Výsledky vyhľadávania - "Mycobacterium tuberculosis drug effects"

Intranasal Administration of Bedaquiline-Loaded Fucosylated Liposomes Provides Anti-Tubercular Activity while Reducing the Potential for Systemic Side Effects

Autori: Marwitz, Franziska Hädrich, Gabriela Redinger, Natalja a ďalší

Zdroj: ACS Infect Dis

Predmety: 301205 Pharmakokinetik, liposomes, 0301 basic medicine, Diarylquinolines/pharmacokinetics, Antitubercular Agents, 301205 Pharmacokinetics, Lung/metabolism, Mice, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Fucose/chemistry, Animals, Tuberculosis, bedaquiline, Diarylquinolines, Lung, Inbred BALB C, Administration, Intranasal, Fucose, Tuberculosis/drug therapy, inhalation, Mice, Inbred BALB C, Mice, Inbred C3H, 0303 health sciences, Antitubercular Agents/administration & dosage, Animal, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis, Inbred C3H, 3. Good health, Disease Models, Animal, Intranasal, tuberculosis, SDG 3 – Gesundheit und Wohlergehen, Administration, Disease Models, Liposomes, Female, Liposomes/chemistry, pharmacokinetics

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39136125

Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis

Autori: Biao Zhou Yamin Gao Heyu Zhao a ďalší

Zdroj: Nat Commun
Nature Communications, Vol 16, Iss 1, Pp 1-18 (2025)
Zhou, B, Gao, Y, Zhao, H, Liu, B, Zhang, H, Fang, C, Yuan, H, Wang, J, Li, Z, Zhao, Y, Huang, X, Wang, X, Oliveira, A S F, Spencer, J, Mulholland, A J, Burston, S G, Hu, J, Su, N, Chen, X, He, J, Zhang, T & Xiong, X 2025, 'Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis', Nature Communications, vol. 16, no. 1, 3466. https://doi.org/10.1038/s41467-025-58410-4

Predmety: Models, Molecular, Molecular Chaperones/metabolism, Bacterial Proteins/metabolism, Science, Cryoelectron Microscopy, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis, Endopeptidase Clp, Article, Bortezomib, Bortezomib/pharmacology, Bacterial Proteins, Endopeptidase Clp/metabolism, name=Physical & Theoretical, Catalytic Domain, name=Bristol BioDesign Institute, Molecular Chaperones, Protein Binding

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40216758
https://doaj.org/article/6eec1a8103ce4ca0a63fb7a0043cadc0
https://research-information.bris.ac.uk/ws/files/454113417/Zhou_et_al_2025_Nature_Comms.pdf
https://hdl.handle.net/1983/99b6a72a-a0b4-4ade-8b7b-18c9aedb5df9

Real-time evaluation of macozinone activity against Mycobacterium tuberculosis through bacterial nanomotion analysis

Autori: Anthony Vocat Amanda Luraschi-Eggemann Claudia Antoni a ďalší

Zdroj: Antimicrob Agents Chemother
Antimicrobial agents and chemotherapy, vol. 69, no. 1, pp. e0131824

Predmety: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Susceptibility, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis/genetics, Microbial Sensitivity Tests, Antitubercular Agents/pharmacology, Thiazines/pharmacology, Bacterial Proteins/genetics, Bacterial Proteins/metabolism, Alcohol Oxidoreductases, Piperazines, DprE1 inhibitors, Mycobacterium tuberculosis, antibiotic susceptibility test, macozinone, nanomotion

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39601550
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_C1A51AF18AEE3
https://serval.unil.ch/notice/serval:BIB_C1A51AF18AEE
https://serval.unil.ch/resource/serval:BIB_C1A51AF18AEE.P001/REF.pdf

Expanding Xpert MTB/RIF Ultra® and LF-LAM testing for diagnosis of tuberculosis among HIV-positive adults admitted to hospitals in Tanzania and Mozambique: a randomized controlled trial (the EXULTANT trial)

Autori: Mangu, Chacha Cossa, Marta Ndege, Robert a ďalší

Zdroj: BMC Infect Dis
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-9 (2024)

