Suchergebnisse - "N-end rule"

An alternative pocket for binding the N‐degrons by the UBR1 and UBR2 ubiquitin E3 ligases

Autoren: Huang, Shih‐Ting Chen, Dai‐Hua Ren, Tianchen et al.

Quelle: Protein Science. 34(8)

Schlagwörter: 3101 Biochemistry and Cell Biology (for-2020), 31 Biological Sciences (for-2020), Ubiquitin-Protein Ligases (mesh), Humans (mesh), Crystallography, X-Ray (mesh), Models, Molecular (mesh), Protein Binding (mesh), Saccharomyces cerevisiae Proteins (mesh), Binding Sites (mesh), Degrons (mesh), crystal structure, fluorescence polarization, N-end rule, ubiquitin, UBR1, UBR2, Humans (mesh), Ubiquitin-Protein Ligases (mesh), Saccharomyces cerevisiae Proteins (mesh), Crystallography, X-Ray (mesh), Binding Sites (mesh), Protein Binding (mesh), Models, Molecular (mesh), Degrons (mesh), N‐end rule, UBR1, UBR2, crystal structure, fluorescence polarization, ubiquitin, Ubiquitin-Protein Ligases (mesh), Humans (mesh), Crystallography, X-Ray (mesh), Models, Molecular (mesh), Protein Binding (mesh), Saccharomyces cerevisiae Proteins (mesh), Binding Sites (mesh), Degrons (mesh), 0601 Biochemistry and Cell Biology (for), 0802 Computation Theory and Mathematics (for), 0899 Other Information and Computing Sciences (for), Biophysics (science-metrix), 3101 Biochemistry and cell biology (for-2020), 3404 Medicinal and biomolecular chemistry (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/3f8020kv
https://escholarship.org/content/qt3f8020kv/qt3f8020kv.pdf

New pathways regulating MBF-dependent transcription in fission yeast

Autoren: Pazo Pelegrí, Esther

Weitere Verfasser: University/Department: Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut

Thesis Advisors: Ayté del Olmo, José

Quelle: TDX (Tesis Doctorals en Xarxa)

Schlagwörter: MBF, Schizosaccaromyces pombe, Cicle cel.lular, G1/S transition, Transcripció, N-end rule pathway, TORC, Nutritional depletion, Glucosa, Short-lived reporter

Dateibeschreibung: application/pdf

Zugangs-URL: http://hdl.handle.net/10803/672476

An Enigma of N-termini dependent protein degradation

Autoren: Lina Alhourani Alaa M. Elgohary Richard P. Fahlman

Quelle: Biochemistry and Biophysics Reports, Vol 44, Iss , Pp 102247- (2025)

Schlagwörter: N-Degron, N-End rule, Protein degradation, Biology (General), QH301-705.5, Biochemistry, QD415-436

Dateibeschreibung: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405580825003346; https://doaj.org/toc/2405-5808

Zugangs-URL: https://doaj.org/article/2f995da0afbf4a9292cdb054d5cc9fc4

N-Degron-Based PROTAC Targeting PLK1: A Potential Therapeutic Strategy for Cervical Cancer

Autoren: Pethaiah Gunasekaran Sang Chul Shin Yeon Sil Hwang et al.

Quelle: Pharmaceutics, Vol 17, Iss 8, p 1027 (2025)

Schlagwörter: PLK1, PROTAC, N-end rule pathway, anticancer, N-degron, Pharmacy and materia medica, RS1-441

Dateibeschreibung: electronic resource

Relation: https://www.mdpi.com/1999-4923/17/8/1027; https://doaj.org/toc/1999-4923

Zugangs-URL: https://doaj.org/article/1fe8956e20d94f3fadb8593ed849d438

Evolution of the Genetic Code in the Ascoideales (CUG-Ser2) Yeast Clade: The Ancestral tRNA-Leu(CAG) Gene Is Retained in Most Saccharomycopsis Species but Is Nonessential and Not Used for Translation

Autoren: Eoin Ó Cinnéide Caitriona Scaife Eugène T Dillon et al.

