Suchergebnisse - "Mycobacterium tuberculosis"

11,12-dihydrolactaroviolin from edible mushroom Lactarius hatsudake Tanaka as a selective inhibitor of Mycobacterium tuberculosis.

Autoren: Zhong P Bi L Chang S et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 30; Vol. 497, pp. 146964. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/metabolism , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemistry , Antitubercular Agents*/isolation & purification , Basidiomycota*/chemistry , Agaricales*/chemistry, Microbial Sensitivity Tests ; Molecular Docking Simulation ; Humans ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/chemistry ; Molecular Structure

Structural Studies on the M. tuberculosis Nucleoid-associated-Protein, NapA, Indicates DNA Bridging Mechanism.

Autoren: Schumacher MA Singh RR Salinas R

Quelle: Journal of molecular biology [J Mol Biol] 2025 Dec 15; Vol. 437 (24), pp. 169486. Date of Electronic Publication: 2025 Oct 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/metabolism , Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/chemistry , Bacterial Proteins*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , DNA-Binding Proteins*/chemistry , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , DNA, Bacterial*/metabolism , DNA, Bacterial*/chemistry, Models, Molecular ; Protein Multimerization ; Protein Binding ; Crystallography, X-Ray ; Protein Conformation ; Binding Sites

Understanding the role of PezAT and MbcTA toxin-antitoxin systems in the pathophysiology of Mycobacterium tuberculosis.

Autoren: Singh M Chaudhary D Sharma A et al.

Quelle: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2025 Dec; Vol. 155, pp. 102703. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100971555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-281X (Electronic) Linking ISSN: 14729792 NLM ISO Abbreviation: Tuberculosis (Edinb) Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/metabolism , Mycobacterium tuberculosis*/pathogenicity , Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/growth & development , Toxin-Antitoxin Systems*/genetics , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Bacterial Toxins*/genetics , Bacterial Toxins*/metabolism , Tuberculosis*/microbiology , Tuberculosis*/physiopathology, Animals ; Guinea Pigs ; Oxidative Stress ; Gene Expression Regulation, Bacterial ; Macrophages/microbiology ; Rifampin/pharmacology ; Humans ; Peptidoglycan/biosynthesis ; Disease Models, Animal ; Virulence

Whole-genome sequencing-based surveillance system for Mycobacterium tuberculosis in Portugal.

Autoren: Pinto M Macedo R

Quelle: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2025 Dec; Vol. 155, pp. 102691. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100971555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-281X (Electronic) Linking ISSN: 14729792 NLM ISO Abbreviation: Tuberculosis (Edinb) Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/isolation & purification , Whole Genome Sequencing* , Tuberculosis, Multidrug-Resistant*/epidemiology , Tuberculosis, Multidrug-Resistant*/microbiology , Tuberculosis, Multidrug-Resistant*/drug therapy , Tuberculosis, Multidrug-Resistant*/diagnosis , Genome, Bacterial*, Portugal/epidemiology ; Humans ; Retrospective Studies ; Prospective Studies ; Genotype ; Antitubercular Agents/therapeutic use ; Polymorphism, Single Nucleotide ; Drug Resistance, Multiple, Bacterial/genetics

Analyzing the distribution of virulence factors of Mycobacterium tuberculosis and the impact of virulence gene mutations on treatment outcomes in different lineages using whole-genome sequencing in Urumqi.

Autoren: Yang J Lu Y Chen Y et al.

Quelle: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2552875. Date of Electronic Publication: 2025 Sep 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH-Schlagworte: Virulence Factors*/genetics , Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/pathogenicity , Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/classification , Mutation* , Tuberculosis*/microbiology , Tuberculosis*/drug therapy , Tuberculosis*/epidemiology, Humans ; Whole Genome Sequencing ; Male ; Female ; Adult ; Treatment Outcome ; Antitubercular Agents/therapeutic use ; Antitubercular Agents/pharmacology ; Middle Aged ; Genome, Bacterial ; China/epidemiology ; Aged ; Bacterial Proteins/genetics ; Young Adult

Evaluation of the diagnostic efficacy of CRISPR-based tuberculosis diagnostics, GeneXpert MTB/RIF, and innowave DX MTB/RIF across diverse tuberculosis patient populations.