Predmety: Adult, Male, Lipopolysaccharides, 0301 basic medicine, Enhanced screening, HIV Infections, Infectious and parasitic diseases, RC109-216, Tanzania, TB diagnosis, Study Protocol, Feces, 03 medical and health sciences, 0302 clinical medicine, Humans, Tuberculosis, Mozambique, TB case-finding, Sputum, HIV, Mycobacterium tuberculosis, 16. Peace & justice, 6. Clean water, 3. Good health, Hospitalization, Female [MeSH], Mycobacterium tuberculosis/drug effects [MeSH], HIV Infections/complications [MeSH], Feces/virology [MeSH], Hospitalization [MeSH], Adult [MeSH], Tuberculosis/complications [MeSH], Tuberculosis/diagnosis [MeSH], Humans [MeSH], Tanzania [MeSH], Mycobacterium tuberculosis/genetics [MeSH], Tuberculosis/drug therapy [MeSH], Male [MeSH], Mozambique [MeSH], Feces/microbiology [MeSH], Sputum/microbiology [MeSH], Mycobacterium tuberculosis/isolation, Lipopolysaccharides/urine [MeSH], Female

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39148008
https://doaj.org/article/e8ff71986d5249bd86e48add2cf630d4
https://repository.publisso.de/resource/frl:6503863

Diagnostic accuracy of a liquid chromatography-tandem mass spectrometry assay in small hair samples for rifampin-resistant tuberculosis drug concentrations in a routine care setting.

Autori: Metcalfe, John Bacchetti, Peter Esmail, Ali a ďalší

Zdroj: BMC infectious diseases. 21(1)

Predmety: Adult, Antitubercular Agents: analysis, therapeutic use, Chromatography, Liquid, Drug Monitoring: methods, Female, Hair: chemistry, Humans, Male, Middle Aged, Mycobacterium tuberculosis: drug effects, Rifampin: pharmacology, Sensitivity and Specificity, Tandem Mass Spectrometry, Tuberculosis: drug therapy, Tuberculosis, Multidrug-Resistant: drug therapy

Prístupová URL adresa: https://escholarship.org/uc/item/0tb5d2zx

Triage test for all-oral drug-resistant tuberculosis (DR-TB) regimen : a phase IV study to assess effectiveness, feasibility, acceptability and cost-effectiveness of the Xpert MTB/XDR assay for rapid triage and treatment of DR-TB

Autori: Naidoo, Kogieleum Naidoo, Anushka Abimiku, Alash'le G a ďalší

Prispievatelia: Naidoo, Kogieleum Naidoo, Anushka Abimiku, Alash'le G a ďalší

Predmety: Humans, Triage/methods, Mycobacterium tuberculosis/drug effects, Cost-benefit analysis, Antitubercular agents/therapeutic use, Tuberculosis, multidrug-resistant/drug therapy, Sputum/microbiology, Rifampin/therapeutic use, Feasibility studies, South Africa, Extensively drug-resistant tuberculosis/drug therapy, Ethiopia, Nigeria, Adult, Administration, oral, NDAS, SDG 3 - Good Health and Well-being, MCC

Popis súboru: application/pdf

Relation: BMJ Open; 308292163; 85211208351; https://hdl.handle.net/10023/30999

Dostupnosť: https://hdl.handle.net/10023/30999
https://doi.org/10.1136/bmjopen-2024-084722

Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity

Autori: Villemagne, Baptiste Machelart, Arnaud Tran, Ngoc Chau a ďalší

Prispievatelia: Villemagne, Baptiste Machelart, Arnaud Tran, Ngoc Chau a ďalší

Zdroj: ACS infectious diseases, 6 (3

Predmety: 0301 basic medicine, Ethionamide booster, mice, in vivo POC, Antitubercular Agents, Crystallography, X-Ray, Mice, Structure-Activity Relationship, 03 medical and health sciences, [CHIM] Chemical Sciences, Drug Discovery, Animals, Tuberculosis, Ethionamide, Ethionamide/chemistry, Tuberculosis/drug therapy, Mice, Inbred BALB C, Oxadiazoles, 0303 health sciences, Mycobacterium tuberculosis/drug effects, Oxadiazoles/chemistry, Mycobacterium tuberculosis, Sciences bio-médicales et agricoles, Structure-activity relationship, 3. Good health, Repressor Proteins, Repressor Proteins/antagonists & inhibitors, Antitubercular Agents/chemistry, Drug Design, Female, Fragment-based drug design