Quelle: Genome Biol Evol
Genome Biology and Evolution

Schlagwörter: 0301 basic medicine, 3101 Biochemistry and cell biology, RNA, Transfer, Leu, N-END RULE, TRANSFER-RNA, LEUCINE, translation, Saccharomycopsis, yeast, 0601 Biochemistry and Cell Biology, 3105 Genetics, Article, Evolution, Molecular, 03 medical and health sciences, proteomics, 0603 Evolutionary Biology, Anticodon, TOOL, ALGORITHM, tRNA, TREE, 3104 Evolutionary biology, Phylogeny, RNA, Transfer, Ser, Genetics & Heredity, Evolutionary Biology, 0604 Genetics, 0303 health sciences, Science & Technology, SERINE, CUG CODON, genetic code, Genetic Code, Protein Biosynthesis, REASSIGNMENT, GENOMICS, Life Sciences & Biomedicine, Developmental Biology

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39081261
https://lirias.kuleuven.be/handle/20.500.12942/761228
https://doi.org/10.1093/gbe/evae166

Uncovering non-canonical functions for the E3 ubiquitin ligase UBR2 in the mouse

Autoren: Raymond, Eleanor Siân Adams, Ian Wood, Andrew

Weitere Verfasser: Raymond, Eleanor Siân Adams, Ian Wood, Andrew

Schlagwörter: 572, ubiquitin, ubiquitin ligase enzyme, UBR2, N-end Rule pathway, cohesin, CRISPR-Cas9

Zugangs-URL: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.802355

N-degron and C-degron pathways of protein degradation

Autoren: Varshavsky, Alexander

Quelle: Proceedings of the National Academy of Sciences of the United States of America, 2019 Jan 01. 116(2), 358-366.

Zugangs-URL: https://www.jstor.org/stable/26574038

Distinct branches of the N-end rule pathway modulate the plant immune response

Autoren: Vicente, Jorge Mendiondo, Guillermina M. Pauwels, Jarne et al.

Quelle: The New Phytologist, 2019 Jan 01. 221(2), 988-1000.

Zugangs-URL: https://www.jstor.org/stable/26557269

Life and death of proteins after protease cleavage : protein degradation by the N-end rule pathway

Quelle: New Phytologist, 2018 May 01. 218(3), 929-935.

Zugangs-URL: https://www.jstor.org/stable/90020517

N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway

Quelle: New Phytologist, 2018 May 01. 218(3), 1106-1126.

Zugangs-URL: https://www.jstor.org/stable/90020531

N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis

Autoren: Yoo, Young Dong Mun, Su Ran Ji, Chang Hoon et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America, 2018 Mar . 115(12), E2716-E2724.

Zugangs-URL: https://www.jstor.org/stable/26509043

Engineering posttranslational proofreading to discriminate nonstandard amino acids

Autoren: Kunjapur, Aditya M. Stork, Devon A. Kuru, Erkin et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America, 2018 Jan . 115(3), 619-624.

Zugangs-URL: https://www.jstor.org/stable/26506391

Real-time detection of N-end rule-mediated ubiquitination via fluorescently labeled substrate probes

Quelle: New Phytologist, 2018 Jan 01. 217(2), 613-624.

Zugangs-URL: https://www.jstor.org/stable/90016930

Spatio-temporal patterning of arginyl-tRNA protein transferase (ATE) contributes to gametophytic development in a moss

Quelle: New Phytologist, 2016 Feb 01. 209(3), 1014-1027.

Zugangs-URL: https://www.jstor.org/stable/newphytologist.209.3.1014

Amino Acid and Essential Fatty Acid in Evacuation Shelter Food in the Noto Peninsula Earthquake: Comparison with the 2024 Simultaneous National Survey in Japan

Autoren: Takamitsu Sakamoto Hiroyo Miyata Ayako Tsunou et al.

