.

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Jul 31; Vol. 52 (1), pp. 772. Date of Electronic Publication: 2025 Jul 31.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: Heart Failure*/drug therapy , Heart Failure*/genetics , Heart Failure*/metabolism , Tumor Necrosis Factor-alpha*/antagonists & inhibitors , Tumor Necrosis Factor-alpha*/genetics , Tumor Necrosis Factor-alpha*/metabolism, Humans ; Signal Transduction/drug effects ; Receptors, Tumor Necrosis Factor, Type II/metabolism ; Receptors, Tumor Necrosis Factor, Type II/genetics ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Receptors, Tumor Necrosis Factor, Type I/genetics ; Animals

TNFSF14 (LIGHT) in intestinal inflammation: balancing immune activation and resolution in IBD.

Autoren: Mousa RS Invernizzi P Jones JL et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Sep 15; Vol. 16, pp. 1657071. Date of Electronic Publication: 2025 Sep 15 (Print Publication: 2025).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Tumor Necrosis Factor Ligand Superfamily Member 14*/metabolism , Tumor Necrosis Factor Ligand Superfamily Member 14*/immunology , Inflammatory Bowel Diseases*/immunology , Inflammatory Bowel Diseases*/metabolism, Humans ; Animals ; Receptors, Tumor Necrosis Factor, Member 14/metabolism ; Receptors, Tumor Necrosis Factor, Member 14/immunology ; Signal Transduction ; Lymphotoxin beta Receptor/metabolism ; Lymphotoxin beta Receptor/immunology ; Inflammation/immunology ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism

Systemic inhibition of soluble TNF significantly changes glial cell populations leading to improved myelin integrity and better functional outcome after experimental stroke.

Autoren: Thougaard E Nielsen PV Raffaele S et al.

Quelle: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Aug; Vol. 189, pp. 118334. Date of Electronic Publication: 2025 Jul 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

MeSH-Schlagworte: Myelin Sheath*/metabolism , Myelin Sheath*/drug effects , Myelin Sheath*/pathology , Tumor Necrosis Factor-alpha*/antagonists & inhibitors , Tumor Necrosis Factor-alpha*/metabolism , Neuroglia*/drug effects , Neuroglia*/metabolism , Neuroglia*/pathology , Stroke*/drug therapy , Stroke*/metabolism, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Recovery of Function/drug effects ; Disease Models, Animal ; Oligodendroglia/drug effects ; Oligodendroglia/metabolism ; Astrocytes/drug effects ; Astrocytes/metabolism ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Receptors, Tumor Necrosis Factor, Type I/antagonists & inhibitors

TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair potential in degenerative conditions.

Autoren: Gansau J Grossi E Rodriguez L et al.

Quelle: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2025 Jul; Vol. 33 (7), pp. 874-887. Date of Electronic Publication: 2025 Mar 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: W.B. Saunders For The Osteoarthritis Research Society Country of Publication: England NLM ID: 9305697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9653 (Electronic) Linking ISSN: 10634584 NLM ISO Abbreviation: Osteoarthritis Cartilage Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Tumor Necrosis Factor, Type II*/metabolism , Receptors, Tumor Necrosis Factor, Type I*/metabolism , Intervertebral Disc Degeneration*/metabolism , Intervertebral Disc Degeneration*/pathology , Intervertebral Disc Degeneration*/genetics , Cellular Senescence*/physiology , Annulus Fibrosus*/metabolism, Humans ; Signal Transduction ; Middle Aged ; Female ; Male ; Adult ; Aged ; Tumor Necrosis Factor-alpha/metabolism ; Culture Media, Conditioned ; Cells, Cultured ; Intervertebral Disc/metabolism

Targeting GALNT4 suppresses atherosclerosis via TNFR1/NF-κB mediated attenuation of endothelial inflammation.

Autoren: Wei P Li D Chen W et al.

Quelle: Cellular signalling [Cell Signal] 2026 Jan; Vol. 137, pp. 112209. Date of Electronic Publication: 2025 Nov 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH-Schlagworte: N-Acetylgalactosaminyltransferases*/metabolism , N-Acetylgalactosaminyltransferases*/genetics , N-Acetylgalactosaminyltransferases*/antagonists & inhibitors , Atherosclerosis*/metabolism , Atherosclerosis*/pathology , Atherosclerosis*/genetics , NF-kappa B*/metabolism , Inflammation*/pathology , Inflammation*/metabolism , Receptors, Tumor Necrosis Factor, Type I*/metabolism, Animals ; Humans ; Polypeptide N-acetylgalactosaminyltransferase ; Human Umbilical Vein Endothelial Cells/metabolism ; Mice ; Male ; Mice, Inbred C57BL ; Plaque, Atherosclerotic/pathology ; Plaque, Atherosclerotic/metabolism ; Signal Transduction ; Tumor Necrosis Factor-alpha/pharmacology

Comparative safety of ustekinumab versus anti-TNF therapy during pregnancy in patients with inflammatory bowel disease: A systematic review and meta-analysis.

Autoren: Bardak AE Saeed H Teker G et al.

Quelle: Medicine [Medicine (Baltimore)] 2025 Sep 12; Vol. 104 (37), pp. e44393.

Publikationsart: Journal Article; Systematic Review; Meta-Analysis; Comparative Study

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH-Schlagworte: Ustekinumab*/adverse effects , Ustekinumab*/therapeutic use , Inflammatory Bowel Diseases*/drug therapy , Pregnancy Complications*/drug therapy , Tumor Necrosis Factor Inhibitors*/therapeutic use , Tumor Necrosis Factor Inhibitors*/adverse effects, Humans ; Pregnancy ; Female ; Pregnancy Outcome ; Tumor Necrosis Factor-alpha/antagonists & inhibitors

Targeting fibroblast TNF receptor 1 attenuates type 17 skin inflammation.

Autoren: Cavagnero KJ Li F Aguilera C et al.

Quelle: Cell reports [Cell Rep] 2025 Aug 26; Vol. 44 (8), pp. 116111. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH-Schlagworte: Fibroblasts*/metabolism , Fibroblasts*/drug effects , Fibroblasts*/pathology , Receptors, Tumor Necrosis Factor, Type I*/metabolism , Receptors, Tumor Necrosis Factor, Type I*/genetics , Skin*/pathology , Skin*/metabolism , Inflammation*/pathology , Inflammation*/metabolism, Animals ; Humans ; Mice ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-17/metabolism ; Psoriasis/pathology ; Psoriasis/metabolism ; Imiquimod/pharmacology ; Signal Transduction ; Mice, Inbred C57BL ; Neutrophils/metabolism ; Keratinocytes/metabolism ; Mice, Knockout