Popis súboru: 1 full-text file(s): application/pdf; application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/32011115
https://pubs.acs.org/doi/10.1021/acsinfecdis.9b00277
https://europepmc.org/article/MED/32011115
https://www.ncbi.nlm.nih.gov/pubmed/32011115
https://pubmed.ncbi.nlm.nih.gov/32011115/
https://hal.archives-ouvertes.fr/hal-03096012v1
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/308699
https://biblio.vub.ac.be/vubir/fragmentbased-optimized-ethr-inhibitors-with-in-vivo-ethionamide-boosting-activity(bfe9ace9-bb59-4e70-926f-60024ea8be55).html
https://cnrs.hal.science/hal-03096012v1/document
https://cnrs.hal.science/hal-03096012v1
https://doi.org/10.1021/acsinfecdis.9b00277

Evaluación de la virulencia de un mutante de Mycobacterium tuberculosis defectivo en el transporte iónico mediado por una ATPasa tipo P, en modelos experimentales de infección

Autori: López Ruíz, Gina Marcela Soto Ospina, Carlos Yesid Bioquímica y Biología Molecular de las Micobacterias

Prispievatelia: López Ruíz, Gina Marcela Soto Ospina, Carlos Yesid Bioquímica y Biología Molecular de las Micobacterias

Predmety: Mycobacterium tuberculosis/efectos de los fármacos, Virulencia, Virulence, Immune evasion, Mycobacterium tuberculosis/drug effects, Membrane Transport Proteins, ATPasas tipo P1B, 572 - Bioquímica [570 - Biología], Mycobacterium tuberculosis, P1B-type ATPase, Vacunas de cepas vivas atenuadas, Live attenuated whole-cell Mtb vaccine, Proteínas de Transporte de Membrana, Mecanismos de evasión inmune de Mtb, CtpA, Estrés redox, Redox stress, Mutantes atenuados de Mtb

Popis súboru: xx, 154 páginas; application/pdf

Prístupová URL adresa: https://repositorio.unal.edu.co/handle/unal/87645

Contribution of kasA analysis to detection of isoniazid-resistant Mycobacterium tuberculosis in Singapore

Autori: Lee, A. S. Lim, I. H. Tang, L. L. a ďalší

Predmety: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/*genetics Antitubercular Agents/*pharmacology Drug Resistance, Microbial/genetics Genotype Isoniazid/*pharmacology Mutation Mycobacterium tuberculosis/*drug effects/*genetics Singapore

Relation: Antimicrobial Agents and Chemotherapy; https://iris.unil.ch/handle/iris/95193; serval:BIB_23C304437D0A; 000081789200048

Dostupnosť: https://iris.unil.ch/handle/iris/95193

Esters of Pyrazinoic Acid Are Active against Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Other Naturally Resistant Mycobacteria In Vitro and Ex Vivo within Macrophages

Autori: Pires Valente Simões a ďalší

Predmety: Alcohols/pharmacology, Antitubercular Agents/pharmacology, Cell Survival/drug effects, Macrophages/microbiology, Moraxella (Moraxella) bovis/drug effects, Mycobacterium/drug effects, Mycobacterium avium Complex/drug effects, Mycobacterium tuberculosis/drug effects, Pyrazinamide/analogs & derivatives, Pyrazinamide/chemical synthesis, Pyrazinamide/pharmacology

Relation: Antimicrobial Agents and Chemotherapy; https://iris.unil.ch/handle/iris/88280; serval:BIB_1428E6F17299; 000368337300065

Dostupnosť: https://iris.unil.ch/handle/iris/88280
https://doi.org/10.1128/AAC.00936-15

Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level

Autori: Telenti, A. Honore, N. Bernasconi, C. a ďalší

Predmety: Antibiotics, Antitubercular/pharmacology Antitubercular Agents/*pharmacology Bacteriological Techniques/statistics & numerical data Base Sequence DNA Primers/genetics Drug Resistance, Microbial/genetics Genes, Bacterial Genotype Humans Isoniazid/*pharmacology Laboratories Molecular Sequence Data Mutation Mycobacterium tuberculosis/*drug effects/*genetics Phenotype Polymerase Chain Reaction/statistics & numerical data Polymorphism, Single-Stranded Conformational Rifampin/*pharmacology Sensitivity and Specificity