Quelle: Nutrients ; Volume 16 ; Issue 23 ; Pages: 4185

Schlagwörter: disaster, digestible essential amino acid score (DIAAS), European Food Safety Authority (EFSA), half-life, N-end rule, Duplicated Combination Model

Geographisches Schlagwort: agris

Dateibeschreibung: application/pdf

Relation: Geriatric Nutrition; https://dx.doi.org/10.3390/nu16234185

Verfügbarkeit: https://doi.org/10.3390/nu16234185

Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway

Autoren: Kim, Min Kyung Oh, Sun Joo Lee, Byung-Gil et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America, 2016 Nov 01. 113(44), 12438-12443.

Zugangs-URL: https://www.jstor.org/stable/26472296

From start to finish: amino-terminal protein modifications as degradation signals in plants

Quelle: New Phytologist, 2016 Sep 01. 211(4), 1188-1194.

Zugangs-URL: https://www.jstor.org/stable/newphytologist.211.4.1188

A Ratiometric Sensor Based on Plant N-Terminal Degrons Able to Report Oxygen Dynamics in Saccharomyces cerevisiae

Autoren: Daan A. Weits Laura Dalle Carbonare Pierdomenico Perata et al.

Quelle: Journal of Molecular Biology. 431:2810-2820

Schlagwörter: 0301 basic medicine, 0303 health sciences, N-end rule pathwayoxygen sensingplant cysteine oxidasesynthetic biologySaccharomyces cerevisiae, Arabidopsis Proteins, N-end rule pathway, oxygen sensing, plant cysteine oxidase, Saccharomyces cerevisiae, synthetic biology, Arabidopsis, Cysteine Dioxygenase, Gene Expression, Nitric Oxide, Oxygen, Luminescent Proteins, 03 medical and health sciences, Luminescent Measurements, Proteolysis, Oxidation-Reduction

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/31125566
https://www.ncbi.nlm.nih.gov/pubmed/31125566
https://pubag.nal.usda.gov/catalog/6448534
https://www.sciencedirect.com/science/article/pii/S0022283619302955

Structure of a putative ClpS N‐end rule adaptor protein from the malaria pathogen Plasmodium falciparum

Autoren: AhYoung, Andrew P Koehl, Antoine Vizcarra, Christina L et al.

Quelle: Protein Science. 25(3)

Schlagwörter: Biochemistry and Cell Biology, Biological Sciences, Emerging Infectious Diseases, Vector-Borne Diseases, Malaria, Infectious Diseases, Rare Diseases, Infection, Good Health and Well Being, Amino Acid Sequence, Crystallography, X-Ray, Endopeptidase Clp, Humans, Malaria, Falciparum, Models, Molecular, Plasmodium falciparum, Protein Conformation, Sequence Alignment, Substrate Specificity, ClpS, N-end rule, N-degron, crystal structure, malaria, plasmodium, apicoplast, plastid, organelle, phylogeny, Clp chaperone, Clp protease, drug target, carrier-assisted crystallization, Computation Theory and Mathematics, Other Information and Computing Sciences, Biophysics, Biochemistry and cell biology, Medicinal and biomolecular chemistry

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/0jj844ng
https://escholarship.org/content/qt0jj844ng/qt0jj844ng.pdf

Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox inflammasome activation

Autoren: Francesca Ferrara Valeria Cordone Alessandra Pecorelli et al.

Quelle: Redox Biology, Vol 56, Iss , Pp 102440- (2022)

Schlagwörter: Inflammasomes, OxInflammation, Proteasome, UBR2, N-end rule pathway, Medicine (General), R5-920, Biology (General), QH301-705.5

Dateibeschreibung: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231722002129; https://doaj.org/toc/2213-2317

Zugangs-URL: https://doaj.org/article/226bbe00d7474300ba5b0f6786815cb1