Autoren: Zhou X Peng Y Huang M et al.

Quelle: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2025 Dec; Vol. 113 (4), pp. 117059. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article; Evaluation Study

Info zur Zeitschrift: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8305899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0070 (Electronic) Linking ISSN: 07328893 NLM ISO Abbreviation: Diagn Microbiol Infect Dis Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/isolation & purification , Tuberculosis*/diagnosis , Tuberculosis*/microbiology , Molecular Diagnostic Techniques*/methods , Clustered Regularly Interspaced Short Palindromic Repeats*, Humans ; Male ; Female ; Sensitivity and Specificity ; Middle Aged ; Adult ; Case-Control Studies ; Aged ; Young Adult

LncRNA-CFTBS enhances Mycobacterium tuberculosis survival in macrophages by modulating ferroptosis through the miR-515-5p/miR-519e-5p/SAT1 axis.

Autoren: Li Y Bai Y Hei C et al.

Quelle: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2545563. Date of Electronic Publication: 2025 Oct 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/genetics , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/physiology , Mycobacterium tuberculosis*/pathogenicity , MicroRNAs*/genetics , MicroRNAs*/metabolism , Macrophages*/microbiology , Acetyltransferases*/genetics , Acetyltransferases*/metabolism, Humans ; Mice ; Lipid Peroxidation ; Animals ; Tuberculosis/microbiology ; Arachidonate 15-Lipoxygenase/metabolism ; Arachidonate 15-Lipoxygenase/genetics ; Signal Transduction

Targeting HspX of Mycobacterium tuberculosis: Advances in diagnostics, treatment, and vaccine development.

Autoren: Hidalgo-Gajardo A Mangui B Villavicencio C et al.

Quelle: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2025 Dec; Vol. 155, pp. 102702. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100971555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-281X (Electronic) Linking ISSN: 14729792 NLM ISO Abbreviation: Tuberculosis (Edinb) Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/immunology , Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/pathogenicity , Mycobacterium tuberculosis*/metabolism , Tuberculosis Vaccines*/immunology , Bacterial Proteins*/immunology , Bacterial Proteins*/metabolism , Vaccine Development* , alpha-Crystallins*/immunology , alpha-Crystallins*/metabolism , Antitubercular Agents*/therapeutic use , Antitubercular Agents*/adverse effects , Antigens, Bacterial*/immunology , Tuberculosis*/diagnosis , Tuberculosis*/immunology , Tuberculosis*/prevention & control , Tuberculosis*/microbiology, Humans ; Animals ; Latent Tuberculosis/immunology ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/microbiology

Immunoinformatics analysis of the proteins MPT83 and MPT51 to design a possible chimeric vaccine against Mycobacterium tuberculosis.

Autoren: Loureiro RTO Andrade SJT do Carmo EJ et al.

Quelle: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2025 Dec; Vol. 56 (4), pp. 2649-2660. Date of Electronic Publication: 2025 Aug 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer International Publishing Country of Publication: Brazil NLM ID: 101095924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4405 (Electronic) Linking ISSN: 15178382 NLM ISO Abbreviation: Braz J Microbiol Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/immunology , Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/chemistry , Tuberculosis Vaccines*/immunology , Tuberculosis Vaccines*/genetics , Tuberculosis Vaccines*/chemistry , Antigens, Bacterial*/immunology , Antigens, Bacterial*/genetics , Antigens, Bacterial*/chemistry , Bacterial Proteins*/immunology , Bacterial Proteins*/genetics , Bacterial Proteins*/chemistry , Tuberculosis*/prevention & control , Tuberculosis*/immunology , Tuberculosis*/microbiology, Computational Biology ; Epitopes, B-Lymphocyte/immunology ; Epitopes, B-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/immunology ; Epitopes, T-Lymphocyte/genetics ; Humans ; Recombinant Fusion Proteins/immunology ; Recombinant Fusion Proteins/genetics ; Immunoinformatics

Scutellarin suppresses Mycobacterium tuberculosis-induced pyroptosis in macrophages by inhibiting the HIF-1α-mediated Warburg effect.