Relation: Journal of Clinical Microbiology; https://iris.unil.ch/handle/iris/69959; serval:BIB_0CD8C0B7468B; A1997WJ84800036; 9041419

Dostupnosť: https://iris.unil.ch/handle/iris/69959

Genotypic analysis of Mycobacterium tuberculosis in two distinct populations using molecular beacons: implications for rapid susceptibility testing

Autori: Piatek, A. S. Telenti, A. Murray, M. R. a ďalší

Predmety: Base Sequence Drug Resistance, Microbial Drug Resistance, Multiple Genotype Humans Isoniazid/pharmacology Microbial Sensitivity Tests Molecular Sequence Data Mutation Mycobacterium tuberculosis/drug effects/*genetics

Relation: Antimicrobial Agents and Chemotherapy; https://iris.unil.ch/handle/iris/245662; serval:BIB_F347E70EFFD7; 000084287800017

Dostupnosť: https://iris.unil.ch/handle/iris/245662
https://doi.org/10.1128/AAC.44.1.103-110.2000

Genomic and transcriptomic analysis of the streptomycin-dependent Mycobacterium tuberculosis strain 18b.

Autori: Benjak, A. Uplekar, S. Zhang, M. a ďalší

Predmety: Comparative Genomic Hybridization, Genome, Bacterial, High-Throughput Nucleotide Sequencing, INDEL Mutation, Models, Molecular, Molecular Sequence Annotation, Mycobacterium tuberculosis/classification, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis/genetics, Phylogeny, Polymorphism, Single Nucleotide, Protein Structure, Tertiary, RNA, Bacterial/genetics, Ribosomal, 16S/genetics, Ribosome Subunits, Small, Sequence Analysis, Streptomycin/pharmacology, Transcriptome

Popis súboru: application/pdf

Relation: BMC Genomics; https://iris.unil.ch/handle/iris/239647; serval:BIB_FF686038C606; 000371595300005

Dostupnosť: https://iris.unil.ch/handle/iris/239647
https://doi.org/10.1186/s12864-016-2528-2

Direct, automated detection of rifampin-resistant Mycobacterium tuberculosis by polymerase chain reaction and single-strand conformation polymorphism analysis

Autori: Telenti, A. Imboden, P. Marchesi, F. a ďalší

Predmety: Base Sequence DNA, Single-Stranded/*analysis Drug Resistance, Microbial Evaluation Studies Humans Molecular Sequence Data Mutation/*genetics Mycobacterium tuberculosis/*drug effects/*genetics Nucleic Acid Conformation Polymerase Chain Reaction/*methods Polymorphism, Genetic Rifampin/*pharmacology Sputum/microbiology

Relation: Antimicrobial Agents and Chemotherapy; https://iris.unil.ch/handle/iris/208632; serval:BIB_A05CA2BA8748; A1993MA17900002; 8257122

Dostupnosť: https://iris.unil.ch/handle/iris/208632

Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis.

Autori: Fenner, L. Egger, M. Bodmer, T. a ďalší

Prispievatelia: Fenner, L. Egger, M. Bodmer, T. a ďalší

Predmety: Antitubercular Agents/pharmacology, Drug Resistance, Multiple, Bacterial/genetics, Ethambutol/pharmacology, Genotype, Isoniazid/pharmacology, Microbial Sensitivity Tests, Mutation, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis/genetics, Rifampin/pharmacology, Tuberculosis, Multidrug-Resistant/microbiology

Relation: Antimicrobial Agents and Chemotherapy; https://iris.unil.ch/handle/iris/189186; serval:BIB_923073356BA0; 000304432800035

Dostupnosť: https://iris.unil.ch/handle/iris/189186
https://doi.org/10.1128/AAC.06460-11

Mutation position and type of substitution in the beta-subunit of the RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant Mycobacterium tuberculosis.

Autori: Bodmer, T. Zürcher, G. Imboden, P. a ďalší

Predmety: Antitubercular Agents/pharmacology, DNA-Directed RNA Polymerases/genetics, Drug Resistance, Microbial/genetics, Genes, Bacterial/drug effects, Genotype, Humans, Microbial Sensitivity Tests, Mutation, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis/enzymology, Phenotype, Rifabutin/pharmacology, Rifampin/analogs &, derivatives, Rifampin/pharmacology, Tuberculosis, Pulmonary/microbiology

Relation: Journal of Antimicrobial Chemotherapy; https://iris.unil.ch/handle/iris/177147; serval:BIB_8139A8FA3011; A1995QJ46100012; 7759399

Dostupnosť: https://iris.unil.ch/handle/iris/177147
https://doi.org/10.1093/jac/35.2.345

Molecular beacon sequence analysis for detecting drug resistance in Mycobacterium tuberculosis

Autori: Piatek, A. S. Tyagi, S. Pol, A. C. a ďalší

Predmety: Antibiotics, Antitubercular/pharmacology Drug Resistance, Microbial/*genetics Microbial Sensitivity Tests Mycobacterium tuberculosis/*drug effects/genetics Plant Proteins/genetics *Point Mutation Polymerase Chain Reaction Rifampin/pharmacology

Relation: Nature Biotechnology; https://iris.unil.ch/handle/iris/161789; serval:BIB_7485BF2BBB9E; 000072786200028; 9555727

Dostupnosť: https://iris.unil.ch/handle/iris/161789
https://doi.org/10.1038/nbt0498-359

Added Value of Xpert MTB/RIF Ultra for Diagnosis of Pulmonary Tuberculosis in a Low-Prevalence Setting.

Autori: Opota, O. Zakham, F. Mazza-Stalder, J. a ďalší

Predmety: Adolescent, Adult, Aged, 80 and over, Antitubercular Agents/pharmacology, Drug Resistance, Bacterial, Female, Humans, Male, Microbial Sensitivity Tests/methods, Middle Aged, Molecular Diagnostic Techniques/methods, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis/genetics, Mycobacterium tuberculosis/isolation & purification, Rifampin/pharmacology, Sensitivity and Specificity, Switzerland, Tuberculosis, Pulmonary/diagnosis, Young Adult, Mycobacterium tuberculosis, Xpert MTB/RIF, Xpert MTB/RIF Ultra, acid-fast bacilli, airborne isolation, clinical microbiology, diagnostic microbiology, point-of-care test

Popis súboru: application/pdf

Relation: Journal of Clinical Microbiology; https://iris.unil.ch/handle/iris/156665; serval:BIB_7A47A167126E; 000457592200035

Dostupnosť: https://iris.unil.ch/handle/iris/156665
https://doi.org/10.1128/JCM.01717-18

Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations

Autori: Sreevatsan, S. Stockbauer, K. E. Pan, X. a ďalší

Predmety: Antitubercular Agents/*pharmacology DNA Mutational Analysis DNA, Bacterial/*genetics Drug Resistance, Microbial/genetics Ethambutol/*pharmacology Microbial Sensitivity Tests Molecular Sequence Data Mycobacterium tuberculosis/*drug effects/genetics Pentosyltransferases/*genetics Point Mutation Polymorphism, Single-Stranded Conformational Variation (Genetics)

Relation: Antimicrobial Agents and Chemotherapy; https://iris.unil.ch/handle/iris/148710; serval:BIB_6713E8591E9B; A1997XP60500009; 9257740

Dostupnosť: https://iris.unil.ch/handle/iris/148710

Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing

Autori: Kapur, V. Li, L. L. Hamrick, M. R. a ďalší

Predmety: Alleles Bacteriological Techniques Base Sequence Drug Resistance, Microbial/genetics Genes, Bacterial/*genetics Humans Molecular Sequence Data Mutation/*genetics Mycobacterium/genetics/*isolation & purification Mycobacterium tuberculosis/drug effects/genetics Sequence Analysis, DNA/*methods Sputum/microbiology

Relation: Archives of Pathology & Laboratory Medicine; https://iris.unil.ch/handle/iris/144084; serval:BIB_D70B1425308C; A1995QF54000007; 7848059

Dostupnosť: https://iris.unil.ch/handle/iris/144084