Autoren: Wu J Liu F Shen J et al.

Quelle: Redox report : communications in free radical research [Redox Rep] 2025 Dec; Vol. 30 (1), pp. 2565861. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9511366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-2928 (Electronic) Linking ISSN: 13510002 NLM ISO Abbreviation: Redox Rep Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis*/drug effects , Macrophages*/drug effects , Macrophages*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Apigenin*/pharmacology , Glucuronates*/pharmacology , Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/pathogenicity, Animals ; Mice ; Humans ; Glycolysis/drug effects ; Inflammasomes/metabolism ; Inflammasomes/drug effects ; Tuberculosis/drug therapy ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mice, Inbred C57BL

ESAT-6 of Mycobacterium tuberculosis downregulates cofilin1, leads to filamentous actin enrichment and reduces the phagosome acidification in infected macrophages, which are partially reversed by a single methionine mutation.

Autoren: Mahesh PP Retnakumar RJ Sivakumar KC et al.

Quelle: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2025 Dec; Vol. 155, pp. 102680. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100971555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-281X (Electronic) Linking ISSN: 14729792 NLM ISO Abbreviation: Tuberculosis (Edinb) Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/pathogenicity , Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Actins*/metabolism , Macrophages*/microbiology , Macrophages*/metabolism , Cofilin 1*/metabolism , Cofilin 1*/genetics , Phagosomes*/metabolism , Phagosomes*/microbiology , Antigens, Bacterial*/genetics , Antigens, Bacterial*/metabolism , Mutation* , Methionine*/genetics , Methionine*/metabolism , Actin Cytoskeleton*/metabolism , Actin Cytoskeleton*/microbiology , Tuberculosis*/metabolism , Tuberculosis*/microbiology , Tuberculosis*/genetics, Animals ; Humans ; Down-Regulation ; Reactive Oxygen Species/metabolism ; Host-Pathogen Interactions ; Mice ; Hydrogen-Ion Concentration

Description of bacterial RNA transcripts detected in Mycobacterium tuberculosis - infected cells from peripheral human granulomas.

Autoren: Moos PJ Carey AF Joseph J et al.

Quelle: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2547326. Date of Electronic Publication: 2025 Aug 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/isolation & purification , RNA, Bacterial*/genetics , Granuloma*/microbiology , Tuberculosis*/microbiology, Humans ; Gene Expression Profiling ; Transcriptome ; Genome, Bacterial

Characterization and anti-tuberculosis effects of γδ T cells expanded and activated by Mycobacterium tuberculosis heat-resistant antigen.

Autoren: Guo F Song Y Dong S et al.

Quelle: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2462092. Date of Electronic Publication: 2025 Feb 08.

Publikationsart: Journal Article; Review; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/immunology , Antigens, Bacterial*/immunology , Tuberculosis*/immunology , Tuberculosis*/microbiology , Receptors, Antigen, T-Cell, gamma-delta*/immunology , Intraepithelial Lymphocytes*/immunology , T-Lymphocytes*/immunology, Humans ; Animals ; Lymphocyte Activation ; Cytokines/immunology ; Cytokines/metabolism ; Hot Temperature

Mycobacterium tuberculosis uses intrinsically disordered, fast evolving proteins to interact with conserved host factors.

Autoren: Pozzoli U Forni D Arrigoni F et al.

Quelle: Genome biology [Genome Biol] 2025 Nov 24; Vol. 26 (1), pp. 387. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/pathogenicity , Mycobacterium tuberculosis*/metabolism , Mycobacterium tuberculosis*/genetics , Intrinsically Disordered Proteins*/metabolism , Intrinsically Disordered Proteins*/chemistry , Intrinsically Disordered Proteins*/genetics , Host-Pathogen Interactions* , Bacterial Proteins*/metabolism , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics, Humans ; Evolution, Molecular ; Proteome ; Virulence

Chemical Synthesis of Arabinogalactans from the Mycobacterium tuberculosis Cell Wall up to the 92-mer and Structure-Conformation-Activity Relationship Studies.

Autoren: Ma Y Nieto-Fabregat F Fan H et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Nov 24; Vol. 64 (48), pp. e202515896. Date of Electronic Publication: 2025 Oct 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Galactans*/chemistry , Galactans*/chemical synthesis , Galactans*/pharmacology , Mycobacterium tuberculosis*/chemistry , Mycobacterium tuberculosis*/cytology , Cell Wall*/chemistry, Structure-Activity Relationship ; Humans ; Glycosylation

Transmission characteristics of tuberculosis in the high-TB-burden region of Southwest China.

Autoren: Yang X Ru H Chen T et al.

Quelle: Frontiers in public health [Front Public Health] 2025 Nov 19; Vol. 13, pp. 1670514. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/isolation & purification , Tuberculosis*/transmission , Tuberculosis*/epidemiology , Tuberculosis, Pulmonary*/transmission , Tuberculosis, Pulmonary*/epidemiology, Humans ; China/epidemiology ; Male ; Retrospective Studies ; Female ; Adult ; Middle Aged ; Risk Factors ; Whole Genome Sequencing ; Aged ; Adolescent ; Cluster Analysis ; Young Adult

Proposing Bromo-Epi-Androsterone for Host-Directed Therapy Against Tuberculosis.

Autoren: Dow CT Obaid L

Quelle: Pathogens (Basel, Switzerland) [Pathogens] 2025 Nov 18; Vol. 14 (11). Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article; Review; Comment

Info zur Zeitschrift: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-0817 (Electronic) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/immunology , Tuberculosis*/drug therapy , Tuberculosis*/immunology , Antitubercular Agents*/therapeutic use , Antitubercular Agents*/pharmacology , Dehydroepiandrosterone*/analogs & derivatives , Dehydroepiandrosterone*/therapeutic use , Dehydroepiandrosterone*/pharmacology, Humans ; Animals ; Mice

High-throughput cytological profiling uncovers genotype-phenotype associations in Mycobacterium tuberculosis clinical isolates.

Autoren: Liu Q Liu YJ Liu R et al.

Quelle: MSystems [mSystems] 2025 Nov 18; Vol. 10 (11), pp. e0097225. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101680636 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-5077 (Electronic) Linking ISSN: 23795077 NLM ISO Abbreviation: mSystems Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/isolation & purification , Mycobacterium tuberculosis*/cytology , Tuberculosis*/microbiology , Genetic Association Studies*/methods, Humans ; Phenotype ; Genetic Variation ; Mutation ; Genotype ; High-Throughput Screening Assays/methods

Mycobacterium tuberculosis curli pili (MTP) facilitates pathogenicity by modulating oxidative phosphorylation and carbon flux during early infection of A549 epithelial cells.

Autoren: Naidoo TJ Ashokcoomar S Truebody B et al.

Quelle: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2025 Nov 15; Vol. 21 (6), pp. 173. Date of Electronic Publication: 2025 Nov 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 101274889 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-3890 (Electronic) Linking ISSN: 15733882 NLM ISO Abbreviation: Metabolomics Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/pathogenicity , Mycobacterium tuberculosis*/metabolism , Oxidative Phosphorylation* , Fimbriae, Bacterial*/metabolism , Carbon*/metabolism , Epithelial Cells*/metabolism , Epithelial Cells*/microbiology, Humans ; A549 Cells

Discovery of novel Cytochrome bd oxidase inhibitors against Mycobacterium tuberculosis.

Autoren: Wu X Zhang X Xia W et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 118010. Date of Electronic Publication: 2025 Jul 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/enzymology , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemistry , Antitubercular Agents*/chemical synthesis , Drug Discovery* , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Oxidoreductases*/antagonists & inhibitors , Oxidoreductases*/metabolism, Microbial Sensitivity Tests ; Structure-Activity Relationship ; Molecular Structure ; Humans ; Dose-Response Relationship, Drug